Inflammatory alterations in the glomeruli of the kidney, known as glomerulonephritis, rank as the second or third most common causative factor in the development of chronic kidney disease (CKD). Therefore, studying these conditions is of great significance. Among glomerulonephritides, those displaying so-called crescent formation in histological samples are particularly prone to progressing to end-stage renal disease (ESRD).
Findings from other research groups suggest that myeloid cells may play a crucial role in kidney damage in various inflammatory conditions. However, the specific signaling pathways involved in these cells in the process of kidney injury remain unclear. By gaining a deeper understanding of the signaling mechanisms examined in our research, we may contribute to the development of more effective treatments for kidney diseases and the improvement of patients’ quality of life.