{"id":8016,"date":"2022-04-28T08:36:25","date_gmt":"2022-04-28T06:36:25","guid":{"rendered":"https:\/\/semmelweis.hu\/gyermekklinika2\/?page_id=8016"},"modified":"2026-03-25T14:04:30","modified_gmt":"2026-03-25T13:04:30","slug":"all-ic","status":"publish","type":"page","link":"https:\/\/semmelweis.hu\/tuzoltoklinika\/en\/researches\/all-ic\/","title":{"rendered":"ALL-IC REL"},"content":{"rendered":"<p><a href=\"#background\">Background<\/a><br \/>\n<a href=\"#steering_committee\">Steering Committee<\/a><br \/>\n<a href=\"#national_coordinators\">National Coordinators<\/a><br \/>\n<a href=\"#treatment_guidance_and_data_registry\">Treatment Guidance and Data Registry<\/a><br \/>\n<a href=\"#results\">Results<\/a><br \/>\n<a href=\"#mini_symposia\">Mini-Symposia<\/a><br \/>\n<a href=\"#how_to_join\">How to Join<\/a><\/p>\n<p><a name=\"background\"><\/a><\/p>\n<h4><strong>BACKGROUND<\/strong><\/h4>\n<p>The Acute Lymphoblastic Leukaemia Inter Continental (ALL-IC) Study Group has completed its second frontline ALL trial. By standardizing therapy and involving flow cytometry based MRD in treatment stratification, patient outcomes improved further. Still 15-20% of patients relapse. When looked up in 2013, survival of relapsed patients in the ALL-IC Study Group lagged behind that achieved in best contemporary studies. Hence, a project was initiated by Prof. Janez Jazbec specifically dedicated to improve ALL 1<sup>st<\/sup> relapse results. This is the ALL-IC REL project, by the ALL-IC REL Study Group. There is much but not total overlap between countries \/ centres joining the 1<sup>st<\/sup> line ALL-IC trials and the ALL-IC REL project.<\/p>\n<div align=\"right\"><a class=\"bookmark\" href=\"#\">Back to Top \u2191<\/a><\/div>\n<p><a name=\"steering_committee\"><\/a><\/p>\n<h4><strong>Steering committee<\/strong><\/h4>\n<ul>\n<li>D\u00e1niel Erd\u00e9lyi, Semmelweis University, Budapest, Hungary (Chair from 2023)<\/li>\n<li>Goran Milosevic, University Children\u2019s Hospital, Belgrade, Serbia<\/li>\n<li>Juan Tordecilla, Hospital Roberto del R\u00edo, Universidad de Chile, Santiago, Chile<\/li>\n<li>Marko Kav\u010di\u010d, University Medical Centre, Ljubljana, Slovenia<\/li>\n<li>Mirella Ampatzidou, Aghia Sophia Children&#8217;s Hospital, Athens, Greece<\/li>\n<li>Monica Makiya, Hospital Italiano de Buenos Aires, Buenos Aires, Argentina<\/li>\n<li>Sophia Polychronopoulou, Aghia Sophia Children\u2019s Hospital, Athens, Greece<\/li>\n<li>Volkan Hazar, Memorial Health Group Medstar Yildiz Hospital, Antalya, T\u00fcrkiye<\/li>\n<\/ul>\n<div align=\"right\"><a class=\"bookmark\" href=\"#\">Back to Top \u2191<\/a><\/div>\n<p><a name=\"national_coordinators\"><\/a><\/p>\n<h4><strong>NATIONAL COORDINATORS<\/strong><\/h4>\n<p><strong>Argentina (GATLA)<\/strong><\/p>\n<ul>\n<li>Monica Makiya, Hospital Italiano de Buenos Aires, Buenos Aires, Argentina (<a href=\"mailto:monica.makiya@hospitalitaliano.org.ar\" target=\"_blank\" rel=\"noopener\">monica.makiya@hospitalitaliano.org.ar<\/a>)<\/li>\n<li>Federico Manni, Hospital de<span style=\"color: #000000\"> Ni\u00f1os &#8222;Dr. Orlando Alassia&#8221;, Santa Fe, Argentina (<a href=\"mailto:federicomanni@hotmail.com\" target=\"_blank\" rel=\"noopener\">federicomanni@hotmail.com<\/a>)<\/span><\/li>\n<li>Cristina Ferraro, Hospital de Ni\u00f1os Ricardo Gutierrez, Buenos Aires, Argentina (<a href=\"mailto:crislucianaferraro@hotmail.com\">crislucianaferraro@hotmail.com<\/a>)<\/li>\n<\/ul>\n<p><strong>Argentina (SAHOP)<\/strong><\/p>\n<ul>\n<li>Myriam Guitter, Hospital de Pediatr\u00eda Juan P. Garrahan, Buenos Aires, Argentina (<a href=\"mailto:myriamguitter@gmail.com\">myriamguitter@gmail.com<\/a>)<\/li>\n<li>Carla Pennella, Hospital de Pediatr\u00eda Juan P. Garrahan, Buenos Aires, Argentina (<a href=\"mailto:carlapen@gmail.com\">carlapen@gmail.com<\/a>)<\/li>\n<\/ul>\n<p><strong>Azerbaijan<\/strong><\/p>\n<ul>\n<li>Konul Baghirova, National Center for Hematology and Transfusiology, Baku, Azerbaijan (<a href=\"mailto:dr.konulbagirova@gmail.com\">dr.konulbagirova@gmail.com<\/a>)<\/li>\n<\/ul>\n<p><strong>Bosnia and Herzegovina<\/strong><\/p>\n<ul>\n<li>Lejla Pilav, Sarajevo University Clinical Center, Sarajevo, Bosnia and Herzegovina (<a href=\"mailto:leki.ped.lp@gmail.com\">leki.ped.lp@gmail.com<\/a>)<\/li>\n<\/ul>\n<p><strong>Bulgaria<\/strong><\/p>\n<ul style=\"font-weight: 400\">\n<li style=\"text-align: justify\">Boryana Avramova,\u00a0 University Hospital &#8222;Tsaritsa Johanna-ISUL\u201d , Sofia, Bulgaria (<a href=\"mailto:b.avramova@sbaldohz.com\">b.avramova@sbaldohz.com<\/a>)<\/li>\n<li style=\"text-align: justify\">Tanya Dimitrova Hristova, University Hospital &#8222;Tsaritsa Johanna-ISUL\u201d, Sofia, Bulgaria (<a href=\"mailto:dr.tanyahris@gmail.com\" target=\"_blank\" rel=\"noopener\">dr.tanyahris@gmail.com<\/a>)<\/li>\n<\/ul>\n<p><strong>Chile<\/strong><\/p>\n<ul>\n<li>Juan Tordecilla, Hospital Roberto del R\u00edo, Universidad de Chile, Santiago, Chile (<a href=\"mailto:juantorde@mi.cl\" target=\"_blank\" rel=\"noopener\">juantorde@mi.cl<\/a>)<\/li>\n<li>Andrea Reyes, Hospital Roberto del R\u00edo, Santiago, Chile (<a href=\"mailto:andreareyesb37@hotmail.com\" target=\"_blank\" rel=\"noopener\">andreareyesb37@hotmail.com<\/a>)<\/li>\n<li>Catalina D\u00edaz, Hospital Roberto del R\u00edo, Universidad de Chile, Santiago, Chile (<a href=\"mailto:catalina.diaz.m@gmail.com\">catalina.diaz.m@gmail.com<\/a>)<\/li>\n<\/ul>\n<p><strong>Croatia<\/strong><\/p>\n<ul>\n<li>Ernest Bili\u0107, University Hospital Centre Zagreb, Zagreb, Croatia (<a href=\"mailto:ernestbilic@gmail.com\" target=\"_blank\" rel=\"noopener\">ernestbilic@gmail.com<\/a>)<\/li>\n<li>Zrinko \u0160alek, University Hospital Centre Zagreb, Zagreb, Croatia (<a href=\"mailto:zrinko.salek@gmail.com\" target=\"_blank\" rel=\"noopener\">zrinko.salek@gmail.com<\/a>)<\/li>\n<\/ul>\n<p><strong>Georgia<\/strong><\/p>\n<ul>\n<li>Nino Totogashvili, Iashvili Children Central Hospital, Tbiliszi, Georgia (<a href=\"mailto:nino_totogashvili@yahoo.com\">nino_totogashvili@yahoo.com<\/a>)<\/li>\n<li>Ketevan Chkheidze, Iashvili Children Central Hospital, Tbiliszi, Georgia (<a href=\"mailto:ketevanchkheidze23@gmail.com\">ketevanchkheidze23@gmail.com<\/a>)<\/li>\n<\/ul>\n<p><strong>Greece<\/strong><\/p>\n<ul>\n<li>Sophia Polychronopoulou, Aghia Sophia Children\u2019s Hospital, Athens, Greece (<a href=\"mailto:sophpol@otenet.gr\" target=\"_blank\" rel=\"noopener\">sophpol@otenet.gr<\/a>)<\/li>\n<li>Mirella Ampatzidou, Aghia Sophia Children\u2019s Hospital, Athens, Greece (<a href=\"mailto:mirellaaba@yahoo.gr\" target=\"_blank\" rel=\"noopener\">mirellaaba@yahoo.gr<\/a>)<\/li>\n<\/ul>\n<p><strong>Hungary<\/strong><\/p>\n<ul>\n<li>D\u00e1niel Erd\u00e9lyi, Semmelweis University, Budapest, Hungary (<a href=\"mailto:erdelyi.daniel@semmelweis.hu\" target=\"_blank\" rel=\"noopener\">erdelyi.daniel@semmelweis.hu<\/a>)<\/li>\n<li>Bence H\u0151b\u00f6r, Semmelweis University, Budapest, Hungary (<a href=\"mailto:hobor.bence@semmelweis.hu\">hobor.bence@semmelweis.hu<\/a>)<\/li>\n<li>Anna Moh\u00e1s, Semmelweis University, Budapest, Hungary (<a href=\"mailto:anna.mohas@gmail.com\" target=\"_blank\" rel=\"noopener\">anna.mohas@gmail.com<\/a>)<\/li>\n<li>Veronika Enzs\u00f6l, Heim Pal Children\u2019s Hospital, Budapest, Hungary (<a href=\"mailto:wera.en@gmail.com\" target=\"_blank\" rel=\"noopener\">wera.en@gmail.com<\/a>)<\/li>\n<\/ul>\n<p><strong>Iran<\/strong><\/p>\n<ul>\n<li>Babak Abdolkarimi, Lorestan University of Medical Sciences, Khorramabad, Iran (<a href=\"mailto:b.abdolkarimi@yahoo.com\">b.abdolkarimi@yahoo.com<\/a>)<\/li>\n<\/ul>\n<p><strong>Jordan<\/strong><\/p>\n<ul>\n<li>Rawad Rihani, King Hussein Cancer Center, Amman, Jordan (<a href=\"mailto:rrihani@khcc.jo\">rrihani@khcc.jo<\/a>)<\/li>\n<\/ul>\n<p><strong>Lebanon<\/strong><\/p>\n<ul>\n<li>Roula Farah, Lebanese American University, Beirut, Lebanon (<span lang=\"EN-US\"><a href=\"mailto:dr.roulafarah@gmail.com\" target=\"_blank\" rel=\"noopener noreferrer\">dr.roulafarah@gmail.com<\/a>)<\/span><\/li>\n<\/ul>\n<p><strong>North Macedonia<\/strong><\/p>\n<ul>\n<li>Svetlana Kocheva, Medical faculty St Cyril and Methodius University, Skopje, North Macedonia (<a href=\"mailto:dr.kocheva@gmail.com\">dr.kocheva@gmail.com<\/a>)<\/li>\n<\/ul>\n<p><strong>Romania<\/strong><\/p>\n<ul>\n<li>Anca Colita, &#8222;Carol Davila&#8221; University of Medicine and Pharmacy, Fundeni Clinical Institute, Bucharest, Romania (<a href=\"mailto:ancacolita@yahoo.com\" target=\"_blank\" rel=\"noopener\">ancacolita@yahoo.com<\/a>)<\/li>\n<li>Letitia Elena Radu, &#8222;Carol Davila&#8221; University of Medicine and Pharmacy, Fundeni Clinical Institute, Bucharest, Romania (<a href=\"mailto:letitia_radu@yahoo.com\" target=\"_blank\" rel=\"noopener\">letitia_radu@yahoo.com<\/a>)<\/li>\n<\/ul>\n<p><strong>Russia<\/strong><\/p>\n<ul>\n<li>Natalia Batmanova, N.N. Blokhin National Medical Research Center of Oncology, Moscow, Russia (<a href=\"mailto:batmanova_nataly@mail.ru\">batmanova_nataly@mail.ru<\/a>)<\/li>\n<li>Timur Valiev, Timur,\u00a0 N.N. Blokhin National Medical Research Center of Oncology, Moscow, Russia (<a href=\"mailto:timurvaliev@mail.ru\">timurvaliev@mail.ru)<\/a><\/li>\n<li>Mery Shervashidze, N.N. Blokhin National Medical Research Center of Oncology, Moscow, Russia (<a href=\"mailto:shervashidze85@gmail.com\">shervashidze85@gmail.com<\/a>)<\/li>\n<li>Valeria Fominih, N.N. Blokhin National Medical Research Center of Oncology, Moscow, Russia (<a href=\"mailto:valeryafominih@yandex.ru\">valeryafominih@yandex.ru<\/a>)<\/li>\n<\/ul>\n<p><strong>Serbia<\/strong><\/p>\n<ul>\n<li>Goran Milosevic, University Children&#8217;s Hospital, Belgrade, Serbia (<a href=\"mailto:dr.gmilosevic@gmail.com\" target=\"_blank\" rel=\"noopener\">dr.gmilosevic@gmail.com<\/a>)<\/li>\n<li>Danijela Jovancic, Clinic for Pediatrics, University Clinical Center Ni\u0161, Serbia (<a href=\"mailto:jovancic.danijela@yahoo.com\">jovancic.danijela@yahoo.com<\/a>)<\/li>\n<\/ul>\n<p><strong>Slovenia<\/strong><\/p>\n<ul>\n<li>Marko Kav\u010di\u010d, University Medical Centre, Ljubljana, Slovenia (<a href=\"mailto:marko.kavcic@kclj.si\" target=\"_blank\" rel=\"noopener\">marko.kavcic@kclj.si<\/a>)<\/li>\n<li>Tomaz Prelog, Ljubljana University Medical Centre, Ljubljana, Slovenia (<a href=\"mailto:tomaz.prelog@kclj.si\" target=\"_blank\" rel=\"noopener\">tomaz.prelog@kclj.si<\/a>)<\/li>\n<li>Aida Zeckanovic, Universitats-Kinderspital Z\u00fcrich, Z\u00fcrich, Switzerland (<a href=\"mailto:aida.zeckanovic@gmail.com\" target=\"_blank\" rel=\"noopener\">aida.zeckanovic@gmail.com<\/a>)<\/li>\n<\/ul>\n<p><strong>T\u00fcrkiye<\/strong><\/p>\n<ul>\n<li>Volkan Hazar, Memorial Health Group Medstar Yildiz Hospital, Antalya, T\u00fcrkiye\u00a0(<a href=\"mailto:volkanhazar62@gmail.com\" target=\"_blank\" rel=\"noopener\">volkanhazar62@gmail.com<\/a>)<\/li>\n<li>Koray Yal\u00e7in, Acibadem University, Istanbul, T\u00fcrkiye (<a href=\"mailto:koray.ylc@gmail.com\" target=\"_blank\" rel=\"noopener\">koray.ylc@gmail.com<\/a>)<\/li>\n<\/ul>\n<p><strong>Ukraine<\/strong><\/p>\n<ul>\n<li>Mykhailo Adyrov, Lviv Territorial Medical Association #1, Lviv, Ukraine (<a href=\"mailto:adyrov.m@gmail.com\">adyrov.m@gmail.com<\/a>)<\/li>\n<li>Oleksandr Lysytsia, National Specialized Children&#8217;s Hospital &#8222;Ohmtadyt&#8221;, Kyiv, Ukraine (<a href=\"mailto:a.lysystsiabmt@gmail.com\">a.lysystsiabmt@gmail.com<\/a>)<\/li>\n<li>Oleksandr Istomin, National Specialized Children&#8217;s Hospital &#8222;Ohmtadyt&#8221;, Kyiv, Ukraine (<a href=\"mailto:alexis19950107@gmail.com\">alexis19950107@gmail.com<\/a>)<\/li>\n<\/ul>\n<div align=\"right\"><a class=\"bookmark\" href=\"#\">Back to Top \u2191<\/a><\/div>\n<p><a name=\"treatment_guidance_and_data_registry\"><\/a><\/p>\n<h4><strong>TREATMENT GUIDANCE AND DATA REGISTRY<\/strong><\/h4>\n<p>In 2017, the group agreed and distributed a unified treatment protocol addressing first relapse cases. This and later protocol versions are based mostly on the non-experimental arms of the IntReALL study protocols, and we regard them as current best practice guidance optimized for the resources available in ALL-IC conuntries. As flow-cytometric determination of minimal residual disease was already an integral part of the frontline ALL-IC studies and is a technology available, standardised, quality controlled in ALL-IC countries, flow-cytometry is used for assessment of treatment response in these protocols.<\/p>\n<p>A common patient-registry was also established using the REDCap platform. Pseudonimised patient data are entered here with follow up MRD values, toxicity grading and data on outcome.<\/p>\n<p>A monthly virtual tumour board meeting was initiated, which later merged into the FEDRRAL tumour board meetings organized by the IntReALL Study Group. We recommend submitting difficult cases for discussion there.<\/p>\n<p>Old protocol versions:<\/p>\n<ul style=\"text-align: justify\">\n<li>From 2017: <a href=\"https:\/\/semmelweis.hu\/tuzoltoklinika\/files\/2024\/05\/ALL-IC-REL-2016_v1-2017-10-30b_final.pdf\" target=\"_blank\" rel=\"noopener\">ALL-IC-REL-2016_v1-2017-10-30b_final.pdf<\/a>\u00a0<\/li>\n<li>From 2019: <a href=\"https:\/\/semmelweis.hu\/tuzoltoklinika\/files\/2024\/05\/ALL-IC-REL-2016_v1.1_2019-09-16.pdf\" target=\"_blank\" rel=\"noopener\">ALL-IC-REL-2016_v1.1_2019-09-16.pdf<\/a>\u00a0<\/li>\n<li>From 2022: <a href=\"https:\/\/semmelweis.hu\/tuzoltoklinika\/files\/2024\/05\/ALL-IC-REL-guidance-update_2022-11-05.pdf\" target=\"_blank\" rel=\"noopener\">ALL-IC-REL-guidance-update-2022-11-05.pdf<\/a>\u00a0This was not a fully written protocol, rather an urgent notification what changes should be applied before the next full protocol version can be produced.<\/li>\n<\/ul>\n<p>Actual protocol, with many relevant changes from the previous versions:<\/p>\n<ul style=\"text-align: justify\">\n<li>From 2024: <a href=\"https:\/\/semmelweis.hu\/tuzoltoklinika\/files\/2024\/05\/ALL-IC-Rel-2024-protocol_240513_02.pdf\" target=\"_blank\" rel=\"noopener\">ALL-IC Rel 2024 protocol_240513_02.pdf<\/a> \u00a0<\/li>\n<\/ul>\n<p>As per the knowledge of the steering committee, our guidance is applied in the following countries, either in all or just some of the centres: Argentina (GATLA** and SAHOP**), Armenia, Azerbaijan**, Bosnia, Bulgaria*, Chile**, Croatia**, Cyprus, Georgia, Greece*, Hungary**, Iran, Jordan, Lebanon, North Macedonia, Romania*, Russia*, Serbia**, Slovenia**, T\u00fcrkiye*, Ukraine.<br \/>\n* <em>groups registering data of some centres or some patients into the registry<\/em><br \/>\n** <em>groups registering data of all their ALL first relapses into the registry<\/em><\/p>\n<p>See below the recruitment diagram of the ALL-IC REL REDCap patient registry. Columns represent cumulative patient numbers as per the dates of their 1<sup>st<\/sup> relapses.<\/p>\n<p><a href=\"https:\/\/semmelweis.hu\/tuzoltoklinika\/files\/2026\/03\/Recruitment_v20260312.jpg\"><img loading=\"lazy\" decoding=\"async\" class=\"aligncenter wp-image-12166 size-large\" src=\"https:\/\/semmelweis.hu\/tuzoltoklinika\/files\/2026\/03\/Recruitment_v20260312-1024x563.jpg\" alt=\"\" width=\"753\" height=\"414\" srcset=\"https:\/\/semmelweis.hu\/tuzoltoklinika\/files\/2026\/03\/Recruitment_v20260312-1024x563.jpg 1024w, https:\/\/semmelweis.hu\/tuzoltoklinika\/files\/2026\/03\/Recruitment_v20260312-400x220.jpg 400w, https:\/\/semmelweis.hu\/tuzoltoklinika\/files\/2026\/03\/Recruitment_v20260312-768x422.jpg 768w, https:\/\/semmelweis.hu\/tuzoltoklinika\/files\/2026\/03\/Recruitment_v20260312-753x414.jpg 753w, https:\/\/semmelweis.hu\/tuzoltoklinika\/files\/2026\/03\/Recruitment_v20260312.jpg 1137w\" sizes=\"auto, (max-width: 753px) 100vw, 753px\" \/><\/a><\/p>\n<p>Due to improving frontline treatment, the relapse rate is decreasing in many countries. However, our registry\u2019s recruitment is quite constant around a yearly 100-120 cases so far. We think this is partly due to the high fertility rate and growing paediatric population of the larger countries contributing to our registry, partly because more countries and groups keep joining our project and register their cases.<\/p>\n<p>The ALL-IC REL study group would welcome further centres or countries to join. The protocol is open for use to anyone.<\/p>\n<div align=\"right\"><a class=\"bookmark\" href=\"#\">Back to Top \u2191<\/a><\/div>\n<p><a name=\"results\"><\/a><\/p>\n<h4><strong>RESULTS<\/strong><\/h4>\n<p>Results achieved with the first set of our protocols, ALL-IC REL 2016 versions 1.0 and 1.1 are downloadable from here:<\/p>\n<ul>\n<li>Gross survival analysis of the full cohort: <a href=\"https:\/\/semmelweis.hu\/tuzoltoklinika\/files\/2025\/10\/Bridging-the-gap-in-ped-rel.pdf\" target=\"_blank\" rel=\"noopener\">Pediatr Blood Cancer 2025 Oct 3:e32063. Online ahead of print.<\/a><\/li>\n<li>Detailed analysis of survival after 1<sup>st<\/sup> relapses involving the CNS: <a href=\"https:\/\/semmelweis.hu\/tuzoltoklinika\/files\/2026\/01\/O_CNS-relapse-in-child-ALL-results-from-ALL-IC-REL-2016_2025_Hazar.pdf\" target=\"_blank\" rel=\"noopener\">Leuk Lymphoma 2025 Dec 16:1-7. Online ahead of print.<\/a>; <a href=\"https:\/\/semmelweis.hu\/tuzoltoklinika\/files\/2026\/01\/O_CNS-relapse-in-child-ALL-results-from-ALL-IC-REL-2016_2025_Hazar.pdf_SUPPL.zip\" target=\"_blank\" rel=\"noopener\">Supplementary files<\/a><\/li>\n<\/ul>\n<div align=\"right\"><a class=\"bookmark\" href=\"#\">Back to Top \u2191<\/a><\/div>\n<p><a name=\"mini_symposia\"><\/a><\/p>\n<h4><strong>MINI-SYMPOSIA<\/strong><\/h4>\n<p>Three times a year, always in January, June and September, we organize online educative events on various aspects of pediatric ALL relapse management. These last about 1.5 hours each.<\/p>\n<p>Deatailed programs and recordings of recent mini-symposia:<\/p>\n<table class=\"aligncenter\" style=\"width: 100%;border-collapse: collapse\" border=\"2\">\n<thead>\n<tr>\n<td style=\"width: 25%\" scope=\"row\">DATE<\/td>\n<td style=\"width: 25%\">TOPIC<\/td>\n<td style=\"width: 25%\">PROGRAM<\/td>\n<td style=\"width: 25%\">RECORDING<\/td>\n<\/tr>\n<\/thead>\n<tbody>\n<tr>\n<td style=\"width: 25%\">29 Sept 2024<\/td>\n<td style=\"width: 25%\">Cardiotoxicity, Novel Therapies<\/td>\n<td style=\"width: 25%\"><a href=\"https:\/\/semmelweis.hu\/tuzoltoklinika\/files\/2026\/03\/20240912_ALLIC-REL-mini-symp_Program.pdf\" target=\"_blank\" rel=\"noopener\">Click here<\/a><\/td>\n<td style=\"width: 25%\">\u00a0<\/td>\n<\/tr>\n<tr>\n<td style=\"width: 25%\">13 Jan 2025<\/td>\n<td style=\"width: 25%\">Case-based discussions<\/td>\n<td style=\"width: 25%\"><a href=\"https:\/\/semmelweis.hu\/tuzoltoklinika\/files\/2026\/02\/20250113_ALLIC-REL-mini-symp_Program.pdf\" target=\"_blank\" rel=\"noopener\">Click here<\/a><\/td>\n<td style=\"width: 25%\">\u00a0<\/td>\n<\/tr>\n<tr>\n<td style=\"width: 25%\">19 June 2025<\/td>\n<td style=\"width: 25%\">Testicular relapses<\/td>\n<td style=\"width: 25%\"><a href=\"https:\/\/semmelweis.hu\/tuzoltoklinika\/files\/2026\/03\/20250619_ALLIC-REL-mini-symp_Program.pdf\" target=\"_blank\" rel=\"noopener\">Click here<\/a><\/td>\n<td style=\"width: 25%\">\u00a0<\/td>\n<\/tr>\n<tr>\n<td style=\"width: 25%\">02 Oct 2025<\/td>\n<td style=\"width: 25%\">Ocular leukaemia<\/td>\n<td style=\"width: 25%\"><a href=\"https:\/\/semmelweis.hu\/tuzoltoklinika\/files\/2026\/02\/20251002_ALLIC-REL-mini-symp_Program_v0929.pdf\" target=\"_blank\" rel=\"noopener\">Click here<\/a><\/td>\n<td style=\"width: 25%\">\u25b6\ufe0f <a href=\"https:\/\/drive.google.com\/file\/d\/1IcGx-32eqmLOufdW8LKIcOA_GR13IsPt\/view?usp=drive_link\" target=\"_blank\" rel=\"noopener\">Watch video<\/a><\/td>\n<\/tr>\n<tr>\n<td style=\"width: 25%\">08 Jan 2026<\/td>\n<td style=\"width: 25%\">Venetoclax<\/td>\n<td style=\"width: 25%\"><a href=\"https:\/\/semmelweis.hu\/tuzoltoklinika\/files\/2026\/02\/ALL-IC-REL-mini-symposium_20260108_Program.pdf\" target=\"_blank\" rel=\"noopener\">Click here<\/a><\/td>\n<td style=\"width: 25%\">\u25b6\ufe0f <a href=\"https:\/\/drive.google.com\/file\/d\/1MsypeFcJyxAb4s94hDBdJkW3QMTfItxp\/view?usp=drive_link\" target=\"_blank\" rel=\"noopener\">Watch video<\/a><\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n<div align=\"right\"><a class=\"bookmark\" href=\"#\">Back to Top \u2191<\/a><\/div>\n<p><a name=\"how_to_join\"><\/a><\/p>\n<h4><strong>HOW TO JOIN<\/strong><\/h4>\n<p>We encourage non-ALL-IC member centres or countries, too, to join our efforts, our team. You can use the registry and upload data of patients treated (even if just partly) along this protocol. These data make it possible for us to learn and continuously improve our protocol. The register is at REDCap, a free secure IT platform. Patient stories, even modified or totally different treatment backbones, can be easily and conveniently recorded here with only name initials and date of birth required of patients. All users can download their or their countries\u2019 own uploaded data any time. Those who contribute to the data registry will be acknowledged, moreover usually highlighted as co-authors in publications of this project.<\/p>\n<p>If you are thinking about joining, please email D\u00e1niel Erd\u00e9lyi at <a href=\"mailto:erdelyi.daniel@semmelweis.hu\">erdelyi.daniel@semmelweis.hu<\/a>.<br \/>\nFor access to the registry, please email Marko Kavcic at <a href=\"mailto:marko.kavcic@kclj.si\">marko.kavcic@kclj.si<\/a> or <a href=\"mailto:hobor.bence@semmelweis.hu\">hobor.bence@semmelweis.hu<\/a>.<\/p>\n","protected":false},"excerpt":{"rendered":"<p><a href=\"#background\">Background<\/a> <a href=\"#steering_committee\">Steering Committee<\/a> <a href=\"#national_coordinators\">National Coordinators<\/a> <a href=\"#treatment_guidance_and_data_registry\">Treatment Guidance and Data Registry<\/a> <a href=\"#results\">Results<\/a> <a href=\"#mini_symposia\">Mini-Symposia<\/a> <a href=\"#how_to_join\">How to Join<\/a> <a name=\"background\"><\/a> BACKGROUND The Acute Lymphoblastic Leukaemia Inter Continental (ALL-IC) Study Group has completed its second frontline ALL trial. By standardizing therapy and involving flow cytometry based MRD in treatment stratification, patient outcomes improved further. Still 15-20% of patients relapse. When looked up in 2013, survival of relapsed patients in the ALL-IC Study Group lagged behind that &hellip;<\/p>\n","protected":false},"author":101602,"featured_media":0,"parent":8014,"menu_order":0,"comment_status":"closed","ping_status":"closed","template":"","meta":{"_acf_changed":false,"footnotes":""},"categories":[],"tags":[],"class_list":["post-8016","page","type-page","status-publish","hentry"],"acf":[],"_links":{"self":[{"href":"https:\/\/semmelweis.hu\/tuzoltoklinika\/wp-json\/wp\/v2\/pages\/8016","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/semmelweis.hu\/tuzoltoklinika\/wp-json\/wp\/v2\/pages"}],"about":[{"href":"https:\/\/semmelweis.hu\/tuzoltoklinika\/wp-json\/wp\/v2\/types\/page"}],"author":[{"embeddable":true,"href":"https:\/\/semmelweis.hu\/tuzoltoklinika\/wp-json\/wp\/v2\/users\/101602"}],"replies":[{"embeddable":true,"href":"https:\/\/semmelweis.hu\/tuzoltoklinika\/wp-json\/wp\/v2\/comments?post=8016"}],"version-history":[{"count":12,"href":"https:\/\/semmelweis.hu\/tuzoltoklinika\/wp-json\/wp\/v2\/pages\/8016\/revisions"}],"predecessor-version":[{"id":12260,"href":"https:\/\/semmelweis.hu\/tuzoltoklinika\/wp-json\/wp\/v2\/pages\/8016\/revisions\/12260"}],"up":[{"embeddable":true,"href":"https:\/\/semmelweis.hu\/tuzoltoklinika\/wp-json\/wp\/v2\/pages\/8014"}],"wp:attachment":[{"href":"https:\/\/semmelweis.hu\/tuzoltoklinika\/wp-json\/wp\/v2\/media?parent=8016"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/semmelweis.hu\/tuzoltoklinika\/wp-json\/wp\/v2\/categories?post=8016"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/semmelweis.hu\/tuzoltoklinika\/wp-json\/wp\/v2\/tags?post=8016"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}