{"id":13245,"date":"2024-03-08T16:22:12","date_gmt":"2024-03-08T15:22:12","guid":{"rendered":"https:\/\/semmelweis.hu\/pharmacology\/?p=13245"},"modified":"2024-03-08T16:22:30","modified_gmt":"2024-03-08T15:22:30","slug":"microscopy-upgrade-expands-further-our-research-capabilities","status":"publish","type":"post","link":"https:\/\/semmelweis.hu\/pharmacology\/en\/2024\/03\/08\/microscopy-upgrade-expands-further-our-research-capabilities\/","title":{"rendered":"Microscopy upgrade expands further our research capabilities"},"content":{"rendered":"<p>Unlike traditional fluorescence microscopy, <i>Leica&#8217;s Thunder Imager<\/i> module allows us to:<\/p>\n<ul>\n<li>\n<p>Optimal imaging of large slice thickness samples by software removal of out-of-focus light<\/p>\n<\/li>\n<li>\n<p>maximize the signal-to-noise ratio of the imaging system, thus providing the detail required for further image analysis<\/p>\n<\/li>\n<li>\n<p>provide near confocal microscopic quality images, but in a faster and simpler way<\/p>\n<\/li>\n<\/ul>\n<p><img loading=\"lazy\" decoding=\"async\" class=\"wp-image-13233 size-large aligncenter\" src=\"https:\/\/semmelweis.hu\/pharmacology\/files\/2024\/03\/mikroszkop_fejlesztes1-1024x702.jpg\" alt=\"\" width=\"753\" height=\"516\" srcset=\"https:\/\/semmelweis.hu\/pharmacology\/files\/2024\/03\/mikroszkop_fejlesztes1-1024x702.jpg 1024w, https:\/\/semmelweis.hu\/pharmacology\/files\/2024\/03\/mikroszkop_fejlesztes1-400x274.jpg 400w, https:\/\/semmelweis.hu\/pharmacology\/files\/2024\/03\/mikroszkop_fejlesztes1-768x527.jpg 768w, https:\/\/semmelweis.hu\/pharmacology\/files\/2024\/03\/mikroszkop_fejlesztes1-1536x1054.jpg 1536w, https:\/\/semmelweis.hu\/pharmacology\/files\/2024\/03\/mikroszkop_fejlesztes1-2048x1405.jpg 2048w, https:\/\/semmelweis.hu\/pharmacology\/files\/2024\/03\/mikroszkop_fejlesztes1-175x120.jpg 175w, https:\/\/semmelweis.hu\/pharmacology\/files\/2024\/03\/mikroszkop_fejlesztes1-753x517.jpg 753w\" sizes=\"auto, (max-width: 753px) 100vw, 753px\" \/><\/p>\n<p align=\"center\">Our microscope can now be used not only for conventional fluorescence microscopy and laser microdissection, but also for fast and easy acquisition of near-confocal microscopy-quality images.<\/p>\n<p align=\"center\"><img loading=\"lazy\" decoding=\"async\" class=\"wp-image-13243 size-large aligncenter\" src=\"https:\/\/semmelweis.hu\/pharmacology\/files\/2024\/03\/mikroszkop_fejlesztes23-1024x512.png\" alt=\"\" width=\"753\" height=\"377\" srcset=\"https:\/\/semmelweis.hu\/pharmacology\/files\/2024\/03\/mikroszkop_fejlesztes23-1024x512.png 1024w, https:\/\/semmelweis.hu\/pharmacology\/files\/2024\/03\/mikroszkop_fejlesztes23-400x200.png 400w, https:\/\/semmelweis.hu\/pharmacology\/files\/2024\/03\/mikroszkop_fejlesztes23-768x384.png 768w, https:\/\/semmelweis.hu\/pharmacology\/files\/2024\/03\/mikroszkop_fejlesztes23-753x377.png 753w, https:\/\/semmelweis.hu\/pharmacology\/files\/2024\/03\/mikroszkop_fejlesztes23.png 1079w\" sizes=\"auto, (max-width: 753px) 100vw, 753px\" \/><\/p>\n<p align=\"center\">Image of a section from mouse kidney<br \/>\nbefore and after running the background removal algorithm.<\/p>\n<p>The upgrade of the fluorescence microscope was supported by the Project no. RRF-2.3.1-21-2022-00003, which has been implemented with the support provided by the European Union.<\/p>\n<p><img loading=\"lazy\" decoding=\"async\" class=\"wp-image-13236 size-full alignright\" src=\"https:\/\/semmelweis.hu\/pharmacology\/files\/2024\/03\/mikroszkop_fejlesztes4.png\" alt=\"\" width=\"645\" height=\"196\" srcset=\"https:\/\/semmelweis.hu\/pharmacology\/files\/2024\/03\/mikroszkop_fejlesztes4.png 645w, https:\/\/semmelweis.hu\/pharmacology\/files\/2024\/03\/mikroszkop_fejlesztes4-400x122.png 400w\" sizes=\"auto, (max-width: 645px) 100vw, 645px\" \/><\/p>\n","protected":false},"excerpt":{"rendered":"<p>Unlike traditional fluorescence microscopy, Leica&#8217;s Thunder Imager module allows us to: Optimal imaging of large slice thickness samples by software removal of out-of-focus light maximize the signal-to-noise ratio of the imaging system, thus providing the detail required for further image analysis provide near confocal microscopic quality images, but in a faster and simpler way Our &hellip;<\/p>\n","protected":false},"author":102322,"featured_media":13233,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":false,"footnotes":""},"categories":[473],"tags":[],"class_list":["post-13245","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-news"],"acf":[],"_links":{"self":[{"href":"https:\/\/semmelweis.hu\/pharmacology\/wp-json\/wp\/v2\/posts\/13245","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/semmelweis.hu\/pharmacology\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/semmelweis.hu\/pharmacology\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/semmelweis.hu\/pharmacology\/wp-json\/wp\/v2\/users\/102322"}],"replies":[{"embeddable":true,"href":"https:\/\/semmelweis.hu\/pharmacology\/wp-json\/wp\/v2\/comments?post=13245"}],"version-history":[{"count":1,"href":"https:\/\/semmelweis.hu\/pharmacology\/wp-json\/wp\/v2\/posts\/13245\/revisions"}],"predecessor-version":[{"id":13246,"href":"https:\/\/semmelweis.hu\/pharmacology\/wp-json\/wp\/v2\/posts\/13245\/revisions\/13246"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/semmelweis.hu\/pharmacology\/wp-json\/wp\/v2\/media\/13233"}],"wp:attachment":[{"href":"https:\/\/semmelweis.hu\/pharmacology\/wp-json\/wp\/v2\/media?parent=13245"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/semmelweis.hu\/pharmacology\/wp-json\/wp\/v2\/categories?post=13245"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/semmelweis.hu\/pharmacology\/wp-json\/wp\/v2\/tags?post=13245"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}