Tömegspektrometriai és Elválasztástechnikai Laboratórium

1.

Fehér A, Vincze I, Rudge J, Domján G, Vásárhelyi B, Karvaly GB. Assays for monitoring apixaban and rivaroxaban in emergency settings-. State-of- the-art routine analysis, and volumetric absorptive microsamples deliver discordant results. Diagnostics (Basel) 2024;14:1939.

2.

Karvaly GB, Vásárhelyi B. Therapeutic drug monitoring and pharmacokinetics-based individualization of drug therapy. Pharmaceutics 2024;16:792.

3.

Kovácsházi C, Hambalkó S, Sayour NV, Gergely TG, Brenner GB, Pelyhe C, Kapui D, Weber BY, Hültenschmidt AL, Pállinger É, Buzás EI, Zolcsák Á, Kiss B, Bozó T, Csányi C, Kósa N, Kellermayer M, Farkas R, Karvaly GB, Wynne K, Matallanas D, Ferdinandy P, Giricz Z. Effect of hypercholesterolaemia on circulating and cardiomyocyte-derives extravcellular vesicles. Sci Rep 2024;14:12016.

4.

Karvaly GB, Vincze I, Neely MN, Zátroch I, Nagy Z, Kocsis I, Kopitkó Cs. Modeling pharmacokinetics in individual patients using therapeutic drug monitoring and artificial populaion quasi-models: a study with piperacillin. Pharmaceutics 2024;16:358.

5.

Gulyás E, Horváth IL, Engh MA, Bunduc S, Dembrovszky F, Fehérvári P, Bánvölgyi A, Csupor D, Hegyi P, Karvaly GB. Assessment of the practical impact of adjusting beta-lactam dosages based on therapeutic drug monitoring in critically ill adult patients: a systematic review and meta- analysis of randomized clinical trials and observational studies. Sci Rep 2024;14:7793.

6.

Karvaly G, Kovács K, Gyarmati M, Gerszi D, Nagy S, Jalal DA, Tóth Z, Vásárhelyi B, Gyarmati B. Reference data on estrogen metabolome in healthy pregnancy. Mol Cell Probes 2024;74:101953.

7.

Bányai B, Vass Z, Kiss S, Balogh A, Brandhuber D, Karvaly G, Kovács K, Nádasy GL, Hunyady L, Dörnyei G, Horváth EM, Szekeres M. Role of CB1 cannabinoid receptors in vascular responses and vascular remodeling of the aorta in female mice. Int J Mol Sci 2023;24:16429.

8.

Holub L, Szabó BG, Závorszky L, Hümpfner R, Andréka P, Karvaly GB, Lakatos B. Kritikus állapotú szeptikus felnőtt betegek antibiotikumkezelésének farmakokinetikai és farmakodinamikai megfontolásai. Orv Hetil 2024;165:403-15.

9.

Závorszky L, Rádler A, Galgóczi J, Tóth B, Csomós Á, Erőss A, Farkas R, Karvaly G, Holub L, Szabó BG, Lakatos B. Therapeutic drug monitoring of beta-lactam antibiotics in critically ill adult patients. Orv Hetil 2023;164:1904-1911.

10.

Gerszi D, Orosz G, Török M, Szalay B, Karvaly G, Orosz L, Hetthéssy J, Vásárhelyi B, Török O, Horváth EM, Várbíró S. Risk estimation of gestational diabetes mellitus in the first trimester. J Clin Endocrinol Metab 2023;108:e1214-e1223.

11.

Kópházi LK, Kárpáthi IK, Kesztyűs V, Holndonner-Kirst E, Gulyás E, Karvaly GB, Gál J, Hermann CG,. A modern intenzív terápia kihívása: az elhúzódó kritikus állapot kórélettani háttere és terápiás lehetőségei. Orv Hetil 2023;164:702-712.

12.

Köllő Z, Garami M, Vincze I, Vásárhelyi B, Karvaly GB. Therapeutic monitoring of orally administered, small-molecule anticancer medications with tumor-specific cellular protein targets in peripheral fluid spaces – a review. Pharmaceutics 2023;15:239.

13.

Csöndör É, Karvaly GB, Ligetvári R, Kovács K, Komka Z, Móra Á, Stromájer-Rácz T, Oláh A, Tóth M, Ács P. Adrenal, gonadal and peripheral steroid changes in response to extreme physical stress for characterizing load capacity in athletes. Metabolites 2022;12:91.

14.

Karvaly GB, Vincze I, Balogh A, Köllő Z, Bödör C, Vásárhelyi B. A high- throughput clinical laboratory methodology for the theapeutic monitoring of ibrutinib and dihydrodiol ibrutinib. Molecules 2022;27:4766.

15.

Kovács K, Karvaly GB, Farkas R, Vásárhelyi B. Az aszimmetrikus és szimmetrikus dimetilált arginin (ADMA/SDMA) klinikai és diagnosztikai jelentősége. Orv Hetil 2022;163:500-505.

16.

Vincze I, Czermann R, Nagy Z, Kovács M, Neely MN, Farkas R, Kocsis I, Karvaly G, Kopitkó Cs. Assessment of antibiotic pharmacokinetics, molecular biomarkers and clinical status in critically ill adults diagnosed with community-acquired pneumonia and receiving intravenous piperacillin/tazobactam and hydrocortisone over the first five days of intensive care: an observational study (STROBE-compliant). J Clin Med 2022;11:4140.

17.

Barta BA, Ruppert M, Frühlich KE, Contreras M de JM, Oláh A, Sayour AA, Kovács K, Karvaly GB, Biniossek M, Merkely B, Schilling O, Radovits T. Sex-related differences of early cardiac functional and proteomic alterations in a rat model of myocardial ischemia. J Transl Med 2021;42:ehab724.3261.

18.

Aczél T, Körtési T, Kun J, Urbán P, Bauer W, Herczeg R, Farkas R, Kovács K, Vásárhelyi B, Karvaly GB, Gyenesei A, Tuka B, Tajti J, Vécsei L, Bölcskei K, Helyes Z. Identification of disease-and headache-specific mediators and pathways in migraine using blood transcriptomic and metabolomic analysis. J Headache Pain 2021;22:1-18.

19.

Karvaly GB, Karádi I, Vincze I, Neely MN, Trojnár E, Prohászka Z, Imreh É, Vásárhelyi B, Zsáry A. A pharmacokinetics-based approach to the monitoring of pateint adherence to atorvastatin therapy. Pharmacol Res Perspect 2021;9:e00856.

20.

Karvaly GB, Vincze I, Karádi I, Vásárhelyi B, Zsáry A. Sensitive, high- throughput liquid chromatography-tandem mass spectrometry analysis of atorvastatin and its pharmacologically active metabolites in serum for supporting precision pharmacotherapy. Molecules 2021;26:1324.

21.

Vincze I, Rudge J, Vásárhelyi B, Karvaly GB. Analysis of 14 drugs in dried blood microsamples in a single workflow using blood and serum calibrators. Bioanalysis 2020;12:1243-1261.

22.

Karvaly GB, Neely MN, Kovács K, Vincze I, Vásárhelyi B, Jelliffe RW. Development of a methodology to make individual estimates of the precision of liquid chromatography-tandem mass spectrometry drug assay results for use in population pharmacokinetic modeling and the optimization of dosage regimens. Plos One 2020;15:e0229873.

23.

Sumánszki Cs, Kovács K, Karvaly GB, Kiss E, Simon E, Patócs A, Tóth M, Komka Zs, Reismann P. Metabolic and catecholamine response to sympathetic stimulation in early-treated adult male patients with phenylketonuria. Hormones (Athens) 2020;19:395-402.

24.

Kalász H, Szimrók Z, Karvaly G, Adeghate J, Tekes K. Pharmacokinetics of two chlorine-substituted bis-pyridinium mono-aldoximes with regenerating effect of butyrylcholinesterase. Molecules 2020;25:1250.

25.

Tekes K, Karvaly G, Nurulain S, Kuca K, Musilek K, Adeghate E, Jung Y- S, Kalász H. Pharmacokinetics of K117 and K127, two novel antidote candidates to treat Tabun poisoning. Chem-biol Interact 2019;310:108737.

26.

Kovács K, Vásárhelyi B, Gyarmati B, Karvaly G. Az ösztrogén metabolizmus várandósság alatt. Orv Hetil 2019;160:1007-1014.