Leader: Prof. Zoltán Wiener
About the group
About the group
Colorectal cancer (CRC) is one of the leading causes of cancer related death in Hungary and in the Western countries. Despite the progress in understanding colorectal tumorigenesis, this disease still represents an outstanding health problem. Recent reports have proved that not only the tumor cells, but also the stromal cells critically contribute to the tumor progression and patient survival.
The 5-year patient survival is extremely low in pancreatic and lung cancers, partially due to the late diagnosis and the lack of early signs of these diseases.
Our mission is to identify novel communication mechanisms between tumor cells and the stroma that can form the basis of future therapeutic interventions in CRC, PDAC and lung cancer. Furthermore, we aim at identifying novel early biomarkers for lung and pancreatic cancers. One of our interests is the function of the extracellular vesicles that represent a novel form of cell-to-cell communication.
We use a large array of state-of-the-art methods to answer our biological questions, such as the patient-derived organoid technology and the genome editing CRISPR-Cas9 method. Our research group is financed by grants from the Semmelweis University and by the National Research, Development and Innovation Office (Hungary).
Collaborations
- Prof. Kari Alitalo, Research Programs Units, University of Helsinki, Finland
- Prof. László Harsányi, Dr. Ákos Szűcs, 1st Department of Surgery, Semmelweis University, Budapest, Hungary
- Dr. Tamás Beke-Somfai, Institute of Materials and Environmental Chemistry, Hungarian Academy of Sciences
- Dr. Attila Bursics, Dr. Kristóf Dede, Dr. Tamás Tölgyes, Uzsoki Hospital, Budapest, Hungary
- Dr. Judit Moldvay, Korányi National Institute for Pulmonology, Budapest, Hungary
- Prof. Edit Buzás, Institute of Genetics, Cell- and Immunobiology, Semmelweis University, Budapest, Hungary
Members
Members
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Undergraduate students
- Zsófia Simon, MD Student
- Farzan Farzin, MD Student
- Laura Igaz, MD Student
Former members
- Idan Carmi, PhD (2026)
- András Áron Soós, PhD (2023)
- Andrea Kelemen, PhD (2022)
- Gyöngyvér Orsolya Sándor, PhD (2022)
- Zsuzsanna Szvicsek, PhD (2021)
- Ádám Oszvald-Haibach, PhD (2021)
- Regina Szász, MSc
- Maya Litner, MD
- Kata Barabás, MD
- Dániel Szabó, MD
- Iván Seress, MD
- Ádám Nagy, MD
- István Kovács, MD
- Lili Szabó, MSc
- Márton Pápai, MSc
- Anna Kiss, MD
- Réka Kormány, MSc