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MTA-SE “Momentum” Program

Research groups of the Hungarian Academy of Sciences and Semmelweis University

MTA-SE “Momentum” Peroxidase Enzyme Research Group

Project leader:     Prof. Dr. Miklós Geiszt – Department of Physiology
E-mail: geiszt.miklos@med.semmelweis-univ.hu
Tel: +36-1-459-1500 ext. 60415
Research topic:
The production and effects of reactive oxygen species (ROS), analysis of peroxidase enzymes

Duration: 2011-2016

 

MTA-SE “Momentum” Diabetes Research Group

Project leader:     Dr. Andrea Fekete – 1st Department of Paediatrics
E-mail: fekete.andrea@med.semmelweis-univ.hu
Tel:
+36-1-210-2930 ext. 52712
Research topic:
New mechanisms of action and point of attack of drugs in the treatment of conditions leading to chronic renal failure: diabetes in focus

Overview

Diabetes mellitus is an endemic disease, its prevention and treatment is a high priority task of health care and society. The concomitant diseases evolving from diabetes determine the patients’ quality of life and their life expectancy. Up till now there have been no data available that would be able to forecast the development and evolution of complications resulting from diabetes in case of individual patients.

Duration: 2011-2017

 
 MTA-SE “Momentum” Neurobiochemistry Research Group

Project leader:     Dr. Christos Chinopoulos – Department of Medical Biochemistry
E-mail: chinopoulos.christos@med.semmelweis-univ.hu
Mobile: +36-20-666-0024
Research topic:
The identification of components responsible for reduced permeability of the mitochondrial membrane

Overview

The mechanisms of mitochondria or organelles have a key role in the human organism: they convert the energy of the consumed food into a functional “currency”.

Adenosine triphosphate (ATP), which is a universal energy currency, can be used for any kind of energy consuming process by the cell, such as in case of muscle contractions. External (eg. toxin) or internal (the release of free radicals) impacts are able to convert mitchondria into ATP consumers instead of ATP producers. Moreover, they may generate mitochondrial swelling which can lead to the rupture of organelles. This process releases molecules which cause cell death by spreading to different parts of the cell.

Dr. Christos Chinopoulos aims to identify this mechanism with the help of proteomics, the large-scale study of proteins. (Source: mta.hu)

Duration: 2012-2017

 

MTA-SE “Momentum” Ion Channel Research Group

Project leader:     Dr. László Csanády – Department of Medical Biochemistry
E-mail: csanady.laszlo@med.semmelweis-univ.hu
Tel: +36-1-459-1500 ext. 60048
Research topic:
The structure and functions of CFTR and TRPM2 ion channels. Understanding the conserved mechanisms of ABC proteins

Overview

The quantitative study of the mechanisms of CFTR-ion channels (source: mta.hu)

László Csanády studies ion channels that are found within cells and function as the pores of transmembrane proteins. Transmembrane proteins are building blocks of cells reaching over the entire diameter of the cell’s membrane and are connected to both of its surfaces transporting substrates across extra- and intracellular membranes.

The research is aimed at the study of the CFTR-channel, a type of protein present in the human body in large quantities, which transports chloride ions through the epithelial surfaces. Mutations of the CTR-channel leads to the development of the most frequent congenital metabolic disorder, cystic fibrosis (CF).

The research focusing on this protein, member of the ABC family, aims to identify the structure and mechanisms of other similar proteins and at the same time may find a treatment for cystic fibrosis, still incurable today.

László Csanády pays dedicated attention to new generation researchers. His objective is to create a strong and highly qualified research community, which will be able to achieve internationally competitive and recognised results.

Duration: 2012-2017

 

MTA-SE “Momentum” Cardiovascular Research Group

Project leader:     Dr. Pál Maurovich-Horvát, PhD, MPH – Heart and Vascular Center
E-mail: office@cirg.hu; p.maurovich-horvat@cirg.hu
Mob: +36-20-825-6889
Research topic:
The study of vulnerable coronary plaques: form genomics to imaging biomarkers

Overview

The research aims to support the early prevention of heart attack, thus having a potentially significant impact on public health. The objective of the research group is the early identification of the formation of atherosclerotic plaques in the coronary arteries by the combined use of new biomarkers and various imaging technologies. In two thirds of the patients the rupture of the coronary plaques causes heart attack or sudden cardiac arrest without any warning symptoms. However, at the moment there is no diagnostic procedure available that could predict the risk of the rupture of the plaques. The research group may reach conclusions that could further reduce txhe high mortality rate of patients with cardiovascular diseases. Moreover, the research also aims at the development of cardiovascular risk assessment with the help of big data and other IT methods.

Duration: 2013-2018

 

MTA-SE “Momentum” Inflammation Physiology Research Group

Project leader:     Prof. Dr. Attila Mócsai – Department of Physiology
E-mail: mocsai.attila@med.semmelweis-univ.hu
Tel: +36-1-459-1500 ext. 60409
Research topic:
Signal transmission of myeloid cells in inflammatory diseases

Overview

The exploration of the mechanisms forming inflammatory diseases and the identification of new drug development targets. Inflammatory diseases are a great concern for society, but their origin is barely known, thus the development of new therapies is slow. The role of two intracellular signal transmission molecules is being researched in case of the formation of a rare autoimmune cutaneous disorders and contact dermatitis. The objective is to reach internationally competitive results which serve Hungary and the Hungarian scientific community.

Duration: 2013-2018

 

MTA-SE “Momentum” Hereditary Endocrine Tumours Research Group

Project leader:     Dr. Attila Patócs – Department of Laboratory Medicine
E-mail: patocs.attila@med.semmelweis-univ.hu
Tel:
+36-1-459-1500 ext. 55545
Research topic:
Genetic, epigenetic and biochemical markers in hereditary endocrine diseases

Overview

The objective of the research group is the complex genetic and genomic analysis of the tumours of the hormone system in order to identify new pathomechanisms and markers. The research primarily targets the study of tumours developing from hereditary endocrine syndromes, but the examination of the identified variations will be carried out in case of sporadic tumours as well. The second part of the research studies the molecular process of glucocorticoid sensitivity in order to understand the mechanisms behind steroid resistance.

Duration: 2013-2018

 

MTA-SE “Momentum” Lymphatic Physiology Research Group

Project leader:     Dr. Zoltán Péter Jakus, MD, PhD – Department of Physiology
E-mail: jakus.zoltan@med.semmelweis-univ.hu
Tel:
+36-1-459-1500 ext. 60429
Research topic:
The development and role of the pulmonary lymphatic system in the preparation of fetuses for neonatal breathing 

Overview

The research group studies the growth of lymph vessels, the molecular mechanisms driving the process and the physiological and pathophysiological role of lymph vessels. The development of the lung’s lymphatic system is to be explored in order to understand the exact role of pulmonary lymph vessels in the development of neonatal breathing. The thorough study of the area may help reveal the causes of breathing defects often present in premature babies.

Duration: 2014-2019

 

MTA-SE “Momentum” Molecular Oncohematology Research Group

Project leader:     Dr. Csaba Bödör – 1st Department of Pathology and Experimental Cancer Research
E-mail: bodor.csaba1@med.semmelweis-univ.hu
Tel:
+36-1-459-1500 ext. 54462
Research topic:
Personalised and targeted tumour treatment: The study of the epigenetic background of B-cell malignancies 

Overview

The main area of research is the genome level study of B-cell lymphomas and other haematologic cancers. The process of how the mutations of the so-called epigenetic regulatory molecules regulating gene expression affect the patients’ therapeutic responses to traditional and experimental treatments are being studied with the help of modern genomic procedures. Besides the better understanding of the origin of the disease, the results of the research programme may lead to the development of diagnostic methods that will enable personalised treatment based on the patients’ genetic profiles. Furthermore, these observations may promote the identification of new therapeutic targets that could serve as a basis for drug development in the future.

Duration: 2015-2020

Weblink: http://scholar.semmelweis.hu/bodorc/en/

 

MTA-SE “Momentum” Nephrogenetic Research Group

Project leader:     Dr. Kálmán Tory – 1st Department of Paediatrics
E-mail: tory.kalman@med.semmelweis-univ.hu
Tel: +36-1-3343-186 ext. 52620
Mob: +36-20-825-8166
Research toppic:
Interallelic interactions and new genes in monogenic paediatric diseases

Overview

The research has two main directions. The first is the identification of the role of intralellic interactions in common autosomal recessive diseases. In a bioinformatics/epidemiology approach variants are being researched, whose pathogenicity is dependent on a trans associated variant (inherited from the other parent). In order to understand the origin of the interaction, either the coexpression of the protein variants triggering the identified intralellic interaction are studied in cell culture or an n animal model provides the environment for analysis.

The other direction focuses on the identification of the pathogenic gene in rare monogenic (kidney) diseases by linkage studies/exom-sequencing, bioinformatic analysis and the verification and the understanding of the link between the function of the coded protein and the disease by means of studies in cell cultures or on animal models. The identification of an intralellic interaction and a new gene is a significant step towards the understanding of the evolution of the diseases and provides a basis for genetic consultation.

Duration: 2015-2020