The type 1 (AT1) angiotensin II receptor (AT1R) has important role in cardiovascular regulation and salt-water homeostasis, and drugs targeting the reninangiotensin system are widely used in medicine. The aim of this laboratory is to reveal the relationship between the structure and function of AT1Rs. Molecular biological and biophysical methods are employed to investigate these questions, including studies in expression systems using confocal microscopy, biochemical analysis of signal transduction and intracellular trafficking pathways, and resonance energy transfer methods. The laboratory participates in international collaborations, collaborative studies with clinical scientists to identify geneticai abnormalities in endocrine or metabolic disorders and in a project aimed to develop compounds that modify the signal transduction for the treatment of cardiovascular diseases.