Rheumatoid arthritis and gouty arthritis are inflammatory diseases characterized by acute flare-ups as well as chronic, progressive courses, leading to significant tissue damage and joint destruction, which consequently result in decreased quality of life in the affected population.
Our research group investigates the underlying cellular and molecular mechanisms involved in both the effector phase of autoimmune rheumatoid arthritis and the autoinflammatory (non-autoimmune) nature of gouty arthritis in experimental disease models. These studies may contribute to a better understanding of the pathomechanisms of these diseases, as well as the identification of new therapeutic targets. Our investigations focus on the role of tyrosine kinase signaling pathways initiated by cell surface Fcγ receptors and β2-integrins, with several components of these pathways identified over the past few years.
Previous publications related to the project:
Futosi, Kása et al., Arthritis Rheumatol. 2021
Csepregi et al., J Immunol. 2018
Németh et al., Front Immunol. 2018
Németh et al., Nat Commun. 2016
Kovács et al., J Exp Med. 2014
Németh et al., J Immunol. 2010
Jakus et al., Arthritis Rheumatol. 2010