Peer-reviewed publications from CardioLab members.
Selected team publications, 2016–2026
Milestones in core lab work, multicentre trials, photon-counting CT and phantom research.
2026
Photon-counting CT: from images to patient care
Invited editorial on the clinical translation of photon-counting CT.
Szilveszter B. JACC Cardiovasc Imaging. doi:10.1016/j.jcmg.2026.08.014
2026
Phantom ground truth for low-attenuation plaque
In a mixed-plaque phantom, ultra-high-resolution photon-counting CT with sharp kernels best reproduced LAP attenuation; calcium and iodine masked LAP at low keV.
Szilveszter B, et al. Eur Heart J Imaging Methods Pract. doi:10.1093/ehjimp/qyag119
2026
Plaque quantification across software platforms
A novel plaque analysis software compared with an established tool on photon-counting and energy-integrating CT: rapid, reproducible quantification, with fewer manual corrections and less inter-platform variability on photon-counting CT.
Sipos B, Vattay B, …, Szilveszter B. Eur J Radiol. doi:10.1016/j.ejrad.2026.112928
2026
High-risk plaque and outcomes in DISCHARGE
Prespecified DISCHARGE secondary analysis: high-risk plaque features, including CAC ≥400, predicted MACE with prognostic value similar to obstructive CAD.
Szilveszter B, et al. Eur Radiol. doi:10.1007/s00330-025-12146-3
2025
CT phenotype-guided statin therapy
Statin benefit on MACE depended on the CTA-defined CAD phenotype and increased with disease extent and high-risk plaque; patients without CAD showed no MACE benefit.
Szilveszter B, et al. JACC Cardiovasc Imaging. doi:10.1016/j.jcmg.2025.05.018
2024
Ultra-high-resolution photon-counting CT for stenosis grading
Compared with conventional CT, UHR photon-counting CT measured stenosis in calcified plaques more accurately and reclassified CAD-RADS in 49% of patients.
Vecsey-Nagy M, et al. Circ Cardiovasc Imaging. doi:10.1161/CIRCIMAGING.124.017112
2024
Head-to-head comparison of plaque quantification tools
Two contemporary quantitative plaque tools compared in single-centre and multicentre cohorts: more automation meant better reproducibility and shorter reading times.
Weichsel L, …, Szilveszter B, et al. Diagnostics (Basel). doi:10.3390/diagnostics14020154
2023
Perfusion CT in high-risk vascular patients
Pilot study: coronary CTA with dynamic perfusion CT was feasible for detecting functionally significant CAD despite heavy calcification in chronic limb-threatening ischaemia.
Nagy FT, …, Szilveszter B. J Cardiovasc Dev Dis. doi:10.3390/jcdd10110443
2023
Low-attenuation plaque and troponin release
Tested whether ischaemia (CT-FFR), inflammation or pericoronary fat mediate the link between LAP burden and hs-troponin T in chronic coronary syndrome; none did.
Vecsey-Nagy M, …, Szilveszter B. J Cardiovasc Comput Tomogr. doi:10.1016/j.jcct.2023.10.011
2023
DISCHARGE: patients with diabetes
In patients with diabetes, a CT-first strategy showed no difference in MACE and fewer major procedure-related complications than invasive angiography.
Benedek T, …, Szilveszter B, et al. Diabetes Care. doi:10.2337/dc23-0710
2022
Serial CT: beyond CAD-RADS
On serial coronary CTA, CAD-RADS missed plaque progression in almost half of patients, which supports quantitative metrics for longitudinal studies.
Szilveszter B, et al. Eur Heart J Cardiovasc Imaging. doi:10.1093/ehjci/jeab215
2022
DISCHARGE trial
European randomized trial: a CT-first strategy had similar MACE and fewer major complications than invasive coronary angiography. Semmelweis was a participating site.
DISCHARGE Trial Group N Engl J Med. doi:10.1056/NEJMoa2200963
2019
CT strain imaging
Feature-tracking left ventricular and left atrial strain on cardiac CT was validated against echocardiography, with high reproducibility.
Szilveszter B, et al. J Cardiovasc Comput Tomogr. doi:10.1016/j.jcct.2019.12.004
2019
Core lab reads in PROMISE
Core lab analysis of the PROMISE trial: CAD-RADS added prognostic value beyond ASCVD risk score and calcium score.
Bittner DO, …, Szilveszter B, et al. JACC Cardiovasc Imaging. doi:10.1016/j.jcmg.2019.09.012
Recent publications
Imported from PubMed
- Szilveszter B. New Eyes for an Old Problem. JACC Cardiovasc Imaging. 2026. doi:10.1016/j.jcmg.2026.08.014 | PubMed
- Huszti BB, et al. Cumulative Duration of Severe Psoriasis: A Novel Cardiovascular Risk Predictor for Dermatologists. Dermatol Ther (Heidelb). 2026. doi:10.1007/s13555-026-01872-1 | PubMed
- Szilveszter B, Kolossváry M, et al. Mixed coronary plaque phantom analysis by photon-counting CT: impact of calcium and iodine on low-attenuation plaque detection. Eur Heart J Imaging Methods Pract. 2026. doi:10.1093/ehjimp/qyag119 | PubMed
- Vecsey-Nagy M, et al. Coronary plaque quantification on energy-integrating and photon-counting detector CT: reproducibility and power modeling for mixed-platform trials. Eur Radiol. 2026. doi:10.1007/s00330-026-12773-4 | PubMed
- Hyska S, et al. Deep-learning denoising for ultrahigh-resolution photon-counting detector CT: phantom and in vivo evaluation of non-calcified coronary plaques. Int J Cardiovasc Imaging. 2026. doi:10.1007/s10554-026-03774-x | PubMed
- Sipos B, Vattay B, Boussoussou M, et al. Reproducibility and workflow efficiency of a novel software for quantitative coronary plaque characterization using photon-counting and energy-integrating detector computed tomography. Eur J Radiol. 2026. doi:10.1016/j.ejrad.2026.112928 | PubMed
- Hagar MT, Vecsey-Nagy M, et al. Photon-counting CT in cardiac imaging: multi-institutional guidance on technical principles, clinical evidence, and practical protocols. Eur J Radiol. 2026. doi:10.1016/j.ejrad.2026.112904 | PubMed
- Vecsey-Nagy M, et al. Bridging scanner variability and biological change: Power modeling for studies involving both energy-integrating and photon-counting detector CT. J Cardiovasc Comput Tomogr. 2026. doi:10.1016/j.jcct.2026.03.001 | PubMed
- Szilveszter B, Hagar MT, Kulyassa P, et al. Assessing coronary in-stent restenosis using ultrahigh-resolution photon-counting detector CT: results from a two-center study. Eur J Radiol. 2026. doi:10.1016/j.ejrad.2026.112766 | PubMed
- Szilveszter B, et al. Association of high-risk CT coronary artery plaque features with major adverse cardiovascular events: a prespecified secondary analysis of the DISCHARGE trial. Eur Radiol. 2026. doi:10.1007/s00330-025-12146-3 | PubMed