Nyitólap /

Laboratory of Neuromorphology

Dr. Miklós Palkovits
Dr. Miklós Palkovits
Dr. Árpád Dobolyi
Dr. Árpád Dobolyi

Head of the Laboratory:
Dr. Árpád Dobolyi, PhD, DSc, research professor

Scientific Advisor:
Dr. Miklós Palkovits, MD, PhD, professor, member of the Hungarian Academy of Sciences

Members of the Laboratory:
• János Barna, PhD, research associate
• Melinda Cservenák , PhD, postdoctoral fellow
• András Lékó, MD, PhD 
• Fanni Dóra, PhD fellow
• Dávid Keller, PhD fellow
• Viktória Dellaszéga-Lábas, scientific technician
• Erzsébet Horváthné Oszwald, laboratory technician

Ongoing research activity in the Laboratory of Neuromorphology:

1. Neurobiology of parenthood

  • Dobolyi A., Lékó A.H. (2019) The insulin-like growth factor-1 system in the adult mammalian brain and its implications in central maternal adaptations. Front. Neuroendocrinol. 52:181-194.
  • Olah S., Cservenák M., Keller D., Fazekas E.A., Renner E., Low P., Dobolyi A. (2018) Prolactin-induced and neuronal activation in the brain of mother mice. Brain Struct. Funct. 223:3229-3250.
  • Cservenák M., Keller D., Kis V., Fazekas E.A., Öllös H., Lékó A., Szabó É.R., Renner É., Usdin T.B., Palkovits M., Dobolyi A. (2017) A thalamo-hypothalamic pathway that activates oxytocin neurons in social contexts in female rats. Endocrinology 158:335-348.
  • Cservenák M., Szabó É.R., Bodnár I., Lékó A., Palkovits M., Nagy G.M., Usdin T.B., Dobolyi A. (2013) The thalamic neuropeptide TIP39 mediates the effects of nursing on lactation and maternal motivation. Psychoneuroendocrinology 38:3070-3084.
  • Szabó E.R., Cservenák M., Dobolyi A. (2012) Amylin is a novel neuropeptide with potential maternal functions. FASEB J. 26:272-281.

2. Brain pathology of stroke

  • Völgyi K., Gulyássy P., Todorov M.I., Puska G., Badics K., Hlatky D., Kékesi K.A., Nyitrai G., Czurkó A., Drahos L., Dobolyi A. (2018) Chronic cerebral hypoperfusion induced synaptic proteome changes in the rat cerebral cortex. Mol. Neurobiol. 55:4253-4266.
  • Pál G., Vincze C., Renner É., Wappler E.A., Nagy Z., Lovas G., Dobolyi A. (2012) Time course, distribution and cell types of induction of transforming growth factor betas following middle cerebral artery occlusion in the rat brain. PLoS One 7:e46731.
  • Dobolyi A., Vincze C., Pál G., Lovas G. (2012) The neuroprotective functions of transforming growth factor beta proteins. Int. J. Mol. Sci. 13:8219-8258.

3. Neuronal function of nucleosides

  • Lakatos R.K., Dobolyi A., Todorov M.I., Kékesi K.A., Juhász G., Aleksza M., Kovács Z. (2016) Guanosine may increase absence epileptic activity by means of A2A adenosine receptors in Wistar Albino Glaxo Rijswijk rats. Brain Res. Bull. 124:172-181.
  • Kovács Z., Dobolyi A., Kékesi A.K., Juhász G. (2013) 5′-nucleotidases, nucleosides, and their distribution in the brain: pathological and therapeutic implications. Curr. Med. Chem. 20:4217-4240.
  • Dobolyi A., Kovács Z., Juhasz G., Kardos J. (2011) Uridine function in the central nervous system. Curr. Top. Med. Chem. 11:1058-1067.

4. Pathomechanisms of epilepsy

  • Lakatos R.K., Dobolyi Á., Kovács Z. (2018) Uric acid and allopurinol aggravate absence epileptic activity in Wistar Albino Glaxo Rijswijk rats. Brain Res. 1686:1-9.
  • Kovács Z., Lakatos R.K., Barna J., Dobolyi A. (2017) Absence epileptic activity in Wistar Albino Glaxo Rijswijk rat mothers. Brain Res. 1657:368-376.
  • Dobolyi A., Kékesi A.K., Juhász G., Székely A.D., Lovas G., Kovács Z. (2014) Receptors of peptides as therapeutic targets in epilepsy research. Curr. Med. Chem. 21:764-787.

5. Neurochemistry of mitochondria

  • Dobolyi A., Bago A., Palkovits M., Nemeria N.S., Jordan F., Doczi J., Ambrus A., Adam-Vizi V., Chinopoulos C. (2020) Exclusive neuronal detection of KGDHC-specific subunits in the adult human brain cortex despite pancellular protein lysine succinylation. Brain Struct. Funct. 225:639-667.
  • Barna J., Dimén D., Puska G., Kovács D., Csikós V., Oláh S., Udvari E.B., Pál G., Dobolyi A. (2019) Complement component 1q subcomponent binding protein in the brain of the rat. Sci. Rep. 9:4597.
  • Dobolyi A., Ostergaard E., Bagó A.G., Dóczi T., Palkovits M., Gál A., Molnár M.J., Ádám-Vizi V., Chinopoulos C. (2015) Exclusive neuronal expression of SUCLA2 in the human brain. Brain Struct. Funct. 220:135-151.

6. Neuronal control of food intake

  • Csikós V., Varró P., Bódi V., Oláh S., Világi I., Dobolyi A. (2020) The mycotoxin Deoxynivalenol activates GABAergic neurons in the reward system and inhibits feeding and maternal behaviours. Arch. Toxicol. 94:3297-3313.
  • Barna J., Renner E., Arszovszki A., Cservenák M., Kovács Z., Palkovits M., Dobolyi A. (2018) Suckling induced activation pattern in the brain of rat pups. Nutr. Neurosci. 21:317-327.
  • Renner E., Puskás N., Dobolyi A., Palkovits M. (2012) Glucagon-like peptide-1 of brainstem origin activates dorsomedial hypothalamic neurons in satiated rats. Peptides 35:14-22.

  Techniques and methods used routinely in the Laboratory:

  • Animal operations
  • Occlusion of the middle cerebral artery and other models of focal brain ischemia
  • Canulations, sampling of blood and cerebrospinal fluid in rodents
  • Behavioral tests of anxiety, depression and maternal motivation
  • Stereotaxic operations, brain lesions, pathway transections, tracer injections
  • Neuronal tract-tracing using viruses and transgenic mice
  • Laser capture microdissection and real-time RT-PCR
  • Basic molecular biological techniques
  • RNA amplification for microarray and sequencing
  • In situ hybridization histochemistry and dark-field microscopy
  • Immunolabeling and fluorescent microscopy
  • Western blotting