(Péter Nagy, MD,PhD, DSc and Sándor Paku, PhD, DSc)
Aims and areas of interest:
Our group’s research concentrates on understanding how the liver regenerates from stem cells, and we are also focused on studying angiogenesis and tumor metastasis.
Results:
We have characterized the small bile ducts harbouring adult stem cells in human and rat liver; the canals of Hering can be identified by a unique immunophenotype. We have analysed the architectural changes in the regenerated liver. Our results show that during liver regeneration the enlargement of the hepatic lobules is exclusively responsible for the regenerative liver growth. Analysing the vascularization of cirrhotic livers we have found that the developing regenerative nodules in advanced cirrhosis are positioned along the portal tree and are directly supplied by terminal portal venules.
We have examined the vascularization process of experimental metastases in three different organs (liver, brain and lung) and we have found that the tumours incorporated the pre-existing capillaries (i.e. vessel co-option) of the host tissue.
Publications:
Paku S, Laszlo V, Dezso K, Nagy P, Hoda MA, Klepetko W, Renyi-Vamos F, Timar J, Reynolds AR, Dome B. The evidence for and against different modes of tumour cell extravasation in the lung: diapedesis, capillary destruction, necroptosis and endothelialisation. Journal of Pathology 2016 Dec 27. doi: 10.1002/path.4855. [Epub ahead of print] IF:7,33
Dezső K, Rókusz A, Bugyik E, Szücs A, Szuák A, Dorogi B, Kiss M, Nemeskéri Á, Nagy P, Paku S. Human liver regeneration in advanced cirrhosis is organized by the portal tree. J Hepatol. 2016 Nov 29. pii: S0168-8278(16)30690-0. doi: 10.1016/j.jhep.2016.11.014. [Epub ahead of print] IF: 10,59
Szabo V, Bugyik E, Dezso K, Ecker N, Nagy P, Timar J, Tovari J, Laszlo V, Bridgeman VL, Wan E, Frentzas S, Vermeulen PB, Reynolds AR, Dome B, Paku S Mechanism of tumour vascularisation in experimental lung metastases. Journal of Pathology, 235: 384-396, 2015, IF: 7,33
Papp V, Rókusz A, Dezső K, Bugyik E, Szabó V, Pávai Z, Paku S, Nagy P. Expansion of hepatic stem cell compartment boosts liver regeneration. Stem Cells Dev, 23:56-65, 2014. IF: 4,67
Dezső K, Papp V, Bugyik E, Hegyesi H, Sáfrány G, Bödör C, Nagy P, Paku S. Structural analysis of oval cell mediated liver regeneration in rats. Hepatology. 56:1457-67, 2012. IF: 12,003
Dezső K, Bugyik E, Papp V, Laszló V, Döme B, Tóvári J, Timár J, Nagy P, Paku S Development of arterial blood supply in experimental liver metastases Am J Pathol, 175:835-43, 2009 IF.: 5,673
Bugyik E, Dezso K, Reiniger L, László V, Tóvári J, Tímár J, Nagy P, Klepetko W, Döme B, Paku S. Lack of angiogenesis in experimental brain metastases. J Neuropathol Exp Neurol, 70:979-91, 2011. IF: 4,19
The research group:
Péter Nagy, professor
Sándor Paku, senior research fellow
Katalin Dezső, senior lecturer
Bugyik Edina, post-doctor
Armanda Szücs, PhD student
Dóra Trojnár, scientific student worker
Bálint Jiling, scientific student worker
Collaborators:
Prof. Ezio Laconi – Università degli studi di Cagliari, Sardinia
Dr Andrew Reynolds – The Institute of Cancer Research, London, UK
Dr.Peter Vermeulen – Universiteit Antwerpen, Belgium