{"id":332,"date":"2021-02-17T11:38:58","date_gmt":"2021-02-17T10:38:58","guid":{"rendered":"https:\/\/semmelweis.hu\/transzfuziologia\/?page_id=332"},"modified":"2025-06-12T13:13:38","modified_gmt":"2025-06-12T11:13:38","slug":"kalcium-jelatviteli-kutatocsoport","status":"publish","type":"page","link":"https:\/\/semmelweis.hu\/transzfuziologia\/kutatas\/kalcium-jelatviteli-kutatocsoport\/","title":{"rendered":"Kalcium Jel\u00e1tviteli Kutat\u00f3csoport"},"content":{"rendered":"
Kutat\u00e1si t\u00e9ma<\/strong><\/span><\/div>\n
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Kutat\u00e1sunk k\u00f6z\u00e9ppontj\u00e1ban a kalciumtranszport feh\u00e9rj\u00e9k biok\u00e9miai \u00e9s sejtbiol\u00f3giai vizsg\u00e1lata \u00e1ll, k\u00fcl\u00f6n\u00f6s tekintettel ezek szerep\u00e9re a kalcium szign\u00e1l dinamik\u00e1j\u00e1nak szab\u00e1lyoz\u00e1s\u00e1ban. Tanulm\u00e1nyozzuk, hogyan befoly\u00e1solj\u00e1k ezek a feh\u00e9rj\u00e9k a jel\u00e1tviteli folyamatokat eg\u00e9szs\u00e9ges \u00e9s daganatos sejtekben, k\u00fcl\u00f6n\u00f6s figyelmet ford\u00edtva az expresszi\u00f3jukban \u00e9s m\u0171k\u00f6d\u00e9s\u00fckben bek\u00f6vetkez\u0151 v\u00e1ltoz\u00e1sokra eml\u0151daganatokban \u00e9s BRAF mut\u00e1ns melan\u00f3m\u00e1ban.<\/span><\/div>\n
Munk\u00e1nk egyik f\u0151 ir\u00e1nya a plazmamembr\u00e1n Ca\u00b2\u207a-ATP\u00e1z 4-es izoform\u00e1ja (PMCA4), amelyet a metaszt\u00e1zis g\u00e1tl\u00f3jak\u00e9nt azonos\u00edtottunk. Eml\u0151r\u00e1k eset\u00e9n kimutattuk, hogy a PMCA4 expresszi\u00f3ja a daganat el\u0151rehaladt\u00e1val jelent\u0151sen cs\u00f6kken, \u00e9s hormonreceptor-pozit\u00edv esetekben \u00f6sszef\u00fcgg\u00e9st mutat a betegek t\u00fal\u00e9l\u00e9s\u00e9vel. Eredm\u00e9nyeink nemcsak a daganatos betegs\u00e9gek alapvet\u0151 biol\u00f3gi\u00e1j\u00e1nak m\u00e9lyebb meg\u00e9rt\u00e9s\u00e9hez j\u00e1rulnak hozz\u00e1, hanem hossz\u00fa t\u00e1von az innovat\u00edv ter\u00e1pi\u00e1s strat\u00e9gi\u00e1k kidolgoz\u00e1s\u00e1t is el\u0151seg\u00edthetik.<\/span><\/div>\n
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Research Focus<\/span><\/div>\n
Our research investigates the biochemistry and cell biology of calcium transport proteins, with a particular emphasis on their roles in shaping calcium signaling dynamics. We study how these proteins influence signal transduction in both healthy and cancerous cells, focusing on changes in their expression and function in breast tumors and BRAF-mutant melanoma.<\/span><\/div>\n<\/div>\n<\/div>\n
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A major focus of our work is the plasma membrane Ca\u00b2\u207a ATPase isoform 4 (PMCA4), which we identified as a suppressor of metastasis. In breast cancer, we found that PMCA4 expression is significantly reduced during tumor progression and correlates with patient survival in hormone receptor-positive cases. These findings not only deepen our understanding of fundamental cancer biology but may also guide the development of innovative therapeutic strategies in the future.<\/span><\/div>\n<\/div>\n<\/div>\n
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https:\/\/doi.org\/10.1113\/JP284179<\/p>\n

Naffa et al.<\/strong> Plasma membrane Ca2+<\/sup>\u00a0pump isoform 4 function in cell migration and cancer metastasis. J Physiol 602.8 (2024) pp 1551\u20131564 Review-Symposium. <\/strong><\/p>\n<\/div>\n

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Publik\u00e1ci\u00f3s lista:<\/strong><\/h4>\n

https:\/\/m2.mtmt.hu\/gui2\/?type=authors&mode=browse&sel=10015745<\/a>\u00a0<\/p>\n

Munkat\u00e1rsak<\/strong><\/h4>\n
    \n
  • Dr. Enyedi \u00c1gnes, MTA doktora<\/li>\n
  • Dr. T\u00f3th Sarolta, tudom\u00e1nyos munkat\u00e1rs<\/li>\n
  • Nagy R\u00e9ka, PhD hallgat\u00f3, kutat\u00e1si asszisztens<\/li>\n
  • Zhanerke Kenzhebayeva PhD hallgat\u00f3<\/li>\n
  • Gergely Csilla, asszisztens<\/li>\n<\/ul>\n

    \u00a0<\/p>\n","protected":false},"excerpt":{"rendered":"

    Kutat\u00e1si t\u00e9ma \u00a0 Kutat\u00e1sunk k\u00f6z\u00e9ppontj\u00e1ban a kalciumtranszport feh\u00e9rj\u00e9k biok\u00e9miai \u00e9s sejtbiol\u00f3giai vizsg\u00e1lata \u00e1ll, k\u00fcl\u00f6n\u00f6s tekintettel ezek szerep\u00e9re a kalcium szign\u00e1l dinamik\u00e1j\u00e1nak szab\u00e1lyoz\u00e1s\u00e1ban. Tanulm\u00e1nyozzuk, hogyan befoly\u00e1solj\u00e1k ezek a feh\u00e9rj\u00e9k a jel\u00e1tviteli folyamatokat eg\u00e9szs\u00e9ges \u00e9s daganatos sejtekben, k\u00fcl\u00f6n\u00f6s figyelmet ford\u00edtva az expresszi\u00f3jukban \u00e9s m\u0171k\u00f6d\u00e9s\u00fckben bek\u00f6vetkez\u0151 v\u00e1ltoz\u00e1sokra eml\u0151daganatokban \u00e9s BRAF mut\u00e1ns melan\u00f3m\u00e1ban. Munk\u00e1nk egyik f\u0151 ir\u00e1nya a plazmamembr\u00e1n …<\/p>\n","protected":false},"author":101660,"featured_media":0,"parent":368,"menu_order":0,"comment_status":"closed","ping_status":"closed","template":"","meta":{"_acf_changed":false,"footnotes":""},"categories":[],"tags":[],"class_list":["post-332","page","type-page","status-publish","hentry"],"acf":[],"_links":{"self":[{"href":"https:\/\/semmelweis.hu\/transzfuziologia\/wp-json\/wp\/v2\/pages\/332","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/semmelweis.hu\/transzfuziologia\/wp-json\/wp\/v2\/pages"}],"about":[{"href":"https:\/\/semmelweis.hu\/transzfuziologia\/wp-json\/wp\/v2\/types\/page"}],"author":[{"embeddable":true,"href":"https:\/\/semmelweis.hu\/transzfuziologia\/wp-json\/wp\/v2\/users\/101660"}],"replies":[{"embeddable":true,"href":"https:\/\/semmelweis.hu\/transzfuziologia\/wp-json\/wp\/v2\/comments?post=332"}],"version-history":[{"count":10,"href":"https:\/\/semmelweis.hu\/transzfuziologia\/wp-json\/wp\/v2\/pages\/332\/revisions"}],"predecessor-version":[{"id":697,"href":"https:\/\/semmelweis.hu\/transzfuziologia\/wp-json\/wp\/v2\/pages\/332\/revisions\/697"}],"up":[{"embeddable":true,"href":"https:\/\/semmelweis.hu\/transzfuziologia\/wp-json\/wp\/v2\/pages\/368"}],"wp:attachment":[{"href":"https:\/\/semmelweis.hu\/transzfuziologia\/wp-json\/wp\/v2\/media?parent=332"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/semmelweis.hu\/transzfuziologia\/wp-json\/wp\/v2\/categories?post=332"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/semmelweis.hu\/transzfuziologia\/wp-json\/wp\/v2\/tags?post=332"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}