Projects
- Deciphering the pathogenesis of small intestinal damage caused by non-steroidal antiinflammatory drugs – the role of microbes, bile acids, and other luminal factors
- Glycine transporter type 1 (GlyT-1) – potential therapeutic target in retinal neurodegenerative disorders
- Looking for new ways for analgesia
- Neurobiology of enhancer regulation
Experimental methods
- Measurement of the electrophysiological parameters of receptor pool and receptor kinetics of in vitro isolated organs.
- Immunohistochemistry
- In vivo antinociceptive tests, tolerance-dependence measurments, intracerebral, spinal application methods
- Electrochemical HPLC measurement of transmitter release in isolated organs (rabbit ear artery, rabbit pulmonary artery, rat vas deferens, etc) and to detect specific enhancer effect in isolated brain regions (tuberculum olfactorium, substantia nigra, striatum, raphe, locus coeruleus)
- Measuring transmitter release from in vitro tissue preparations (GABA, endomorphine 2, CGRP, [3H]-norepinephrine, dopamine, serotonin) by radioactive isotope and immunological technics
- Measuring enhancer activity on cell cultures (PC12, HBEC) and stroke models
- In vivo ulcer models
- Measurement of gastrointestinal motility in vivo and in vitro
- Acute and chronic inflammatory models
- Measurement of microcirculation with Laser Doppler flowmetry and LASCA technique
- Stereotaxic injection into given brain nuclei
- Brain microdialysis in anesthetised and conscious rats. Measurements of biogenic amines and amino acids with HPLC and electrochemistry.
- Measurements of radiolabelled neurotransmitter release from isolated brain slices and retina preparation using superfusion techniques.
Main cooperators
- Department of Organic Chemistry, Semmelweis University
- Department of Pharmacodynamics, Semmelweis University
- Department of Pharmacology and Pharmacotherapy, University of Debrecen
- Karl-Franzens University of Graz, Dept. of Experimental and Clinical Pharmacology, Graz, Austria
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National Institute of Health and Medical Research (INSERM), Paris, France
Members
- Susanna Fürst, professor emerita
- Klára Gyires, Doctor of the Hungarian Academy of Sciences, professor emerita
- Laszlo G. Harsing, MD, PhD, DSc, scientific consultant
- Pál Riba, MD, PhD, associate professor
- Júlia Tímár, MD, PhD, consultant
- Ildikó Miklya, PharmD, PhD, consultant
- Mahmoud Al-Khrasani, MD, PhD, associate professor
- Zoltán Zádori, MD, PhD, associate professor
- Erzsébet Kató, MD, PhD, assistant professor
- Kornél Király, MD, PhD, assistant professor
- Gerda Wachtl, PhD, research associate
- Arezoo Haghighi, PhD student
- Zsuzsanna Demeter, laboratory assistant
- Nariman Gomaa PhD student
- Sarah Kadhim PhD student
- Anna Galambos, PhD student