{"id":18,"date":"2024-10-17T11:21:41","date_gmt":"2024-10-17T09:21:41","guid":{"rendered":"https:\/\/semmelweis.hu\/tumorimmune\/?page_id=18"},"modified":"2026-03-26T09:59:29","modified_gmt":"2026-03-26T08:59:29","slug":"about-us","status":"publish","type":"page","link":"https:\/\/semmelweis.hu\/tumorimmune\/en\/about-us\/","title":{"rendered":"About us"},"content":{"rendered":"
\n

The Laboratory for Immunology and Tumor Microenvironment is an in situ imaging-based research group<\/strong> in the Department of Anatomy, Histology and Embryology. Our core mission is to understand how the tumor microenvironment (TME)\u2014tumor cells, immune cells, stroma, vessels and their spatial arrangement\u2014shapes tumor progression and the response or resistance to immunotherapies.<\/p>\n<\/div>\n

A central concept in modern TME research is that \u201cwhere cells are\u201d can be as important as \u201cwhich cells are present.\u201d Therefore, we focus on spatial biology and morphology-driven mapping of human tumor tissue. Using high-resolution histology, multiplex immunostaining and digital pathology, we quantify immune infiltration patterns, antigen-presentation status, stromal architecture, hypoxia-associated niches, and tumor\u2013immune interfaces. We integrate these spatial readouts with clinical outcome data and, when available, systemic immune measurements.<\/p>\n

We also study how microbes influence anti-tumor immunity, both indirectly through the gut microbiome and, in selected settings, through intratumoral bacterial signals and microbe-derived products (including bacterial extracellular vesicles). Beyond \u201cmolecular mimicry,\u201d we evaluate broader mechanisms such as immune priming, myeloid programming, barrier-linked inflammation, and microbial metabolites.<\/p>\n

Our primary disease focus is lung cancer, where improved predictive and prognostic biomarkers are urgently needed to support earlier detection and better therapy selection. The lab operates within a translational network, collaborating with in vitro and clinical teams to move from tissue-level mechanisms to clinically useful signatures and targets.<\/p>\n

\n

It is possible to join the research group\u2019s work as part of a TDK or PhD program<\/a>.<\/p>\n<\/div>\n

\"\"<\/p>\n

Key research pillars<\/h2>\n