The subject is recommended for the students interested in several fields of traditional pharmaceuticalé compounding of dosage forms, especially for individual patients. The course focuses on: the history of compounding, profiles of patient centric compounding, career for pharmacists; pharmaceutical technological aspects of product authorization, evolution of dosage forms. Innovation and intellectual property; reformulation and formulation studies; optimization of dosage form composition; control of active substance and excipients, physic-chemical and solid state characterization; novel drug delivery systems; design of the manufacturing process; critical formulation attributes and process parameters; comparison of scaling-up methods.
Lecture topics:
- The significance of the pharmaceutical compounding.
- Past and future of pharmaceutical compounding.
- Combined preparations for individual therapy.
- Pharmacopoeial aspects of compounded dosage forms.
- Practical guidelines for traditional compounding (Formulae Normales).
- Pharmaceutical substances, synonyms.
- Dose calculations.
- Functional excipients in the formulation. The quality of starting materials.
- Practical problems of incompatibilities in combined preparations.
- The evolution of the patient centric formulation.
- Technological aspects of the quality for individual preparations.
- Operations and equipments.
- Procedures and techniques.
- Summary and overview, consultation.