{"id":966,"date":"2014-03-12T12:34:47","date_gmt":"2014-03-12T12:34:47","guid":{"rendered":"http:\/\/semmelweis.hu\/pharmacology\/?page_id=966"},"modified":"2025-03-26T09:12:00","modified_gmt":"2025-03-26T08:12:00","slug":"behavioural-pharmacology","status":"publish","type":"page","link":"https:\/\/semmelweis.hu\/pharmacology\/en\/behavioural-pharmacology\/","title":{"rendered":"Cognitive Translational Behavioural Pharmacology Group"},"content":{"rendered":"<p><a href=\"https:\/\/semmelweis.hu\/pharmacology\/files\/2021\/09\/visfarm_logo.png\"><img loading=\"lazy\" decoding=\"async\" class=\"alignright\" src=\"https:\/\/semmelweis.hu\/pharmacology\/files\/2021\/09\/visfarm_logo-150x150.png\" alt=\"\" width=\"130\" height=\"130\" \/><\/a><a href=\"https:\/\/semmelweis.hu\/pharmacology\/files\/2022\/01\/Kekes-tura9-scaled.jpg\"><img loading=\"lazy\" decoding=\"async\" class=\" wp-image-11068 alignnone\" src=\"https:\/\/semmelweis.hu\/pharmacology\/files\/2022\/01\/Kekes-tura9-scaled.jpg\" alt=\"\" width=\"451\" height=\"338\" srcset=\"https:\/\/semmelweis.hu\/pharmacology\/files\/2022\/01\/Kekes-tura9-scaled.jpg 2560w, https:\/\/semmelweis.hu\/pharmacology\/files\/2022\/01\/Kekes-tura9-300x225.jpg 300w, https:\/\/semmelweis.hu\/pharmacology\/files\/2022\/01\/Kekes-tura9-1024x768.jpg 1024w, https:\/\/semmelweis.hu\/pharmacology\/files\/2022\/01\/Kekes-tura9-768x576.jpg 768w, https:\/\/semmelweis.hu\/pharmacology\/files\/2022\/01\/Kekes-tura9-352x264.jpg 352w, https:\/\/semmelweis.hu\/pharmacology\/files\/2022\/01\/Kekes-tura9-1536x1152.jpg 1536w, https:\/\/semmelweis.hu\/pharmacology\/files\/2022\/01\/Kekes-tura9-2048x1536.jpg 2048w\" sizes=\"auto, (max-width: 451px) 100vw, 451px\" \/><\/a><\/p>\n<div class=\"responsive-tabs\">\n<h2 class=\"tabtitle\">Projects<\/h2>\n<div class=\"tabcontent\">\n\n<h4><strong>Establishment of a cognitive test battery with high translational value<\/strong><\/h4>\n<p><iframe loading=\"lazy\" src=\"\/\/www.youtube.com\/embed\/WBC9kWCAfZw?list=PLk43oIip64DM5-S91kNQh6aH9w0UGRezS&amp;index=6\" width=\"560\" height=\"314\"><\/iframe><\/p>\n<div class=\"keretes w-100\">\n<p>The aim of this project is to establish a complex cognitive animal test battery, which is able to identify clinically effective cognitive enhancer mechanims with higher hit ratio and precision than the currently applied methods.<\/p>\n<\/div>\n<p>Learning and memory are impaired in several neurological and psychiatric illnesses. The most well-known example for memory loss and mental deterioration is Alzheimer\u2019s disease, but severe cognitive deficits are also observed in e.g. schizophrenia or autism.<br \/>\nThe current medical treatments of these symptoms are poorly efficacious. As mental state hugely determines the chance of patients to return to normal life and to regain their working capability, the unmet need for effective cognitive enhancers is very high.<br \/>\nUnfortunately, despite that basic research keeps on identifying newer and newer cognitive enhancer mechanisms, clinical development of these drugs faced 100% attrition rate in the last decade. The factors underlying this considerable translational gap are manifold, but inappropriate selection of molecular targets and low translational value of animal models are certainly major contributors.<\/p>\n<p><a href=\"https:\/\/semmelweis.hu\/pharmacology\/files\/2019\/02\/viselkedes1.jpg\"><img loading=\"lazy\" decoding=\"async\" class=\"aligncenter size-full wp-image-8596\" src=\"https:\/\/semmelweis.hu\/pharmacology\/files\/2019\/02\/viselkedes1.jpg\" alt=\"\" width=\"757\" height=\"667\" srcset=\"https:\/\/semmelweis.hu\/pharmacology\/files\/2019\/02\/viselkedes1.jpg 757w, https:\/\/semmelweis.hu\/pharmacology\/files\/2019\/02\/viselkedes1-300x264.jpg 300w\" sizes=\"auto, (max-width: 757px) 100vw, 757px\" \/><\/a>Molecular targets coming out from basic research need rigorous validation in relevant animal models to check their suitability for industrial drug development projects. However, animal models used so far detected a large number of false positive (i.e. clinically ineffective) compounds. The inappropriateness of these methods may lie in their simplicity: impairing a relatively elementary memory function (e.g. passive avoidance or novel object recognition) by a single dose of a pharmacological agent (e.g. scopolamine) may not be a valid model of the robust cognitive deficits characterizing the human disease. More complex paradigms with better face and construct validity should be used.<\/p>\n<p><a href=\"https:\/\/semmelweis.hu\/pharmacology\/files\/2019\/02\/viselkedes2.jpg\"><img loading=\"lazy\" decoding=\"async\" class=\"aligncenter size-full wp-image-8598\" src=\"https:\/\/semmelweis.hu\/pharmacology\/files\/2019\/02\/viselkedes2.jpg\" alt=\"\" width=\"425\" height=\"319\" srcset=\"https:\/\/semmelweis.hu\/pharmacology\/files\/2019\/02\/viselkedes2.jpg 425w, https:\/\/semmelweis.hu\/pharmacology\/files\/2019\/02\/viselkedes2-300x225.jpg 300w, https:\/\/semmelweis.hu\/pharmacology\/files\/2019\/02\/viselkedes2-352x264.jpg 352w\" sizes=\"auto, (max-width: 425px) 100vw, 425px\" \/><\/a><\/p>\n<p>In this project rats and mice are tested in several distinct learning paradigms (see the list of methods). In a subset of the tasks, the learning and memory performance of the animals is measured in a harmless condition (e.g. social recognition test), in other tests the subjects have to \u201cwork\u201d for food reward (e.g. reaction time tasks, maze navigation). In a few paradigms, aversive stimuli are used to force the animals to complete the task (e.g. escaping from water). Each task represents a model of a human cognitive domain from those which are usually measured in clinical trials. In order to reach a better cognitive performance, animals are kept in environmentally enriched cages, and habituated gradually to the behavioural task. A group of animals is trained for multiple tasks thereby a population with \u201ewide-spread knowledge\u201d is brought about.<\/p>\n<p><a href=\"https:\/\/semmelweis.hu\/pharmacology\/files\/2019\/02\/viselkedes3.jpg\"><img loading=\"lazy\" decoding=\"async\" class=\"aligncenter size-full wp-image-8599\" src=\"https:\/\/semmelweis.hu\/pharmacology\/files\/2019\/02\/viselkedes3.jpg\" alt=\"\" width=\"4160\" height=\"2336\" srcset=\"https:\/\/semmelweis.hu\/pharmacology\/files\/2019\/02\/viselkedes3.jpg 2560w, https:\/\/semmelweis.hu\/pharmacology\/files\/2019\/02\/viselkedes3-300x168.jpg 300w, https:\/\/semmelweis.hu\/pharmacology\/files\/2019\/02\/viselkedes3-768x431.jpg 768w, https:\/\/semmelweis.hu\/pharmacology\/files\/2019\/02\/viselkedes3-1024x575.jpg 1024w, https:\/\/semmelweis.hu\/pharmacology\/files\/2019\/02\/viselkedes3-470x264.jpg 470w\" sizes=\"auto, (max-width: 4160px) 100vw, 4160px\" \/><\/a><\/p>\n<p>For testing cognitive enhancers, the performance of the animals must be impaired. The mode of impairment is a crucial point in modelling the cognitive deficits of a certain disorder. Learning performance can be disrupted in several ways, e.g. by administration of impairing agents, or by genetic modification, or by exposure to environmental stress. Alternatively, drugs can be tested on animals displaying low performance ab ovo (poor learners, aged animals). By applying a particluar cognitive impairing intervention the above group of animals can be transformed to a \u2018patient population\u2019 (i.e. subjects with cognitive defect).<\/p>\n<p><a href=\"https:\/\/semmelweis.hu\/pharmacology\/files\/2019\/02\/viselkedes5.jpg\"><img loading=\"lazy\" decoding=\"async\" class=\"aligncenter size-full wp-image-8601\" src=\"https:\/\/semmelweis.hu\/pharmacology\/files\/2019\/02\/viselkedes5.jpg\" alt=\"\" width=\"578\" height=\"433\" srcset=\"https:\/\/semmelweis.hu\/pharmacology\/files\/2019\/02\/viselkedes5.jpg 578w, https:\/\/semmelweis.hu\/pharmacology\/files\/2019\/02\/viselkedes5-300x225.jpg 300w, https:\/\/semmelweis.hu\/pharmacology\/files\/2019\/02\/viselkedes5-352x264.jpg 352w\" sizes=\"auto, (max-width: 578px) 100vw, 578px\" \/><\/a><\/p>\n<p>Putative cognitive enhancer compunds can then be tested on the wide spectrum of cognitive functions in this \u2018patient population\u2019. This is carried out in a \u201eclinical trial\u201d design: double blind, placebo controlled randomized studies are run with (sub)chronic drug treatments.<\/p>\n<p id=\"item3\">\n<\/div><h2 class=\"tabtitle\">Experimental methods<\/h2>\n<div class=\"tabcontent\">\n<\/p>\n<h4><strong>Experimental methods<\/strong><\/h4>\n<ul>\n<li>5-choice serial reaction time task \u2013 attention and impulsivity<\/li>\n<li>Morris Water-maze \u2013 spatial memory<\/li>\n<li>Barnes maze \u2013 spatial memory<\/li>\n<li>Place recognition \u2013 spatial memory<\/li>\n<li>Spontaneous alternation \u2013 short term spatial memory<\/li>\n<li>Cooperation task in the Skinner box \u2013 social cognition<\/li>\n<li>Cooperation task on the See-saw \u2013 social cognition<\/li>\n<li>Release box \u2013 social cognition<\/li>\n<li>Novel object recognition \u2013 recognition memory<\/li>\n<li>Fear conditioning \u2013 fear memory<\/li>\n<li>Passive avoidance \u2013 fear memory<\/li>\n<li>Shuttle-box \u2013 fear memory<\/li>\n<li>Pot jumping \u2013 motor learning<\/li>\n<li>Locomotor activity measurement \u2013 locomotor activity<\/li>\n<li>Elevated plus-maze \u2013 anxiety<\/li>\n<li>Conditioned place preference \u2013 testing addictive and aversive drugs<\/li>\n<\/ul>\n\n<\/div><h2 class=\"tabtitle\">Main publications<\/h2>\n<div class=\"tabcontent\">\n\n<h4><strong>Main publications<\/strong><\/h4>\n<ul>\n<li><a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/30910702\/\">Kozma, K.; Kassai, F.; Ernyey, A.J.; Gyerty\u00e1n, I. Establishment of a rodent cooperation assay as a model of social cognition. J. Pharmacol. Toxicol. Meth., 97:44-51. (2019)<\/a><\/li>\n<li><a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/31976324\/\">Ernyey, A.J.; B\u00f6gi, E.; Kassai, F.; Plang\u00e1r, I.; Gyerty\u00e1n, I. Translational Difficulties in Querying Rats on \u201cOrientation\u201d. Biomed. Res. Internat., 6149023, 11 p. (2019)<\/a><\/li>\n<li><a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/31129861\/\">Ernyey, A.J.; Grohmann P.T.; Kozma, K.; Kouhnavardi, S.; Kassai, F.; Gyerty\u00e1n, I. Following of aging process in a new motor skill learning model, &#8222;pot jumping&#8221; in rats. Geroscience, 41: 3:309-319. (2019)<\/a><\/li>\n<li><a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/27855993\/\">Gyerty\u00e1n I, (2017) Cognitive \u201cOmics\u201d: Pattern-Based Validation of Potential Drug Targets. TIPS 38:113-126.<\/a><\/li>\n<li><a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/33086133\/\">Gyertyan, I.; Kassai, F.; Kozma, K.; Kitka, T.; Ernyey, A.J. Procognitive profiling of a serotonin 5-HT6 receptor antagonist in a complex model system in rats: A novel translational approach for clinical prediction. Brain research Bulletin, 165:238-245. (2020)<\/a><\/li>\n<li><a href=\"https:\/\/www.sciencedirect.com\/science\/article\/abs\/pii\/S0924977X20305563?via%3Dihub\">Gyerty\u00e1n, I.; Kozma, K.; Kassai, F.; Ernyey, A.J. Rats with long learning experience showed resistance to the impairing effect of MK-801 in several cognitive assays. European Neuropsychopharmacology, 40. S217. P.377 (2020)<\/a><\/li>\n<li><a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC8671572\/\">Gyerty\u00e1n, I. ; Lubec, J. ; Ernyey, A.J. ; Gerner, C. ; Kassai, F. ; Kalaba, P. ; Kozma, K. ; Cobankovic, I. ; Brenner, G.; Wackerlig, J. et al., Cognitive profiling and proteomic analysis of the modafinil analogue S-CE-123 in experienced aged rats. Scientific Reports 11: 23962, (2021)<\/a><\/li>\n<li><a href=\"https:\/\/www.sciencedirect.com\/science\/article\/abs\/pii\/S0924977X21012906?via%3Dihub\">Gyerty\u00e1n, I.; Kassai, F.; G\u00e1sp\u00e1r, A.; Varga, B.T.; Ernyey, A.J. A complex experimental design for measuring the learning impairing effect of repeat dose scopolamine in experienced aged rats. Eur. Neuropsychopharmacol. 53:Suppl. 1,\u00a0 S404. (2021)<\/a><\/li>\n<li>Varga, B.T.; Ernyey, A.J.; Tajti, B.T.; G\u00e1sp\u00e1r, A.; Gyerty\u00e1n, I. Freezing and ultrasound vocalization in response to contextual and discrete conditional stimuli in a fear conditioning paradigm. Eur. Neuropsychopharmacol. 53:Suppl. 1, S621. (2021)<\/li>\n<li><a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC8138205\/\">G\u00e1sp\u00e1r, A.; Hutka, B.; Ernyey, A.J.; Tajti, B.T.; Varga, B.T.; Z\u00e1dori, Z.S.; Gyerty\u00e1n, I. Intracerebroventricularly Injected Streptozotocin Exerts Subtle Effects on the Cognitive Performance of Long-Evans Rats. Front. Pharmacol., 12:662173, 11 p. (2021)<\/a><\/li>\n<li><a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/35164448\/\">Kassai, F.; Ernyey, A.J.; Kozma, K.; Plang\u00e1r, I.; Gyerty\u00e1n, I. Lack of general learning ability factor in a rat test battery measuring a wide spectrum of cognitive domains. J. Integrative Neurosci, 21:012, (2022)<\/a><\/li>\n<li><a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/36057105\/\">Varga, B.T.; G\u00e1sp\u00e1r, A.; Ernyey, A.J.; Hutka, B.; Tajti, B.T.; Z\u00e1dori, Z.S.; Gyerty\u00e1n, Istv\u00e1n. Introduction of a pharmacological neurovascular uncoupling model in rats based on results of mice. Physiol. Internat. 109:405-418. (2022)<\/a><\/li>\n<li>G\u00e1sp\u00e1r A., Ernyey A.J., Tajti, B.T., Varga B.T., Gyerty\u00e1n I. Cognitive characterization of the scopolamine-induced dementia model in experienced rats. Neurosci, App, 1:100112 100355, (2022)<\/li>\n<li><a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/36424423\/\">G\u00e1sp\u00e1r, A.; Hutka, B.; Ernyey, A.J.; Tajti, B.T.; Varga, B.T.; Z\u00e1dori, Z.S.; Gyerty\u00e1n, I. Performance of the intracerebroventricularly injected streptozotocin Alzheimer\u2019s disease model in a translationally relevant, aged and experienced rat population. Scientific Reports 12(1)20247, 13 p. (2022)<\/a><\/li>\n<li><a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/38149091\/\">Tajti, B.T.; Yoon, O.; Ernyey, A.J.; G\u00e1sp\u00e1r, A.; Varga, B.T.; Gyerty\u00e1n, I. Using appetitive motivation to train mice for spatial learning in the Barnes maze. Biomed Res. Internat., 6625491, 16 p (2023)<\/a><\/li>\n<li><a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/37306892\/\">Ernyey, A.J.; Kassai, F.; Kozma, K.; Plang\u00e1r, I.; Somfai, Zs.; Miklya, I.; Gyerty\u00e1n, I. Age-related decline of various cognitive functions in well-experienced male rats treated with the putative anti-aging compound (2R)-1-(1-benzofuran-2-yl)-N-propylpentane2-amine (( )BPAP). Geroscience: 46:417-429, (2024)<\/a><\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n\n<\/div><h2 class=\"tabtitle\">Main cooperations<\/h2>\n<div class=\"tabcontent\">\n\n<h4><strong>Main cooperations<\/strong><\/h4>\n<ul>\n<li>University of Vienna, Department of Pharmaceutical Chemistry<\/li>\n<li>University of Medicine and Pharmacy of T\u00e2rgu Mure\u0219, Faculty of Pharmacy, Department of Pharmacology and clinical Pharmacy, Laboratory of Neurophychopharmacology and Ethological Studies<\/li>\n<li>P\u00e1zm\u00e1ny P\u00e9ter Catholic University, Faculty of Information Technology and Bionics<\/li>\n<li>E\u00f6tv\u00f6s Lor\u00e1nd University, Department of Physiology and Neurobiology<\/li>\n<li>Hungarian Academy of Sciences (HAS) Institute of Experimental Medicine<\/li>\n<li>Hungarian Academy of Sciences (HAS) Research Center for Natural Sciences<\/li>\n<li>University of P\u00e9cs, Institute of Pharmacology and Pharmacotherapy<\/li>\n<\/ul>\n\n<\/div><h2 class=\"tabtitle\">Members<\/h2>\n<div class=\"tabcontent\">\n\n<p><strong>Workgroup leader<\/strong>:<\/p>\n<p><a href=\"https:\/\/semmelweis.hu\/telefonkonyv\/?emp_id=10511\" target=\"_blank\" rel=\"noopener\">Istv\u00e1n Gyerty\u00e1n<\/a>, MSc, PhD<\/p>\n<p><strong>Researcher \/ postdoc:<\/strong><\/p>\n<p><a href=\"https:\/\/semmelweis.hu\/telefonkonyv\/?emp_id=10514\" target=\"_blank\" rel=\"noopener\">Aliz Judit Ernyey<\/a>, MSc, PhD<\/p>\n<p><strong>PhD student:<\/strong><\/p>\n<p><a href=\"https:\/\/semmelweis.hu\/english\/phonebook\/?emp_id=18886\">Bence Tam\u00e1s Varga<\/a>, MSc<br \/>\nYashar Chalabiani<br \/>\nSandra Marouf<\/p>\n<p><strong>Assistant:<\/strong><\/p>\n<p><a href=\"https:\/\/semmelweis.hu\/telefonkonyv\/?emp_id=7658\" target=\"_blank\" rel=\"noopener\">Ildik\u00f3 Kerekesn\u00e9 Csontos<\/a><\/p>\n\n<\/div><h2 class=\"tabtitle\">Gallery<\/h2>\n<div class=\"tabcontent\">\n\n\r\n        [slb_exclude]\r\n        <div class=\"row galeria-wrapper mx-0 h-auto\">\r\n            <div class=\"col-9 pl-0 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[\/slb_exclude]\r\n\t\n<\/div><\/div>\n","protected":false},"excerpt":{"rendered":"<p><a href=\"https:\/\/semmelweis.hu\/pharmacology\/files\/2021\/09\/visfarm_logo.png\"><\/a> <a href=\"https:\/\/semmelweis.hu\/pharmacology\/files\/2022\/01\/Kekes-tura9-scaled.jpg\"><\/a> Establishment of a cognitive test battery with high translational value The aim of this project is to establish a complex cognitive animal test battery, which is able to identify clinically effective cognitive enhancer mechanims with higher hit ratio and precision than the currently applied methods. Learning and memory are impaired in several neurological and psychiatric &hellip;<\/p>\n","protected":false},"author":110,"featured_media":0,"parent":0,"menu_order":0,"comment_status":"closed","ping_status":"closed","template":"","meta":{"_acf_changed":false,"footnotes":""},"categories":[],"tags":[],"class_list":["post-966","page","type-page","status-publish","hentry"],"acf":[],"_links":{"self":[{"href":"https:\/\/semmelweis.hu\/pharmacology\/wp-json\/wp\/v2\/pages\/966","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/semmelweis.hu\/pharmacology\/wp-json\/wp\/v2\/pages"}],"about":[{"href":"https:\/\/semmelweis.hu\/pharmacology\/wp-json\/wp\/v2\/types\/page"}],"author":[{"embeddable":true,"href":"https:\/\/semmelweis.hu\/pharmacology\/wp-json\/wp\/v2\/users\/110"}],"replies":[{"embeddable":true,"href":"https:\/\/semmelweis.hu\/pharmacology\/wp-json\/wp\/v2\/comments?post=966"}],"version-history":[{"count":13,"href":"https:\/\/semmelweis.hu\/pharmacology\/wp-json\/wp\/v2\/pages\/966\/revisions"}],"predecessor-version":[{"id":14258,"href":"https:\/\/semmelweis.hu\/pharmacology\/wp-json\/wp\/v2\/pages\/966\/revisions\/14258"}],"wp:attachment":[{"href":"https:\/\/semmelweis.hu\/pharmacology\/wp-json\/wp\/v2\/media?parent=966"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/semmelweis.hu\/pharmacology\/wp-json\/wp\/v2\/categories?post=966"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/semmelweis.hu\/pharmacology\/wp-json\/wp\/v2\/tags?post=966"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}