List of Diploma Theses in the Academic Year 2015/2016

Regulatory roles of lysophosphatidic acid in the cardiovascular system.
Tutor: Zoltán Benyó M.D., Ph.D. D.M.Sc.
Review of literature from basic research to clinical applications and experimental work.

Signalling pathways of the urinary bladder in the control of micturition.
Tutor: Zoltán Benyó M.D., Ph.D. D.M.Sc.
Review of literature from basic research to clinical applications and experimental work.

Adaptation mechanisms of the cerebral circulation to carotid artery occlusion.
Tutor: Zoltán Benyó M.D., Ph.D. D.M.Sc.
Review of literature from basic research to clinical applications and experimental work.

Mechanism of orthostatic intolerance
Tutor: Emil Monos, M.D., Ph.D., D.M.Sc.
Survey of the literature.

Cardiovascular adaptation to gravitation.
Tutor: Emil Monos, M.D., Ph.D., D.M.Sc.
Survey of the literature.

Regulatory role of endogenous vasoactive substances in the cerebrovascular bed
Tutor: Péter Sándor, M.D., Ph.D., D.M.Sc.
Survey of the literature.

Ischemia-induced circulatory and molecular biological changes in the cerebrocortical microvessels
Tutor: Péter Sándor, M.D., Ph.D., D.M.Sc.
Survey of the literature.

Regulation of the cerebellar blood flow. Interactions between the regulation of the cerebral and cerebellar circulation
Tutor: Péter Sándor M.D., Ph.D., D.M.Sc.
Survey of the literature

Biomechanical factors in control of angiogenetic processes
Tutor: György Nádasy M.D., Ph.D.
Experimental work and survey of the literature

Viscoelasticity of large arteries
Tutor: György Nádasy M.D., Ph.D.
Experimental work and survey of the literature

Remodeling of coronary vessels in hypertension and with aging
Tutor: György Nádasy M.D., Ph.D.
Survey of the literature

Control of venous tone
Tutor: György Nádasy M.D., Ph.D.
Experimental work and survey of the literature

Network and wall remodeling in the venous system of the leg
Tutor: György Nádasy M.D., Ph.D.
Experimental work and survey of the literature

Physiology of ureteral movements
Tutor: György Nádasy M.D., Ph.D.
Survey of the literature

Pharmacological and mechanical remodeling of coronary arteries in response to chronic  quercetin substitution
Tutor: György Nádasy M.D., Ph.D. and Anna Monori-Kiss

Structure and biomechanical properties of the aneurysm wall
Tutor: György Nádasy M.D., Ph.D.

Impairment of myocardial calcium handling in heart failure
Tutor: Tamás Ivanics M.D., Ph.D.
Relationship between intracellular calcium homeostasis and subcellular mechanisms (energy metabolism, membrane integrity, ionfluxes and signal transduction) in different types of heart failure (hypertonic, diabetic, etc.) needs to be reviewed.

Intracellular calcium handling in the diabetic heart
Tutor: Tamás Ivanics, M.D., Ph.D.
The candidate has to give a thorough overview on the physiology and pathophysiology of calcium release and sequestration in the diabetic myocardium in conjunction with functional changes.

Development of cardiac malfunction in diabetes
Tutor: Zsuzsanna Miklós M.D., PhD.
Diabetes mellitus is frequently associated with cardiac dysfunction which is characterized by complex functional disorders of cardiomyocytes. The goal of the thesis is to describe diabetic alterations in cardiomyocyte homeostasis based on literature data and experimental work carried out in our isolated heart lab, with special focus on the changes and pathogenetic role of processes regulating Ca-cycling.

Myocardial ischemic/postischemic reperfusion damage
Tutor: Tamás Ivanics, M.D., Ph.D
Overview of literature data on pathophysiologic changes developing during transient ischemia and the subsequent reperfusion period (energy metabolism, membrane processes, ion movements, signal transduction).

Alterations of intracellular calcium homeostasis during ischemia and their role in ischemic cell damage
Tutor: Tamás Ivanics, M.D., Ph.D
Literature review of pathophysiological events related to ischemic cell damage with special emphasis on the role of intracellular Ca concentration. The candidate has to discuss methodological considerations, and include tissue specific disorders of brain and liver with special emphasis.

The mechanisms of female sexual steroid mediated cardioprotection
Tutor: Zsuzsanna Miklós M.D., PhD.; Tamás Ivanics M.D., Ph.D.
The cardiovascular protective effects of female sexual steroids, primarily estrogens, are well reported. The candidate has to give a literature review of the cardiac effects of estrogens, and based on own experimental observations to complement it with new information with special regard to the influence of estrogens on cardiac calcium homeostasis.

Cardiac effects of endocannabinoids
Tutor: Zsuzsanna Miklós M.D., PhD

The role of lipid mediators in the regulation of coronary circulation
Tutor: Zsuzsanna Miklós M.D., PhD

Improvement of the regeneration potential of musculoskeletal tissues by stem cell transplantation.
Tutor: Zsombor Lacza, M.D., Ph.D.
Survey of the literature

In vitro tissue engineeringand cell therapy strategies.
Tutor: Zsombor Lacza, M.D., Ph.D.
Survey of the literature

Antibacterial coating of implants used in orthopedic surgery, formulation and dissolution kinetics in vitro
Tutor: Zsombor Lacza, M.D., Ph.D.; István Hornyák, MsC 
Survey of the literature

Development of novel phosphodiesterase inhibitors
Tutor: Zsombor Lacza, M.D., Ph.D.; István Hornyák, MsC
Survey of the literature