- Investigation of the Peyronie-disease in rat models.
Peyronie’s disease is a chronic disease with abnormal accumulation of connective tissue scarring in the penile mass, which can take various forms (solitary or multiple) and can have a major impact on quality of life. In our animal model, we aim to better understand the pathomechanism of this disease in order to develop effective treatment methods. -
Histological investigation of the PIM cells (pulmonary intravascular macrophages) in pig models – Is it a key player in the side effects of nanodrugs?
Pulmonary intravascular macrophages are a special subpopulation of the pulmonary immune system. These cells may be partly responsible for the acute immune response induced by certain nanopharmaceuticals, an adverse immune reaction that is currently an almost insoluble barrier to the widespread dissemination of these drugs, carrier molecules in particular. We are investigating lung tissue from pigs, rats and other laboratory animals in collaboration with specialists to understand how these cells can be imaged, stained, labelled and differentiated from other macrophages to help understand the processes involved.Note: You can be involved in active PhD research project, with significant contribution as a co-author of the publications!
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Systematic review of mini laparoscopy in rat and rabbit models.
Mini laparoscopy is a specialised but highly promising area of minimally invasive surgery. We will review the technical details, advantages, limitations and experimental results of this technique in rat and rabbit models. We will also try to identify research directions that have not been explored so far, which could be suitable as a topic for a future joint research, even at PhD level. -
Systematic review of microsurgical induced cardiovascular models in mouse, rat and rabbit.
To date, several surgically induced cardiovascular models have been developed. These are designed to induce pathological conditions in which the primary focus is on the study of circulatory system lesions. But what exactly are they? Which are invasive and which are non-invasive? Which are acute and which are chronic? What are the advantages and disadvantages? What is the ideal animal model? We will review the technical details, advantages, limitations and experimental results of the methods in mouse, rat and rabbit models. We will also try to identify research directions that have not been explored so far, which could be suitable as a topic for a future joint research project, even at PhD level. -
Systematic review of catheterization techniques in mouse, rat and rabbit models.
Catheterisation for short to long periods is a very common and widely used surgical procedure in laboratory animals. It can be used in many areas, often as an introductory step to a substantial experiment. What are the catheterisation methods? What are the exact technical parameters (which often have the greatest impact on success)? Which organs can be catheterised? For what purpose? For how long? What are the advantages and disadvantages? What is the ideal animal model? We will review the technical details, advantages, limitations and experimental results of the methods in mouse, rat and rabbit models. We will also try to identify research directions that have not been explored so far, which could be suitable as a topic for a future joint research project, even at PhD level.