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2026-ban megjelent publikációink

  1. Bartha, Á., Győrffy, B., 2026. TNMplot: An enhanced platform for pharmacological target identification through cross-stage and pan-cancer gene expression analysis. J. Pharmacol. https://doi.org/10.1111/bph.70390
  2. Fekete, J.T., Komócsi, A., Győrffy, B., 2026. NetMetaEasy: enabling rapid and user-friendly network meta-analysis (NMA) for comparative effectiveness research. J. Pharmacol. https://doi.org/10.1111/bph.70391
  3. Győrffy, B., Weltz, B., Szabó, I., 2026. A global interdisciplinary platform for academic age-normalized researcher evaluation. https://doi.org/10.1007/s11192-026-05608-y
  4. Lózsa, R., Szikriszt, B., Németh, E., Szeltner, Z., Martinek, R., Póti, Á., Feik, T., Kollarics, S., Márkus, B.G., Kanu, N., Sztupinszki, Z., Simon, F., Shibata, T., Swanton, C., Szallasi, Z., Richardson, A.L., Szüts, D., 2026. Long-term exposure to the ethanol-derived metabolite acetaldehyde elevates structural genomic alterations but not base substitutions. Biol. 9, 243. https://doi.org/10.1038/s42003-026-09521-1
  5. Meler, A., Gusi-Vives, M., de Barrios, O., Azagra, A., Collazo, O., Melchor, J., Del Monte-Monge, A., Győrffy, B., Verdu-Bou, M., Navarro, J.-T., Martín-Subero, J.I., Roué, G., Ramiro, A.R., Roa, S., Parra, M., 2026. HDAC7 is a key factor for the germinal center reaction and its underexpression is associated with DLBCL prognosis. J. Immunol. 215, vkag015. https://doi.org/10.1093/jimmun/vkag015
  6. Menyhart, O., Müller, D., Győrffy, B., DNA methylation-mediated extracellular matrix gene silencing in colorectal cancer. Semin. Oncol. 53, 152469. https://doi.org/10.1016/j.seminoncol.2026.152469
  7. Nugnes, M.V., Bouhraoua, K.E.A., Zoubiri, M., Pancsa, R., Fichó, E., DisProt Consortium, Tompa, P., Piovesan, D., Tosatto, S.C.E., Aspromonte, M.C., 2026. DisProt in 2026: enhancing intrinsically disordered proteins accessibility, deposition, and annotation. Nucleic Acids Res. 54, D383–D392. https://doi.org/10.1093/nar/gkaf1175
  8. Pósfai, B., Jenei, A., Forika, G., Fintha, A., Sápi, Z., Somorácz, Á., Dénes, B., Salamon, F., Eizler, K.V., Giba, N., Semjén, D., Illyés, I., Kovács, K.A., Munkácsy, G., Papp, J., Sánta, F., Butz, H., Kuthi, L., 2026. Hemangioblastoma of the Kidney-A Comprehensive Clinical, Pathological, and Genetic Analysis of Four Cases. APMIS Acta Pathol. Microbiol. Immunol. Scand. 134, e70147. https://doi.org/10.1111/apm.70147
  9. Szepesi-Nagy, I., Borosta, R., Szabo, Z., Tusnady, G.E., Pongor, L.S., Rona, G., 2026. Frag’n’Flow: automated workflow for large-scale quantitative proteomics in high performance computing environments. BMC Bioinformatics 27, 18. https://doi.org/10.1186/s12859-025-06305-y
  10. Ungvari, Z., Fekete, J.T., Fekete, M., Lehoczki, A., Gulej, R., Sorond, F., Liotta, E., Prodan, C.I., Toth, P., Kiss, C., Ungvari, A., Győrffy, B., 2026a. Mortality, functional outcome, and bleeding risk after early versus delayed thrombectomy. GeroScience 48, 2029–2042. https://doi.org/10.1007/s11357-025-01915-z
  11. Ungvari, Z., Fekete, M., Buda, A., Lehoczki, A., Fekete, J.T., Munkácsy, G., Varga, P., Ungvari, A., Győrffy, B., 2026b. No detectable impact of short-term treatment delays on lung cancer survival. GeroScience 48, 793–805. https://doi.org/10.1007/s11357-025-01684-9
  12. Ungvari, Z., Fekete, M., Buda, A., Lehoczki, A., Fekete, J.T., Varga, P., Ungvari, A., Győrffy, B., 2026c. Depression increases cancer mortality by 23-83%: a meta-analysis of 65 studies across five major cancer types. GeroScience 48, 293–309. https://doi.org/10.1007/s11357-025-01676-9
  13. Ungvari, Z., Fekete, M., Buda, A., Lehoczki, A., Munkácsy, G., Scaffidi, P., Bonaldi, T., Fekete, J.T., Bianchini, G., Varga, P., Ungvari, A., Győrffy, B., 2026d. Quantifying the impact of treatment delays on breast cancer survival outcomes: a comprehensive meta-analysis. GeroScience 48, 1173–1187. https://doi.org/10.1007/s11357-025-01719-1
  14. Ungvari, Z., Menyhart, O., Lehoczki, A., Fekete, M., Bianchini, G., Győrffy, B., 2026e. PCSK9 expression and cancer survival: a prognostic biomarker at the intersection of oncology and geroscience. GeroScience 48, 435–449. https://doi.org/10.1007/s11357-025-01733-3
  15. Ungvari, Z., Menyhart, O., Lehoczki, A., Fekete, M., Fazekas-Pongor, V., Ocana, A., Varga, P., Győrffy, B., 2026f. NRF2 pathway activation predicts poor prognosis in lung cancer: a cautionary note on antioxidant interventions. GeroScience 48, 1345–1356. https://doi.org/10.1007/s11357-025-01736-0
  16. Ungvári, Z., Menyhart, O., Ocana, A., Fekete, M., Lehoczki, A., Győrffy, B., Senescence-associated gene signatures predict survival in lung cancer: a multi-cohort analysis. GeroScience 48, 577–590. https://doi.org/10.1007/s11357-025-01894-1
  17. Ungvari, Z., Menyhárt, O., Ocana, A., Lehoczki, A., Fekete, M., Bianchini, G., Győrffy, B., Subtype-specific sirtuin expression signatures link mitochondrial-epigenetic networks to breast cancer survival. GeroScience. https://doi.org/10.1007/s11357-026-02143-9
  18. Huffman, B.M., Diossy, M., Yurgelun, M.B., Horick, N., Li, Y.Y., Crowdis, J., Nguyen, H., Parmar, K., Kochupurakkal, B.S., Vonk, L., Lam, H., Ramsey, K., Andrews, E., Loeb, S.C., Culnane, L., Biller, L.H., Bullock, A.J., Enzinger, A., Giannakis, M., Jackson, N.A., Ng, K., Nowak, J.A., Patel, A.K., Perez, K.J., Rattani, A., Rubinson, D.A., Schlechter, B.L., Singh, H., Cai, M., Raghavan, S., Clark, J.W., Peters, M.L., Weipert, C.M., Wolpin, B.M., D’Andrea, A.D., Shapiro, G.I., Aguirre, A.J., Szallasi, Z., Cleary, J.M., 2026. A Phase II Trial of Niraparib in Patients with Advanced Pancreatic Cancer Harboring Pathogenic Variants in ATM, BRCA1, BRCA2, PALB2, and CHEK2. Clin. Cancer Res. 32, 1666–1677. https://doi.org/10.1158/1078-0432.CCR-24-3766
  19. Kuffa, K., Langó, T., Czirók, A., Tárnoki-Zách, J., Bősze, S., László, L., Vas, V., Szabó, Z., Tusnády, G.E., 2026. Decoding the Apical–Basal Surfaceome of Colon Epithelial Cells via Side-Selective Biotinylation. Biomolecules 16, 865. https://doi.org/10.3390/biom16060865
  20. Lózsa, R., Szikriszt, B., Németh, E., Szeltner, Z., Martinek, R., Póti, Á., Feik, T., Kollarics, S., Márkus, B.G., Kanu, N., Sztupinszki, Z., Simon, F., Shibata, T., Swanton, C., Szallasi, Z., Richardson, A.L., Szüts, D., 2026. Long-term exposure to the ethanol-derived metabolite acetaldehyde elevates structural genomic alterations but not base substitutions. Commun. Biol. 9, 243. https://doi.org/10.1038/s42003-026-09521-1
  21. Meler, A., Gusi-Vives, M., de Barrios, O., Azagra, A., Collazo, O., Melchor, J., Del Monte-Monge, A., Győrffy, B., Verdu-Bou, M., Navarro, J.-T., Martín-Subero, J.I., Roué, G., Ramiro, A.R., Roa, S., Parra, M., 2026. HDAC7 is a key factor for the germinal center reaction and its underexpression is associated with DLBCL prognosis. J. Immunol. 215, vkag015. https://doi.org/10.1093/jimmun/vkag015
  22. Menyhart, O., Müller, D., Győrffy, B., DNA methylation-mediated extracellular matrix gene silencing in colorectal cancer. Semin. Oncol. 53, 152469. https://doi.org/10.1016/j.seminoncol.2026.152469
  23. Munkacsy, G., Lotz, G., Tokes, A.M., Santarpia, L., Gyorffy, B., 2026. Immune landscape in PD-L1- and TROP2-positive triple-negative breast cancer. npj Breast Cancer.
  24. Murmu, A., Győrffy, B., 2026. Targeting the HMGB1-IL32 pathway to alleviate T cell exhaustion in epithelial ovarian cancer. GeroScience 48, 3335–3350. https://doi.org/10.1007/s11357-025-01963-5
  25. Murmu, A., Lánczky, A., Győrffy, B., Integration of a clinical survival model into the KM-plotter to identify high-risk populations in breast cancer. Sci. Rep. https://doi.org/10.1038/s41598-026-60848-5
  26. Nagy, G.R., Munkácsy, G., Murmu, A., Longo, G., López, L.I., Cirigliano, V., Győrffy, B., 2026. Beyond the linear genome: how reference bias threatens preventive medicine and geroscience. GeroScience. https://doi.org/10.1007/s11357-026-02436-z
  27. Nugnes, M.V., Bouhraoua, K.E.A., Zoubiri, M., Pancsa, R., Fichó, E., DisProt Consortium, Tompa, P., Piovesan, D., Tosatto, S.C.E., Aspromonte, M.C., Monzon, A.M., Melo, A.M., Salladini, E., Leonardi, E., Quaglia, F., Nasiribavil, D., Ghafouri, H., Gobeill, J., Pasche, E., Ruch, P., Van Rijen, P., Dobson, L., Schiavina, M., Cordero, T., Kálmán, Z.E., Castro, X., Iglesias, V., Reményi, I., Mehdiabadi, M., Erdős, G., Dosztányi, Z., 2026. DisProt in 2026: enhancing intrinsically disordered proteins accessibility, deposition, and annotation. Nucleic Acids Res. 54, D383–D392. https://doi.org/10.1093/nar/gkaf1175
  28. Pachinger-Molnar, B., Menyhart, O., Systemic immune-inflammation index as a prognostic marker in pancreatic ductal adenocarcinoma: a metaanalysis. Cancer Treat. Res. Commun. 48, 101326. https://doi.org/10.1016/j.ctarc.2026.101326
  29. Pagano, F., Girone, C., Borrelli, F., Romaniello, D., Gelfo, V., Filippini, D.M., Morselli, A., Mazzeschi, M., Querzoli, G., Ambrosi, F., Miano, C., D’Uva, G., Fazi, F., Chaluvally-Raghavan, P., Sgarzi, M., Győrffy, B., Ardizzoni, A., Lauriola, M., 2026. IL-1-mediated inflammation promotes metastatic dissemination and resistance to EGFR-targeted therapy. npj Precision Oncology.
  30. Pósfai, B., Jenei, A., Forika, G., Fintha, A., Sápi, Z., Somorácz, Á., Dénes, B., Salamon, F., Eizler, K.V., Giba, N., Semjén, D., Illyés, I., Kovács, K.A., Munkácsy, G., Papp, J., Sánta, F., Butz, H., Kuthi, L., 2026. Hemangioblastoma of the Kidney—A Comprehensive Clinical, Pathological, and Genetic Analysis of Four Cases. APMIS 134, e70147. https://doi.org/10.1111/apm.70147
  31. Posta, M., Figler, A., Dobolyi, Z., Győrffy, B., 2026. A Secure, Scalable Large Language Model–Based System (CIDER) for High-Throughput Clinical Data Extraction From Medical Reports: Retrospective Validation Study. J. Med. Internet Res. 28, e95780. https://doi.org/10.2196/95780
  32. Surmann, H., Bartha, A., Győrffy, B., Kiesel, L., Hanker, L., Götte, M., 2026. Prognostic influence of small leucine-rich proteoglycans on serous ovarian cancer. J. Cancer Res. Clin. Oncol. 152, 117. https://doi.org/10.1007/s00432-026-06529-2
  33. Szepesi-Nagy, I., Borosta, R., Szabo, Z., Tusnady, G.E., Pongor, L.S., Rona, G., 2026. Frag’n’Flow: automated workflow for large-scale quantitative proteomics in high performance computing environments. BMC Bioinformatics 27, 18. https://doi.org/10.1186/s12859-025-06305-y
  34. Ungvari, Z., Fekete, M., Buda, A., Lehoczki, A., Fekete, J.T., Varga, P., Ungvari, A., Győrffy, B., 2026. Depression increases cancer mortality by 23–83%: a meta-analysis of 65 studies across five major cancer types. GeroScience 48, 293–309. https://doi.org/10.1007/s11357-025-01676-9
  35. Ungvari, Z., Fekete, M., Buda, A., Lehoczki, A., Fekete, J.T., Munkácsy, G., Varga, P., Ungvari, A., Győrffy, B., 2026. No detectable impact of short-term treatment delays on lung cancer survival. GeroScience 48, 793–805. https://doi.org/10.1007/s11357-025-01684-9
  36. Ungvari, Z., Fekete, M., Buda, A., Lehoczki, A., Munkácsy, G., Scaffidi, P., Bonaldi, T., Fekete, J.T., Bianchini, G., Varga, P., Ungvari, A., Győrffy, B., 2026. Quantifying the impact of treatment delays on breast cancer survival outcomes: a comprehensive meta-analysis. GeroScience 48, 1173–1187. https://doi.org/10.1007/s11357-025-01719-1
  37. Ungvari, Z., Menyhart, O., Lehoczki, A., Fekete, M., Fazekas-Pongor, V., Ocana, A., Varga, P., Győrffy, B., 2026. NRF2 pathway activation predicts poor prognosis in lung cancer: a cautionary note on antioxidant interventions. GeroScience 48, 1345–1356. https://doi.org/10.1007/s11357-025-01736-0
  38. Ungvari, Z., Menyhart, O., Lehoczki, A., Fekete, M., Bianchini, G., Győrffy, B., 2026. PCSK9 expression and cancer survival: a prognostic biomarker at the intersection of oncology and geroscience. GeroScience 48, 435–449. https://doi.org/10.1007/s11357-025-01733-3
  39. Ungvari, Z., Fekete, J.T., Fekete, M., Lehoczki, A., Gulej, R., Sorond, F., Liotta, E., Prodan, C.I., Toth, P., Kiss, C., Ungvari, A., Győrffy, B., Mortality, functional outcome, and bleeding risk after early versus delayed thrombectomy. GeroScience 48, 2029–2042. https://doi.org/10.1007/s11357-025-01915-z
  40. Ungvari, Z., Menyhárt, O., Ocana, A., Lehoczki, A., Fekete, M., Bianchini, G., Győrffy, B., 2026. Subtype-specific sirtuin expression signatures link mitochondrial-epigenetic networks to breast cancer survival. GeroScience 48, 3315–3334. https://doi.org/10.1007/s11357-026-02143-9
  41. Ungvari, Z., Fekete, M., Varga, P., Lehoczki, A., Grosso, G., Godos, J., Murmu, A., Ocana, A., Kiss, C., Győrffy, B., 2026. Adherence to the Mediterranean diet is associated with reduced risk of head and neck, gastric, and liver cancers: a systematic review and meta-analysis. GeroScience. https://doi.org/10.1007/s11357-026-02525-z
  42. Ungvári, Z., Menyhart, O., Ocana, A., Fekete, M., Lehoczki, A., Győrffy, B., 2026. Senescence-associated gene signatures predict survival in lung cancer: a multi-cohort analysis. GeroScience 48, 577–590. https://doi.org/10.1007/s11357-025-01894-1
  43. Varga, D., Raduly, Z., Boros-Olah, B., Nagy, E., Karanyi, Z., Halasz, L., Balint, B.L., Vamosi, G., Toth, E., Bai, P., Santangelo, S., Bossolasco, P., Ratti, A., Geli, V., Pommier, Y., Szekvolgyi, L., 2026. TOP1MT rs2293925 is an enhancer-active regulatory SNP that shapes mitochondrial R-loop dynamics. FEBS J. https://doi.org/10.1111/febs.70649
  44. Hajdú, N., Ludvig, Z., Rácz, R., Istenes, I., Békeffy, M., Vági, O.E., Körei, A.E., Horváth, E., Tóbiás, B., Illés, A., Pikó, H., Kósa, J.P., Árvai, K., Posta, M., Lakatos, P.A., Kempler, P., Putz, Z., Tordai, D.Z., 2026. Associations Between Previously Identified Genetic Variants and Clinical Phenotypes of Diabetic Neuropathy in Type 2 Diabetes: An Exploratory Analysis of the Discovery Cohort. Int. J. Mol. Sci. 27, 5487. https://doi.org/10.3390/ijms27125487

Utolsó frissítés: 2026.09.24.