Adrenal tumors
Adrenal tumors are in the focus of Prof. Peter Igaz’s research, mostly on the gene expression profiles of adrenal tumors, microRNAs and other non-coding RNAs are investigated to uncover novel biomarkers and potential novel treatment strategies. The research group was among the first to described the microRNA patterns of adrenocortical and adrenomedullary tumors, and performed the first functional genomics meta-analysis in adrenocortical cancer. Several potential microRNA biomarkers both in tissue and plasma samples (circulating microRNA) have been established by these studies. The research group investigated the potential role of retinoic acid signaling in adrenocortical cancer in several models both in vitro and in vivo. The research group was awarded the Research Title of Excellence by the European Network for the Study of Adrenal Tumors (ENS@T).
Selected publications of the topic:
- Studies on circulating plasma microRNA and extracellular vesicles in adrenocortical tumors
- Tissue microRNAs in pheochromocytomas
- Tissue microRNAs in adrenocortical tumors
- Bioinformatical metaanalysis in adrenocortical cancer
- Bioinformatical analysis of pheochromocytoma and neuroblastoma
- Review on non-coding RNA in adrenocortical cancer
- 9-cis retinoic acid in adrenocortical cancer (xenograft study)
Neuroendocrine tumors
Research linked to the ENETS Research Center of Excellence are being launched. Some of these will be clinical, others are linked to the non-coding RNA research of Prof. Peter Igaz.
Multiple Endocrine Neoplasia Syndromes
These rare, hereditary syndromes represent a focus of research of the former 2nd Department of Internal Medicine and also continued now at the Department of Endocrinology. Several novel genetic variants and mutations have been described by the research group.