Publications
Selection of AmpC β-Lactamase Variants and Metallo-β-Lactamases Leading to Ceftolozane/Tazobactam and Ceftazidime/Avibactam Resistance during Treatment of MDR/XDR Pseudomonas aeruginosa Infections.
Ruedas-López A, Alonso-García I, Lasarte-Monterrubio C, Guijarro-Sánchez P, Gato E, Vázquez-Ucha JC, Vallejo JA, Fraile-Ribot PA, Fernández-Pérez B, Velasco D, Gutiérrez-Urbón JM, Oviaño M, Beceiro A, González-Bello C, Oliver A, Arca-Suárez J, Bou G.Antimicrob Agents Chemother. 2022 Feb 15;66(2):e0206721. doi: 10.1128/AAC.02067-21. Epub 2021 Dec 20.PMID: 34930034 Free PMC article.
Pseudomonas aeruginosa epidemic high-risk clones and their association with horizontally-acquired β-lactamases: 2020 update.
Del Barrio-Tofiño E, López-Causapé C, Oliver A.Int J Antimicrob Agents. 2020 Dec;56(6):106196. doi: 10.1016/j.ijantimicag.2020.106196. Epub 2020 Oct 9.PMID: 33045347 Review.
Susceptibility profiles and resistance genomics of Pseudomonas aeruginosa isolates from European ICUs participating in the ASPIRE-ICU trial.
Torrens G, van der Schalk TE, Cortes-Lara S, Timbermont L, Del Barrio-Tofiño E, Xavier BB, Zamorano L, Lammens C, Ali O, Ruzin A, Goossens H, Kumar-Singh S, Kluytmans J, Paling F, MacLean RC, Köhler T, López-Causapé C, Malhotra-Kumar S, Oliver A; ASPIRE-ICU study team.J Antimicrob Chemother. 2022 Jun 29;77(7):1862-1872. doi: 10.1093/jac/dkac122.PMID: 35451008 Clinical Trial.
Genomics and Susceptibility Profiles of Extensively Drug-Resistant Pseudomonas aeruginosa Isolates from Spain.
Del Barrio-Tofiño E, López-Causapé C, Cabot G, Rivera A, Benito N, Segura C, Montero MM, Sorlí L, Tubau F, Gómez-Zorrilla S, Tormo N, Durá-Navarro R, Viedma E, Resino-Foz E, Fernández-Martínez M, González-Rico C, Alejo-Cancho I, Martínez JA, Labayru-Echverria C, Dueñas C, Ayestarán I, Zamorano L, Martinez-Martinez L, Horcajada JP, Oliver A.Antimicrob Agents Chemother. 2017 Oct 24;61(11):e01589-17. doi: 10.1128/AAC.01589-17. Print 2017 Nov.PMID: 28874376 Free PMC article.
Distinct epidemiology and resistance mechanisms affecting ceftolozane/tazobactam in Pseudomonas aeruginosa isolates recovered from ICU patients in Spain and Portugal depicted by WGS.
Hernández-García M, García-Castillo M, García-Fernández S, Melo-Cristino J, Pinto MF, Gonçalves E, Alves V, Vieira AR, Ramalheira E, Sancho L, Diogo J, Ferreira R, Silva T, Chaves C, Bou G, Cercenado E, Delgado-Valverde M, Oliver A, Pitart C, Rodríguez-Lozano J, Tormo N, Romano J, Pássaro L, Paixão L, López-Mendoza D, Díaz-Regañón J, Cantón R; STEP and SUPERIOR study groups.J Antimicrob Chemother. 2021 Jan 19;76(2):370-379. doi: 10.1093/jac/dkaa430.PMID: 33099623
Molecular mechanisms driving the in vivo development of OXA-10-mediated resistance to ceftolozane/tazobactam and ceftazidime/avibactam during treatment of XDR Pseudomonas aeruginosa infections.
Arca-Suárez J, Lasarte-Monterrubio C, Rodiño-Janeiro BK, Cabot G, Vázquez-Ucha JC, Rodríguez-Iglesias M, Galán-Sánchez F, Beceiro A, González-Bello C, Oliver A, Bou G.J Antimicrob Chemother. 2021 Jan 1;76(1):91-100. doi: 10.1093/jac/dkaa396.PMID: 33083833
Evaluation of in vitro activity of ceftazidime/avibactam and ceftolozane/tazobactam against MDR Pseudomonas aeruginosa isolates from Qatar.
Sid Ahmed MA, Abdel Hadi H, Hassan AAI, Abu Jarir S, Al-Maslamani MA, Eltai NO, Dousa KM, Hujer AM, Sultan AA, Soderquist B, Bonomo RA, Ibrahim EB, Jass J, Omrani AS.J Antimicrob Chemother. 2019 Dec 1;74(12):3497-3504. doi: 10.1093/jac/dkz379.PMID: 31504587 Free PMC article.
The ERACE-PA Global Surveillance Program: Ceftolozane/tazobactam and Ceftazidime/avibactam in vitro Activity against a Global Collection of Carbapenem-resistant Pseudomonas aeruginosa.
Gill CM, Aktaþ E, Alfouzan W, Bourassa L, Brink A, Burnham CD, Canton R, Carmeli Y, Falcone M, Kiffer C, Marchese A, Martinez O, Pournaras S, Satlin M, Seifert H, Thabit AK, Thomson KS, Villegas MV, Nicolau DP; ERACE-PA Global Study Group.Eur J Clin Microbiol Infect Dis. 2021 Dec;40(12):2533-2541. doi: 10.1007/s10096-021-04308-0. Epub 2021 Jul 22.PMID: 34291323 Free PMC article.
Mechanisms leading to in vivo ceftolozane/tazobactam resistance development during the treatment of infections caused by MDR Pseudomonas aeruginosa.
Fraile-Ribot PA, Cabot G, Mulet X, Periañez L, Martín-Pena ML, Juan C, Pérez JL, Oliver A.J Antimicrob Chemother. 2018 Mar 1;73(3):658-663. doi: 10.1093/jac/dkx424.PMID: 29149337
Ceftazidime-avibactam and ceftolozane-tazobactam susceptibility of multidrug resistant Pseudomonas aeruginosa strains in Hungary.
O’Neall D, Juhász E, Tóth Á, Urbán E, Szabó J, Melegh S, Katona K, Kristóf K.Acta Microbiol Immunol Hung. 2020 Mar 26;67(1):61-65. doi: 10.1556/030.2020.01152.PMID: 32208923
Comparative analysis of in vitro dynamics and mechanisms of ceftolozane/tazobactam and imipenem/relebactam resistance development in Pseudomonas aeruginosa XDR high-risk clones.
Gomis-Font MA, Cabot G, López-Argüello S, Zamorano L, Juan C, Moyá B, Oliver A.J Antimicrob Chemother. 2022 Mar 31;77(4):957-968. doi: 10.1093/jac/dkab496.PMID: 35084040
Spanish nationwide survey on Pseudomonas aeruginosa antimicrobial resistance mechanisms and epidemiology.
Del Barrio-Tofiño E, Zamorano L, Cortes-Lara S, López-Causapé C, Sánchez-Diener I, Cabot G, Bou G, Martínez-Martínez L, Oliver A; GEMARA-SEIMC/REIPI Pseudomonas study Group.J Antimicrob Chemother. 2019 Jul 1;74(7):1825-1835. doi: 10.1093/jac/dkz147.PMID: 30989186
Implementation of the Infection Risk Scan (IRIS) in nine hospitals in the Belgian-Dutch border region (i-4-1-Health project).
Verelst M, Willemsen I, Weterings V, De Waegemaeker P, Leroux-Roels I, Nieuwkoop E, Saegeman V, van Alphen L, van Kleef-van Koeveringe S, Kluytmans-van den Bergh M, Kluytmans J, Schuermans A; i-4-1-Health study group.Antimicrob Resist Infect Control. 2022 Feb 28;11(1):43. doi: 10.1186/s13756-022-01083-1.PMID: 35227333
Diversity in the Characteristics of Klebsiella pneumoniae ST101 of Human, Environmental, and Animal Origin.
De Koster S, Rodriguez Ruiz JP, Rajakani SG, Lammens C, Glupczynski Y, Goossens H, Xavier BB.Front Microbiol. 2022 Feb 10;13:838207. doi: 10.3389/fmicb.2022.838207. eCollection 2022.PMID: 35222344 Free PMC article.
Obesity influences the microbiotic biotransformation of chlorogenic acid.
Mortelé O, Xavier BB, Lammens C, Malhotra-Kumar S, Jorens PG, Dirinck E, van Nuijs ALN, Hermans N.J Pharm Biomed Anal. 2022 Mar 20;211:114550. doi: 10.1016/j.jpba.2021.114550. Epub 2021 Dec 28.PMID: 35124448
The impact of non-antimicrobial drug agents on the acquisition of ESBL-producing Enterobacterales in non-critical care wards in a German university hospital: an exploratory, matched case-control study.
Klauke P, Schwab F, Gastmeier P, Maechler F; R-GNOSIS WP5 study group.J Antimicrob Chemother. 2021 Dec 24;77(1):229-236. doi: 10.1093/jac/dkab373.PMID: 34791310
Monitoring the SARS-CoV-2 pandemic: screening algorithm with single nucleotide polymorphism detection for the rapid identification of established and emerging variants.
Mertens J, Coppens J, Loens K, Le Mercier M, Xavier BB, Lammens C, Vandamme S, Jansens H, Goossens H, Matheeussen V.Clin Microbiol Infect. 2022 Jan;28(1):124-129. doi: 10.1016/j.cmi.2021.09.007. Epub 2021 Sep 16.PMID: 34537361 Free PMC article.
Novel vancomycin resistance gene cluster in Enterococcus faecium ST1486, Belgium, June 2021.
Xavier BB, Coppens J, De Koster S, Rajakani SG, Van Goethem S, Mzougui S, Anantharajah A, Lammens C, Loens K, Glupczynski Y, Goossens H, Matheeussen V.Euro Surveill. 2021 Sep;26(36):2100767. doi: 10.2807/1560-7917.ES.2021.26.36.2100767.PMID: 34505571 Free
Assessing the Impact of Flavophospholipol and Virginiamycin Supplementation on the Broiler Microbiota: a Prospective Controlled Intervention Study.
Mysara M, Berkell M, Xavier BB, De Backer S, Lammens C, Hautekiet V, Petkov S, Goossens H, Kumar-Singh S, Malhotra-Kumar S.mSystems. 2021 Aug 31:e0038121. doi: 10.1128/mSystems.00381-21. Online ahead of print.PMID: 34463581 Free article.
Prospective SARS-CoV-2 cohort study among primary health care providers during the second COVID-19 wave in Flanders, Belgium.
Mariën J, Ceulemans A, Bakokimi D, Lammens C, Ieven M, Heytens S, De Sutter A, Verbakel JY, Van den Bruel A, Goossens H, Van Damme P, Ariën KK, Coenen S.Fam Pract. 2022 Jan 19;39(1):92-98. doi: 10.1093/fampra/cmab094.PMID: 34448859
ESBL-Producing, Carbapenem- and Ciprofloxacin-Resistant Escherichia coli in Belgian and Dutch Broiler and Pig Farms: A Cross-Sectional and Cross-Border Study.
De Koster S, Ringenier M, Lammens C, Stegeman A, Tobias T, Velkers F, Vernooij H, Kluytmans-van den Bergh M, Kluytmans J, Dewulf J, Goossens H, On Behalf Of The I-Health Study Group.Antibiotics (Basel). 2021 Aug 4;10(8):945. doi: 10.3390/antibiotics10080945.PMID: 34438995 Free PMC article.
Evaluation of GeneXpert PA assay compared to genomic and (semi-)quantitative culture methods for direct detection of Pseudomonas aeruginosa in endotracheal aspirates.
van der Schalk TE, Coppens J, Timbermont L, Turlej-Rogacka A, Van Heirstraeten L, Berkell M, Yu L, Lammens C, Xavier BB, Matheeussen V, Ieven M, McCarthy M, Jorens PG, Ruzin A, Esser MT, Kumar-Singh S, Goossens H, Malhotra-Kumar S.Antimicrob Resist Infect Control. 2021 Jul 23;10(1):110. doi: 10.1186/s13756-021-00978-9.PMID: 34301343 Free
Harmonization of whole-genome sequencing for outbreak surveillance of Enterobacteriaceae and Enterococci.
Jamin C, De Koster S, van Koeveringe S, De Coninck D, Mensaert K, De Bruyne K, Perales Selva N, Lammens C, Goossens H, Hoebe C, Savelkoul P, van Alphen L.Microb Genom. 2021 Jul;7(7):000567. doi: 10.1099/mgen.0.000567.PMID: 34279213 Free PMC article.
Phenotypic and genotypic characterization of mcr-1-positive multidrug-resistant Escherichia coli ST93, ST117, ST156, ST10, and ST744 isolated from poultry in Poland.
Ćwiek K, Woźniak-Biel A, Karwańska M, Siedlecka M, Lammens C, Rebelo AR, Hendriksen RS, Kuczkowski M, Chmielewska-Władyka M, Wieliczko A.Braz J Microbiol. 2021 Sep;52(3):1597-1609. doi: 10.1007/s42770-021-00538-8. Epub 2021 Jun 10.PMID: 34114111
COMBACTE LAB-Net: building a European laboratory network for clinical trials on anti-infectives.
Kostyanev T, Timbermont L, Vilken T, Lammens C, Malhotra-Kumar S, Glupczynski Y, Goossens H.Future Microbiol. 2021 Jun;16:635-647. doi: 10.2217/fmb-2021-0096. Epub 2021 May 17.PMID: 33998261
Rapid evolution and host immunity drive the rise and fall of carbapenem resistance during an acute Pseudomonas aeruginosa infection.
Wheatley R, Diaz Caballero J, Kapel N, de Winter FHR, Jangir P, Quinn A, Del Barrio-Tofiño E, López-Causapé C, Hedge J, Torrens G, Van der Schalk T, Xavier BB, Fernández-Cuenca F, Arenzana A, Recanatini C, Timbermont L, Sifakis F, Ruzin A, Ali O, Lammens C, Goossens H, Kluytmans J, Kumar-Singh S, Oliver A, Malhotra-Kumar S, MacLean C.Nat Commun. 2021 Apr 28;12(1):2460. doi: 10.1038/s41467-021-22814-9.PMID: 33911082
Efficacy and safety of suvratoxumab for prevention of Staphylococcus aureus ventilator-associated pneumonia (SAATELLITE): a multicentre, randomised, double-blind, placebo-controlled, parallel-group, phase 2 pilot trial.
François B, Jafri HS, Chastre J, Sánchez-García M, Eggimann P, Dequin PF, Huberlant V, Viña Soria L, Boulain T, Bretonnière C, Pugin J, Trenado J, Hernandez Padilla AC, Ali O, Shoemaker K, Ren P, Coenjaerts FE, Ruzin A, Barraud O, Timbermont L, Lammens C, Pierre V, Wu Y, Vignaud J, Colbert S, Bellamy T, Esser MT, Dubovsky F, Bonten MJ, Goossens H, Laterre PF; COMBACTE Consortium and the SAATELLITE Study Group.Lancet Infect Dis. 2021 Sep;21(9):1313-1323. doi: 10.1016/S1473-3099(20)30995-6. Epub 2021 Apr 21.PMID: 33894131 Clinical Trial.
Phenotypic and molecular characterizations of carbapenem-resistant Acinetobacter baumannii isolates collected within the EURECA study.
Kostyanev T, Xavier BB, García-Castillo M, Lammens C, Bravo-Ferrer Acosta J, Rodríguez-Baño J, Cantón R, Glupczynski Y, Goossens H; EURECA/WP1B Group.Int J Antimicrob Agents. 2021 Jun;57(6):106345. doi: 10.1016/j.ijantimicag.2021.106345. Epub 2021 Apr 20.PMID: 33887390
Microbiota-based markers predictive of development of Clostridioides difficile infection.
Berkell M, Mysara M, Xavier BB, van Werkhoven CH, Monsieurs P, Lammens C, Ducher A, Vehreschild MJGT, Goossens H, de Gunzburg J, Bonten MJM, Malhotra-Kumar S; ANTICIPATE study group.Nat Commun. 2021 Apr 14;12(1):2241. doi: 10.1038/s41467-021-22302-0.PMID: 33854066
Incidence and predictive biomarkers of Clostridioides difficile infection in hospitalized patients receiving broad-spectrum antibiotics.
van Werkhoven CH, Ducher A, Berkell M, Mysara M, Lammens C, Torre-Cisneros J, Rodríguez-Baño J, Herghea D, Cornely OA, Biehl LM, Bernard L, Dominguez-Luzon MA, Maraki S, Barraud O, Nica M, Jazmati N, Sablier-Gallis F, de Gunzburg J, Mentré F, Malhotra-Kumar S, Bonten MJM, Vehreschild MJGT; ANTICIPATE Study Group.Nat Commun. 2021 Apr 14;12(1):2240. doi: 10.1038/s41467-021-22269-y.PMID: 33854064 Free
Molecular pathways to high-level azithromycin resistance in Neisseria gonorrhoeae.
Laumen JGE, Manoharan-Basil SS, Verhoeven E, Abdellati S, De Baetselier I, Crucitti T, Xavier BB, Chapelle S, Lammens C, Van Dijck C, Malhotra-Kumar S, Kenyon C.J Antimicrob Chemother. 2021 Jun 18;76(7):1752-1758. doi: 10.1093/jac/dkab084.PMID: 33760080
Prospective One Health genetic surveillance in Vietnam identifies distinct blaCTX-M-harbouring Escherichia coli in food-chain and human-derived samples.
Nguyen MN, Hoang HTT, Xavier BB, Lammens C, Le HT, Hoang NTB, Nguyen ST, Pham NT, Goossens H, Dang AD, Malhotra-Kumar S.Clin Microbiol Infect. 2021 Oct;27(10):1515.e1-1515.e8. doi: 10.1016/j.cmi.2021.01.006. Epub 2021 Jan 18.PMID: 33476808
Identification of mcr-8 in Clinical Isolates From Qatar and Evaluation of Their Antimicrobial Profiles.
Eltai NO, Kelly B, Al-Mana HA, Ibrahim EB, Yassine HM, Al Thani A, Al Maslmani M, Lammens C, Xavier BB, Malhotra-Kumar S.Front Microbiol. 2020 Aug 24;11:1954. doi: 10.3389/fmicb.2020.01954. eCollection 2020.PMID: 32983006 Free PMC article.
Clonal transmission of multidrug-resistant Acinetobacter baumannii harbouring blaOXA-24-like and blaOXA-23-like genes in a tertiary hospital in Albania.
Tafaj S, Kostyanev T, Xavier BB, Fluit AC, Rodrigues CF, Lammens C, Osmalli D, Raka L, Goossens H, Malhotra-Kumar S, Bonten MJM.J Glob Antimicrob Resist. 2020 Dec;23:79-81. doi: 10.1016/j.jgar.2020.07.026. Epub 2020 Sep 2.PMID: 32890841 Free article. No abstract available.
International external quality assessment for SARS-CoV-2 molecular detection and survey on clinical laboratory preparedness during the COVID-19 pandemic, April/May 2020.
Matheeussen V, Corman VM, Donoso Mantke O, McCulloch E, Lammens C, Goossens H, Niemeyer D, Wallace PS, Klapper P, Niesters HG, Drosten C, Ieven M; RECOVER project and collaborating networks.Euro Surveill. 2020 Jul;25(27):2001223. doi: 10.2807/1560-7917.ES.2020.25.27.2001223.PMID: 32672149 Free PMC article.
Emergence of ST654 Pseudomonas aeruginosa co-harbouring blaNDM-1 and blaGES-5 in novel class I integron In1884 from Bulgaria.
Kostyanev T, Nguyen MN, Markovska R, Stankova P, Xavier BB, Lammens C, Marteva-Proevska Y, Velinov T, Cantón R, Goossens H, Malhotra-Kumar S.J Glob Antimicrob Resist. 2020 Sep;22:672-673. doi: 10.1016/j.jgar.2020.06.008. Epub 2020 Jun 22.PMID: 32585404 Free article. No abstract available.
ATP measurement as an objective method to measure environmental contamination in 9 hospitals in the Dutch/Belgian border area.
van Arkel A, Willemsen I, Kilsdonk-Bode L, Vlamings-Wagenaars S, van Oudheusden A, Waegemaeker P, Leroux-Roels I, Verelst M, Maas E, van Oosten A, Willemse P, van Asselen E, Klomp-Berens E, Franssen K, Van Cauwenberg E, Kluytmans J; i-4-1-Health Study Group.Antimicrob Resist Infect Control. 2020 May 28;9(1):77. doi: 10.1186/s13756-020-00730-9.PMID: 32466792 Free PMC article.
Preparedness of European diagnostic microbiology labs for detection of SARS-CoV-2, March 2020.
Matheeussen V, Loens K, Lammens C, Vilken T, Koopmans M, Goossens H, Ieven M; RECOVER consortium.J Clin Virol. 2020 Jul;128:104432. doi: 10.1016/j.jcv.2020.104432. Epub 2020 May 15.PMID: 32422569 Free PMC article.
Quantifying antibiotic impact on within-patient dynamics of extended-spectrum beta-lactamase resistance.
Niehus R, van Kleef E, Mo Y, Turlej-Rogacka A, Lammens C, Carmeli Y, Goossens H, Tacconelli E, Carevic B, Preotescu L, Malhotra-Kumar S, Cooper BS.Elife. 2020 May 7;9:e49206. doi: 10.7554/eLife.49206.PMID: 32379042 Free PMC article.
Lower respiratory tract infection in the community: associations between viral aetiology and illness course.
Vos LM, Bruyndonckx R, Zuithoff NPA, Little P, Oosterheert JJ, Broekhuizen BDL, Lammens C, Loens K, Viveen M, Butler CC, Crook D, Zlateva K, Goossens H, Claas ECJ, Ieven M, Van Loon AM, Verheij TJM, Coenjaerts FEJ; GRACE Consortium.Clin Microbiol Infect. 2021 Jan;27(1):96-104. doi: 10.1016/j.cmi.2020.03.023. Epub 2020 Mar 31.PMID: 32244051 Free PMC article.
BacPipe: A Rapid, User-Friendly Whole-Genome Sequencing Pipeline for Clinical Diagnostic Bacteriology.
Xavier BB, Mysara M, Bolzan M, Ribeiro-Gonçalves B, Alako BTF, Harrison P, Lammens C, Kumar-Singh S, Goossens H, Carriço JA, Cochrane G, Malhotra-Kumar S.iScience. 2020 Jan 24;23(1):100769. doi: 10.1016/j.isci.2019.100769. Epub 2019 Dec 12.PMID: 31887656 Free PMC article.
Mechanical Ventilation Impairs IL-17 Cytokine Family Expression in Ventilator-Associated Pneumonia.
De Winter FHR, ‘s Jongers B, Bielen K, Mancuso D, Timbermont L, Lammens C, Van Averbeke V, Boddaert J, Ali O, Kluytmans J, Ruzin A, Malhotra-Kumar S, Jorens PG, Goossens H, Kumar-Singh S.Int J Mol Sci. 2019 Oct 12;20(20):5072. doi: 10.3390/ijms20205072.PMID: 31614857 Free PMC article.