{"id":1972,"date":"2022-11-14T16:06:49","date_gmt":"2022-11-14T15:06:49","guid":{"rendered":"https:\/\/semmelweis.hu\/psychophysiology\/?p=1972"},"modified":"2022-11-14T16:06:49","modified_gmt":"2022-11-14T15:06:49","slug":"the-sleep-eeg-envelope-is-a-novel-neuronal-firing%e2%80%91based-human-biomarker","status":"publish","type":"post","link":"https:\/\/semmelweis.hu\/psychophysiology\/2022\/11\/14\/the-sleep-eeg-envelope-is-a-novel-neuronal-firing%e2%80%91based-human-biomarker\/","title":{"rendered":"The sleep EEG envelope is a novel, neuronal firing\u2011based human biomarker"},"content":{"rendered":"<p><strong>The sleep EEG envelope is a novel, neuronal firing\u2011based human biomarker<\/strong><\/p>\n<p>Scientific Reports, Volume\u00a012, Article\u00a0number:\u00a018836 (2022)<\/p>\n<p>DOI:\u00a0 <a href=\"https:\/\/doi.org\/10.1038\/s41598-022-22255-4\">10.1038\/s41598-022-22255-4<\/a><\/p>\n<p>P\u00e9ter P. Ujma<sup>1,2<\/sup>*, Martin Dresler<sup>3<\/sup>, P\u00e9ter Simor<sup>4,5<\/sup>, D\u00e1niel Fab\u00f3<sup>2<\/sup>, Istv\u00e1n Ulbert<sup>6,7<\/sup>, Lor\u00e1nd Er\u0151ss<sup>2<\/sup>, R\u00f3bert B\u00f3dizs<sup>1,2<\/sup><\/p>\n<p><sup>1<\/sup>Institute of Behavioural Sciences, Semmelweis University, Budapest, Hungary.<\/p>\n<p><sup>2<\/sup>National Institute of Clinical Neuroscience, Budapest, Hungary.<\/p>\n<p><sup>3<\/sup>Radboud University Medical Center, Donders Institute, Nijmegen,<\/p>\n<p>The Netherlands.<\/p>\n<p><sup>4<\/sup>Institute of Psychology, ELTE, E\u00f6tv\u00f6s Lor\u00e1nd University, Budapest, Hungary.<\/p>\n<p><sup>5<\/sup>UR2NF, Neuropsychology and Functional Neuroimaging Research Unit at CRCN \u2011 Center for Research in Cognition and Neurosciences and UNI \u2011 ULB Neurosciences Institute, Universit\u00e9 Libre de Bruxelles (ULB), Brussels, Belgium.<\/p>\n<p><sup>6<\/sup>Department of Information Technology and Bionics, P\u00e1zm\u00e1ny P\u00e9ter Catholic University, Budapest, Hungary.<\/p>\n<p><sup>7<\/sup>Research Centre for Natural Sciences, Institute for Cognitive Neuroscience and Psychology, Budapest, Hungary.<\/p>\n<p><strong>Abstract<\/strong><\/p>\n<p>Sleep EEG reflects voltage differences relative to a reference, while its spectrum reflects its composition of various frequencies. In contrast, the envelope of the sleep EEG reflects the instantaneous amplitude of oscillations, while its spectrum reflects the rhythmicity of the occurrence of these oscillations. The sleep EEG spectrum is known to relate to demographic, psychological and clinical characteristics, but the envelope spectrum has been rarely studied. In study 1, we demonstrate in human invasive data from cortex-penetrating microelectrodes and subdural grids that the sleep EEG envelope spectrum reflects neuronal firing. In study 2, we demonstrate that the scalp EEG envelope spectrum is stable within individuals. A multivariate learning algorithm could predict age (r = 0.6) and sex (r = 0.5) from the EEG envelope spectrum. With age, oscillations shifted from a 4\u20135 s rhythm to faster rhythms. Our results demonstrate that the sleep envelope spectrum is a promising biomarker of demographic and disease-related phenotypes.<\/p>\n<p><strong>Keywords:<\/strong> Circadian rhythms and sleep; Human behaviour; Neurology<\/p>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>The sleep EEG envelope is a novel, neuronal firing\u2011based human biomarker Scientific Reports, Volume\u00a012, Article\u00a0number:\u00a018836 (2022) DOI:\u00a0 <a href=\"https:\/\/doi.org\/10.1038\/s41598-022-22255-4\">10.1038\/s41598-022-22255-4<\/a> P\u00e9ter P. Ujma1,2*, Martin Dresler3, P\u00e9ter Simor4,5, D\u00e1niel Fab\u00f32, Istv\u00e1n Ulbert6,7, Lor\u00e1nd Er\u0151ss2, R\u00f3bert B\u00f3dizs1,2 1Institute of Behavioural Sciences, Semmelweis University, Budapest, Hungary. 2National Institute of Clinical Neuroscience, Budapest, Hungary. 3Radboud University Medical Center, Donders Institute, Nijmegen, The &hellip;<\/p>\n","protected":false},"author":101277,"featured_media":0,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":false,"footnotes":""},"categories":[6,141],"tags":[],"class_list":["post-1972","post","type-post","status-publish","format-standard","hentry","category-articles-in-professional-journals","category-most-recent-articles"],"acf":[],"_links":{"self":[{"href":"https:\/\/semmelweis.hu\/psychophysiology\/wp-json\/wp\/v2\/posts\/1972","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/semmelweis.hu\/psychophysiology\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/semmelweis.hu\/psychophysiology\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/semmelweis.hu\/psychophysiology\/wp-json\/wp\/v2\/users\/101277"}],"replies":[{"embeddable":true,"href":"https:\/\/semmelweis.hu\/psychophysiology\/wp-json\/wp\/v2\/comments?post=1972"}],"version-history":[{"count":1,"href":"https:\/\/semmelweis.hu\/psychophysiology\/wp-json\/wp\/v2\/posts\/1972\/revisions"}],"predecessor-version":[{"id":1973,"href":"https:\/\/semmelweis.hu\/psychophysiology\/wp-json\/wp\/v2\/posts\/1972\/revisions\/1973"}],"wp:attachment":[{"href":"https:\/\/semmelweis.hu\/psychophysiology\/wp-json\/wp\/v2\/media?parent=1972"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/semmelweis.hu\/psychophysiology\/wp-json\/wp\/v2\/categories?post=1972"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/semmelweis.hu\/psychophysiology\/wp-json\/wp\/v2\/tags?post=1972"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}