Excited to share our new bioRxiv preprint, led by the outstanding PhD student Melinda, co-supervised by Attila and Karolina:
“Cariprazine modulates intrinsic excitability and network dynamics of hippocampal neurons in a cell-type dependent manner.”
This study was a truly interdisciplinary collaboration between Semmelweis University, HCEMM, HUN-REN SZTAKI, ELTE, and the Medical University of Innsbruck. By combining real-world clinical data from schizophrenia patients, multielectrode array (MEA) recordings, patch-clamp electrophysiology, computational modeling, and molecular analyses, we investigated how the antipsychotic drug cariprazine influences neuronal function and network activity.
Our findings suggest that cariprazine modulates hippocampal neuronal excitability through cell-type-specific mechanisms linked to Kv1-mediated potassium currents, while largely preserving network synchronization. Importantly, the study connects these mechanistic observations with nationwide clinical outcome data, offering a translational perspective on antipsychotic drug action in schizophrenia.
We are grateful to all co-authors for bringing together expertise from neuroscience, psychiatry, electrophysiology, bioinformatics, and computational biology.
https://www.biorxiv.org/content/10.64898/2026.05.22.727184v1