{"id":904,"date":"2023-05-03T16:16:57","date_gmt":"2023-05-03T14:16:57","guid":{"rendered":"https:\/\/semmelweis.hu\/stemcell\/?p=904"},"modified":"2024-02-13T11:54:33","modified_gmt":"2024-02-13T10:54:33","slug":"a-vastagbel-kulso-beidegzesenek-kialakitasat-iranyito-fejlodesbiologiai-mechanizmust-feltaro-tudomanyos-publikacionk-jelent-meg-a-development-folyoiratban","status":"publish","type":"post","link":"https:\/\/semmelweis.hu\/stemcell\/2023\/05\/03\/a-vastagbel-kulso-beidegzesenek-kialakitasat-iranyito-fejlodesbiologiai-mechanizmust-feltaro-tudomanyos-publikacionk-jelent-meg-a-development-folyoiratban\/","title":{"rendered":"Laborman\u00f3 a Development foly\u00f3irat c\u00edmlapj\u00e1n"},"content":{"rendered":"<p style=\"text-align: justify\">Az enter\u00e1lis idegrendszer d\u00facl\u00e9c eredet\u0171 \u0151ssejtekb\u0151l sz\u00e1rmazik \u00e9s els\u0151dleges feladata a b\u00e9lmozg\u00e1s koordin\u00e1l\u00e1sa, azonban a vastagb\u00e9l beidegz\u00e9s\u00e9t ir\u00e1ny\u00edt\u00f3 fejl\u0151d\u00e9sbiol\u00f3giai folyamatokr\u00f3l kev\u00e9s ismerettel rendelkez\u00fcnk. Leg\u00fajabb publik\u00e1ci\u00f3nkban laborat\u00f3riumunk PhD hallgat\u00f3ja, Halasy Vikt\u00f3ria \u00e9s munkat\u00e1rsai a CXCL12 kemokint \u00e9s receptor\u00e1t, a CXCR4-et vizsg\u00e1lt\u00e1k: egy olyan molekula p\u00e1rost, amelyek szerepet j\u00e1tszanak a d\u00facl\u00e9c sejtek migr\u00e1ci\u00f3j\u00e1nak \u00e9s axonn\u00f6veked\u00e9s ir\u00e1ny\u00edt\u00e1s\u00e1ban, de a gasztrointesztin\u00e1lis traktus \u00f6sszef\u00fcgg\u00e9sben m\u00e9g nem vizsg\u00e1lt\u00e1k \u0151ket. A szerz\u0151k immunhisztok\u00e9mia \u00e9s <em>in situ<\/em> hibridiz\u00e1ci\u00f3 seg\u00edts\u00e9g\u00e9vel kimutatt\u00e1k, hogy a Cxcl12 az ut\u00f3b\u00e9lben, m\u00edg a CXCR4 a b\u00e9lidegrendszer k\u00e9t strukt\u00far\u00e1j\u00e1ban fejez\u0151dik ki: a madarakra jellemz\u0151 Remak-idegben, valamint a csirke- \u00e9s emberi embri\u00f3k kismedencei plexus\u00e1ban. Embri\u00f3manipul\u00e1ci\u00f3s k\u00eds\u00e9rletek igazolt\u00e1k, hogy a Remak-idegb\u0151l sz\u00e1rmaz\u00f3 idegrostok behatolnak az ut\u00f3b\u00e9lbe, \u00e9s ez a folyamat serkenthet\u0151 rekombin\u00e1ns CXCL12 alkalmaz\u00e1s\u00e1val, tov\u00e1bb\u00e1 CXCL12-vel bevont mikrogy\u00f6ngy\u00f6k bejuttat\u00e1sa a csirkeembri\u00f3k ut\u00f3bel\u00e9be vastagabb Remak-ganglion eredet\u0171 neuritok kialakul\u00e1s\u00e1t seg\u00edti el\u0151. Ezzel szemben a Remak-eredet\u0171 neuritok hossza \u00e9s vastags\u00e1ga cs\u00f6kken a CXCR4 jel\u00e1tviteli g\u00e1tl\u00f3 jelenl\u00e9t\u00e9ben. Ezek az eredm\u00e9nyek egy\u00fcttesen a CXCL12 kemoattrakt\u00e1ns szerep\u00e9t bizony\u00edtj\u00e1k, amely a CXCR4 receptort kifejez\u0151 neuritokat az ut\u00f3b\u00e9lbe ir\u00e1ny\u00edtja a k\u00fcls\u0151 beidegz\u00e9s\u00e9nek kialakul\u00e1sa sor\u00e1n.<\/p>\n<p><img loading=\"lazy\" decoding=\"async\" class=\"wp-image-906 alignright\" src=\"https:\/\/semmelweis.hu\/stemcell\/files\/2023\/05\/develop_150_8.coverfig.png\" alt=\"\" width=\"424\" height=\"551\" srcset=\"https:\/\/semmelweis.hu\/stemcell\/files\/2023\/05\/develop_150_8.coverfig.png 670w, https:\/\/semmelweis.hu\/stemcell\/files\/2023\/05\/develop_150_8.coverfig-308x400.png 308w\" sizes=\"auto, (max-width: 424px) 100vw, 424px\" \/><\/p>\n<p>&nbsp;<\/p>\n<p>&nbsp;<\/p>\n<p style=\"text-align: left\"><strong>C\u00edmlapfot\u00f3<\/strong>: K\u00e9t napos csirke embri\u00f3 <span style=\"color: #ff0000\">laminin<\/span>\u00a0\u00e9s <span style=\"color: #07d907\">SOX10<\/span>\u00a0immunjel\u00f6lt keresztmetszeti k\u00e9pe. SOX10 expresszi\u00f3 jellemz\u0151 a d\u00facl\u00e9c sejtekre \u00e9s a fejl\u0151d\u0151 szemh\u00f3lyag neuroepith\u00e9l sejtjeire. A sejtmagok DAPI (k\u00e9k) jel\u00f6l\u00e9ssel l\u00e1that\u00f3k.<\/p>\n<p>&nbsp;<\/p>\n<p>A teljes publik\u00e1ci\u00f3 <a href=\"https:\/\/journals.biologists.com\/dev\/article\/150\/8\/dev201289\/307118\/CXCR4-and-CXCL12-signaling-regulates-the\">ide<\/a> kattintva olvashat\u00f3.\u00a0<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Az enter\u00e1lis idegrendszer d\u00facl\u00e9c eredet\u0171 \u0151ssejtekb\u0151l sz\u00e1rmazik \u00e9s els\u0151dleges feladata a b\u00e9lmozg\u00e1s koordin\u00e1l\u00e1sa, azonban a vastagb\u00e9l beidegz\u00e9s\u00e9t ir\u00e1ny\u00edt\u00f3 fejl\u0151d\u00e9sbiol\u00f3giai folyamatokr\u00f3l kev\u00e9s ismerettel rendelkez\u00fcnk. Leg\u00fajabb publik\u00e1ci\u00f3nkban laborat\u00f3riumunk PhD hallgat\u00f3ja, Halasy Vikt\u00f3ria \u00e9s munkat\u00e1rsai a CXCL12 kemokint \u00e9s receptor\u00e1t, a CXCR4-et vizsg\u00e1lt\u00e1k: egy olyan molekula p\u00e1rost, amelyek szerepet j\u00e1tszanak a d\u00facl\u00e9c sejtek migr\u00e1ci\u00f3j\u00e1nak \u00e9s axonn\u00f6veked\u00e9s ir\u00e1ny\u00edt\u00e1s\u00e1ban, de &hellip;<\/p>\n","protected":false},"author":102017,"featured_media":981,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":false,"footnotes":""},"categories":[6],"tags":[],"class_list":["post-904","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-hireink"],"acf":[],"_links":{"self":[{"href":"https:\/\/semmelweis.hu\/stemcell\/wp-json\/wp\/v2\/posts\/904","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/semmelweis.hu\/stemcell\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/semmelweis.hu\/stemcell\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/semmelweis.hu\/stemcell\/wp-json\/wp\/v2\/users\/102017"}],"replies":[{"embeddable":true,"href":"https:\/\/semmelweis.hu\/stemcell\/wp-json\/wp\/v2\/comments?post=904"}],"version-history":[{"count":10,"href":"https:\/\/semmelweis.hu\/stemcell\/wp-json\/wp\/v2\/posts\/904\/revisions"}],"predecessor-version":[{"id":980,"href":"https:\/\/semmelweis.hu\/stemcell\/wp-json\/wp\/v2\/posts\/904\/revisions\/980"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/semmelweis.hu\/stemcell\/wp-json\/wp\/v2\/media\/981"}],"wp:attachment":[{"href":"https:\/\/semmelweis.hu\/stemcell\/wp-json\/wp\/v2\/media?parent=904"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/semmelweis.hu\/stemcell\/wp-json\/wp\/v2\/categories?post=904"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/semmelweis.hu\/stemcell\/wp-json\/wp\/v2\/tags?post=904"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}