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NAP project

Participation of the HBTB in the NAP projectNAP

Hungary has launched a National Brain Research Program (Nemzeti Agykutatási Program = NAP) with a government subsidy to explore the most frequent diseases of the brain, including depression, migraine, cerebral metastases, Alzheimer’s and Parkinson’s disease.

Microdissection Researh Group within the HBTB: MTA-SE-NAP A – Human Brain Tissue Bank, Microdissection Laboratory

Head: Eva Dobolyine Renner, PhD

Specific aims for the participation:

  • Keep safety running of the activity of the HBTB requires an increase in human sources in the HBTB.
  • Extension of the donor program, the microdissection capacity and the scientific collaboration activity with Hungarian research laboratories participating in the NAP project (providing reasonable number of microdissected human brain samples) suitable for neurochemical, molecular biological, proteomic and genetic studies.
  • Start with the Lenhossék program in collaboration with the Department of Neurology, Debrecen University for country-wide collections of human brains for biological/medical research purposes. Collection of brains from persons died in neurodegenerative or psychiatric disorders is special important.
  • Increasing the repertoire of the HBTB by further selection of cortical subdivisions for microdissection. Recently, basic and clinical neuroscience information increased rapidly about the topographically and functionally characterized human cortical areas. However, this extension of the microdissection and banking may require an increase in human sources in the HBTB.
  • The next years, teach and train a postdoctoral or young scientist in the human microdissection technique is vital for the future of the HBTB.

Publications

  1. Fuxe K, Borroto-Escuela DO, Romero-Fernandez W, Palkovits M, Tarakanov AO, Ciruela F & Agnati LF (2014) Moonlighting proteins and protein-protein interactions as neurotherapeutic targets in the G protein-coupled receptor field, Neuropsychopharmacology 39: 131-155.  IF: 7.048
  2. Du L, Merali Z, Poulter MO, Palkovits M, Faludi G & Anisman H (2014) Catechol-O-methyltransferase Val158Met polymorphism and altered COMT gene expression in the prefrontal cortex of suicide brains, Prog Neuropsychopharmacol Biol Psychiatry 50: 178-183.  IF: 3.689
  3. Dobolyi A, Ostergaard E, Bagó AG, Dóczi T, Palkovits M, Gál A, Molnár MJ, Adam-Vizi V & Chinopoulos C (2015) Exclusive neuronal expression of SUCLA2 in the human brain, Brain Struct Funct 220: 135-151.  IF: 5.811
  4. Dobolyi A, Bagó AG, Gál A, Molnár MJ, Palkovits M, Adam-Vizi V & Chinopoulos C (2015) Localization of SUCLA2 and SUCLG2 subunits of succinyl CoA ligase within the cerebral cortex suggests the absence of matrix substrate-level phosphorylation in glial cells of the human brain, J Bioenerg Biomembr 47: 33-41.  IF: 2.080
  5. Ádori C, Glück L, Barde S, Yoshitake T, Kovacs GG, Mulder J, Maglóczky Z, Havas L, Bölcskei K, Mitsios N, Uhlén M, Szolcsányi J, Kehr J, Rönnbäck A, Schwartz T, Rehfeld JF, Harkany T, Palkovits M, Schulz S & Hökfelt T (2015) Critical role of somatostatin receptor 2 in the vulnerability of the central noradrenergic system: new aspects on Alzheimer’s disease, Acta Neuropathol 129: 541-563.  IF: 11.360
  6. Durrenberger PF, Fernando FS, Kashefi SN, Bonnert TP, Seilhean D, Nait-Oumesmar B, Schmitt A, Gebicke-Haerter PJ, Falkai P, Grünblatt E, Palkovits M, Arzberger T, Kretzschmar H, Dexter DT & Reynolds R (2015) Common mechanisms in neurodegeneration and neuroinflammation: a BrainNet Europe gene expression microarray study, J Neural Transm 122: 1055-1068.  IF: 2.587
  7. Amy M, Staehlin O, René F, Blasco H, Marouillat S, Daoud H, Vourc’h P, Gordon PH, Camu W, Corcia P, Loeffler JP, Palkovits M, Sommer WH & Andres CR (2015) A common functional allele of the Nogo receptor gene, reticulon 4 receptor (RTN4R), is associated with sporadic amyotrophic lateral sclerosis in a French population, Amyotroph Lat Scl Fr 16: 490-496. IF: 2.677
  8. Hayley S, Du L, Litteljohn D, Palkovits M, Faludi G, Merali Z, Poulter MO & Anisman H (2015) Gender and brain regions specific differences in brain derived neurotrophic factor protein levels of depressed individuals who died through suicide, Neurosci Lett 600: 12-16. IF: 2.107
  9. Aschrafi A, Verheijen JM, Gordebeke PM, Olde Loohuis NF, Menting K, Jager A, Palkovits M, Geenen B, Kos A, Martens GJ, Glennon JC, Kaplan BB, Gaszner B & Kozicz T (2016) MicroRNA-326 acts as a molecular switch in the regulation of midbrain urocortin 1 expression, J Psychiatry Neurosci 41: 342-353. IF: 5.570 (2015)
  10. Barde S, Rüegg J, Prud’homme J, Ekström TJ, Palkovits M, Turecki G, Bagdy G, Ihnatko R, Theodorsson E, Juhasz G, Diaz-Heijtz R, Mechawar N & Hökfelt TGM (2016) Alterations in the neuropeptide galanin system in major depressive disorder involve levels of transcripts, methylation, and peptide, P Natl Acad Sci USA 113: E8472-E8481. IF: 9.423 (2015)
  11. Cservenák M, Keller D, Kis V, Fazekas EA, Öllös H, Lékó A, Szabó ÉR, Renner E, Usdin TB, Palkovits M & Dobolyi A (2017) A thalamo-hypothalamic pathway that activates oxytocin neurons in social contexts in female rats, Endocrinology 158: 335-348. IF: 4.159 (2015)
  12. Roy B, Wang Q, Palkovits M, Faludi G & Dwivedi Y (2017) Molecular insights of dysregulated microRNA network in the locus coeruleus of depressed suicide complements, Scientific Reports, in press: 2016 Dec 9. IF: 5.228 (2015)
  13. Albert M, Barrantes-Freer A, Lohrberg M, Antel JP, Prineas JW, Palkovits M, Wolff JR, Brück W & Stadelmann C (2017) Synaptic pathology in the cerebellar dentate nucleus in chronic multiple sclerosis, Brain Pathol, online: 2016 Oct 5 doi: 10.1111/bpa.12450 [Epub ahead of print]. IF: 5.256 (2015)
  14. Barna J, Renner E, Arszovszki A, Cservenák M, Kovács Z, Palkovits M & Dobolyi A (2017) Suckling induced activation pattern in the brain of rat pups, Nutr Neurosci 2017 Feb 10:1-11. [Epub ahead of print] doi: 10.1080/1028415X.2017.1286446. IF: 2.616 (2015)

 Partners within the NAP project

  • Department of Anatomy, Histology and Embryology, Semmelweis University (Alán Alpár)
  • Institute of Physiology, University of Pécs Medical School (István Ábrahám)
  • Department of Physiology and Neurobiology, Eötvös Loránd University (Árpád Dobolyi)
  • Department of Pharmacology and Pharmacotherapy, University of Pécs Medical School (Zsuzsanna Helyes)
  • Department of Biochemistry, Eötvös Loránd University (József Kardos)
  • Institute of Genomic Medicine and Rare Disorders, Semmelweis University (Mária Judit Molnár)
  • Department of Physiology, Anatomy and Neuroscience, University of Szeged (Gábor Tamás)

Number of samples we sent to NAP partners:

  • 2014: 133
  • 2015: 27
  • 2016: 609
  • 2017: 617

Hatvanezer mintát tárolnak a világszinten is egyedülálló Humán Agyszövet Bank és Laboratóriumban

 

Minden tudás c. tévéműsor (2017. március 3-i adása, M1 csatorna)