Our lab contributed to a new study published in Aging Cell investigating how cardiorespiratory fitness influences epigenetic aging across different organs. Using a rat model of high- and low-capacity runners, the research found:
• Significant organ-specific differences in DNA methylation patterns related to fitness
• The soleus muscle showed the most pronounced epigenetic changes
• Seven genes displayed consistent methylation changes across all organs studied
• Epigenetic aging rates varied substantially between tissues
The findings highlight the complex relationship between exercise, epigenetics and aging, emphasizing the importance of organ-specific approaches in aging research.
We’re grateful to have collaborated on this important work!
🔗 Read the study: https://onlinelibrary.wiley.com/doi/10.1111/acel.70110