{"id":2090,"date":"2025-02-03T10:31:03","date_gmt":"2025-02-03T09:31:03","guid":{"rendered":"https:\/\/semmelweis.hu\/psychophysiology\/?p=2090"},"modified":"2025-02-03T10:37:29","modified_gmt":"2025-02-03T09:37:29","slug":"jasz-biro-et-al-szalardy-bodizs-et-al-persistently-increased-post-stress-activity-of-paraventicular-thalamic-neurons-is-essential-for-the-emergence-of-stress-induced-alterations-in-behaviour","status":"publish","type":"post","link":"https:\/\/semmelweis.hu\/psychophysiology\/2025\/02\/03\/jasz-biro-et-al-szalardy-bodizs-et-al-persistently-increased-post-stress-activity-of-paraventicular-thalamic-neurons-is-essential-for-the-emergence-of-stress-induced-alterations-in-behaviour\/","title":{"rendered":"J\u00e1sz-Bir\u00f3-et-al-Szal\u00e1rdy-B\u00f3dizs-et-al: Persistently increased post-stress activity of paraventicular thalamic neurons is essential for the emergence of stress-induced alterations in behaviour"},"content":{"rendered":"

Persistently increased post-stress activity of paraventicular thalamic neurons is essential for the emergence of stress-induced alterations in behaviour
\n<\/strong>PLoS Biol 23(1): e3002962 (2025)
\nDOI: 10.1371\/journal.pbio.3002962<\/a>
\nJ\u00e1sz A1,2<\/sup>, Bir\u00f3 L1,3<\/sup>, Buday Z1,2,3<\/sup>, Kir\u00e1ly B1,3,4<\/sup>, Szal\u00e1rdy O5<\/sup>, Horv\u00e1th K6<\/sup>, Koml\u00f3si G1,3<\/sup>, B\u00f3dizs R5<\/sup>, Kov\u00e1cs K6<\/sup>, Diana MA7<\/sup>, Hangya B1,3<\/sup>, Acs\u00e1dy L1,3<\/sup><\/p>\n

1 Lend\u00fclet Laboratory of Thalamus Research, HUN-REN Institute of Experimental Medicine, Budapest, Hungary
\n2 Neurosciences PhD School, Semmelweis University, Budapest, Hungary
\n3 Institute of Experimental Medicine, Budapest, Hungary
\n4 Department of Biological Physics, Institute of Physics, E\u00f6tv\u00f6s Lor\u00e1nd University, Budapest, Hungary\u00a0
\n5 Psychophysiology and Chronobiology Research Group, Institute of Behavioral Sciences, Semmelweis University, Budapest, Hungary
\n6 Laboratory of Molecular Neuroendocrinology, Institute of Experimental Medicine, Budapest, Hungary
\n7 Universit\u00e9 Paris Cit\u00e9, CNRS, Saint-P\u00e8res Paris Institute for the Neurosciences, Paris, France<\/p>\n

\n

ABSTRACT<\/p>\n

A single exposure to a stressful event can result in enduring changes in behaviour. Long-term modifications in neuronal networks induced by stress are well explored but the initial steps leading to these alterations remain incompletely understood. In this study, we found that acute stress exposure triggers an immediate increase in the firing activity of calretinin-positive neurons in the paraventricular thalamic nucleus (PVT\/CR+) that persists for several days in mice. This increase in activity had a causal role in stress-induced changes in spontaneous behaviour. Attenuating PVT\/CR+ neuronal activity for only 1 h after the stress event rescued both the protracted increase in PVT\/CR+ firing rate and the stress-induced behavioural alterations. Activation of the key forebrain targets (basolateral amygdala, prelimbic cortex, and nucleus accumbens) that mediate defensive behaviour has also been reduced by this post-stress inhibition. Reduction of PVT\/CR+ cell activity 5 days later remained still effective in ameliorating stress-induced changes in spontaneous behaviour. The results demonstrate a critical role of the prolonged, post-stress changes in firing activity of PVT\/CR+ neurons in shaping the behavioural changes associated with stress. Our data proposes a therapeutic window for intervention in acute stress-related disorders, offering potential avenues for targeted treatment strategies.<\/p>\n<\/div>\n","protected":false},"excerpt":{"rendered":"

Persistently increased post-stress activity of paraventicular thalamic neurons is essential for the emergence of stress-induced alterations in behaviour PLoS Biol 23(1): e3002962 (2025) DOI: 10.1371\/journal.pbio.3002962<\/a> J\u00e1sz A1,2, Bir\u00f3 L1,3, Buday Z1,2,3, Kir\u00e1ly B1,3,4, Szal\u00e1rdy O5, Horv\u00e1th K6, Koml\u00f3si G1,3, B\u00f3dizs R5, Kov\u00e1cs K6, Diana MA7, Hangya B1,3, Acs\u00e1dy L1,3 1 Lend\u00fclet Laboratory of Thalamus Research, HUN-REN …<\/p>\n","protected":false},"author":101277,"featured_media":0,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":false,"footnotes":""},"categories":[6,141],"tags":[],"class_list":["post-2090","post","type-post","status-publish","format-standard","hentry","category-articles-in-professional-journals","category-most-recent-articles"],"acf":[],"_links":{"self":[{"href":"https:\/\/semmelweis.hu\/psychophysiology\/wp-json\/wp\/v2\/posts\/2090","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/semmelweis.hu\/psychophysiology\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/semmelweis.hu\/psychophysiology\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/semmelweis.hu\/psychophysiology\/wp-json\/wp\/v2\/users\/101277"}],"replies":[{"embeddable":true,"href":"https:\/\/semmelweis.hu\/psychophysiology\/wp-json\/wp\/v2\/comments?post=2090"}],"version-history":[{"count":2,"href":"https:\/\/semmelweis.hu\/psychophysiology\/wp-json\/wp\/v2\/posts\/2090\/revisions"}],"predecessor-version":[{"id":2092,"href":"https:\/\/semmelweis.hu\/psychophysiology\/wp-json\/wp\/v2\/posts\/2090\/revisions\/2092"}],"wp:attachment":[{"href":"https:\/\/semmelweis.hu\/psychophysiology\/wp-json\/wp\/v2\/media?parent=2090"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/semmelweis.hu\/psychophysiology\/wp-json\/wp\/v2\/categories?post=2090"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/semmelweis.hu\/psychophysiology\/wp-json\/wp\/v2\/tags?post=2090"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}