What are we studying?
Our lab studies structure and function of ion channels: transmembrane protein pores which allow passage of some type of inorganic ion across a biological membrane. Our studies are focused on two target proteins, the CFTR chloride channel and the TRPM2 cation channel. Our experimental approaches include real-time recording of ionic currents of single ion channel proteins and of large channel populations using the patch-clamp technique, kinetic analysis of current time courses, site-directed mutagenesis, protein biochemistry and structural methods, as well as mathematical modeling.
How do we research?
- Molecular mechanism of CFTR channel gating by ATP binding and hydrolysis
- Molecular mechanism of CFTR channel activation by cAMP-dependent protein kinase
- Molecular pathology of CFTR mutations associated with cystic fibrosis
- Pharmacological profiling of mutant CFTR channels
- Molecular evolution of the TRPM2 channel
- Molecular mechanism of TRPM2 channel gating by ADP ribose, Ca2+ and phosphatydil-inositol-bisphosphate
Staff members and publications
- László Csanády, professor
- Beáta Törőcsik, associate professor
- András Szöllősi, senior research associate
- Iordan Iordanov, research associate
- Balázs Tóth, research associate
- Ádám Bartók, research associate
- Mihályi Csaba, research associate
- Márton Simon, PhD student
- Krisztián Bálint, research assistant