Clinical module – compulsory optional subject
Lecturer: Prof. Mária Judit Molnár
The subject gets announced at the 1st semester of each school year.
Date: 1st term/2016/2017 / – at 18.00 every Monday from September
Venue: 1083 Budapest, Tömő Street 25-29. 1083 Budapest, 1st Floor, Lecturer Hall
Aim of the subject: acquiring genomic and genetic based knowledge, contributing the clinical diagnostic, examination, prevention and treatment of hereditary diseases and polygenic multifactorial diagnosis.
Credit: 2 points
The curriculum consists of 14 x 2 lectures:
1.1. The connection between genes and diseases 1×2 lectures – Mária Judit Molnár
1.2. Genetic in diagnostic 1×2 lectures
Molecular biologic diagnostic in oncology – József Tímár
1.3. Genetic background of congenital disorders and dysmorphic syndromes 1×2 lectures – György Fekete
1.4 Pharmacogenetics 1×2 lectures – Mária Judit Molnár
1.5.– 2.1.8. Clinical manifestations of monogenic diseases 4×2 lectures
- Neurogenetic diseases – 2 lectures – Mária Judit Molnár
- Internal Medicine Diseases – 2 lectures – Péter Igaz
- Hematologic diseases – 1 lecture – Irén Haltrich
- Cardiovascular diseases – 1 lecture – Zsolt Szelíd
- Ophthalmologic diseases – 1 lecture – János Németh
- Dermatologic diseases – 1 lecture – Sarolta Kárpáti
1.9. Genetic of polygenic and multifactorial common diseases (genetic factors predisposing to common diseases, diabetes mellitus, hypertension, cardio- and cerebrovascular diseases, autism, schizophrenia, epilepsy, Alzheimer’s disease, venous thrombosis, old age related macular degeneration) 1×2 lecture – Viktória Reményi
1.10. Basics and clinical application of personalized medicine 1×2 lecture – György Németh / Mária Judit Molnár
1.11. Prevention of genetic diseases: examination, genetic consultancy, risk calculation. Legal and principled aspects. 1×2 lecture – Mária Judit Molnár
1.12. Possible treatments of genetic diseases (gene therapy, enzyme replacement therapy, cell therapy, stem-cell, induced stem-cell) 1x 2 lecture – Mária Judit Molnár
1.13. Genomic bioinformatics in everyday clinical practice 1×2 lecture – Krisztián Buza
1.14. TEST Exam
Requirements of attendance, the possibilities of supplement: Each student is allowed to absent twice per semester. In case of more than 2 absences the signature for the semester is denied.
Requirement subjects: biochemistry, molecular and cell biology, genetics and genomics.
Requirements of the signature for the semester: Maximum 2 absences, Passing the semester exam test
Type of exam: Written
Evaluation method: test exam at the end of the semester
Pass: 60% Satisfactory: 70% Good: 80% Excellent: 90% and above
Exam requirements: acquiring the knowledge on the basis of the above syllabus
How to apply for the exam: –
Way of modifying the application for the exam: –
Students who are absent from the exam are required to submit: an original medical certificate. If the absence is authorized, the student can make arrangements with the instructor to make up for the exam.
Connecting notes, books, study aids, literature: Papp Zoltán (szerk.): Klinikai genetika. Golden Book Kiadó, Budapest, 1995. Oláh Éva: A klinikai genetika alapjai. Medicina, Budapest, 1999. Turnpenny PD, Ellard S: Emery’s Elements of medical Genetics. Chirchill Livingstone 13th ed. 2007.
The presentations of the lectures can be found on the “Knowledgebase” site at: http://lib.semmelweis.hu/