Research group of Dr. Peter Igaz Research on adrenal tumors and microRNAs


Head of research group:

Dr. Peter Igaz MD MSc PhD DSc full professor of medicine
e-mail: igaz.peter@med.semmelweis-univ.hu

Personal website


Main research topics:

  • studies on the pathogenesis of adrenal tumors
  • studies on microRNAs in tumor pathogenesis
  • tissue and circulating microRNAs as biomarkers
  • identifying novel treatment targets in adrenal tumors
  • bioinformatical approaches in endocrine tumors
  • multiple endocrine neoplasia syndromes

Former PhD students Dr. Szabó Péter Márton (PhD awarded in 2011) Dr. Tömböl Zsófia (PhD awarded in 2011) Dr. Zsippai Adrienn (PhD awarded in 2013) Bódi-Szabó Diána Rita Dr. Nagy Zoltán PhD
Present PhD students: Dr. Perge Pál (PhD theses already submitted) Dr. Decmann Ábel

Selected publications of the research group:

Integrative molecular bioinformatics study of human adrenocortical tumors: microRNA, tissue-specific target prediction, and pathway analysis. Tömböl Z, Szabó PM, Molnár V, Wiener Z, Tölgyesi G, Horányi J, Riesz P, Reismann P, Patócs A, Likó I, Gaillard RC, Falus A, Rácz K, Igaz P. Endocr Relat Cancer. 2009 Sep;16(3):895-906. doi: 10.1677/ERC-09-0096. Epub 2009 Jun 22.

Differences in the expression of histamine-related genes and proteins in normal human adrenal cortex and adrenocortical tumors. Szabó PM, Wiener Z, Tömböl Z, Kovács A, Pócza P, Horányi J, Kulka J, Riesz P, Tóth M, Patócs A, Gaillard RC, Falus A, Rácz K, Igaz P. Virchows Arch. 2009 Aug;455(2):133-42. doi: 10.1007/s00428-009-0807-x. Epub 2009 Jul 1.

Meta-analysis of adrenocortical tumour genomics data: novel pathogenic pathways revealed. Szabó PM, Tamási V, Molnár V, Andrásfalvy M, Tömböl Z, Farkas R, Kövesdi K, Patócs A, Tóth M, Szalai C, Falus A, Rácz K, Igaz P. Oncogene. 2010 May 27;29(21):3163-72. doi: 10.1038/onc.2010.80. Epub 2010 Mar 22.

MicroRNA expression profiling in benign (sporadic and hereditary) and recurring adrenal pheochromocytomas. Tömböl Z, Eder K, Kovács A, Szabó PM, Kulka J, Likó I, Zalatnai A, Rácz G, Tóth M, Patócs A, Falus A, Rácz K, Igaz P. Mod Pathol. 2010 Dec;23(12):1583-95. doi: 10.1038/modpathol.2010.164. Epub 2010 Sep 3.

Underexpression of C-myc in adrenocortical cancer: a major pathogenic event? Szabó PM, Rácz K, Igaz P. Horm Metab Res. 2011 May;43(5):297-9. doi: 10.1055/s-0031-1273762. Epub 2011 Mar 16.

mRNA and microRNA expression patterns in adrenocortical cancer. Zsippai A, Szabó DR, Szabó PM, Tömböl Z, Bendes MR, Nagy Z, Rácz K, Igaz P. Am J Cancer Res. 2011;1(5):618-28. Epub 2011 Apr 25.

Effects of mitotane on gene expression in the adrenocortical cell line NCI-H295R: a microarray study. Zsippai A, Szabó DR, Tömböl Z, Szabó PM, Eder K, Pállinger E, Gaillard RC, Patócs A, Tóth S, Falus A, Rácz K, Igaz P. Pharmacogenomics. 2012 Sep;13(12):1351-61. doi: 10.2217/pgs.12.116.

Antitumoral effects of 9-cis retinoic acid in adrenocortical cancer. Szabó DR, Baghy K, Szabó PM, Zsippai A, Marczell I, Nagy Z, Varga V, Éder K, Tóth S, Buzás EI, Falus A, Kovalszky I, Patócs A, Rácz K, Igaz P. Cell Mol Life Sci. 2014 Mar;71(5):917-32. doi: 10.1007/s00018-013-1408-z. Epub 2013 Jun 27.

In silico analysis of pathways affected by differentially expressed microRNA in adrenocortical tumors. Zsippai A, Szabó PM, Szabó DR, Nagy Z, Patócs A, Rácz K, Igaz P. J Endocrinol Invest. 2013 Dec;36(11):1011-9. doi: 10.3275/9024. Epub 2013 Jul 1.

Analysis of circulating microRNAs in adrenocortical tumors. Szabó DR, Luconi M, Szabó PM, Tóth M, Szücs N, Horányi J, Nagy Z, Mannelli M, Patócs A, Rácz K, Igaz P. Lab Invest. 2014 Mar;94(3):331-9. doi: 10.1038/labinvest.2013.148. Epub 2013 Dec 16.

Tumor surveillance by circulating microRNAs: a hypothesis. Igaz I, Igaz P. Cell Mol Life Sci. 2014 Nov;71(21):4081-7. doi: 10.1007/s00018-014-1682-4. Epub 2014 Jul 19.

Possible role for microRNAs as inter-species mediators of epigenetic information in disease pathogenesis: is the non-coding dark matter of the genome responsible for epigenetic interindividual or interspecies communication? Igaz I, Igaz P. Med Hypotheses. 2015 Feb;84(2):150-4. doi: 10.1016/j.mehy.2014.11.021. Epub 2014 Dec 8.

Suggested roles for microRNA in tumors. Perge P, Nagy Z, Igaz I, Igaz P. Biomol Concepts. 2015 Apr;6(2):149-55. doi: 10.1515/bmc-2015-0002.

MicroRNAs in adrenal tumors: relevance for pathogenesis, diagnosis, and therapy. Igaz P, Igaz I, Nagy Z, Nyírő G, Szabó PM, Falus A, Patócs A, Rácz K. Cell Mol Life Sci. 2015 Feb;72(3):417-28. doi: 10.1007/s00018-014-1752-7. Review.

Evaluation of 9-cis retinoic acid and mitotane as antitumoral agents in an adrenocortical xenograft model. Nagy Z, Baghy K, Hunyadi-Gulyás É, Micsik T, Nyírő G, Rácz G, Butz H, Perge P, Kovalszky I, Medzihradszky KF, Rácz K, Patócs A, Igaz P. Am J Cancer Res. 2015 Nov 15;5(12):3645-58.

Potential relevance of microRNAs in inter-species epigenetic communication, and implications for disease pathogenesis. Perge P, Nagy Z, Decmann Á, Igaz I, Igaz P. RNA Biol. 2016 Oct 28:0. [Epub ahead of print]

Evaluation and diagnostic potential of circulating extracellular vesicle-associated microRNAs in adrenocortical tumors. Perge P, Butz H, Pezzani R, Bancos I, Nagy Z, Pálóczi K, Nyírő G, Decmann Á, Pap E, Luconi M, Mannelli M, Buzás EI, Tóth M, Boscaro M, Patócs A, Igaz P. Sci Rep. 2017 Jul 14;7(1):5474. doi: 10.1038/s41598-017-05777-0. Adrenal myelolipoma: a comprehensive review. Decmann Á, Perge P, Tóth M, Igaz P. Endocrine. 2018 Jan;59(1):7-15. doi: 10.1007/s12020-017-1473-4. Epub 2017 Nov 21. Review.

Analysis of circulating extracellular vesicle-associated microRNAs in cortisol-producing adrenocortical tumors. Perge P, Decmann Á, Pezzani R, Bancos I, Fassina A, Luconi M, Canu L, Tóth M, Boscaro M, Patócs A, Igaz P. Endocrine. 2018 Feb;59(2):280-287. doi: 10.1007/s12020-017-1506-z. Epub 2018 Jan 3.

MicroRNA expression profiling in adrenal myelolipoma. Decmann A, Perge P, Nyíro G, Darvasi O, Likó I, Borka K, Micsik T, Tóth Z, Bancos I, Pezzani R, Iacobone M, Patócs A, Igaz P. J Clin Endocrinol Metab. 2018 Jun 21. doi: 10.1210/jc.2018-00817. [Epub ahead of print]

Research grants: Hungarian Scientific Fund (OTKA) K project 2015-2019 K115398 Hungarian Scientific Fund (OTKA) K project 2012-2015 K100295 OTKA postdoctoral grant PD 72306 April 2008- March 2010 ETT (Hungarian Health Scientific Council) 2006-2008 Semmelweis University Research Fund 2006