Research

Teams in our Department and their fields of research

Lipid metabolism

Dr. Miklós Csala, Dr. Éva Kereszturi, Dr. Farkas Sarnyai, Dr. Szabolcs Sipeki, Dr. Péter Szelényi, Dr. Viola Tamási, Dr. Veronika Zámbó, Kinga Tibori, Viktória Novákné Molnár

Field of research

• Role of ER stress in lipotoxicity and lipoapoptosis
• Metabolism and effects of trans fatty acids
• Physiological and pathological functions of novel Ncb5or enzyme
• Human stearyl-CoA desaturase enzymes

In vitro biology

Dr. Tamás Mészáros, Dr. Szilvia Krisztina Nagy, Anna Gyurkovics, Dr. Brigitta Kállai, Dr. Krisztina Percze, Ákos Harkai, Dr. Zsuzsanna Szeitner, Alexandra Tar

Field of research

• Protein synthesis by in vitro translation
• Functional studies on proteins
• Production of aptamers for diagnostic and therapeutic applications

Endoplasmic reticulum, cell cycle, apoptosis, autophagy

Dr. Beáta Lizák, Dr. Orsolya Kapuy, Dr. Norbert Gyöngyösi, Dr. Laura Simon-Szabó, Dr. Ibolya Stiller, Marianna Dr. Holczer, Margita Márton, Béláné Szénási, Eszter Kálmán, Bence Hajdú, Zsolt Nagy, Patrik Szekér

Field of research

• Redox homeostasis of the endoplasmic reticulum (ER)
• Ascorbate and glutathione transporters in the ER
• ER redox and survival or death decision mechanisms
• Role of low molecular weight electron carriers in oxidative folding
• ER redox and ERAD

Networks, stress and aging

Dr. Péter Csermely, Dr. Csaba Sőti, Dr. Minh Tu Nguyen, Dr. Milán Somogyvári, Dr. Péter Mendik, Dr. Bánk Fenyves, Dr. Borbála Kovács, Dávid Keresztes, Zsolt Vassy, Gábor Hajdú, Dávid Deritei, Zsolt Nagy, Klára Schulc, Donát Buszlai, Beatrix Gillányi

Field of research

• Structure and dynamics of molecular networks and their use in drug design
• Molecular mechanisms of stress, aging and chaperone function

Molecular genetics

Dr. Zsolt Rónai, Dr. Csaba Barta, Dr. Gergely Keszler, Dr. Réka Kovács-Nagy, Dr. Andrea Szabó-Vereczkei, Dr. Zsuzsanna Molnár, Dr. Zsófia Bánlaki, Helga Németh, Andrea Alexandra Belik 

Field of research

• Molecular and phenotypic effects of genetic polymorphisms
• Psychogenetics – Genetic background of Tourette Syndrome, ADHD (Attention Deficit Hyperactivity Disorder), addictions (drug abuse, smoking, alcohol, gambling, etc.), OCD (obsessive compulsive disorder), depression, etc.
• Functional effect of genetic variation on gene expression
• Functional studies on microRNAs
• Epigenetic studies
• Genetic background of Type 1 and Type 2 diabetes and its association with depression
• Genetics of normal human behavioral variation (personality, cognitive function in the young and elderly)
• Genetic factors influencing animal models, such as social behavior of different dog breeds and domestication of wolves

Tumor biology

Dr. Miklós Csala, Dr. Attila Varga, Bianka Gurbi, István Móra

Field of research

• Analysis of tumor signaling pathways
• Identification of prognostic and predictive biomarkers
• Investigation of drug resistance mechanisms

Arginin metabolism

Dr. András Hrabák, Dr. Zoltán Kukor

Field of research

• Role of NO synthesis and arginase in inflammation
• Studies on placental NO synthase activity

Epigenetics in Health and Disease

Dr. Tamás Arányi, Dr. Zsófia Nemoda, Dr. Mária Ashaber, Dr. Dániel Tóth, Dr. Nóra Angyal

Field of research

• Analysis of pathophysiologic role of DNA methyltransferases and TeT dioxygenases
• Studying environmental epigenetics with DNA methylation measurements
• The (epi)genetic regulation of ectopic calcification
• SAnalyzing gene-environment interactions

Rare metabolic diseases

Dr. Tamás Kardon, Dr. Gábor Bőgel, Dr. Csilla Emese Németh, Dr. Balázs Legeza, Dr. Zsigmond Lédeczi, Dr. Rebeka Pittner, Klaudia Németh, Mónika Mesziár

Field of research

• Studies on the pathomechanism of metabolic diseases causing chronic neutropenia
• Investigation of rare hereditary diseases using CRISPR/Cas9 genome editing technique
• Role of altered intracellular signaling pathways in heritable disorders of the connective tissue