{"id":964,"date":"2014-03-12T12:33:33","date_gmt":"2014-03-12T12:33:33","guid":{"rendered":"http:\/\/semmelweis.hu\/pharmacology\/?page_id=964"},"modified":"2024-06-19T15:43:30","modified_gmt":"2024-06-19T13:43:30","slug":"translational-neuropharmacology","status":"publish","type":"page","link":"https:\/\/semmelweis.hu\/pharmacology\/en\/translational-neuropharmacology\/","title":{"rendered":"Translational neuropharmacology research group"},"content":{"rendered":"<p style=\"text-align: justify\"><a href=\"https:\/\/semmelweis.hu\/pharmacology\/files\/2024\/02\/thumbnail__BAL8360.jpg\"><img loading=\"lazy\" decoding=\"async\" class=\"wp-image-13208 alignnone\" src=\"https:\/\/semmelweis.hu\/pharmacology\/files\/2024\/02\/thumbnail__BAL8360.jpg\" alt=\"\" width=\"338\" height=\"225\" srcset=\"https:\/\/semmelweis.hu\/pharmacology\/files\/2024\/02\/thumbnail__BAL8360.jpg 1920w, https:\/\/semmelweis.hu\/pharmacology\/files\/2024\/02\/thumbnail__BAL8360-400x267.jpg 400w, https:\/\/semmelweis.hu\/pharmacology\/files\/2024\/02\/thumbnail__BAL8360-1024x683.jpg 1024w, https:\/\/semmelweis.hu\/pharmacology\/files\/2024\/02\/thumbnail__BAL8360-768x512.jpg 768w, https:\/\/semmelweis.hu\/pharmacology\/files\/2024\/02\/thumbnail__BAL8360-1536x1024.jpg 1536w, https:\/\/semmelweis.hu\/pharmacology\/files\/2024\/02\/thumbnail__BAL8360-753x502.jpg 753w, https:\/\/semmelweis.hu\/pharmacology\/files\/2024\/02\/thumbnail__BAL8360-203x135.jpg 203w\" sizes=\"auto, (max-width: 338px) 100vw, 338px\" \/><\/a><a href=\"https:\/\/semmelweis.hu\/pharmacology\/files\/2019\/02\/DSCN0086.jpg\"><img loading=\"lazy\" decoding=\"async\" class=\"size-medium wp-image-8482 alignnone\" src=\"https:\/\/semmelweis.hu\/pharmacology\/files\/2019\/02\/DSCN0086-300x225.jpg\" alt=\"\" width=\"300\" height=\"225\" \/><\/a><a href=\"https:\/\/semmelweis.hu\/pharmacology\/files\/2019\/02\/DSCN0076.jpg\"><img loading=\"lazy\" decoding=\"async\" class=\"size-medium wp-image-8483 alignnone\" src=\"https:\/\/semmelweis.hu\/pharmacology\/files\/2019\/02\/DSCN0076-300x225.jpg\" alt=\"\" width=\"300\" height=\"225\" \/><\/a><\/p>\n<div class=\"responsive-tabs\">\n<h2 class=\"tabtitle\">Projects<\/h2>\n<div class=\"tabcontent\">\n\n<p><iframe loading=\"lazy\" src=\"\/\/www.youtube.com\/embed\/AQUBvURaWeQ\" width=\"560\" height=\"314\"><\/iframe><\/p>\n<p><iframe loading=\"lazy\" src=\"\/\/www.youtube.com\/embed\/2nG7bDYVGPU\" width=\"560\" height=\"314\"><\/iframe><\/p>\n<ul>\n<li><a href=\"https:\/\/semmelweis.hu\/pharmacology\/deciphering-the-pathogenesis-of-small-intestinal-damage-caused-by-non-steroidal-antiinflammatory-drugs-the-role-of-microbes-bile-acids-and-other-luminal-factors\/\">Deciphering the pathogenesis of small intestinal damage caused by non-steroidal antiinflammatory drugs &#8211; the role of microbes, bile acids, and other luminal factors<\/a><\/li>\n<li><a href=\"https:\/\/semmelweis.hu\/pharmacology\/glycine-transporter-type-1-glyt-1-potential-therapeutic-target-in-retinal-neurodegenerative-disorders\/\">Glycine transporter type 1 (GlyT-1) &#8211; potential therapeutic target in retinal neurodegenerative disorders<\/a><\/li>\n<li><a href=\"https:\/\/semmelweis.hu\/pharmacology\/?p=3698\" rel=\"noopener noreferrer\">Looking for new ways for analgesia<\/a><\/li>\n<li><a href=\"https:\/\/semmelweis.hu\/pharmacology\/research\/groups\/translational-neuropharmacology\/neurobiology-of-enhancer-regulation\/\">Neurobiology of enhancer regulation<\/a><\/li>\n<\/ul>\n\n<\/div><h2 class=\"tabtitle\">Experimental methods<\/h2>\n<div class=\"tabcontent\">\n\n<ul>\n<li>Measurement of the electrophysiological parameters of receptor pool and receptor kinetics of in vitro isolated organs.<\/li>\n<li>Immunohistochemistry<\/li>\n<li>In vivo antinociceptive tests, tolerance-dependence measurments, intracerebral, spinal application methods<\/li>\n<li>Electrochemical HPLC measurement of transmitter release in isolated organs (rabbit ear artery, rabbit pulmonary artery, rat vas deferens, etc) and to detect specific enhancer effect in isolated brain regions (tuberculum olfactorium, substantia nigra, striatum, raphe, locus coeruleus)<\/li>\n<li>Measuring transmitter release from in vitro tissue preparations (GABA, endomorphine 2, CGRP, [3H]-norepinephrine, dopamine, serotonin) by radioactive isotope and immunological technics<\/li>\n<li>Measuring enhancer activity on cell cultures (PC12, HBEC) and stroke models<\/li>\n<li>In vivo ulcer models<\/li>\n<li>Measurement of gastrointestinal motility in vivo and in vitro<\/li>\n<li>Acute and chronic inflammatory models<\/li>\n<li>Measurement of microcirculation with Laser Doppler flowmetry and LASCA technique<\/li>\n<li>Stereotaxic injection into given brain nuclei<\/li>\n<li>Brain microdialysis in anesthetised and conscious rats. Measurements of biogenic amines and amino acids with HPLC and electrochemistry.<\/li>\n<li>Measurements of radiolabelled neurotransmitter release from isolated brain slices and retina preparation using superfusion techniques.<\/li>\n<\/ul>\n\n<\/div><h2 class=\"tabtitle\">Main cooperators<\/h2>\n<div class=\"tabcontent\">\n\n<ul>\n<li>Department of Organic Chemistry, Semmelweis University<\/li>\n<li>Department of Pharmacodynamics, Semmelweis University<\/li>\n<li>Department of Pharmacology and Pharmacotherapy, University of Debrecen<\/li>\n<li>Karl-Franzens University of Graz, Dept. of Experimental and Clinical Pharmacology, Graz, Austria<\/li>\n<li>\n<p>National Institute of Health and Medical Research (INSERM), Paris, France<\/p>\n<\/li>\n<\/ul>\n\n<\/div><h2 class=\"tabtitle\">Members<\/h2>\n<div class=\"tabcontent\">\n\n<ul>\n<li><a href=\"https:\/\/semmelweis.hu\/english\/phonebook\/?emp_id=1934\">Susanna F\u00fcrst<\/a>, professor emerita<\/li>\n<li><a href=\"https:\/\/semmelweis.hu\/english\/phonebook\/?emp_id=1936\">Kl\u00e1ra Gyires<\/a>, Doctor of the Hungarian Academy of Sciences, professor emerita<\/li>\n<li><a href=\"https:\/\/semmelweis.hu\/english\/phonebook\/?emp_id=1955\">Laszlo G. Harsing,<\/a> MD, PhD, DSc, scientific consultant<\/li>\n<li><a href=\"https:\/\/semmelweis.hu\/english\/phonebook\/?emp_id=1941\">P\u00e1l Riba<\/a>, MD, PhD, associate professor<\/li>\n<li><a href=\"https:\/\/semmelweis.hu\/english\/phonebook\/?emp_id=1943\">J\u00falia T\u00edm\u00e1r<\/a>, MD, PhD, consultant<\/li>\n<li><a href=\"https:\/\/semmelweis.hu\/english\/phonebook\/?emp_id=1944\">Ildik\u00f3 Miklya<\/a>, PharmD, PhD, consultant<\/li>\n<li><a href=\"https:\/\/semmelweis.hu\/english\/phonebook\/?emp_id=1933\">Mahmoud Al-Khrasani<\/a>, MD, PhD, associate professor<\/li>\n<li><a href=\"https:\/\/semmelweis.hu\/english\/phonebook\/?emp_id=2004\">Zolt\u00e1n Z\u00e1dori<\/a>, MD, PhD, associate professor<\/li>\n<li><a href=\"https:\/\/semmelweis.hu\/english\/phonebook\/?emp_id=6354\">Erzs\u00e9bet Kat\u00f3<\/a>, MD, PhD, assistant professor<\/li>\n<li><a href=\"https:\/\/semmelweis.hu\/english\/phonebook\/?emp_id=1950\">Korn\u00e9l Kir\u00e1ly<\/a>, MD, PhD, assistant professor<\/li>\n<li><a href=\"https:\/\/semmelweis.hu\/telefonkonyv\/?emp_id=21922\">Gerda Wachtl<\/a>, PhD, research associate<\/li>\n<li>Arezoo Haghighi, PhD student<\/li>\n<li><a href=\"https:\/\/semmelweis.hu\/english\/phonebook\/?emp_id=18879\">Zsuzsanna Demeter<\/a>, laboratory assistant\u00a0<\/li>\n<li>Nariman Gomaa PhD student<\/li>\n<li>Sarah Kadhim PhD student<\/li>\n<li>Anna Galambos, PhD student<\/li>\n<\/ul>\n<p><span style=\"font-size: 1rem\"><\/div><\/div><\/span><\/p>\n","protected":false},"excerpt":{"rendered":"<p><a href=\"https:\/\/semmelweis.hu\/pharmacology\/files\/2024\/02\/thumbnail__BAL8360.jpg\"><\/a> <a href=\"https:\/\/semmelweis.hu\/pharmacology\/files\/2019\/02\/DSCN0086.jpg\"><\/a> <a href=\"https:\/\/semmelweis.hu\/pharmacology\/files\/2019\/02\/DSCN0076.jpg\"><\/a> <a href=\"https:\/\/semmelweis.hu\/pharmacology\/deciphering-the-pathogenesis-of-small-intestinal-damage-caused-by-non-steroidal-antiinflammatory-drugs-the-role-of-microbes-bile-acids-and-other-luminal-factors\/\">Deciphering the pathogenesis of small intestinal damage caused by non-steroidal antiinflammatory drugs &#8211; the role of microbes, bile acids, and other luminal factors<\/a> <a href=\"https:\/\/semmelweis.hu\/pharmacology\/glycine-transporter-type-1-glyt-1-potential-therapeutic-target-in-retinal-neurodegenerative-disorders\/\">Glycine transporter type 1 (GlyT-1) &#8211; potential therapeutic target in retinal neurodegenerative disorders<\/a> <a href=\"https:\/\/semmelweis.hu\/pharmacology\/?p=3698\" rel=\"noopener noreferrer\">Looking for new ways for analgesia<\/a> <a href=\"https:\/\/semmelweis.hu\/pharmacology\/research\/groups\/translational-neuropharmacology\/neurobiology-of-enhancer-regulation\/\">Neurobiology of enhancer regulation<\/a> Measurement of the electrophysiological parameters of receptor pool and receptor kinetics of in vitro isolated organs. Immunohistochemistry In vivo antinociceptive tests, tolerance-dependence measurments, intracerebral, spinal application methods Electrochemical HPLC measurement of transmitter release in isolated organs (rabbit ear artery, rabbit pulmonary artery, rat vas deferens, etc) and to detect specific enhancer effect in isolated brain &hellip;<\/p>\n","protected":false},"author":110,"featured_media":0,"parent":0,"menu_order":1,"comment_status":"closed","ping_status":"open","template":"","meta":{"_acf_changed":false,"footnotes":""},"categories":[],"tags":[],"class_list":["post-964","page","type-page","status-publish","hentry"],"acf":[],"_links":{"self":[{"href":"https:\/\/semmelweis.hu\/pharmacology\/wp-json\/wp\/v2\/pages\/964","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/semmelweis.hu\/pharmacology\/wp-json\/wp\/v2\/pages"}],"about":[{"href":"https:\/\/semmelweis.hu\/pharmacology\/wp-json\/wp\/v2\/types\/page"}],"author":[{"embeddable":true,"href":"https:\/\/semmelweis.hu\/pharmacology\/wp-json\/wp\/v2\/users\/110"}],"replies":[{"embeddable":true,"href":"https:\/\/semmelweis.hu\/pharmacology\/wp-json\/wp\/v2\/comments?post=964"}],"version-history":[{"count":13,"href":"https:\/\/semmelweis.hu\/pharmacology\/wp-json\/wp\/v2\/pages\/964\/revisions"}],"predecessor-version":[{"id":13341,"href":"https:\/\/semmelweis.hu\/pharmacology\/wp-json\/wp\/v2\/pages\/964\/revisions\/13341"}],"wp:attachment":[{"href":"https:\/\/semmelweis.hu\/pharmacology\/wp-json\/wp\/v2\/media?parent=964"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/semmelweis.hu\/pharmacology\/wp-json\/wp\/v2\/categories?post=964"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/semmelweis.hu\/pharmacology\/wp-json\/wp\/v2\/tags?post=964"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}