{"id":1808,"date":"2020-03-27T09:28:45","date_gmt":"2020-03-27T08:28:45","guid":{"rendered":"http:\/\/semmelweis.hu\/psychophysiology\/?p=1808"},"modified":"2020-03-27T09:28:45","modified_gmt":"2020-03-27T08:28:45","slug":"polygenic-impact-of-morningness-on-the-overnight-dynamics-of-sleep-spindle-amplitude","status":"publish","type":"post","link":"https:\/\/semmelweis.hu\/psychophysiology\/2020\/03\/27\/polygenic-impact-of-morningness-on-the-overnight-dynamics-of-sleep-spindle-amplitude\/","title":{"rendered":"Polygenic impact of morningness on the overnight dynamics of sleep spindle amplitude"},"content":{"rendered":"<p>Genes, Brain and Behavior. 2020;e12641 (2020) DOI: <a href=\"https:\/\/doi.org\/10.1111\/gbb.12641\" target=\"_blank\" rel=\"noopener noreferrer\">10.1111\/gbb.12641<\/a><\/p>\n<p>Anu-Katriina Pesonen<sup>1<\/sup>, Ilona Merikanto<sup>1,2<\/sup>, Risto Halonen<sup>1<\/sup>, Peter Ujma<sup>3,4<\/sup>, Tommi Makkonen<sup>5<\/sup>, Katri Raikk\u00f6nen<sup>5<\/sup>, Jari Lahti<sup>5<\/sup>, Liisa Kuula<sup>1<\/sup><\/p>\n<p><sup>1<\/sup>SleepWell Research Program, Faculty of Medicine, University of Helsinki, Helsinki, Finland<br \/>\n<sup>2<\/sup>National Institute for Health and Welfare, Helsinki, Finland<br \/>\n<sup>3<\/sup>Institute of Behavioural Sciences, Semmelweis University, Budapest, Hungary<br \/>\n<sup>4<\/sup>Epilepsy Centre, National Institute of Clinical Neurosciences, Budapest, Hungary<br \/>\n<sup>5<\/sup>Department of Psychology and Logopedics, Faculty of Medicine, University of Helsinki, Helsinki, Finland<\/p>\n<p>Sleep spindles are thalamocortical oscillations that contribute to sleep maintenance and sleep\u2010related brain plasticity. The current study is an explorative study of the circadian dynamics of sleep spindles in relation to a polygenic score (PGS) for circadian preference towards morningness. The participants represent the 17\u2010year follow\u2010up of a birth cohort having both genome\u2010wide data and an ambulatory sleep electroencephalography measurement available ( <i>N<\/i> =\u2009154, Mean age = 16.9, SD = 0.1 years, 57% girls). Based on a recent genome\u2010wide association study, we calculated a PGS for circadian preference towards morningness across the whole genome, including 354 single\u2010nucleotide polymorphisms. Stage 2 slow (9\u201012.5 Hz, <i>N<\/i> =\u2009186\u2009739) and fast (12.5\u201016\u2009Hz, <i>N<\/i> =\u2009135\u2009504) sleep spindles were detected using an automated algorithm with individual time tags and amplitudes for each spindle. There was a significant interaction of PGS for morningness and timing of sleep spindles across the night. These growth curve models showed a curvilinear trajectory of spindle amplitudes: those with a higher PGS for morningness showed higher slow spindle amplitudes in frontal derivations, and a faster dissipation of spindle amplitude in central derivations. Overall, the findings provide new evidence on how individual sleep spindle trajectories are influenced by genetic factors associated with circadian type. The finding may lead to new hypotheses on the associations previously observed between circadian types, psychiatric problems and spindle activity.<\/p>\n<p>\n<strong>Keywords<\/strong>: brain, circadian rhythm, gene, plasticity, polygenic score, polysomnography, sleep, sleep EEG, sleep spindle, sleep timing, young adult<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Genes, Brain and Behavior. 2020;e12641 (2020) DOI: <a href=\"https:\/\/doi.org\/10.1111\/gbb.12641\" target=\"_blank\" rel=\"noopener noreferrer\">10.1111\/gbb.12641<\/a> Anu-Katriina Pesonen1, Ilona Merikanto1,2, Risto Halonen1, Peter Ujma3,4, Tommi Makkonen5, Katri Raikk\u00f6nen5, Jari Lahti5, Liisa Kuula1 1SleepWell Research Program, Faculty of Medicine, University of Helsinki, Helsinki, Finland 2National Institute for Health and Welfare, Helsinki, Finland 3Institute of Behavioural Sciences, Semmelweis University, Budapest, Hungary 4Epilepsy Centre, National Institute of &hellip;<\/p>\n","protected":false},"author":101277,"featured_media":0,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":false,"footnotes":""},"categories":[6,141],"tags":[206,117,207,208,209,10,43,27,150,210,211],"class_list":["post-1808","post","type-post","status-publish","format-standard","hentry","category-articles-in-professional-journals","category-most-recent-articles","tag-brain","tag-circadian-rhythm","tag-gene","tag-plasticity","tag-polygenic-score","tag-polysomnography","tag-sleep","tag-sleep-eeg","tag-sleep-spindle","tag-sleep-timing","tag-young-adult"],"acf":[],"_links":{"self":[{"href":"https:\/\/semmelweis.hu\/psychophysiology\/wp-json\/wp\/v2\/posts\/1808","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/semmelweis.hu\/psychophysiology\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/semmelweis.hu\/psychophysiology\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/semmelweis.hu\/psychophysiology\/wp-json\/wp\/v2\/users\/101277"}],"replies":[{"embeddable":true,"href":"https:\/\/semmelweis.hu\/psychophysiology\/wp-json\/wp\/v2\/comments?post=1808"}],"version-history":[{"count":1,"href":"https:\/\/semmelweis.hu\/psychophysiology\/wp-json\/wp\/v2\/posts\/1808\/revisions"}],"predecessor-version":[{"id":1809,"href":"https:\/\/semmelweis.hu\/psychophysiology\/wp-json\/wp\/v2\/posts\/1808\/revisions\/1809"}],"wp:attachment":[{"href":"https:\/\/semmelweis.hu\/psychophysiology\/wp-json\/wp\/v2\/media?parent=1808"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/semmelweis.hu\/psychophysiology\/wp-json\/wp\/v2\/categories?post=1808"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/semmelweis.hu\/psychophysiology\/wp-json\/wp\/v2\/tags?post=1808"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}