Our study, “Phosphoproteomic profiling reveals post-translational dysregulation in Huntington’s disease patient-derived neurons,” is now published in Cellular & Molecular Biology Letters.
Using directly reprogrammed neurons from Huntington’s disease patients, we generated the first phosphoproteomic map of this human age-preserved neuronal model and integrated it with matched proteomic and transcriptomic datasets. The study identified widespread signaling alterations affecting RNA splicing, autophagy, and stress-response pathways, and highlighted MXRA8 as a phospho-switch candidate linked to disrupted proteostasis and autophagy.
This work was led by shared first authors Lea Danics and Chandramouli Muralidharan, in collaboration with partners from Semmelweis University, HCEMM, HUN-REN, Lund University, the University of Cambridge, and the University of Montreal.
🔗 https://link.springer.com/article/10.1186/s11658-026-00948-2