Hungarian Brain Research Program
NAP research groups of Semmelweis University
Project: Bioelectric Brain Imaging and Functional Connectivity Mapping for the investigation of Neural mechanisms of Psychiatric Diseases
Leaders: Prof. Dr. István Bitter, Dr. Pál Czobor
E-mail: firstname.lastname@example.org; email@example.com
Clinic: Department of Psychiatry and Psychotherapy
The general aim is to develop a high-density, 256-channel measurement system for EEG tomography which allows for the precise temporal and spatial characterization of neurobiological processes impaired in psychiatric illnesses. We hypothesize that a deficient pattern of functional connectivity will be manifested in neural networks that subserve the critical emotion- and information processing functions as well as behavioral monitoring, inhibition, and cognitive control processes (e.g., lateral pre-frontal, medial and orbitofrontal regions). The Semmelweis University Department of Psychiatry and Psychotherapy will serve as the projects facility (SE PPK), where an already available system will be further expanded, and made portable during the project. Besides the investigation in laboratory environment, this would allow EEG recordings at the bedside. It would also permit examinations off-site.
Project: Integrated genomic and biochemical examinations in neurodegenerative diseases for the recognition of the basic molecular aspects of the disease and for the improvement of new therapy targets
Leader: Dr. Veronika Ádám, Dr. Mária Judit Molnár
E-mail: firstname.lastname@example.org; email@example.com
Tel: +36-1-267-0031, +36-1-459-1492
Institutes: Department of Medical Biochemistry & Institute of Genomic Medicine and Rare Disorders
Molecular mechanisms and clinical biomarkers in neurodegenerative disorders (mitochondrial diseases, oxidative stress, reactive oxygen species, dihydrolipoamide dehydrogenase mutants, glycerophosphate shunt, glycerophosphate dehydrogenase, succinyl-CoA ligase, methylene blue, alpha-ketoglutarate dehydrogenase complex). Providing genomic and biochemical examinations in neurodegenerative diseases (dementia and Parkinson disease), and comparison of the results and the phenotype. Research of the molecular basics of the disease, and identification of new therapy targets.
Duration: 01.12.2013 – 30.11.2017
Project: Identification of new antidepressant drug targets
Leader: Prof. György Bagdy, PhD, DSc
Tel: +36-1-210-4411, +36-1-459-1500 ext. 56331, 56336, 56217
Institute: Department of Pharmacodynamics
The research group tries to identify new drug targets for the treatment of depression. They are mapping the entire genome searching for unknown genetic variants that could lead to the development of the disease. Keywords: depression, anxiety, genetics, antidepressants, personality traits, temperaments, environmental stress, financial difficulties, drug discovery, NewMood, GWAS, microarray.
Duration: 01.12. 2014 – 30.11.2017
Project: Collection of human brain tissue samples for scientific research
Research group: MTA-SE-NAP-A Human Brain Tissue Bank Microdissection Laboratory
Leader: Dr. Éva Renner Dobolyiné
Tel: +36-1-215-6920 ext. 53634
Institute: Human Brain Tissue Bank /Department of Anatomy, Histology and Embryology
Extension of the donor program, the microdissection capacity and the scientific collaboration activity with Hungarian research laboratories participating in the NAP project. Providing microdissected human brain samples suitable exploratory and clinical research studies.
Duration: 12.01.2013 – 11.30.2017
Project: The role of secretagogin, a calcium-sensor protein in the mammalian brain
Research group: Experimental Neuroanatomical and Developmental Biology Group
Leader: Dr. Alán Alpár
Tel: +36-1-459-1500 ext. 53609
Institute: Department of Anatomy, Histology and Embryology
Neurodegenerative disorder, developmental neurobiology, cell migration, neuronal differentitation.
Duration: 01.04.2014 – 31.12.2017
Project: Complex functional and imaging examinations in diseases of the peripheral nervous system
Research group: Peripheral Nervous System Research Group
Leader: Dr. Zsuzsanna Arányi, PhD, med.habil.
Clinic: Department of Neurology
High resolution ultrasound of peripheral nerves.
Duration: 22.04.2014 – 31.12.2017
Project: Cognitive translational behavioural pharmacology research
Research group: Cognitive Translational Behavioural Pharmacology Group
Leader: Dr. István Gyertyán
Tel: +36-1-459-1500 ext. 56560
Institute: Department of Pharmacology and Pharmacotherapy
Establishment of a cognitive test battery with high translational value, CNS drug research.
Duration: 01.08.2014 – 31.12.2017
Project: Functional magnetic resonance imaging (MRI) and genetic biomarker investigations in migraine
Research group: MTA-SE-NAP B Genetic Brain Imaging Migraine Research Group
Leader: Dr. Gabriella Juhász, PhD
Tel: +36-1-459-1500 ext. 56362
Institute: Department of Pharmacodynamics
Migraine, stress, brain imaging biomarkers, psychological stress-reduction, genetic regulatory mechanisms.
Duration: 01.01.2015 – 31.12.2017
Project: Invetigating molecular and cellular alterations in schizophrenia using next generation sequencing and induced pluripotent stem cell based in vitro disease modelling
Research group: Molecular Psychiatry and in vitro Disease Modelling Research Group
Leader: Dr. Zsófia Nemoda (Previous group leader: Dr. János Réthelyi)
Institutions: Department of Medical Chemistry, Molecular Biology and Pathobiochemistry & Department of Psychiatry and Psychotherapy
Schizophrenia, exome sequencing, induced pluripotent stem cells (IPSCs), in vitro disease modelling, psychiatric genetics, epigenetics.
Duration: 01.05.2015 – 31.12.2017
Project: Genomic analysis of brain metastases
Research group: Brain Metastasis Research Group
Leader: Dr. Zoltán Szállási (Boston Children’s Hospital, Harvard Medical School)
Institute: 2nd Department of Pathology, Semmelweis University, Budapest, Hungary
Next generation sequencing of tumor brain metastases, whole exome sequencing, whole genome sequencing. In this project we establish a brain metastasis biobank in lung-, colorectal-, breast cancers and malignant melanoma as the most frequent causes. Sources will be collection of samples from brain metastasis surgeries (from collaborating Neurosurgery Departments), authopsies (from collaborating Pathology Departments) and from our own retrospective pathology archives. We will analyse the genomic evolution of brain metastasis of lung-, breast-, colorectal cancers and malignant melanoma. Next generation sequencing will be used to compare brain metastases to the primary tumor of the four cancer types in order to identify the genetic mechanisms enabling various tumors to establish brain metastasis.
Duration: 01.10.2014 – 30.09.2017