{"id":7922,"date":"2018-10-05T10:41:15","date_gmt":"2018-10-05T08:41:15","guid":{"rendered":"http:\/\/semmelweis.hu\/pharmacology\/?page_id=7922"},"modified":"2026-03-06T12:12:58","modified_gmt":"2026-03-06T11:12:58","slug":"ev-munkacsoport","status":"publish","type":"page","link":"https:\/\/semmelweis.hu\/pharmacology\/kutatas\/kardiovaszkularis-es-metabolizmus\/ev-munkacsoport\/","title":{"rendered":"Extracellul\u00e1ris vezikula munkacsoport"},"content":{"rendered":"<p><iframe loading=\"lazy\" title=\"Extracellular vesicle research group\" width=\"753\" height=\"424\" src=\"https:\/\/www.youtube.com\/embed\/hDUTmsd-hGo?feature=oembed\" frameborder=\"0\" allow=\"accelerometer; autoplay; clipboard-write; encrypted-media; gyroscope; picture-in-picture; web-share\" referrerpolicy=\"strict-origin-when-cross-origin\" allowfullscreen><\/iframe><\/p>\n<p>&nbsp;<\/p>\n<div class=\"responsive-tabs\">\n<h2 class=\"tabtitle\">Projektek<\/h2>\n<div class=\"tabcontent\">\n\n<p>Az extracellul\u00e1ris vezikul\u00e1k (exosz\u00f3m\u00e1k, mikrovezikul\u00e1k) az intercellul\u00e1ris kommunik\u00e1ci\u00f3 nemr\u00e9giben felfedezett r\u00e9sztvev\u0151i, melyek szerep\u00e9t \u00fajabban sz\u00e1mos fiziol\u00f3gi\u00e1s \u00e9s patol\u00f3gi\u00e1s \u00e1llapotban bizony\u00edtott\u00e1k.<\/p>\n<p><a href=\"https:\/\/semmelweis.hu\/pharmacology\/files\/2018\/10\/EVcomunication_Szempruchetal2016.jpg\"><img loading=\"lazy\" decoding=\"async\" class=\"aligncenter size-full wp-image-7924\" src=\"https:\/\/semmelweis.hu\/pharmacology\/files\/2018\/10\/EVcomunication_Szempruchetal2016.jpg\" alt=\"\" width=\"685\" height=\"543\" srcset=\"https:\/\/semmelweis.hu\/pharmacology\/files\/2018\/10\/EVcomunication_Szempruchetal2016.jpg 685w, https:\/\/semmelweis.hu\/pharmacology\/files\/2018\/10\/EVcomunication_Szempruchetal2016-300x238.jpg 300w, https:\/\/semmelweis.hu\/pharmacology\/files\/2018\/10\/EVcomunication_Szempruchetal2016-333x264.jpg 333w\" sizes=\"auto, (max-width: 685px) 100vw, 685px\" \/><\/a><br \/>\n1. \u00e1bra: a | A donor sejtek extracellul\u00e1ris vezikul\u00e1kat (EVk) bocs\u00e1jtanak ki, melyek k\u00fcll\u00f6nb\u00f6z\u0151 cargo molekul\u00e1kat (lipid, feh\u00e9rje, RNS, DNS) tartalmazhatnak. b | Az EVket recipiens sejtek vehetik fel, ami t\u00f6rt\u00e9nhet membr\u00e1n f\u00fazi\u00f3val vagy receptorok seg\u00edts\u00e9g\u00e9vel egyar\u00e1nt. (Forr\u00e1s: <a href=\"https:\/\/www.nature.com\/articles\/nrmicro.2016.110\">Szempruch et al., 2016<\/a>)<\/p>\n<p><a href=\"https:\/\/semmelweis.hu\/pharmacology\/files\/2018\/10\/patkanyverEV_EMphoto_sajat.jpg\"><img loading=\"lazy\" decoding=\"async\" class=\"aligncenter\" src=\"https:\/\/semmelweis.hu\/pharmacology\/files\/2018\/10\/patkanyverEV_EMphoto_sajat-300x170.jpg\" alt=\"\" width=\"386\" height=\"219\" \/><\/a><br \/>\n2. \u00e1bra: Patk\u00e1nyv\u00e9rb\u0151l izol\u00e1lt extracellul\u00e1ris vezikul\u00e1k elektronmikroszk\u00f3pos k\u00e9pe.<\/p>\n<p>Kutat\u00f3csoportunk a sz\u00edv iszk\u00e9mi\u00e1s \u00e1llapotai (pl. angina, infarktus) ter\u00e1pi\u00e1s lehet\u0151s\u00e9geit kutatja a kardioprotekt\u00edv intevenci\u00f3k \u00e9s kezel\u00e9sek sor\u00e1n felszabadul\u00f3 extracellul\u00e1ris vezikul\u00e1k, illetve azok mikroRNS- \u00e9s feh\u00e9rjetartalm\u00e1nak tanulm\u00e1nyoz\u00e1s\u00e1val. Kutat\u00e1saink c\u00e9lja \u00faj, extracellul\u00e1ris vezikula-alap\u00fa ter\u00e1pi\u00e1s \u00e9s diagnosztikus c\u00e9lpontok keres\u00e9se, melyeket k\u00e9s\u0151bb a klinikai betegell\u00e1t\u00e1sban is lehet alkalmazni.<\/p>\n<p>T\u00e9macsoport vezet\u0151: <a href=\"http:\/\/scholar.semmelweis.hu\/giriczz\/hu\/bemutatkozas\/\">Dr Giricz Zolt\u00e1n<\/a> tudom\u00e1nyos f\u0151munkat\u00e1rs (<a href=\"https:\/\/scholar.google.com\/citations?user=GxWbUygAAAAJ&amp;hl=en\">Google Scholar<\/a>)<\/p>\n<p>A t\u00e9m\u00e1ban kor\u00e1bban megjelent cikkeink:<\/p>\n<ul>\n<li>On\u00f3di Z, Pelyhe C, Nagy CT, Brenner GB, Alm\u00e1si L, Kittel \u00c1, Mancek Keber M, Ferdinandy P, Buz\u00e1s EI and Giricz G. Isolation of high-purity extracellular vesicles by the combination of iodixanol density gradient ultracentrifugation and bind-elute chromatography from blood plasma. Front Physiol. 2018 Oct 23;9:1479. (<a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/30405435\">link<\/a>)<\/li>\n<li>Sluijter JPG, Davidson SM, Boulanger CM, Buz\u00e1s EI, de Kleijn DPV, Engel FB8, Giricz Z, Hausenloy DJ, Kishore R, Lecour S, Leor J, Madonna R, Perrino C, Prunier F, Sahoo S, Schiffelers RM, Schulz R, Van Laake LW, Ytrehus K, Ferdinandy P. Extracellular vesicles in diagnostics and therapy of the ischaemic heart: Position Paper from the Working Group on Cellular Biology of the Heart of the European Society of Cardiology. Cardiovasc Res. 2018 Jan 1;114(1):19-34. (<a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/29106545\">link<\/a>)<\/li>\n<li>S\u00f3dar BW, Kittel \u00c1, P\u00e1l\u00f3czi K, Vukman KV, Osteikoetxea X, Szab\u00f3-Taylor K, N\u00e9meth A, Sperl\u00e1gh B, Baranyai T, Giricz Z, Wiener Z, Turi\u00e1k L, Drahos L, P\u00e1llinger \u00c9, V\u00e9key K, Ferdinandy P, Falus A, Buz\u00e1s EI. Low-density lipoprotein mimics blood plasma-derived exosomes and microvesicles during isolation and detection. Sci Rep. 2016 Apr 18; 6:24316. (<a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/27087061\">link<\/a>)<\/li>\n<li>Baranyai T, Herczeg K, Onodi Z, Voszka I, Modos K, Marton N, Nagy G, M\u00e4ger I, Wood MJ, El Andaloussi S, Palinkas Z, Kumar V, Nagy P, Kittel A, Buzas E, Ferdinandy P, Giricz Z. Isolation of Exosomes from Blood Plasma: Qualitative and Quantitative Comparison of Ultracentrifugation and Size Exclusion Chromatography Methods. PLoS One. 2015 Dec 21; 10 (12): e0145686. (<a href=\"https:\/\/journals.plos.org\/plosone\/article?id=10.1371\/journal.pone.0145686\">link<\/a>)<\/li>\n<li>Giricz Z, Varga ZV, Baranyai T, Sipos P, P\u00e1l\u00f3czi K, Kittel \u00c1, Buz\u00e1s EI, Ferdinandy P. Cardioprotection by remote ischemic preconditioning of the rat heart is mediated by extracellular vesicles. J Mol Cell Cardiol. 2014 Mar;68:75-8. (<a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/24440457\">link<\/a>)<\/li>\n<\/ul>\n<p>A t\u00e9m\u00e1ban TDK hallgat\u00f3k \u00e1ltal el\u00e9rt eredm\u00e9nyek:<\/p>\n<ul>\n<li>Alm\u00e1si Laura, Semmelweis Egyetem TDK Konferencia, Budapest, Magyarorsz\u00e1g, 2019, III. d\u00edj<\/li>\n<li>Kenyeres Bence, Semmelweis Egyetem TDK Konferencia, Budapest, Magyarorsz\u00e1g, 2019, III. d\u00edj<\/li>\n<li>Alm\u00e1si Laura, XXIII. Kor\u00e1nyi Frigyes Tudom\u00e1nyos F\u00f3rum, Gy\u00f3gyszerfejleszt\u00e9s, biometodika, biol\u00f3giai modellek, future medicine szekci\u00f3, Budapest, Magyarorsz\u00e1g, 2018, II. d\u00edj<\/li>\n<li>On\u00f3di Zs\u00f3fia TDK hallgat\u00f3, Semmelweis Egyetem, XXXIII OTDK, Budapest, Magyarorsz\u00e1g, 2017, I. d\u00edj<\/li>\n<\/ul>\n<p><strong>Az extracellul\u00e1ris vezikul\u00e1k szerep\u00e9nek vizsg\u00e1lata kardioprotekt\u00edv mechanizmusokban<\/strong><\/p>\n<p>In vitro k\u00f6r\u00fclm\u00e9nyek k\u00f6z\u00f6tt, k\u00fcl\u00f6nb\u00f6z\u0151 sejtvonalakb\u00f3l, vagy izol\u00e1lt kardi\u00e1lis sejtekb\u0151l\u00a0<a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/28453734\">kardioprotekt\u00edv elj\u00e1r\u00e1sok<\/a>\u00a0hat\u00e1s\u00e1ra felszabadul\u00f3 extracellul\u00e1ris vezikul\u00e1k karakteriz\u00e1l\u00e1sa, mennyis\u00e9gi \u00e9s min\u0151s\u00e9gi jellemz\u00e9se, \u00e9s felt\u00e9telezhet\u0151 ter\u00e1pi\u00e1s felhaszn\u00e1l\u00e1suk vizsg\u00e1lata szimul\u00e1lt iszk\u00e9mia reperf\u00fazi\u00f3s (sI\/R) k\u00e1rosod\u00e1sban, sejtkult\u00far\u00e1s modellekben.<\/p>\n<p>Elsaj\u00e1t\u00edthat\u00f3 k\u00e9pess\u00e9gek: sejtteny\u00e9szt\u00e9s, fluoreszcens mikroszk\u00f3p kezel\u00e9se<\/p>\n<p>T\u00e9mavezet\u0151: <a href=\"https:\/\/semmelweis.hu\/pharmacology\/dr-pelyhe-csilla\/\">Dr Pelyhe Csilla<\/a> tudom\u00e1nyos munkat\u00e1rs,\u00a0<a href=\"http:\/\/scholar.semmelweis.hu\/giriczz\/hu\/bemutatkozas\/\">Dr Giricz Zolt\u00e1n<\/a> tudom\u00e1nyos f\u0151munkat\u00e1rs<\/p>\n<p><strong>Az extracellul\u00e1ris vezikul\u00e1k szerep\u00e9nek vizsg\u00e1lata metabolikus betegs\u00e9gmodellekben<\/strong><\/p>\n<p>Metabolikus stressznek kitett \u00e1llatok (<a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/27521417\">diab\u00e9tesz<\/a>, <a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/29971762\">elh\u00edz\u00e1s, hiperlipid\u00e9mia<\/a>)\u00a0v\u00e9r\u00e9b\u0151l izol\u00e1lt extracellul\u00e1ris vezikul\u00e1k karakteriz\u00e1l\u00e1sa \u00e9s hat\u00e1s\u00e1nak vizsg\u00e1lata szimul\u00e1lt iszk\u00e9mia reperf\u00fazi\u00f3s (sI\/R) k\u00e1rosod\u00e1sban sejtes modellekben. A metabolikus egyens\u00faly felboml\u00e1sa kihat\u00e1ssal lehet az EV-k tartalm\u00e1ra, illetve azok membr\u00e1n\u00f6sszet\u00e9tel\u00e9re is. A projekt c\u00e9lja, az EV-k fizikai jellemz\u0151inek vizsg\u00e1lata k\u00fcl\u00f6nb\u00f6z\u0151 metabolikus betegs\u00e9gmodellekben. Tov\u00e1bb\u00e1 c\u00e9lunk a metabolikus betegs\u00e9gmodellekb\u0151l sz\u00e1rmaz\u00f3 EV-k kardioprotekt\u00edv hat\u00e1sainak vizsg\u00e1lata, sejtvonalakban \u00e9s primer izol\u00e1lt (feln\u0151tt \u00e9s neonat\u00e1lis) patk\u00e1ny kardiomiocit\u00e1kon, szimul\u00e1lt iszk\u00e9mia\/reoxigeniz\u00e1ci\u00f3s k\u00eds\u00e9rletekben. A vizsg\u00e1latokban m\u00e9rj\u00fck a sejtek t\u00fal\u00e9l\u00e9s\u00e9t, g\u00e9n- \u00e9s feh\u00e9rje expresszi\u00f3s v\u00e1ltoz\u00e1sait, melyb\u0151l k\u00f6vetkeztet\u00e9seket tudunk levonni a sejtek EV-kre adott v\u00e1lasz\u00e1r\u00f3l \u00e9s az \u00e1ltaluk aktiv\u00e1lt v\u00e9delmi mechanizmusokr\u00f3l.<\/p>\n<p><a href=\"https:\/\/semmelweis.hu\/pharmacology\/files\/2018\/10\/invivocollectedEV_SIRcells_concept.jpg\"><img loading=\"lazy\" decoding=\"async\" class=\"aligncenter size-full wp-image-7937\" src=\"https:\/\/semmelweis.hu\/pharmacology\/files\/2018\/10\/invivocollectedEV_SIRcells_concept.jpg\" alt=\"\" width=\"559\" height=\"129\" srcset=\"https:\/\/semmelweis.hu\/pharmacology\/files\/2018\/10\/invivocollectedEV_SIRcells_concept.jpg 559w, https:\/\/semmelweis.hu\/pharmacology\/files\/2018\/10\/invivocollectedEV_SIRcells_concept-300x69.jpg 300w\" sizes=\"auto, (max-width: 559px) 100vw, 559px\" \/><\/a><\/p>\n<p>3. \u00e1bra: In vivo izol\u00e1l\u00e1st k\u00f6vet\u0151en az EV-k hat\u00e1s\u00e1nak vizsg\u00e1lata szimul\u00e1lt iszk\u00e9mia reperf\u00fazi\u00f3s (sI\/R) k\u00e1rosod\u00e1sban sejtes modellekben.<\/p>\n<p>Elsaj\u00e1t\u00edthat\u00f3 k\u00e9pess\u00e9gek: EV izol\u00e1l\u00e1s, Western Blot, qPCR, sejtteny\u00e9szt\u00e9s, viabilit\u00e1s tesztek, fluoreszcens mikroszk\u00f3p kezel\u00e9se, biofizikai vizsg\u00e1latok (Atomer\u0151-mikroszk\u00f3p, light sheet mikroszk\u00f3p), szimul\u00e1lt iszk\u00e9mia\/reperf\u00fazi\u00f3 sejt modellekben.<\/p>\n<p>T\u00e9mavezet\u0151: <a href=\"http:\/\/scholar.semmelweis.hu\/giriczz\/hu\/bemutatkozas\/\">Dr Giricz Zolt\u00e1n<\/a> tudom\u00e1nyos f\u0151munkat\u00e1rs<\/p>\n<p><strong>Extracellul\u00e1ris vezikul\u00e1k szerepe az iszk\u00e9mi\u00e1s kond\u00edcion\u00e1l\u00e1sban<\/strong><\/p>\n<p>Kutat\u00e1sunk t\u00e9m\u00e1ja az iszk\u00e9mi\u00e1s kond\u00edcion\u00e1l\u00e1s sor\u00e1n l\u00e9trej\u00f6v\u0151 protekt\u00edv hat\u00e1sok vizsg\u00e1lata in vitro k\u00f6r\u00fclm\u00e9nyek k\u00f6z\u00f6tt. Ennek sor\u00e1n, a protekt\u00edv tulajdons\u00e1gokkal b\u00edr\u00f3 extracellul\u00e1ris vezikul\u00e1k (EVk) biofizikai param\u00e9tereit tanulm\u00e1nyozzuk transzg\u00e9nikus sejtvonalak seg\u00edts\u00e9g\u00e9vel. Emellett, az iszk\u00e9mia\/reperf\u00fazi\u00f3 sor\u00e1n fell\u00e9p\u0151 gyullad\u00e1sos folyamatok elind\u00edt\u00e1s\u00e1ban szerepet j\u00e1tsz\u00f3 jel\u00e1tviteli \u00fatvonalak is vizsg\u00e1ljuk, melyhez CRISPR\/Cas9 vez\u00e9relt g\u00e9nki\u00fct\u00e9ses m\u00f3dszert alkalmazunk.<\/p>\n<p><img loading=\"lazy\" decoding=\"async\" class=\"aligncenter size-full wp-image-7938\" src=\"https:\/\/semmelweis.hu\/pharmacology\/files\/2018\/10\/florescentEV_isolationandtreatment_concept.jpg\" alt=\"\" width=\"560\" height=\"180\" srcset=\"https:\/\/semmelweis.hu\/pharmacology\/files\/2018\/10\/florescentEV_isolationandtreatment_concept.jpg 560w, https:\/\/semmelweis.hu\/pharmacology\/files\/2018\/10\/florescentEV_isolationandtreatment_concept-300x96.jpg 300w\" sizes=\"auto, (max-width: 560px) 100vw, 560px\" \/><br \/>\n4. \u00e1bra:\u00a0Fluoreszcens feh\u00e9rj\u00e9vel jel\u00f6lt EVk izol\u00e1l\u00e1sa, biofizikai param\u00e9terek vizsg\u00e1lata, in vivo \u00e9s in vitro vizualiz\u00e1l\u00e1sa \u00e9s nyomonk\u00f6vet\u00e9se\u00a0<\/p>\n<p>Elsaj\u00e1t\u00edthat\u00f3 k\u00e9pess\u00e9gek: sejtteny\u00e9szt\u00e9s, fluoreszcens mikroszk\u00f3p kezel\u00e9se, DNS \u00e9s feh\u00e9rje munk\u00e1k, g\u00e9nki\u00fct\u00e9s (CRISPR\/Cas9), transzg\u00e9nikus sejtvonalak l\u00e9trehoz\u00e1sa<\/p>\n<p>T\u00e9mavezet\u0151: <a href=\"http:\/\/scholar.semmelweis.hu\/giriczz\/hu\/bemutatkozas\/\">Dr Giricz Zolt\u00e1n<\/a> tudom\u00e1nyos f\u0151munkat\u00e1rs<\/p>\n<p>&nbsp;<\/p>\n\n<\/div><h2 class=\"tabtitle\">Tagok<\/h2>\n<div class=\"tabcontent\">\n\n<p><strong>Munkacsoport vezet\u0151<\/strong>:<\/p>\n<p><a href=\"https:\/\/semmelweis.hu\/telefonkonyv\/?emp_id=10510\">Dr. Giricz Zolt\u00e1n, PhD<\/a><\/p>\n<p><strong>Kutat\u00f3k \/ posztdoktorok<\/strong>:<\/p>\n<p><a href=\"https:\/\/semmelweis.hu\/telefonkonyv\/?emp_id=15800\">Hambalk\u00f3 Szabolcs<\/a><br \/>\n<a href=\"https:\/\/semmelweis.hu\/telefonkonyv\/?emp_id=15789\">Kov\u00e1csh\u00e1zi Csenger<\/a><\/p>\n<p><strong>PhD hallgat\u00f3k<\/strong>:<\/p>\n<p><a href=\"https:\/\/semmelweis.hu\/telefonkonyv\/?emp_id=25645\">Artuner Yavuz<\/a><br \/>\n<a href=\"https:\/\/semmelweis.hu\/telefonkonyv\/?emp_id=21926\">Kapui D\u00f3ra<\/a><br \/>\n<a href=\"https:\/\/semmelweis.hu\/telefonkonyv\/?emp_id=18882\">Dr. Sayour Viktor Nabil<\/a><br \/>\n<a href=\"https:\/\/semmelweis.hu\/telefonkonyv\/?emp_id=22515\">R\u00e1cz Rich\u00e1rd<\/a><br \/>\n<a href=\"https:\/\/semmelweis.hu\/telefonkonyv\/?emp_id=26446\">Teresa Hung<\/a><\/p>\n<p><strong>Asszisztensek<\/strong>:<\/p>\n<p><a href=\"https:\/\/semmelweis.hu\/telefonkonyv\/?emp_id=20518\">Zsidai S\u00e1ndor<\/a><\/p>\n\n<\/div><h2 class=\"tabtitle\">Gal\u00e9ria<\/h2>\n<div class=\"tabcontent\">\n\n\r\n        [slb_exclude]\r\n        <div class=\"row galeria-wrapper mx-0 h-auto\">\r\n            <div class=\"col-9 pl-0 pr-2\">\r\n            <span class=\"gallery-item frame\">\r\n\t\t\t\t<div class=\"galeria-left-img\"><a href=\"https:\/\/semmelweis.hu\/pharmacology\/files\/2025\/06\/EV_Group_20260605-scaled.jpg\"><img src=https:\/\/semmelweis.hu\/pharmacology\/files\/2025\/06\/EV_Group_20260605-scaled.jpg  \r\n                            alt=\"\" \r\n                            class=\"attachment-sote-gallery-big size-sote-gallery-big\" \r\n                            srcset=\"https:\/\/semmelweis.hu\/pharmacology\/files\/2025\/06\/EV_Group_20260605-400x180.jpg 400w, https:\/\/semmelweis.hu\/pharmacology\/files\/2025\/06\/EV_Group_20260605-1024x462.jpg 1024w, https:\/\/semmelweis.hu\/pharmacology\/files\/2025\/06\/EV_Group_20260605-768x346.jpg 768w, https:\/\/semmelweis.hu\/pharmacology\/files\/2025\/06\/EV_Group_20260605-1536x692.jpg 1536w, https:\/\/semmelweis.hu\/pharmacology\/files\/2025\/06\/EV_Group_20260605-2048x923.jpg 2048w, https:\/\/semmelweis.hu\/pharmacology\/files\/2025\/06\/EV_Group_20260605-753x339.jpg 753w\" ><\/a><\/div>\r\n            <\/span>\r\n\r\n            <\/div>\r\n\r\n\t\t\t<div class=\"col-3 pl-0 pr-0\">\r\n\t\t\t\t<div class=\"galeria-right-img d-flex justify-content-between flex-column h-100 w-100 px-0 mx-0 \">\r\n                <div class=\"galeria-box\">\r\n\t\t\t\t\t<h3 class=\"galeria-title\">Gal\u00e9ria<\/h3>\r\n\t\t\t\t\t<div class=\"galeria-subtitle\">\r\n\r\n\t\t\t\t\t\t<div class=\"galeria-page-counter\"><span>11<\/span>k\u00e9p<\/div>\r\n                    <\/div> <\/div>\r\n                    <span class=\"gallery-item frame d-none d-md-flex\">\r\n\t\t\t\t\t<div class=\"galeria-small-img mt-0\"><a href=\"https:\/\/semmelweis.hu\/pharmacology\/files\/2024\/08\/BAL7906-scaled.jpg\"><img src=https:\/\/semmelweis.hu\/pharmacology\/files\/2024\/08\/BAL7906-scaled.jpg \r\n                                alt=\"\"  \r\n                                class=\"attachment-sote-gallery-small size-sote-gallery-small\" \r\n                                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src=https:\/\/semmelweis.hu\/pharmacology\/files\/2024\/08\/BAL8438-scaled.jpg alt=\"\" class=\"attachment-sote-gallery-big size-sote-gallery-big\" srcset=\"https:\/\/semmelweis.hu\/pharmacology\/files\/2024\/08\/BAL8438-400x267.jpg 400w, https:\/\/semmelweis.hu\/pharmacology\/files\/2024\/08\/BAL8438-1024x683.jpg 1024w, https:\/\/semmelweis.hu\/pharmacology\/files\/2024\/08\/BAL8438-768x512.jpg 768w, https:\/\/semmelweis.hu\/pharmacology\/files\/2024\/08\/BAL8438-1536x1024.jpg 1536w, https:\/\/semmelweis.hu\/pharmacology\/files\/2024\/08\/BAL8438-2048x1365.jpg 2048w, https:\/\/semmelweis.hu\/pharmacology\/files\/2024\/08\/BAL8438-753x502.jpg 753w, https:\/\/semmelweis.hu\/pharmacology\/files\/2024\/08\/BAL8438-203x135.jpg 203w\" >\r\n        <\/a><\/div><\/span><span class=\"gallery-item\"><div class=\"hidden\"><a href=\"https:\/\/semmelweis.hu\/pharmacology\/files\/2024\/08\/BAL7937-scaled.jpg\">\r\n        <img src=https:\/\/semmelweis.hu\/pharmacology\/files\/2024\/08\/BAL7937-scaled.jpg alt=\"\" class=\"attachment-sote-gallery-big size-sote-gallery-big\" srcset=\"https:\/\/semmelweis.hu\/pharmacology\/files\/2024\/08\/BAL7937-400x267.jpg 400w, https:\/\/semmelweis.hu\/pharmacology\/files\/2024\/08\/BAL7937-1024x683.jpg 1024w, https:\/\/semmelweis.hu\/pharmacology\/files\/2024\/08\/BAL7937-768x512.jpg 768w, https:\/\/semmelweis.hu\/pharmacology\/files\/2024\/08\/BAL7937-1536x1024.jpg 1536w, https:\/\/semmelweis.hu\/pharmacology\/files\/2024\/08\/BAL7937-2048x1366.jpg 2048w, https:\/\/semmelweis.hu\/pharmacology\/files\/2024\/08\/BAL7937-753x502.jpg 753w, https:\/\/semmelweis.hu\/pharmacology\/files\/2024\/08\/BAL7937-203x135.jpg 203w\" >\r\n        <\/a><\/div><\/span><span class=\"gallery-item\"><div class=\"hidden\"><a href=\"https:\/\/semmelweis.hu\/pharmacology\/files\/2024\/08\/BAL7878-scaled.jpg\">\r\n        <img 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src=https:\/\/semmelweis.hu\/pharmacology\/files\/2024\/08\/BAL7966-scaled.jpg alt=\"\" class=\"attachment-sote-gallery-big size-sote-gallery-big\" srcset=\"https:\/\/semmelweis.hu\/pharmacology\/files\/2024\/08\/BAL7966-400x267.jpg 400w, https:\/\/semmelweis.hu\/pharmacology\/files\/2024\/08\/BAL7966-1024x683.jpg 1024w, https:\/\/semmelweis.hu\/pharmacology\/files\/2024\/08\/BAL7966-768x512.jpg 768w, https:\/\/semmelweis.hu\/pharmacology\/files\/2024\/08\/BAL7966-1536x1024.jpg 1536w, https:\/\/semmelweis.hu\/pharmacology\/files\/2024\/08\/BAL7966-2048x1365.jpg 2048w, https:\/\/semmelweis.hu\/pharmacology\/files\/2024\/08\/BAL7966-753x502.jpg 753w, https:\/\/semmelweis.hu\/pharmacology\/files\/2024\/08\/BAL7966-203x135.jpg 203w\" >\r\n        <\/a><\/div><\/span><span class=\"gallery-item\"><div class=\"hidden\"><a href=\"https:\/\/semmelweis.hu\/pharmacology\/files\/2024\/08\/BAL8028-scaled.jpg\">\r\n        <img src=https:\/\/semmelweis.hu\/pharmacology\/files\/2024\/08\/BAL8028-scaled.jpg alt=\"\" class=\"attachment-sote-gallery-big size-sote-gallery-big\" srcset=\"https:\/\/semmelweis.hu\/pharmacology\/files\/2024\/08\/BAL8028-400x267.jpg 400w, https:\/\/semmelweis.hu\/pharmacology\/files\/2024\/08\/BAL8028-1024x683.jpg 1024w, https:\/\/semmelweis.hu\/pharmacology\/files\/2024\/08\/BAL8028-768x512.jpg 768w, https:\/\/semmelweis.hu\/pharmacology\/files\/2024\/08\/BAL8028-1536x1024.jpg 1536w, https:\/\/semmelweis.hu\/pharmacology\/files\/2024\/08\/BAL8028-2048x1365.jpg 2048w, https:\/\/semmelweis.hu\/pharmacology\/files\/2024\/08\/BAL8028-753x502.jpg 753w, https:\/\/semmelweis.hu\/pharmacology\/files\/2024\/08\/BAL8028-203x135.jpg 203w\" >\r\n        <\/a><\/div><\/span><span class=\"gallery-item\"><div class=\"hidden\"><a href=\"https:\/\/semmelweis.hu\/pharmacology\/files\/2024\/08\/BAL8472-scaled.jpg\">\r\n        <img src=https:\/\/semmelweis.hu\/pharmacology\/files\/2024\/08\/BAL8472-scaled.jpg alt=\"\" class=\"attachment-sote-gallery-big size-sote-gallery-big\" srcset=\"https:\/\/semmelweis.hu\/pharmacology\/files\/2024\/08\/BAL8472-400x267.jpg 400w, https:\/\/semmelweis.hu\/pharmacology\/files\/2024\/08\/BAL8472-1024x683.jpg 1024w, https:\/\/semmelweis.hu\/pharmacology\/files\/2024\/08\/BAL8472-768x512.jpg 768w, https:\/\/semmelweis.hu\/pharmacology\/files\/2024\/08\/BAL8472-1536x1024.jpg 1536w, https:\/\/semmelweis.hu\/pharmacology\/files\/2024\/08\/BAL8472-2048x1365.jpg 2048w, https:\/\/semmelweis.hu\/pharmacology\/files\/2024\/08\/BAL8472-753x502.jpg 753w, https:\/\/semmelweis.hu\/pharmacology\/files\/2024\/08\/BAL8472-203x135.jpg 203w\" >\r\n        <\/a><\/div><\/span>\r\n            <\/div>\r\n\r\n            [\/slb_exclude]\r\n\t\n<p>&nbsp;<\/p>\n<\/div><\/div>\n","protected":false},"excerpt":{"rendered":"<p>&nbsp; Az extracellul\u00e1ris vezikul\u00e1k (exosz\u00f3m\u00e1k, mikrovezikul\u00e1k) az intercellul\u00e1ris kommunik\u00e1ci\u00f3 nemr\u00e9giben felfedezett r\u00e9sztvev\u0151i, melyek szerep\u00e9t \u00fajabban sz\u00e1mos fiziol\u00f3gi\u00e1s \u00e9s patol\u00f3gi\u00e1s \u00e1llapotban bizony\u00edtott\u00e1k. <a href=\"https:\/\/semmelweis.hu\/pharmacology\/files\/2018\/10\/EVcomunication_Szempruchetal2016.jpg\"><\/a> 1. \u00e1bra: a | A donor sejtek extracellul\u00e1ris vezikul\u00e1kat (EVk) bocs\u00e1jtanak ki, melyek k\u00fcll\u00f6nb\u00f6z\u0151 cargo molekul\u00e1kat (lipid, feh\u00e9rje, RNS, DNS) tartalmazhatnak. b | Az EVket recipiens sejtek vehetik fel, ami t\u00f6rt\u00e9nhet membr\u00e1n f\u00fazi\u00f3val vagy &hellip;<\/p>\n","protected":false},"author":101230,"featured_media":0,"parent":336,"menu_order":2,"comment_status":"closed","ping_status":"closed","template":"","meta":{"_acf_changed":false,"footnotes":""},"categories":[],"tags":[],"class_list":["post-7922","page","type-page","status-publish","hentry"],"acf":[],"_links":{"self":[{"href":"https:\/\/semmelweis.hu\/pharmacology\/wp-json\/wp\/v2\/pages\/7922","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/semmelweis.hu\/pharmacology\/wp-json\/wp\/v2\/pages"}],"about":[{"href":"https:\/\/semmelweis.hu\/pharmacology\/wp-json\/wp\/v2\/types\/page"}],"author":[{"embeddable":true,"href":"https:\/\/semmelweis.hu\/pharmacology\/wp-json\/wp\/v2\/users\/101230"}],"replies":[{"embeddable":true,"href":"https:\/\/semmelweis.hu\/pharmacology\/wp-json\/wp\/v2\/comments?post=7922"}],"version-history":[{"count":12,"href":"https:\/\/semmelweis.hu\/pharmacology\/wp-json\/wp\/v2\/pages\/7922\/revisions"}],"predecessor-version":[{"id":15643,"href":"https:\/\/semmelweis.hu\/pharmacology\/wp-json\/wp\/v2\/pages\/7922\/revisions\/15643"}],"up":[{"embeddable":true,"href":"https:\/\/semmelweis.hu\/pharmacology\/wp-json\/wp\/v2\/pages\/336"}],"wp:attachment":[{"href":"https:\/\/semmelweis.hu\/pharmacology\/wp-json\/wp\/v2\/media?parent=7922"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/semmelweis.hu\/pharmacology\/wp-json\/wp\/v2\/categories?post=7922"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/semmelweis.hu\/pharmacology\/wp-json\/wp\/v2\/tags?post=7922"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}