Prolongation of cortical sleep spindles during hippocampal interictal epileptiform discharges in epilepsy patients<\/p>\n
Epilepsia, 2022;<\/p>\n
https:\/\/doi.org\/10.1111\/epi.17337<\/u><\/p>\n
<\/p>\n
Anna S\u00e1kovics1, 2, G\u00e1bor Csukly3, Csaba Borb\u00e9ly1, M\u00e1rta Vir\u00e1g1, Anna Kelemen1, R\u00f3bert B\u00f3dizs1, 4, Lor\u00e1nd Er\u0151ss5, D\u00e1niel Fab\u00f31<\/p>\n
1 Dept of Neurology, National Institute of Mental Health, Neurology and Neurosurgery, Budapest 1145, Hungary<\/p>\n
2 School of PhD, Semmelweis University, Budapest 1089, Hungary<\/p>\n
3 Dept of Psychiatry and Psychotherapy, Semmelweis University, Budapest 1089, Hungary<\/p>\n
4 Institute of Behavioral Sciences, Semmelweis University, Budapest 1089, Hungary<\/p>\n
5 Dept of Functional Neurosurgery, National Institute of Mental Health, Neurology and Neurosurgery, Budapest 1145, Hungary<\/p>\n
<\/p>\n
Abstract<\/strong><\/p>\n Objective<\/strong><\/p>\n Memory deficits are frequent among patients with epilepsies affecting the temporal lobe. Hippocampal interictal epileptic discharges (hIED), the presumed epileptic exaggeration of sharp wave-ripples (SWR) are known to contribute to memory dysfunctions, but the potential underlying mechanism is unknown. The precise temporal coordination between hippocampal SWRs and corticothalamic spindles during sleep is critical for memory consolidation. Moreover, previous investigation indicated that hIEDs induce neocortical spindle like oscillation. In the present study we aimed to assess the influence of hIEDs on neocortical spindles.<\/p>\n Methods<\/strong><\/p>\n We analyzed the spindle characteristics (duration, amplitude, frequency) of 21 epilepsy patients implanted with foramen ovale (FO) electrodes during a whole night sleep. Scalp sleep spindles were categorized based on their temporal relationship to hIEDs detected on the FO electrodes. Three groups were created: (i) spindles coinciding with hIEDs, (ii) spindles \u201cinduced\u201d by hIEDs, and (iii) spindles without hIEDs co-occurrence.<\/p>\n Results<\/strong><\/p>\n We found that spindles co-occurring with hIEDs had altered characteristics in all measured properties, they lasted longer by 126 \u00b1\u200948 ms (mean\u00b1std), had higher amplitude by 3.4 \u00b1\u20093.2 \u03bcV and their frequency range shifted towards the higher frequencies within the 13\u201315 Hz range. Also hIED-induced spindles had identical oscillatory properties with spindles without any temporal relationships with hIEDs. In more than half of our subjects clear temporal coherence was revealed between hIEDs and spindles, but the direction of the coupling was patient-specific.<\/p>\n Significance<\/strong><\/p>\n We investigated the effect of hippocampal IEDs on neocortical spindle activity and found spindle alterations in cases of spindle-hIED co-occurrence, but not in cases of hIED-initiated spindles. We propose that this is a marker of a pathologic process, where IEDs may have direct effect on spindle generation. It could mark a potential mechanism where IEDs disrupt memory processes, and also provide a potential therapeutic target to treat memory disturbances in epilepsy.<\/p>\n Keywords<\/strong>: interictal epileptiform discharges, sleep spindle, epilepsy, hippocampus<\/p>\n","protected":false},"excerpt":{"rendered":" Prolongation of cortical sleep spindles during hippocampal interictal epileptiform discharges in epilepsy patients Epilepsia, 2022; https:\/\/doi.org\/10.1111\/epi.17337 Anna S\u00e1kovics1, 2, G\u00e1bor Csukly3, Csaba Borb\u00e9ly1, M\u00e1rta Vir\u00e1g1, Anna Kelemen1, R\u00f3bert B\u00f3dizs1, 4, Lor\u00e1nd Er\u0151ss5, D\u00e1niel Fab\u00f31 1 Dept of Neurology, National Institute of Mental Health, Neurology and Neurosurgery, Budapest 1145, Hungary 2 School of PhD, Semmelweis …<\/p>\n","protected":false},"author":101277,"featured_media":0,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":false,"footnotes":""},"categories":[6,141],"tags":[],"class_list":["post-1935","post","type-post","status-publish","format-standard","hentry","category-articles-in-professional-journals","category-most-recent-articles"],"acf":[],"_links":{"self":[{"href":"https:\/\/semmelweis.hu\/psychophysiology\/wp-json\/wp\/v2\/posts\/1935","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/semmelweis.hu\/psychophysiology\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/semmelweis.hu\/psychophysiology\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/semmelweis.hu\/psychophysiology\/wp-json\/wp\/v2\/users\/101277"}],"replies":[{"embeddable":true,"href":"https:\/\/semmelweis.hu\/psychophysiology\/wp-json\/wp\/v2\/comments?post=1935"}],"version-history":[{"count":1,"href":"https:\/\/semmelweis.hu\/psychophysiology\/wp-json\/wp\/v2\/posts\/1935\/revisions"}],"predecessor-version":[{"id":1936,"href":"https:\/\/semmelweis.hu\/psychophysiology\/wp-json\/wp\/v2\/posts\/1935\/revisions\/1936"}],"wp:attachment":[{"href":"https:\/\/semmelweis.hu\/psychophysiology\/wp-json\/wp\/v2\/media?parent=1935"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/semmelweis.hu\/psychophysiology\/wp-json\/wp\/v2\/categories?post=1935"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/semmelweis.hu\/psychophysiology\/wp-json\/wp\/v2\/tags?post=1935"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}