of Semmelweis University
48 days
21 hours
39 min
30 sec

Hungarian Brain Research Program (HBRP) 2.0
NAP research groups of Semmelweis University


National Brain Research Program to be continued
http://nkfih.gov.hu/the-office/press-coverage/national-brain-research

 

Project: The role of secretagogin, a calcium-sensor protein in the mammalian brain

Research group: Experimental Neuroanatomical and Developmental Biology Group
Leader:    Dr. Alán Alpár
E-mail: alpar.alan@med.semmelweis-univ.hu
Institute: Department of Anatomy, Histology and Embryology

Research topic

Neurodegenerative disorder, developmental neurobiology, cell migration, neuronal differentiation.

Duration: 01.12.2017 – 30.11.2021

Weblink: http://semmelweis.hu/anatomia/research/laboratories/400-2/

 

Project: Integrated genomic and biochemical examinations in neurodegenerative diseases for the recognition of the basic molecular aspects of the disease and for the improvement of new therapy targets

Leader:    Dr. Veronika Ádám, Dr. Mária Judit Molnár
E-mail: 
adam.veronika@med.semmelweis-univ.hu; molnarmj@gmail.com
Institutes: Department of Medical Biochemistry & Institute of Genomic Medicine and Rare Disorders

Research topic

Molecular mechanisms and clinical biomarkers in neurodegenerative disorders (mitochondrial diseases, oxidative stress, reactive oxygen species, dihydrolipoamide dehydrogenase mutants, glycerophosphate shunt, glycerophosphate dehydrogenase, succinyl-CoA ligase, methylene blue, alpha-ketoglutarate dehydrogenase complex).
Providing genomic and biochemical examinations in neurodegenerative diseases (dementia and Parkinson disease), and comparison of the results and the phenotype.  Research of the molecular basics of the disease, and identification of new therapy targets.

Duration: 01.12.2017 – 30.11.2021

Weblink: http://semmelweis.hu/biokemia/scientific-research-2/neurobiochemistry-research-divisions/

 

Project: Identification of new antidepressant drug targets

Leader:    Prof. György Bagdy, PhD, DSc
E-mail: bag13638@iif.hu
Institute: Department of Pharmacodynamics

Research topic

The research group tries to identify new drug targets for the treatment of depression. They are mapping the entire genome searching for unknown genetic variants that could lead to the development of the disease. Keywords: depression, anxiety, genetics, antidepressants, personality traits, temperaments, environmental stress, financial difficulties, drug discovery, NewMood, GWAS, microarray.

Duration: 01.12.2017 – 30.11.2021

Weblink: http://semmelweis.hu/gyogyszerhatastan/nap-a-research-group/

 

Project: Electromagnetic tomography and multimodal imaging to uncover brain mechanisms of psychiatric disorders

Research group: High density EEG and multimodal imaging in psychiatry
Leaders: Prof. Dr. István Bitter (Clinical), Dr. Pál Czobor (EEG/Imaging)
E-mail: 
bitter.istvan@med.semmelweis-univ.hu; czobor.pal@med.semmelweis-univ.hu
Clinic: Department of Psychiatry and Psychotherapy

Research topic

To gain better insight into the neurobiological underpinnings of mental disorders, we propose to build on our prior infrastructure and EEG source localization results with a further extension of the established methodology. Planning to build on a collaboration with other research groups, including the SE MR Kutató központ (MRKK), our general aim is to augment the EEG-source localization approaches, with a combined, multimodal imaging using EEG and fMRI simultaneously. This would offer a unique opportunity to gain further insights, at an enhanced spatial resolution, into the impairments of brain processes and structures we have identified in the initial project phase. The complementarity of these approaches, and the fusion of their data, is considered critical for a better understanding of the pathophysiology of psychiatric conditions, neurologic, neurovascular and neurodegenerative diseases.

Duration: 01.12.2017 – 30.11.2021

 

Project: Collection of human brain tissue samples for scientific research

Research group: SE-NAP – Human Brain Tissue Bank Microdissection Laboratory
Leader:    Dr. Éva Renner Dobolyiné
E-mail: renner.eva@med.semmelweis-univ.hu
Institute: Human Brain Tissue Bank / Department of Anatomy, Histology and Embryology

Research topic

Extension of the donor program, the microdissection capacity and the scientific collaboration activity with Hungarian research laboratories participating in the NAP project. Providing microdissected human brain samples suitable exploratory and clinical research studies.

Duration: 01.12.2017 – 30.11.2021

Weblink: http://semmelweis.hu/hbtb/nap-project/

 

Project: Cognitive translational behavioural pharmacology research

Research group: Cognitive Translational Behavioural Pharmacology Group
Leader: Dr. István Gyertyán
Email: gyertyan.istvan@med.semmelweis-univ.hu
Institute: Department of Pharmacology and Pharmacotherapy

Research topic

Establishment of a cognitive test battery with high translational value, CNS drug research.

Duration: 01.12.2017 – 30.11.2021

Weblink: http://semmelweis.hu/pharmacology/establishment-of-a-cognitive-test-battery-with-high-translational-value/

 

Project: Functional magnetic resonance imaging (MRI) and genetic biomarker investigations in migraine

Research group: SE-NAP 2 Genetic Brain Imaging Migraine Research Group
Leader:    Dr. Gabriella Juhász, PhD, associate professor
E-mail: juhasz.gabriella@pharma.semmelweis-univ.hu
Institute: Department of Pharmacodynamics

Research topic

The aim of the research group is to identify migraine specific biomarkers and new drug targets by investigating the neural response (brain activity) and genetics of people with migraine, tension headache and in healthy control subjects.

Duration: 01.12.2017 – 30.11.2021

Weblink: http://semmelweis.hu/gyogyszerhatastan/nap-2-research-groups/se-nap-2-genetic-brain-imaging-migraine-research-group/

 

Project: Clinicomorphological studies in degenerative nervous system disorders

Leader:    Dr. Tibor Kovács
E-mail: kovacs.tibor@med.semmelweis-univ.hu
Institute: Department of Neurology

Research topic

Alzheimer’s disease (AD) and Parkinson’s disease (PD) are the most frequent degenerative disorders of the central nervous system. Both disorders develop slowly, starting with a preclinical phase, followed by mild symptoms progressing to dementia and movement disorders, respectively.
Factors influencing the progression of the disease development and the efficacy of the cholinergic and dopaminergic therapy are scarcely known. Most of the data are about the coexisting vascular risk factors, mainly in AD, but the distinction between macro- and microvascular risk factors is rare. Clinical parameters and factors influencing the progression of AD and PD in their different stages, markers of co-existing Lewy-body pathology in AD, the effect of coexisting vascular factors and factors modifying the effect of cholinergic and dopaminergic therapies are planned to be studied by clinical and neuropathological research methods.

Duration: 01.12.2017 – 30.11.2021

 

Project: De novo mutations and rare genetic variants in schizophrenia and attention-deficit hyperactivity disorder: Investigations using genetic analysis, in vitro cellular modelling, and functional brain imaging

Research group: Molecular Psychiatry and in vitro Disease Modelling Research Group
Leader:    Dr. János Réthelyi
E-mail: rethelyi.janos@med.semmelweis-univ.hu
Institutions: Department of Psychiatry and Psychotherapy & Department of Medical Chemistry, Molecular Biology and Pathobiochemistry

Research topic

Schizophrenia, exome sequencing, induced pluripotent stem cells (IPSCs), in vitro disease modelling, psychiatric genetics, epigenetics.

Duration: 01.01.2018 – 31.12.2021

 

Project: Genomic analysis of brain metastases

Research group: Brain Metastasis Research Group
Leader:    Dr. Zoltán Szállási (Boston Children’s Hospital, Harvard Medical School)
E-mail: Zoltan.Szallasi@childrens.harvard.edu
Institute: 2nd Department of Pathology, Semmelweis University, Budapest, Hungary

Research topic

Next generation sequencing of tumour brain metastases, whole exome sequencing, whole genome sequencing. In this project we establish a brain metastasis biobank in lung-, colorectal-, breast cancers and malignant melanoma as the most frequent causes. Sources will be collection of samples from brain metastasis surgeries (from collaborating Neurosurgery Departments), autopsies (from collaborating Pathology Departments) and from our own retrospective pathology archives. We will analyse the genomic evolution of brain metastasis of lung-, breast-, colorectal cancers and malignant melanoma. Next generation sequencing will be used to compare brain metastases to the primary tumour of the four cancer types in order to identify the genetic mechanisms enabling various tumours to establish brain metastasis.

Duration: 01.12.2017 – 30.11.2021

 

Previous HBRP 1.0 Research Group


Project: Complex functional and imaging examinations in diseases of the peripheral nervous system

Research group: Peripheral Nervous System Research Group
Leader:    Dr. Zsuzsanna Arányi, PhD, med.habil.
E-mail: aranyi.zsuzsanna@med.semmelweis-univ.hu
Clinic: Department of Neurology

Research topic

High-resolution ultrasound of peripheral nerves.

Duration: 22.04.2014 – 31.12.2017