{"id":1012,"date":"2018-05-08T14:51:31","date_gmt":"2018-05-08T12:51:31","guid":{"rendered":"http:\/\/semmelweis.hu\/psychophysiology\/?p=1012"},"modified":"2019-01-23T16:51:46","modified_gmt":"2019-01-23T15:51:46","slug":"depressive-symptoms-are-associated-with-objectively-measured-sleep-parameters-in-kidney-transplant-recipients","status":"publish","type":"post","link":"https:\/\/semmelweis.hu\/psychophysiology\/2018\/05\/08\/depressive-symptoms-are-associated-with-objectively-measured-sleep-parameters-in-kidney-transplant-recipients\/","title":{"rendered":"Depressive symptoms are associated with objectively measured sleep parameters in kidney transplant recipients"},"content":{"rendered":"<p><em>Journal of Clinical Sleep Medicine (JCSM) <\/em>13:(4) pp. 557\u2013564. (2017)<\/p>\n<p><a href=\"http:\/\/dx.doi.org\/10.5664\/jcsm.6542\" target=\"_blank\" rel=\"noopener\">Free full-text<\/a><\/p>\n<p>DOI: <a href=\"http:\/\/dx.doi.org\/10.5664\/jcsm.6542\" target=\"_blank\" rel=\"noopener\">10.5664\/jcsm.6542<\/a><\/p>\n<p style=\"text-align: justify\">Katalin Z. Ronai, MD<sup>1<\/sup>; Andras Szentkiralyi, MD, PhD<sup>1,2<\/sup>; Alpar S. Lazar, PhD<sup>1,3<\/sup>; Akos Ujszaszi, MD, PhD<sup>4<\/sup>; Csilla Turanyi, MD, PhD<sup>1<\/sup>; Ferenc Gombos, MSc<sup>5<\/sup>; Istvan Mucsi, MD, PhD<sup>1,6<\/sup>; Robert Bodizs, PhD<sup>1,5<\/sup>; Miklos Z. Molnar, MD, PhD<sup>7,8<\/sup>; Marta Novak, MD, PhD<sup>1,9<\/sup><\/p>\n<p style=\"text-align: justify\"><sup>1<\/sup>Institute of Behavioural Sciences, Semmelweis University, Budapest, Hungary;<\/p>\n<p style=\"text-align: justify\"><sup>2<\/sup>Institute of Epidemiology and Social Medicine, University of Muenster, Muenster, Germany;<\/p>\n<p style=\"text-align: justify\"><sup>3<\/sup>Faculty of Medicine and Health Sciences, University of East Anglia, Norwich, United Kingdom;<\/p>\n<p style=\"text-align: justify\"><sup>4<\/sup>Institute of Pathophysiology, Semmelweis University, Budapest, Hungary;<\/p>\n<p style=\"text-align: justify\"><sup>5<\/sup>Department of General Psychology, P\u00e1zm\u00e1ny P\u00e9ter Catholic University, Budapest, Hungary; 6Department of Medicine, Division of Nephrology, University Health Network, University of Toronto, Toronto, Canada;<\/p>\n<p style=\"text-align: justify\"><sup>7<\/sup>Division of Nephrology, Department of Medicine, University of Tennessee Health Science Center, Tennessee;<\/p>\n<p style=\"text-align: justify\"><sup>8<\/sup>Department of Transplantation and Surgery, Semmelweis University, Budapest, Hungary;<\/p>\n<p style=\"text-align: justify\"><sup>9<\/sup>Centre for Mental Health, University Health Network and Department of Psychiatry, University of Toronto, Toronto, Canada<\/p>\n<p style=\"text-align: justify\">\u00a0<\/p>\n<h4 style=\"text-align: justify\"><strong>Abstract<\/strong><\/h4>\n<h5 style=\"text-align: justify\"><strong>Study Objectives<\/strong><\/h5>\n<p style=\"text-align: justify\">Both depression and sleep complaints are very prevalent among kidney transplant (kTx) recipients. However, details of the complex relationship between sleep and depression in this population are not well documented. Thus, we investigated the association between depressive symptoms and sleep macrostructure parameters among prevalent kTx recipients.<\/p>\n<h5 style=\"text-align: justify\"><strong>Methods<\/strong><\/h5>\n<p style=\"text-align: justify\">Ninety-five kTx recipients participated in the study (54 males, mean \u00b1 standard devation age 51 \u00b1 13 years, body mass index 26 \u00b1 4 kg\/m2, estimated glomerular filtration rate 53 \u00b1 19 ml\/min\/1.73 m2). Symptoms of depression were assessed by the Center for Epidemiologic Studies \u2013 Depression Scale (CES-D). After 1-night polysomnography each recording was visually scored and sleep macrostructure was analyzed.<\/p>\n<h5 style=\"text-align: justify\"><strong>Results<\/strong><\/h5>\n<p style=\"text-align: justify\">The CES-D score was significantly associated with the amount of stage 2 sleep (r = 0.20, P &lt; .05), rapid eye movement (REM) latency (r = 0.21, P &lt; .05) and REM percentage (r = \u22120.24, P &lt; .05), but not with the amount of slow wave sleep (r = \u22120.12, P &gt; .05). In multivariable linear regression models the CES-D score was independently associated with the amount of stage 2 sleep (\u03b2: 0.205; confidence interval: 0.001\u20130.409; P = .05) and REM latency (\u03b2: 0.234; confidence interval: 0.001\u20130.468; P = .05) after adjustment for potential confounders.<\/p>\n<h5 style=\"text-align: justify\"><strong>Conclusions<\/strong><\/h5>\n<p style=\"text-align: justify\">Depressive symptoms among kTx recipients are associated with increased amount of stage 2 sleep and prolonged REM latency. Further studies are needed to confirm our findings and understand potential clinical implications.<\/p>\n<h5 style=\"text-align: justify\"><strong>\u00a0Keywords: <\/strong>depressive symptoms, sleep quality, kidney transplant recipients<strong><br \/>\n<\/strong><\/h5>\n","protected":false},"excerpt":{"rendered":"<p>Journal of Clinical Sleep Medicine (JCSM) 13:(4) pp. 557\u2013564. (2017) <a href=\"http:\/\/dx.doi.org\/10.5664\/jcsm.6542\" target=\"_blank\" rel=\"noopener\">Free full-text<\/a> DOI: <a href=\"http:\/\/dx.doi.org\/10.5664\/jcsm.6542\" target=\"_blank\" rel=\"noopener\">10.5664\/jcsm.6542<\/a> Katalin Z. Ronai, MD1; Andras Szentkiralyi, MD, PhD1,2; Alpar S. Lazar, PhD1,3; Akos Ujszaszi, MD, PhD4; Csilla Turanyi, MD, PhD1; Ferenc Gombos, MSc5; Istvan Mucsi, MD, PhD1,6; Robert Bodizs, PhD1,5; Miklos Z. Molnar, MD, PhD7,8; Marta Novak, MD, PhD1,9 1Institute of Behavioural Sciences, Semmelweis &hellip;<\/p>\n","protected":false},"author":101277,"featured_media":0,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":false,"footnotes":""},"categories":[6],"tags":[133,130,44],"class_list":["post-1012","post","type-post","status-publish","format-standard","hentry","category-articles-in-professional-journals","tag-depressive-symptoms","tag-kidney-transplant-recipients","tag-sleep-quality"],"acf":[],"_links":{"self":[{"href":"https:\/\/semmelweis.hu\/psychophysiology\/wp-json\/wp\/v2\/posts\/1012","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/semmelweis.hu\/psychophysiology\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/semmelweis.hu\/psychophysiology\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/semmelweis.hu\/psychophysiology\/wp-json\/wp\/v2\/users\/101277"}],"replies":[{"embeddable":true,"href":"https:\/\/semmelweis.hu\/psychophysiology\/wp-json\/wp\/v2\/comments?post=1012"}],"version-history":[{"count":5,"href":"https:\/\/semmelweis.hu\/psychophysiology\/wp-json\/wp\/v2\/posts\/1012\/revisions"}],"predecessor-version":[{"id":1380,"href":"https:\/\/semmelweis.hu\/psychophysiology\/wp-json\/wp\/v2\/posts\/1012\/revisions\/1380"}],"wp:attachment":[{"href":"https:\/\/semmelweis.hu\/psychophysiology\/wp-json\/wp\/v2\/media?parent=1012"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/semmelweis.hu\/psychophysiology\/wp-json\/wp\/v2\/categories?post=1012"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/semmelweis.hu\/psychophysiology\/wp-json\/wp\/v2\/tags?post=1012"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}