{"id":374,"date":"2015-11-04T00:00:00","date_gmt":"2015-11-03T23:00:00","guid":{"rendered":"http:\/\/semmelweis.hu\/symposium\/method-of-high-pressure-local-intravesical-medicine-application-by-using-special-balloon-catheter\/"},"modified":"2015-11-06T13:28:54","modified_gmt":"2015-11-06T12:28:54","slug":"method-of-high-pressure-local-intravesical-medicine-application-by-using-special-balloon-catheter","status":"publish","type":"page","link":"https:\/\/semmelweis.hu\/symposium\/szimpozium-archiv\/symposium2009-semmelweis\/temak\/method-of-high-pressure-local-intravesical-medicine-application-by-using-special-balloon-catheter\/","title":{"rendered":"Method of High Pressure Local, Intravesical Medicine Application by Using Special Balloon Catheter"},"content":{"rendered":"\n<p>S\u00e1ndor LOV\u00c1SZ, P\u00e9ter TENKE<br \/> <em>Urological Department, Jahn Ferenc Teaching Hospital, Budapest, Hungary<\/em><\/p>\n<p><em>Aim<\/em>: Topical intravesical medication via transurethral instillation<br \/> shows several advantages over oral or systemic therapy.<br \/> Intravesically administered drugs penetrate into vesical mucosa<br \/> and submucosa by passive diffusion. In order to enhance drug<br \/> transport, diuresis reduction had been widely used to prevent concentration<br \/> reduction and to prolong time of action. We sought for<br \/> a new method to enhance drug transport by profiting from high<br \/> pressure difference, and increased surface with thinning of bladder<br \/> mucosa at the same time.<\/p>\n<p><em>Methods<\/em>: We invented the use of a special balloon dilationcatheter<br \/> inside the bladder that let us press any sort of drug previously<br \/> injected around the balloon into the bladder mucosa by growing pressure as balloon grows bigger and bigger. As soon as<br \/> pressure reaches 80 cm H20 intravesical pressure (relative to<br \/> perivesical pressure), it is kept constant for a max. of 20 minutes.<br \/> Intravesical pressure can be measured indirectly inside the balloon<br \/> by subtracting perivesical pressure + balloon&#8217;s characteristics<br \/> from actually measured value.<\/p>\n<p><em>Results<\/em>: Our method let positively influence all parameters influencing<br \/> passive drug diffusion through urothelium (concentration<br \/> gradient, time of action, surface, diameter of urothelium). In<br \/> addition exact measurement of pressure-volume relation can be<br \/> used for the calculation of distensibility of the bladder wall.<br \/> Conclusion: Presented method of high pressure local intravesical<br \/> medical treatment of the bladder may provide a number of clinical<br \/> trials using different drugs (antibiotics, antiphlogistics,<br \/> steroids, hormones, local anaesthetics, etc.) and contribute to<br \/> improved efficacy of instillation therapy.<\/p>\n","protected":false},"excerpt":{"rendered":"<p>S\u00e1ndor LOV\u00c1SZ, P\u00e9ter TENKE Urological Department, Jahn Ferenc Teaching Hospital, Budapest, Hungary Aim: Topical intravesical medication via transurethral instillation shows several advantages over oral or systemic therapy. Intravesically administered drugs penetrate into vesical mucosa and submucosa by passive diffusion. In order to enhance drug transport, diuresis reduction had been widely used to prevent concentration reduction &hellip;<\/p>\n","protected":false},"author":1,"featured_media":0,"parent":323,"menu_order":0,"comment_status":"closed","ping_status":"closed","template":"","meta":{"_acf_changed":false,"footnotes":""},"categories":[],"tags":[],"class_list":["post-374","page","type-page","status-publish","hentry"],"acf":[],"_links":{"self":[{"href":"https:\/\/semmelweis.hu\/symposium\/wp-json\/wp\/v2\/pages\/374","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/semmelweis.hu\/symposium\/wp-json\/wp\/v2\/pages"}],"about":[{"href":"https:\/\/semmelweis.hu\/symposium\/wp-json\/wp\/v2\/types\/page"}],"author":[{"embeddable":true,"href":"https:\/\/semmelweis.hu\/symposium\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/semmelweis.hu\/symposium\/wp-json\/wp\/v2\/comments?post=374"}],"version-history":[{"count":1,"href":"https:\/\/semmelweis.hu\/symposium\/wp-json\/wp\/v2\/pages\/374\/revisions"}],"predecessor-version":[{"id":406,"href":"https:\/\/semmelweis.hu\/symposium\/wp-json\/wp\/v2\/pages\/374\/revisions\/406"}],"up":[{"embeddable":true,"href":"https:\/\/semmelweis.hu\/symposium\/wp-json\/wp\/v2\/pages\/323"}],"wp:attachment":[{"href":"https:\/\/semmelweis.hu\/symposium\/wp-json\/wp\/v2\/media?parent=374"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/semmelweis.hu\/symposium\/wp-json\/wp\/v2\/categories?post=374"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/semmelweis.hu\/symposium\/wp-json\/wp\/v2\/tags?post=374"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}