{"id":193,"date":"2020-06-17T12:52:34","date_gmt":"2020-06-17T10:52:34","guid":{"rendered":"https:\/\/semmelweis.hu\/stressgroup\/?page_id=193"},"modified":"2020-06-17T12:52:34","modified_gmt":"2020-06-17T10:52:34","slug":"hsp90","status":"publish","type":"page","link":"https:\/\/semmelweis.hu\/stressgroup\/hsp90\/","title":{"rendered":"Hsp90"},"content":{"rendered":"<p>Nguyen MT, Somogyv\u00e1ri M, S\u0151ti C. (2018) Hsp90 stabilizes SIRT1 orthologs in mammalian cells and C. elegans. <em>Int. J. Mol. Sci.<\/em> <strong>2018<\/strong>, <em>19<\/em>, 3661. PDF<\/p>\n<p><a href=\"https:\/\/www.mdpi.com\/1422-0067\/19\/11\/3661\">https:\/\/www.mdpi.com\/1422-0067\/19\/11\/3661<\/a><\/p>\n<p>&nbsp;<\/p>\n<p>Somogyv\u00e1ri M, Gecse E, S\u0151ti C. (2018) DAF-21\/Hsp90 is required for <em>C. elegans<\/em> longevity by ensuring DAF-16\/FOXO isoform A function. <em>Sci Rep<\/em><em>.<\/em> <strong>8<\/strong><strong>,<\/strong> 12048. PDF<\/p>\n<p><a href=\"https:\/\/www.nature.com\/articles\/s41598-018-30592-6.pdf?draft=marketing\">https:\/\/www.nature.com\/articles\/s41598-018-30592-6.pdf?draft=marketing<\/a><\/p>\n<p>&nbsp;<\/p>\n<p>Nguyen MT, Csermely P, S\u0151ti C. (2013) Hsp90 chaperones PPAR\u03b3 and regulates differentiation and survival of 3T3-L1 adipocytes. <em>Cell Death Differ.<\/em> 20, 1654-1663. PDF<\/p>\n<p><a href=\"https:\/\/www.nature.com\/articles\/cdd2013129.pdf\">https:\/\/www.nature.com\/articles\/cdd2013129.pdf<\/a><\/p>\n<p>EDITORIAL HIGHLIGHT: <a href=\"https:\/\/www.nature.com\/articles\/cdd2013151.pdf\">https:\/\/www.nature.com\/articles\/cdd2013151.pdf<\/a><\/p>\n<p>&nbsp;<\/p>\n<p>Millson SH, Truman AW, R\u00e1cz A, Hu B, Panaretou B, Nuttall J, Mollapour M, S\u0151ti C, Piper PW. (2007) Expressed as the sole Hsp90 of yeast, the alpha and beta isoforms of human Hsp90 differ with regard to their capacities for activation of certain client proteins, whereas only Hsp90beta generates sensitivity to the Hsp90 inhibitor radicicol. <em>FEBS J<\/em> <strong>274: <\/strong>4453-4463. PDF<\/p>\n<p><a href=\"https:\/\/febs.onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/j.1742-4658.2007.05974.x\">https:\/\/febs.onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/j.1742-4658.2007.05974.x<\/a><\/p>\n<p>&nbsp;<\/p>\n<p>S\u0151ti C, R\u00e1cz A, Csermely P. A nucleotide-dependent molecular switch controls ATP binding at the C-terminal domain of Hsp90: N-terminal nucleotide binding unmasks a C-terminal binding pocket.<em> J Biol Chem<\/em> 2002; <strong>277:<\/strong> 7066-7075. PDF<\/p>\n<p><a href=\"https:\/\/www.jbc.org\/content\/277\/9\/7066.full.pdf\">https:\/\/www.jbc.org\/content\/277\/9\/7066.full.pdf<\/a><\/p>\n","protected":false},"excerpt":{"rendered":"<p>Nguyen MT, Somogyv\u00e1ri M, S\u0151ti C. (2018) Hsp90 stabilizes SIRT1 orthologs in mammalian cells and C. elegans. Int. J. Mol. Sci. 2018, 19, 3661. PDF <a href=\"https:\/\/www.mdpi.com\/1422-0067\/19\/11\/3661\">https:\/\/www.mdpi.com\/1422-0067\/19\/11\/3661<\/a> &nbsp; Somogyv\u00e1ri M, Gecse E, S\u0151ti C. (2018) DAF-21\/Hsp90 is required for C. elegans longevity by ensuring DAF-16\/FOXO isoform A function. Sci Rep. 8, 12048. PDF <a href=\"https:\/\/www.nature.com\/articles\/s41598-018-30592-6.pdf?draft=marketing\">https:\/\/www.nature.com\/articles\/s41598-018-30592-6.pdf?draft=marketing<\/a> &nbsp; Nguyen MT, Csermely &hellip;<\/p>\n","protected":false},"author":101588,"featured_media":0,"parent":0,"menu_order":0,"comment_status":"closed","ping_status":"closed","template":"","meta":{"_acf_changed":false,"footnotes":""},"categories":[],"tags":[],"class_list":["post-193","page","type-page","status-publish","hentry"],"acf":[],"_links":{"self":[{"href":"https:\/\/semmelweis.hu\/stressgroup\/wp-json\/wp\/v2\/pages\/193","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/semmelweis.hu\/stressgroup\/wp-json\/wp\/v2\/pages"}],"about":[{"href":"https:\/\/semmelweis.hu\/stressgroup\/wp-json\/wp\/v2\/types\/page"}],"author":[{"embeddable":true,"href":"https:\/\/semmelweis.hu\/stressgroup\/wp-json\/wp\/v2\/users\/101588"}],"replies":[{"embeddable":true,"href":"https:\/\/semmelweis.hu\/stressgroup\/wp-json\/wp\/v2\/comments?post=193"}],"version-history":[{"count":1,"href":"https:\/\/semmelweis.hu\/stressgroup\/wp-json\/wp\/v2\/pages\/193\/revisions"}],"predecessor-version":[{"id":194,"href":"https:\/\/semmelweis.hu\/stressgroup\/wp-json\/wp\/v2\/pages\/193\/revisions\/194"}],"wp:attachment":[{"href":"https:\/\/semmelweis.hu\/stressgroup\/wp-json\/wp\/v2\/media?parent=193"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/semmelweis.hu\/stressgroup\/wp-json\/wp\/v2\/categories?post=193"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/semmelweis.hu\/stressgroup\/wp-json\/wp\/v2\/tags?post=193"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}