HIT to LEAD drug development – organic synthesis

What we offer

• Custom synthesis of the requested compound
• Chemical synthesis in a high chemical purity (98+%)
• Chemical optimization of the given compound to make a structure-activity-relationship (SAR) study
• Separation of enantiomers for both analytical determination and small preparative scale
• Synthesis of versatile compounds
• Parallel synthesis
• Organometallic coupling reactions
• Enantioselective synthesis

Why work with us

• Synthesis in a short time
• We have a broad knowledge, hands on experience on parallel synthesis, organometallic coupling reactions and enantioselective synthesis
• Our synthetic work is supported by state of art equipments and chemical databases
• Our SFC system is equipped with various chiral columns, which enables the quick separation of enantiomers

equipmentS

• Varian Mercury Plus 400 MHz NMR spectrometer , Varian VNMRS 600 MHz NMR spectrometer (currently out of service, requires reinstallation)
• Shimadzu LCMS-2020
• Shimadzu GC
• Shimadzu GC-MS
• Shimadzu IR spectrometer (single ATR, horizonal ATR, transmittance)
• Jasco 4600 FT-IR, ATR
• ATR-FT-IR, optical polarimeter
• Raman spectrometer
• Waters HR-MS (ESI- and LA-REIMS – qTOF instrument)
• Metrohm Eco potentiometric titrator (Sirius T3 automated titrator equipment purchase would provide extra capacity)
• TECAN Infinite M200 plate reader
• Gut-Box™ (Pion Inc.)
• LC-MS/MS, LC-qTOF and LA-REIMS metods for quantitative and qualitative investigation for early stage metabolism studies
• Shimadzu AA-7000 equipped with graphite furnace atomizer and auto-sampler (new cathode lamps would improve performance)

References

• doi.org/10.1007/s10895-021-02851-9
• doi.org/10.3390/molecules26134043
• doi.org/10.3390/molecules25112571
• doi.org/10.1038/s41598-023-46317-3
• doi.org/10.1007/s10337-020-03911-1
• doi.org/10.3311/PPch.22768
• doi.org/10.3390/molecules27092838