Journal of Neuroscience 16 April 2021, JN-RM-1899-20; DOI: https:\/\/doi.org\/10.1523\/JNEUROSCI.1899-20.2021<\/p>\n
P\u00e9ter Simor1<\/sup><\/a>,2<\/sup><\/a>,3<\/sup><\/a>, Orsolya Szal\u00e1rdy2<\/sup><\/a>,4<\/sup><\/a>, Ferenc Gombos5<\/sup><\/a>, P\u00e9ter Przemyslaw Ujma2<\/sup><\/a>,6<\/sup><\/a>, Zs\u00f3fia Jord\u00e1n6<\/sup><\/a>, L\u00e1szl\u00f3 Hal\u00e1sz6<\/sup><\/a>, Lor\u00e1nd Er\u0151ss6<\/sup><\/a>, D\u00e1niel Fab\u00f36<\/sup><\/a>, and R\u00f3bert B\u00f3dizs2<\/sup><\/a>,4<\/sup><\/a><\/p>\n 1<\/sup>Institute of Psychology, ELTE, E\u00f6tv\u00f6s Lor\u00e1nd University, 1064, Budapest, Hungary<\/p>\n 2<\/sup>Institute of Behavioural Sciences, Semmelweis University, 1089, Budapest, Hungary<\/p>\n 3<\/sup>UR2NF, Neuropsychology and Functional Neuroimaging Research Unit at CRCN – Center for Research in Cognition and Neurosciences and UNI – ULB Neurosciences Institute, Universit\u00e9 Libre de Bruxelles (ULB), 1050, Brussels, Belgium<\/p>\n 4<\/sup>Institute of Cognitive Neuroscience and Psychology, Research Centre for Natural Sciences, 1117, Budapest, Hungary<\/p>\n 5<\/sup>MTA-PPKE Adolescent Development Research Group, 1088, Budapest, Hungary<\/p>\n 6<\/sup>National Institute of Clinical Neurosciences, 1145, Budapest, Hungary<\/p>\n <\/p>\n ABSTRACT<\/strong><\/p>\n Rapid eye movement sleep is an elusive neural state that is associated with a variety of functions from physiological regulatory mechanisms to complex cognitive processing. REM periods consist of the alternation of phasic and tonic REM microstates that differ in spontaneous and evoked neural activity. Although previous studies indicate, that cortical and thalamo-cortical activity differs across phasic and tonic microstates, the characterization of neural activity, particularly in subcortical structures that are critical in the initiation and maintenance of REM sleep is still limited in humans. Here, we examined electric activity patterns of the anterior nuclei of the thalamus as well as their functional connectivity with scalp EEG recordings during REM microstates and wakefulness in a group of epilepsy patients (N = 12, 7 females). Anterothalamic local field potentials showed increased high-alpha and beta frequency power in tonic compared to phasic REM, emerging as an intermediate state between phasic REM and wakefulness. Moreover, we observed increased thalamocortical synchronization in phasic compared to tonic REM sleep, especially in the slow and fast frequency ranges. Wake-like activity in tonic REM sleep may index the regulation of arousal and vigilance facilitating environmental alertness. On the other hand, increased thalamocortical synchronization may reflect the intrinsic activity of fronto-limbic networks supporting emotional and memory processes during phasic REM sleep. In sum, our findings highlight that the heterogeneity of phasic and tonic REM sleep is not limited to cortical activity, but is also manifested by anterothalamic local field potentials and thalamocortical synchronization.<\/p>\n","protected":false},"excerpt":{"rendered":" Journal of Neuroscience 16 April 2021, JN-RM-1899-20; DOI: https:\/\/doi.org\/10.1523\/JNEUROSCI.1899-20.2021 P\u00e9ter Simor 1<\/a> , 2<\/a> , 3<\/a> , Orsolya Szal\u00e1rdy 2<\/a> , 4<\/a> , Ferenc Gombos 5<\/a> , P\u00e9ter Przemyslaw Ujma 2<\/a> , 6<\/a> , Zs\u00f3fia Jord\u00e1n 6<\/a> , L\u00e1szl\u00f3 Hal\u00e1sz 6<\/a> , Lor\u00e1nd Er\u0151ss 6<\/a> , D\u00e1niel Fab\u00f3 6<\/a> , and R\u00f3bert B\u00f3dizs 2<\/a> , 4<\/a> 1Institute of Psychology, ELTE, E\u00f6tv\u00f6s Lor\u00e1nd University, 1064, Budapest, Hungary 2Institute of Behavioural …<\/p>\n","protected":false},"author":101277,"featured_media":0,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":false,"footnotes":""},"categories":[6,141],"tags":[],"class_list":["post-1872","post","type-post","status-publish","format-standard","hentry","category-articles-in-professional-journals","category-most-recent-articles"],"acf":[],"_links":{"self":[{"href":"https:\/\/semmelweis.hu\/psychophysiology\/wp-json\/wp\/v2\/posts\/1872","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/semmelweis.hu\/psychophysiology\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/semmelweis.hu\/psychophysiology\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/semmelweis.hu\/psychophysiology\/wp-json\/wp\/v2\/users\/101277"}],"replies":[{"embeddable":true,"href":"https:\/\/semmelweis.hu\/psychophysiology\/wp-json\/wp\/v2\/comments?post=1872"}],"version-history":[{"count":1,"href":"https:\/\/semmelweis.hu\/psychophysiology\/wp-json\/wp\/v2\/posts\/1872\/revisions"}],"predecessor-version":[{"id":1873,"href":"https:\/\/semmelweis.hu\/psychophysiology\/wp-json\/wp\/v2\/posts\/1872\/revisions\/1873"}],"wp:attachment":[{"href":"https:\/\/semmelweis.hu\/psychophysiology\/wp-json\/wp\/v2\/media?parent=1872"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/semmelweis.hu\/psychophysiology\/wp-json\/wp\/v2\/categories?post=1872"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/semmelweis.hu\/psychophysiology\/wp-json\/wp\/v2\/tags?post=1872"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}