{"id":1246,"date":"2026-10-19T12:56:36","date_gmt":"2026-10-19T10:56:36","guid":{"rendered":"https:\/\/semmelweis.hu\/stemcell\/?p=1246"},"modified":"2026-10-19T13:11:44","modified_gmt":"2026-10-19T11:11:44","slug":"cimlapfotonk-a-development-folyoirat","status":"publish","type":"post","link":"https:\/\/semmelweis.hu\/stemcell\/2026\/10\/19\/cimlapfotonk-a-development-folyoirat\/","title":{"rendered":"Laborat\u00f3riumunk fot\u00f3ja a Development foly\u00f3irat c\u00edmlapj\u00e1n!"},"content":{"rendered":"

B\u00fcszk\u00e9n jelentj\u00fck be, hogy laborat\u00f3riumunk leg\u00fajabb kutat\u00e1sa nem csup\u00e1n fontos fejl\u0151d\u00e9sbiol\u00f3giai felfedez\u00e9st tett, de a publik\u00e1ci\u00f3hoz kapcsol\u00f3d\u00f3 k\u00e9p a rangos Development<\/i> foly\u00f3irat c\u00edmlapj\u00e1n kapott helyet! \ud83d\udd2c<\/p>\n

Leg\u00fajabb cikk\u00fcnkben laborat\u00f3riumunk kutat\u00f3i a b\u00e9lidegrendszeri \u0151ssejtek k\u00eds\u00e9rletes transzplant\u00e1ci\u00f3j\u00e1t k\u00f6vet\u0151 sejtv\u00e1ndorl\u00e1s folyamatait vizsg\u00e1lt\u00e1k. A b\u00e9lidegrendszert \u00e9rint\u0151 fejl\u0151d\u00e9si rendelleness\u00e9gek gyakran a vastagb\u00e9l beidegz\u00e9s\u00e9nek hi\u00e1ny\u00e1val j\u00e1rnak, ami komoly b\u00e9lmotilit\u00e1si probl\u00e9m\u00e1kat okoz. Ezen k\u00f3rk\u00e9pek gy\u00f3gy\u00edt\u00e1s\u00e1ban a regenerat\u00edv ter\u00e1pi\u00e1k \u00e9s az \u0151ssejt-transzplant\u00e1ci\u00f3 jelenthetik a j\u00f6v\u0151t, \u00e1m a Hirschsprung-\u00e1llatmodellekbe \u00e1t\u00fcltetett sejtek alacsony v\u00e1ndorl\u00e1si k\u00e9pess\u00e9ge nem elegend\u0151 a b\u00e9lmotilit\u00e1s helyre\u00e1ll\u00edt\u00e1s\u00e1hoz.\u00a0<\/p>\n

\"\"<\/p>\n

 <\/p>\n

A kutat\u00e1s legfontosabb eredm\u00e9nyek\u00e9nt a szerz\u0151k r\u00e1vil\u00e1g\u00edtottak, hogy az\u00a0extracellul\u00e1ris m\u00e1trix molekul\u00e1k k\u00f6z\u00fcl, a kondroitin-szulf\u00e1t proteoglik\u00e1nok (CSPG-k) \u00e9s kiemelten a CD44 receptor g\u00e1tolj\u00e1k az enter\u00e1lis idegi \u0151ssejtek migr\u00e1ci\u00f3j\u00e1t. A kutat\u00f3csoport bizony\u00edtotta, hogy ezen molekul\u00e1k g\u00e1tl\u00e1s\u00e1val \u00e9s elt\u00e1vol\u00edt\u00e1s\u00e1val jelent\u0151sen serkenthet\u0151 az \u0151ssejtek v\u00e1ndorl\u00e1sa \u00e9s ut\u00f3b\u00e9lbe t\u00f6rt\u00e9n\u0151 integr\u00e1ci\u00f3ja. Ezen eredm\u00e9nyek alapj\u00e1n a CSPG t\u00edpus\u00fa extracellul\u00e1ris m\u00e1trix molekul\u00e1k c\u00e9lzott m\u00f3dos\u00edt\u00e1sa a posztnat\u00e1lis vastagb\u00e9lben el\u0151seg\u00edtheti a neurointesztin\u00e1lis betegs\u00e9gek \u0151ssejtter\u00e1pi\u00e1s hat\u00e9konys\u00e1g\u00e1nak n\u00f6vel\u00e9s\u00e9t.<\/p>\n

C\u00edmlapfot\u00f3:<\/strong> A b\u00e9lidegrendszert kialak\u00edt\u00f3 d\u00facl\u00e9c eredet\u0171 sejtek <\/span>rendk\u00edv\u00fcl hat\u00e9konyan v\u00e1ndorolnak a fibronektinnel bevont fel\u00fcleten, mik\u00f6zben a vel\u00fck v\u00e1ltakoz\u00f3, kondroitin-szulf\u00e1t proteoglik\u00e1nnal (CSPG) bevont s\u00e1vok er\u0151teljesen g\u00e1tolj\u00e1k a sejtek mozg\u00e1s\u00e1t.<\/p>\n

A teljes publik\u00e1ci\u00f3 ide<\/a> kattintva olvashat\u00f3.<\/p>\n","protected":false},"excerpt":{"rendered":"

B\u00fcszk\u00e9n jelentj\u00fck be, hogy laborat\u00f3riumunk leg\u00fajabb kutat\u00e1sa nem csup\u00e1n fontos fejl\u0151d\u00e9sbiol\u00f3giai felfedez\u00e9st tett, de a publik\u00e1ci\u00f3hoz kapcsol\u00f3d\u00f3 k\u00e9p a rangos Development foly\u00f3irat c\u00edmlapj\u00e1n kapott helyet! \ud83d\udd2c Leg\u00fajabb cikk\u00fcnkben laborat\u00f3riumunk kutat\u00f3i a b\u00e9lidegrendszeri \u0151ssejtek k\u00eds\u00e9rletes transzplant\u00e1ci\u00f3j\u00e1t k\u00f6vet\u0151 sejtv\u00e1ndorl\u00e1s folyamatait vizsg\u00e1lt\u00e1k. A b\u00e9lidegrendszert \u00e9rint\u0151 fejl\u0151d\u00e9si rendelleness\u00e9gek gyakran a vastagb\u00e9l beidegz\u00e9s\u00e9nek hi\u00e1ny\u00e1val j\u00e1rnak, ami komoly b\u00e9lmotilit\u00e1si probl\u00e9m\u00e1kat okoz. …<\/p>\n","protected":false},"author":102017,"featured_media":1247,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":false,"footnotes":""},"categories":[6],"tags":[],"class_list":["post-1246","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-hireink"],"acf":[],"_links":{"self":[{"href":"https:\/\/semmelweis.hu\/stemcell\/wp-json\/wp\/v2\/posts\/1246","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/semmelweis.hu\/stemcell\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/semmelweis.hu\/stemcell\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/semmelweis.hu\/stemcell\/wp-json\/wp\/v2\/users\/102017"}],"replies":[{"embeddable":true,"href":"https:\/\/semmelweis.hu\/stemcell\/wp-json\/wp\/v2\/comments?post=1246"}],"version-history":[{"count":10,"href":"https:\/\/semmelweis.hu\/stemcell\/wp-json\/wp\/v2\/posts\/1246\/revisions"}],"predecessor-version":[{"id":1262,"href":"https:\/\/semmelweis.hu\/stemcell\/wp-json\/wp\/v2\/posts\/1246\/revisions\/1262"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/semmelweis.hu\/stemcell\/wp-json\/wp\/v2\/media\/1247"}],"wp:attachment":[{"href":"https:\/\/semmelweis.hu\/stemcell\/wp-json\/wp\/v2\/media?parent=1246"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/semmelweis.hu\/stemcell\/wp-json\/wp\/v2\/categories?post=1246"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/semmelweis.hu\/stemcell\/wp-json\/wp\/v2\/tags?post=1246"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}