Pharmaceutical Technology I. (5. semester)
- The scope of pharmaceutical technology. History of pharmaceutical compounding.
- Dosage forms as drug carrier systems. Classification of dosage forms and methods of administration.
- Biopharmaceutical and pharmacokinetic bases of pharmaceutical technology.
- Technological aspects of drug quality. Quality standards.
- Physico-chemical principles in the pharmaceutical technology. Basic compounding procedures.
- The guide for pharmaceutical compounding in Hungary. Storage of pharmaceuticals. Individual presciptions. Packaging materials in the pharmacy and their quality standards.
- Liquid dosage forms. Solutions and solubility. Preparation of solution.
- Ideal and colloid solutions, aromatic water, syrup, mucilage.
- Elixire, mixture, gargles, enema preparations.
- Drops for internal (Gutta) and external use (Oto-nasogutta). Microbiological preservatives.
- Principles and practice of aseptic preparation. Eye drops.
- Preparations made by extractions. Extractives, infusions, decoctions, tinctures.
- Suspensions. Theory and preparation. Suspending agents. Apparatuses.
- Emulsions. Theory and preparation. Emulsification, emulsifying agents, stability of emulsions.
Pharmaceutical Technology II. (6. semester)
Pharmaceutical Technology III. (7. semester)
- Theoretical background for the Pilot Plant laboratory practices. Introduction into industrial pharmaceutical technology.
- Aspects of the pharmaceutical development. Preformulation. Theoretical background for the Parenteral laboratory practices.
- Condition system of drug manufacturing. Good Manufacturing Practice (GMP). Industrial manufacturing and safety technique.
- Stabilization possibilities of medicinal preparations. Principles of drug stability.
- Chemical engineering, scaling-up, optimization principles. Stability testing.
- Pharmaceutical unit operations. Particle size reduction, milling, sieving. Particle-engineering. Pharmaceutical unit operations. Aggregation, compaction and compression.
- Critical manufacturing parameters. In-process-Control. Quality by design. Pharmaceutical unit operations. Heat transfer, evaporation, distillation.
- Pharmaceutical unit operations. Drying. Pharmaceutical unit operations. Filtering, sedimentation, centrifugation, extraction by squeezing.
- Pharmaceutical unit operations. Freeze-drying and lyophilized products. Pharmaceutical unit operations. Sterilization.
- Pharmaceutical unit operations. Fluidization. Parenteral preparations. Factory design.
- Validation. Large volume parenteral preparations.
- Pharmaceutical unit operations. Crystallization. Pharmaceutical unit operations. Amorphization. Spray-drying.
- Solution and dispersion type injections. Pharmaceutical unit operations. Mixing, dispersing.
- Packaging technology and packaging materials I. Packaging technology and packaging materials II.
Pharmaceutical Technology IV. (8. semester)
- Theoretical considerations of pilot plant practices. Theoretical considerations of parenteral preparations.
- Classification and preformulation of solid dosage forms. Solid state characterization. Granulation I.
- Granulation II. Inhaled preparations, aerosols.
- Pellets and palletization. Particle systems and their characterization.
- Tablets I. Tablets II.
- Capsules I. Capsules II.
- Coating I. Coating materials and procedures, film coating. Coating II. Traditional sugar coating.
- Coating III. Solvent-free coating. Modern dosage form design: modified drug release.
- Innovative pharmaceutical technological products. Generics and supergenerics. Quality by Design, PAT, nondestructive analysis.
- Modern dosage form design: testing and evaluation of drug release profile. Modern dosage form design: improvement of dissolution and solubility.
- Modern dosage form design: colloidal carrier systems, liposomes. Pharmaceutical technological aspects of Pharmacopoeias.
- Modern dosage form design: transdermal therapeutic systems. Modern dosage form design: Molecular pharm. tech. microfabrication.
- Guidelines of preparation. Galenic preparations. Surgical sutures, bandages, implants.
- Pharmaceutical technology and quality assurance. Modern dosage form design: Delivery of biopharmaceuticals