NIH-funded Post-Doctoral Position is available in the research team of Prof. Gabor Tigyi at the University of Tennessee Health Science Center in Memphis to investigate the radiation protective mechanism of action of lysophosphatidic acid analogs (Please read background references: Patil et al., PMID:25619933; Balogh et al. PMID 26027517, Kuo et al. PMID:30063964, Tigyi et al PMID:30692142).
Specifically, we are interested in determining the regulation of signalosomes that are responsible for the augmentation of DNA repair and reduction of apoptosis elicited by the long-duration activation of the lysophosphatidic acid receptor 2. A particular focus of these studies is on the adapter protein encoded by the immediate-early gene product IEX-1. IEX-1 has the ability to form supramolecular complexes with the AKT and ERK1/2 kinases, inhibits the PP2A phosphatase and leads to activation of DNA-dependent Protein Kinase, which in turn promotes high-fidelity double-strand DNA repair in cells exposed to genotoxic stress. An ideal candidate should have strong background and experience in biochemical techniques in molecular signaling and DNA repair. Experience using co-immunoprecipitation, Western blotting, immunohistochemistry, cell culture, transduction/transfection methods is required. NIH-scale salary with benefits will be provided to the successful applicant.
Interested individuals should contact Prof. Gabor Tigyi via email (gtigyi@uthsc.edu).