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Hungarian Brain Research Program

Hungarian Brain Research Program
NAP research groups of Semmelweis University

NAP-A PROJECTS:

Project: Bioelectric Brain Imaging and Functional Connectivity Mapping for the investigation of Neural mechanisms of Psychiatric Diseases

Leaders: Prof. Dr. István Bitter, Dr. Pál Czobor
E-mail:
bitter.istvan@med.semmelweis-univ.hu; czobor.pal@med.semmelweis-univ.hu
Mob: +36-20-825-0171
Clinic: Department of Psychiatry and Psychotherapy

Research topic

The general aim is to develop a high-density, 256-channel measurement system for EEG tomography which allows for the precise temporal and spatial characterization of neurobiological processes impaired in psychiatric illnesses. We hypothesize that a deficient pattern of functional connectivity will be manifested in neural networks that subserve the critical emotion- and information processing functions as well as behavioral monitoring, inhibition, and cognitive control processes (e.g., lateral pre-frontal, medial and orbitofrontal regions). The Semmelweis University Department of Psychiatry and Psychotherapy will serve as the projects facility (SE PPK), where an already available system will be further expanded, and made portable during the project. Besides the investigation in laboratory environment, this would allow EEG recordings at the bedside. It would also permit examinations off-site.

Duration: 2014-2017

 

Project: Integrated genomic and biochemical examinations in neurodegenerative diseases for the recognition of the basic molecular aspects of the disease and for the improvement of new therapy targets

Leader:    Dr. Veronika Ádám, Dr. Mária Judit Molnár
E-mail:
adam.veronika@med.semmelweis-univ.hu; molnarmj@gmail.com
Tel: +36-1-267-0031, +36-1-459-1492
Institutes: Department of Medical Biochemistry & Institute of Genomic Medicine and Rare Disorders

Research topic

Molecular mechanisms and clinical biomarkers in neurodegenerative disorders (mitochondrial diseases, oxidative stress, reactive oxygen species, dihydrolipoamide dehydrogenase mutants, glycerophosphate shunt, glycerophosphate dehydrogenase, succinyl-CoA ligase, methylene blue, alpha-ketoglutarate dehydrogenase complex). Providing genomic and biochemical examinations in neurodegenerative diseases (dementia and Parkinson disease), and comparison of the results and the phenotype. Research of the molecular basics of the disease, and identification of new therapy targets.

Duration: 01.12.2013 – 30.11.2017

Weblink: http://semmelweis.hu/biokemia/scientific-research-2/neurobiochemistry-research-divisions/

 

Project: Identification of new antidepressant drug targets

Leader:    Prof. György Bagdy, PhD, DSc
E-mail: bag13638@iif.hu
Tel:
+36-1-210-4411, +36-1-459-1500 ext. 56331, 56336, 56217
Institute: Department of Pharmacodynamics

Research topic

The research group tries to identify new drug targets for the treatment of depression. They are mapping the entire genome searching for unknown genetic variants that could lead to the development of the disease. Keywords: depression, anxiety, genetics, antidepressants, personality traits, temperaments, environmental stress, financial difficulties, drug discovery, NewMood, GWAS, microarray.

Duration: 01.12. 2014 – 30.11.2017

Weblink: http://semmelweis.hu/gyogyszerhatastan/nap-a-research-group/

 

Project: Collection of human brain tissue samples for scientific research

Research group: MTA-SE-NAP-A Human Brain Tissue Bank Microdissection Laboratory

Leader:    Dr. Éva Renner Dobolyiné
E-mail: renner.eva@med.semmelweis-univ.hu
Tel: +36-1-215-6920 ext. 53634
Institute: Human Brain Tissue Bank /Department of Anatomy, Histology and Embryology

Research topic

Extension of the donor program, the microdissection capacity and the scientific collaboration activity with Hungarian research laboratories participating in the NAP project. Providing microdissected human brain samples suitable exploratory and clinical research studies.

Duration: 12.01.2013 – 11.30.2017

Weblink: http://semmelweis.hu/hbtb/nap-project/

 

NAP-B PROJECTS:

 

Project: The role of secretagogin, a calcium-sensor protein in the mammalian brain

Research group: Experimental Neuroanatomical and Developmental Biology Group

Leader:    Dr. Alán Alpár
E-mail: alpar.alan@med.semmelweis-univ.hu
Tel: +36-1-459-1500 ext. 53609
Institute: Department of Anatomy, Histology and Embryology

Research topic

Neurodegenerative disorder, developmental neurobiology, cell migration, neuronal differentitation.

Duration: 01.04.2014 – 31.12.2017

Weblink: http://semmelweis.hu/anatomia/research/laboratories/400-2/

 

Project: Complex functional and imaging examinations in diseases of the peripheral nervous system

Research group: Peripheral Nervous System Research Group

Leader:    Dr. Zsuzsanna Arányi, PhD, med.habil.
E-mail: aranyi.zsuzsanna@med.semmelweis-univ.hu
Tel: +36-1-210-0330
Clinic: Department of Neurology

Research topic

High resolution ultrasound of peripheral nerves.

Duration: 22.04.2014 – 31.12.2017

 

Project: Cognitive translational behavioural pharmacology research

Research group: Cognitive Translational Behavioural Pharmacology Group

Leader: Dr. István Gyertyán
Email: gyertyan.istvan@med.semmelweis-univ.hu
Tel: +36-1-459-1500 ext. 56560
Institute: Department of Pharmacology and Pharmacotherapy

Research topic

Establishment of a cognitive test battery with high translational value, CNS drug research.

Duration: 01.08.2014 – 31.12.2017

Weblink: http://semmelweis.hu/pharmacology/establishment-of-a-cognitive-test-battery-with-high-translational-value/

 

Project: Functional magnetic resonance imaging (MRI) and genetic biomarker investigations in migraine

Research group: MTA-SE-NAP B Genetic Brain Imaging Migraine Research Group

Leader:    Dr. Gabriella Juhász, PhD
E-mail: gabriella.juhasz@manchester.ac.uk
Tel: +36-1-459-1500 ext. 56362
Institute: Department of Pharmacodynamics

Research topic

Migraine, stress, brain imaging biomarkers, psychological stress-reduction, genetic regulatory mechanisms.

Duration: 01.01.2015 – 31.12.2017

Weblink: http://semmelweis.hu/gyogyszerhatastan/nap-b-research-group/

 

Project: Invetigating molecular and cellular alterations in schizophrenia using next generation sequencing and induced pluripotent stem cell based in vitro disease modelling

Research group: Molecular Psychiatry and in vitro Disease Modelling Research Group

Leader:    Dr. Zsófia Nemoda (Previous group leader: Dr. János Réthelyi)
E-mail: nemoda.zsofia@med.semmelweis-univ.hu
Tel:
+36-1-210-0336
Institutions: Department of Medical Chemistry, Molecular Biology and Pathobiochemistry & Department of Psychiatry and Psychotherapy

Research topic

Schizophrenia, exome sequencing, induced pluripotent stem cells (IPSCs), in vitro disease modelling, psychiatric genetics, epigenetics.

Duration: 01.05.2015 – 31.12.2017

 

Project: Genomic analysis of brain metastases

Research group: Brain Metastasis Research Group

Leader:    Dr. Zoltán Szállási (Boston Children’s Hospital, Harvard Medical School)
E-mail: Zoltan.Szallasi@childrens.harvard.edu
Mob:
+36-30-486-1821
Institute: 2nd Department of Pathology, Semmelweis University, Budapest, Hungary

Research topic

Next generation sequencing of tumor brain metastases, whole exome sequencing, whole genome sequencing. In this project we establish a brain metastasis biobank in lung-, colorectal-, breast cancers and malignant melanoma as the most frequent causes. Sources will be collection of samples from brain metastasis surgeries (from collaborating Neurosurgery Departments), authopsies (from collaborating Pathology Departments) and from our own retrospective pathology archives. We will analyse the genomic evolution of brain metastasis of lung-, breast-, colorectal cancers and malignant melanoma. Next generation sequencing will be used to compare brain metastases to the primary tumor of the four cancer types in order to identify the genetic mechanisms enabling various tumors to establish brain metastasis.

Duration: 01.10.2014 – 30.09.2017