{"id":13607,"date":"2024-05-15T09:30:04","date_gmt":"2024-05-15T07:30:04","guid":{"rendered":"https:\/\/semmelweis.hu\/pharmacology\/?page_id=13607"},"modified":"2024-10-13T15:00:09","modified_gmt":"2024-10-13T13:00:09","slug":"gastrointestinal-pharmacology-workgroup","status":"publish","type":"page","link":"https:\/\/semmelweis.hu\/pharmacology\/en\/research\/neurotranslation-and-neuromodulation-research-group\/gastrointestinal-pharmacology-workgroup\/","title":{"rendered":"Gastrointestinal pharmacology workgroup"},"content":{"rendered":"<p><iframe loading=\"lazy\" title=\"Gastrointestinal Research Group\" width=\"753\" height=\"424\" src=\"https:\/\/www.youtube.com\/embed\/AQUBvURaWeQ?feature=oembed\" frameborder=\"0\" allow=\"accelerometer; autoplay; clipboard-write; encrypted-media; gyroscope; picture-in-picture; web-share\" referrerpolicy=\"strict-origin-when-cross-origin\" allowfullscreen><\/iframe><\/p>\n<div class=\"responsive-tabs\">\n<h2 class=\"tabtitle\">Projects<\/h2>\n<div class=\"tabcontent\">\n\n<p><b><span data-contrast=\"auto\">Deciphering the pathogenesis of small intestinal damage caused by nonsteroidal antiinflammatory drugs<\/span><\/b><span data-ccp-props=\"{&quot;201341983&quot;:0,&quot;335551550&quot;:6,&quot;335551620&quot;:6,&quot;335559731&quot;:284,&quot;335559739&quot;:160,&quot;335559740&quot;:259}\">\u00a0<\/span><\/p>\n<p><span data-contrast=\"auto\">Nonsteroidal anti-inflammatory drugs (NSAIDs) are among the most widely used drugs worldwide. Their mucosal damaging effect in the stomach and duodenum is well-recognized and can be effectively prevented and treated by antisecretory drugs. However, NSAIDs also injure the lower gastrointestinal tract, and the development and introduction of new diagnostic tools (e.g. video capsule endoscopy) have revealed that small intestinal ulcers are much more common and serious than previously recognized.<\/span><span data-ccp-props=\"{&quot;201341983&quot;:0,&quot;335551550&quot;:6,&quot;335551620&quot;:6,&quot;335559731&quot;:284,&quot;335559739&quot;:160,&quot;335559740&quot;:259}\">\u00a0<\/span><\/p>\n<p><span data-contrast=\"auto\">In the last two decades, much effort has been put into understanding the complex pathogenesis of NSAID enteropathy (Fig. 1), but it still remains insufficiently understood.<\/span><span data-ccp-props=\"{&quot;201341983&quot;:0,&quot;335551550&quot;:6,&quot;335551620&quot;:6,&quot;335559731&quot;:284,&quot;335559739&quot;:160,&quot;335559740&quot;:259}\">\u00a0<\/span><\/p>\n<p><span data-ccp-props=\"{&quot;201341983&quot;:0,&quot;335551550&quot;:6,&quot;335551620&quot;:6,&quot;335559731&quot;:284,&quot;335559739&quot;:160,&quot;335559740&quot;:259}\"> <img loading=\"lazy\" decoding=\"async\" class=\"alignnone  wp-image-13604\" src=\"https:\/\/semmelweis.hu\/pharmacology\/files\/2024\/05\/fig1-400x207.png\" alt=\"\" width=\"775\" height=\"401\" srcset=\"https:\/\/semmelweis.hu\/pharmacology\/files\/2024\/05\/fig1-400x207.png 400w, https:\/\/semmelweis.hu\/pharmacology\/files\/2024\/05\/fig1-1024x530.png 1024w, https:\/\/semmelweis.hu\/pharmacology\/files\/2024\/05\/fig1-768x398.png 768w, https:\/\/semmelweis.hu\/pharmacology\/files\/2024\/05\/fig1-753x390.png 753w, https:\/\/semmelweis.hu\/pharmacology\/files\/2024\/05\/fig1.png 1267w\" sizes=\"auto, (max-width: 775px) 100vw, 775px\" \/><\/span><\/p>\n<p><span data-contrast=\"auto\">Fig. 1. Some factors involved in the pathogenesis of NSAID enteropathy. (The figure contains artworks produced by Servier Medical Art (https:\/\/smart.servier.com\/).<\/span><span data-ccp-props=\"{&quot;201341983&quot;:0,&quot;335551550&quot;:6,&quot;335551620&quot;:6,&quot;335559731&quot;:284,&quot;335559739&quot;:160,&quot;335559740&quot;:259}\">\u00a0<\/span><\/p>\n<p><span data-contrast=\"auto\">Our studies aim to identify novel mechanisms and targets in a rat model of NSAID enteropathy, which could potentially be useful for the design of new therapeutic interventions. After treating the animals with different NSAIDs, <\/span><span data-contrast=\"auto\">they are euthanized and their small intestines are removed. The severity of mucosal injury is evaluated macroscopically, histologically, and by various molecular biological techniques (Western blot, ELISA, qPCR, enzyme activity assays, etc.) (Fig. 2).<\/span><span data-ccp-props=\"{&quot;201341983&quot;:0,&quot;335551550&quot;:6,&quot;335551620&quot;:6,&quot;335559731&quot;:284,&quot;335559739&quot;:160,&quot;335559740&quot;:259}\">\u00a0<\/span><\/p>\n<p><span data-ccp-props=\"{&quot;201341983&quot;:0,&quot;335551550&quot;:6,&quot;335551620&quot;:6,&quot;335559731&quot;:284,&quot;335559739&quot;:160,&quot;335559740&quot;:259}\"> <img loading=\"lazy\" decoding=\"async\" class=\"alignnone  wp-image-13603\" src=\"https:\/\/semmelweis.hu\/pharmacology\/files\/2024\/05\/fig2-400x152.png\" alt=\"\" width=\"721\" height=\"274\" srcset=\"https:\/\/semmelweis.hu\/pharmacology\/files\/2024\/05\/fig2-400x152.png 400w, https:\/\/semmelweis.hu\/pharmacology\/files\/2024\/05\/fig2-1024x388.png 1024w, https:\/\/semmelweis.hu\/pharmacology\/files\/2024\/05\/fig2-768x291.png 768w, https:\/\/semmelweis.hu\/pharmacology\/files\/2024\/05\/fig2-753x285.png 753w, https:\/\/semmelweis.hu\/pharmacology\/files\/2024\/05\/fig2.png 1280w\" sizes=\"auto, (max-width: 721px) 100vw, 721px\" \/><\/span><\/p>\n<p><span data-contrast=\"auto\">Fig. 2. Flow chart of experimental design. NSAID-induced mucosal damage is determined by measuring the tissue levels of pro- and anti-inflammatory cytokines, reactive oxygen species, tight junction proteins. (The figure contains artworks produced by Servier Medical Art (https:\/\/smart.servier.com\/).<\/span><span data-ccp-props=\"{&quot;201341983&quot;:0,&quot;335551550&quot;:6,&quot;335551620&quot;:6,&quot;335559731&quot;:284,&quot;335559739&quot;:160,&quot;335559740&quot;:259}\">\u00a0<\/span><\/p>\n<p><span data-contrast=\"auto\">Considering the pivotal role of enteric bacteria and bile acids in the pathogenesis of enteropathy, we also aim to determine the composition of intestinal microflora in NSAID-treated animals, as well as the concentrations of primary and secondary bile acids.<\/span><span data-ccp-props=\"{&quot;201341983&quot;:0,&quot;335551550&quot;:6,&quot;335551620&quot;:6,&quot;335559731&quot;:284,&quot;335559739&quot;:160,&quot;335559740&quot;:259}\">\u00a0<\/span><\/p>\n<p><span data-contrast=\"auto\">Acquirable skills: drug treatment of animals, macroscopic evaluation of enteropathy, histology, Western blot, ELISA, qPCR.<\/span><span data-ccp-props=\"{&quot;201341983&quot;:0,&quot;335551550&quot;:6,&quot;335551620&quot;:6,&quot;335559731&quot;:284,&quot;335559739&quot;:160,&quot;335559740&quot;:259}\">\u00a0<\/span><\/p>\n<p><span data-ccp-props=\"{&quot;201341983&quot;:0,&quot;335551550&quot;:6,&quot;335551620&quot;:6,&quot;335559731&quot;:284,&quot;335559739&quot;:160,&quot;335559740&quot;:259}\">\u00a0<\/span><\/p>\n<p><span data-contrast=\"auto\">Tutor: Dr. Zolt\u00e1n Z\u00e1dori, associate professor<\/span><span data-ccp-props=\"{&quot;201341983&quot;:0,&quot;335551550&quot;:6,&quot;335551620&quot;:6,&quot;335559731&quot;:284,&quot;335559739&quot;:160,&quot;335559740&quot;:259}\">\u00a0<\/span><\/p>\n<p><span data-ccp-props=\"{&quot;201341983&quot;:0,&quot;335551550&quot;:6,&quot;335551620&quot;:6,&quot;335559731&quot;:284,&quot;335559739&quot;:160,&quot;335559740&quot;:259}\">\u00a0<\/span><\/p>\n<p><span data-contrast=\"auto\">Our previous publications related to this project:<\/span><span data-ccp-props=\"{&quot;201341983&quot;:0,&quot;335551550&quot;:6,&quot;335551620&quot;:6,&quot;335559731&quot;:284,&quot;335559739&quot;:160,&quot;335559740&quot;:259}\">\u00a0<\/span><\/p>\n<ul>\n<li data-leveltext=\"\uf0b7\" data-font=\"Symbol\" data-listid=\"1\" data-list-defn-props=\"{&quot;335552541&quot;:1,&quot;335559685&quot;:1004,&quot;335559991&quot;:360,&quot;469769226&quot;:&quot;Symbol&quot;,&quot;469769242&quot;:[8226],&quot;469777803&quot;:&quot;left&quot;,&quot;469777804&quot;:&quot;\uf0b7&quot;,&quot;469777815&quot;:&quot;hybridMultilevel&quot;}\" data-aria-posinset=\"1\" data-aria-level=\"1\"><span data-contrast=\"auto\">Hutka B, V\u00e1rallyay A, L\u00e1szl\u00f3 SB, T\u00f3th AS, Scheich B, Paku S, V\u00f6r\u00f6s I, P\u00f3s Z, Varga ZV, Norman DD, Balogh A, Beny\u00f3 Z, Tigyi G, Gyires K, Z\u00e1dori ZS. A dual role of lysophosphatidic acid type 2 receptor (LPAR2) in nonsteroidal anti-inflammatory drug-induced mouse enteropathy. Acta Pharmacol Sin. 2024 45: 339-53.<\/span><span data-ccp-props=\"{&quot;201341983&quot;:0,&quot;335551550&quot;:6,&quot;335551620&quot;:6,&quot;335559739&quot;:160,&quot;335559740&quot;:259}\">\u00a0<\/span><\/li>\n<li data-leveltext=\"\uf0b7\" data-font=\"Symbol\" data-listid=\"1\" data-list-defn-props=\"{&quot;335552541&quot;:1,&quot;335559685&quot;:1004,&quot;335559991&quot;:360,&quot;469769226&quot;:&quot;Symbol&quot;,&quot;469769242&quot;:[8226],&quot;469777803&quot;:&quot;left&quot;,&quot;469777804&quot;:&quot;\uf0b7&quot;,&quot;469777815&quot;:&quot;hybridMultilevel&quot;}\" data-aria-posinset=\"2\" data-aria-level=\"1\"><span data-contrast=\"auto\">Z\u00e1dori ZS, Kir\u00e1ly K, Al-Khrasani M, Gyires K. Interactions between NSAIDs, opioids and the gut microbiota &#8211; Future perspectives in the management of inflammation and pain. Pharmacol Ther. 2023 241:108327.<\/span><span data-ccp-props=\"{&quot;201341983&quot;:0,&quot;335551550&quot;:6,&quot;335551620&quot;:6,&quot;335559739&quot;:160,&quot;335559740&quot;:259}\">\u00a0<\/span><\/li>\n<li data-leveltext=\"\uf0b7\" data-font=\"Symbol\" data-listid=\"1\" data-list-defn-props=\"{&quot;335552541&quot;:1,&quot;335559685&quot;:1004,&quot;335559991&quot;:360,&quot;469769226&quot;:&quot;Symbol&quot;,&quot;469769242&quot;:[8226],&quot;469777803&quot;:&quot;left&quot;,&quot;469777804&quot;:&quot;\uf0b7&quot;,&quot;469777815&quot;:&quot;hybridMultilevel&quot;}\" data-aria-posinset=\"3\" data-aria-level=\"1\"><span data-contrast=\"auto\">Hutka B, L\u00e1z\u00e1r B, T\u00f3th AS, \u00c1gg B, L\u00e1szl\u00f3 SB, Makra N, Ligeti B, Scheich B, Kir\u00e1ly K, Al-Khrasani M, Szab\u00f3 D, Ferdinandy P, Gyires K, Z\u00e1dori ZS. The Nonsteroidal Anti-Inflammatory Drug Ketorolac Alters the Small Intestinal Microbiota and Bile Acids Without Inducing Intestinal Damage or Delaying Peristalsis in the Rat.Front Pharmacol. 2021 12:664177.<\/span><span data-ccp-props=\"{&quot;201341983&quot;:0,&quot;335551550&quot;:6,&quot;335551620&quot;:6,&quot;335559739&quot;:160,&quot;335559740&quot;:259}\">\u00a0<\/span><\/li>\n<li data-leveltext=\"\uf0b7\" data-font=\"Symbol\" data-listid=\"1\" data-list-defn-props=\"{&quot;335552541&quot;:1,&quot;335559685&quot;:1004,&quot;335559991&quot;:360,&quot;469769226&quot;:&quot;Symbol&quot;,&quot;469769242&quot;:[8226],&quot;469777803&quot;:&quot;left&quot;,&quot;469777804&quot;:&quot;\uf0b7&quot;,&quot;469777815&quot;:&quot;hybridMultilevel&quot;}\" data-aria-posinset=\"4\" data-aria-level=\"1\"><span data-contrast=\"auto\">L\u00e1z\u00e1r B, L\u00e1szl\u00f3 SB, Hutka B, T\u00f3th AS, Mohammadzadeh A, Berekm\u00e9ri E, \u00c1gg B, Balogh M, Sajtos V, Kir\u00e1ly K, Al-Khrasani M, F\u00f6ldes A, Varga G, Makra N, Ostorh\u00e1zi E, Szab\u00f3 D, Ligeti B, Kem\u00e9ny \u00c1, Helyes Z, Ferdinandy P, Gyires K, Z\u00e1dori ZS. A comprehensive time course and correlation analysis of indomethacin-induced inflammation, bile acid alterations and dysbiosis in the rat small intestine.Biochem Pharmacol. 2021 190:114590.<\/span><span data-ccp-props=\"{&quot;201341983&quot;:0,&quot;335551550&quot;:6,&quot;335551620&quot;:6,&quot;335559739&quot;:160,&quot;335559740&quot;:259}\">\u00a0<\/span><\/li>\n<li data-leveltext=\"\uf0b7\" data-font=\"Symbol\" data-listid=\"1\" data-list-defn-props=\"{&quot;335552541&quot;:1,&quot;335559685&quot;:1004,&quot;335559991&quot;:360,&quot;469769226&quot;:&quot;Symbol&quot;,&quot;469769242&quot;:[8226],&quot;469777803&quot;:&quot;left&quot;,&quot;469777804&quot;:&quot;\uf0b7&quot;,&quot;469777815&quot;:&quot;hybridMultilevel&quot;}\" data-aria-posinset=\"5\" data-aria-level=\"1\"><span data-contrast=\"auto\">L\u00e1z\u00e1r B, Brenner GB, Makkos A, Balogh M, L\u00e1szl\u00f3 SB, Al-Khrasani M, Hutka B, Bat\u00f3 E, Ostorh\u00e1zi E, Juh\u00e1sz J, Kem\u00e9ny \u00c1, L\u00e1szl\u00f3 T, Tiszlavicz L, Bihari Z, Giricz Z, Szab\u00f3 D, Helyes Z, Ferdinandy P, Gyires K, Z\u00e1dori ZS. Lack of Small Intestinal Dysbiosis Following Long-Term Selective Inhibition of Cyclooxygenase-2 by Rofecoxib in the Rat. Cells. 2019 8(3):251.<\/span><span data-ccp-props=\"{&quot;201341983&quot;:0,&quot;335551550&quot;:6,&quot;335551620&quot;:6,&quot;335559739&quot;:160,&quot;335559740&quot;:259}\">\u00a0<\/span><\/li>\n<\/ul>\n\n<\/div><h2 class=\"tabtitle\">Members<\/h2>\n<div class=\"tabcontent\">\n\n<p><strong>Workgroup leader<\/strong>:<\/p>\n<p><a href=\"https:\/\/semmelweis.hu\/telefonkonyv\/?emp_id=2004\">Zolt\u00e1n Z\u00e1dori, MD, PhD<\/a><\/p>\n<p><strong>Professor emerita:<\/strong><\/p>\n<p><a href=\"https:\/\/semmelweis.hu\/telefonkonyv\/?emp_id=1936\">Kl\u00e1ra Gyires, MD, PhD, DSc<\/a><\/p>\n<p><strong>Researcher \/ postdoc:<\/strong><\/p>\n<p><a href=\"https:\/\/semmelweis.hu\/telefonkonyv\/?emp_id=21922\">Gerda Wachtl, MSc, PhD<\/a><\/p>\n<p><strong>PhD student:<\/strong><\/p>\n<p><a href=\"https:\/\/semmelweis.hu\/english\/phonebook\/?emp_id=22522\">Arezoo Haghighi, MSc<\/a><br \/>\nAnna Zsidai<br \/>\n<a href=\"https:\/\/semmelweis.hu\/telefonkonyv\/?emp_id=18879\">Zsuzsanna Orsolya Demeter, MSc<\/a><\/p>\n<p><strong>Assistant:<\/strong><\/p>\n<p><a href=\"https:\/\/semmelweis.hu\/telefonkonyv\/?emp_id=7743\">Veronika Pol-Maruzs, MSc<\/a><\/p>\n\n<\/div><h2 class=\"tabtitle\">Gallery<\/h2>\n<div class=\"tabcontent\">\n\n\r\n        [slb_exclude]\r\n        <div class=\"row galeria-wrapper mx-0 h-auto\">\r\n            <div class=\"col-9 pl-0 pr-2\">\r\n            <span class=\"gallery-item frame\">\r\n\t\t\t\t<div class=\"galeria-left-img\"><a href=\"https:\/\/semmelweis.hu\/pharmacology\/files\/2024\/08\/BAL8360-scaled.jpg\"><img src=https:\/\/semmelweis.hu\/pharmacology\/files\/2024\/08\/BAL8360-scaled.jpg  \r\n                            alt=\"\" \r\n                            class=\"attachment-sote-gallery-big size-sote-gallery-big\" \r\n                            srcset=\"https:\/\/semmelweis.hu\/pharmacology\/files\/2024\/08\/BAL8360-400x267.jpg 400w, https:\/\/semmelweis.hu\/pharmacology\/files\/2024\/08\/BAL8360-1024x683.jpg 1024w, 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d-md-flex\">\r\n\t\t\t\t\t<div class=\"galeria-small-img mt-0\"><a href=\"https:\/\/semmelweis.hu\/pharmacology\/files\/2024\/08\/BAL8218-scaled.jpg\"><img src=https:\/\/semmelweis.hu\/pharmacology\/files\/2024\/08\/BAL8218-scaled.jpg \r\n                                alt=\"\"  \r\n                                class=\"attachment-sote-gallery-small size-sote-gallery-small\" \r\n                                srcset=\"https:\/\/semmelweis.hu\/pharmacology\/files\/2024\/08\/BAL8218-400x267.jpg 400w, https:\/\/semmelweis.hu\/pharmacology\/files\/2024\/08\/BAL8218-1024x683.jpg 1024w, https:\/\/semmelweis.hu\/pharmacology\/files\/2024\/08\/BAL8218-768x512.jpg 768w, https:\/\/semmelweis.hu\/pharmacology\/files\/2024\/08\/BAL8218-1536x1024.jpg 1536w, https:\/\/semmelweis.hu\/pharmacology\/files\/2024\/08\/BAL8218-2048x1365.jpg 2048w, https:\/\/semmelweis.hu\/pharmacology\/files\/2024\/08\/BAL8218-753x502.jpg 753w, https:\/\/semmelweis.hu\/pharmacology\/files\/2024\/08\/BAL8218-203x135.jpg 203w\" ><\/a><\/div>\r\n                    <\/span>\r\n                    <span class=\"gallery-item frame d-none d-md-flex\">\r\n\t\t\t\t\t<div class=\"galeria-small-img mt-0\"><a href=\"https:\/\/semmelweis.hu\/pharmacology\/files\/2024\/08\/BAL8198-scaled.jpg\"><img src=https:\/\/semmelweis.hu\/pharmacology\/files\/2024\/08\/BAL8198-scaled.jpg \r\n                                alt=\"\" \r\n                                class=\"attachment-sote-gallery-small size-sote-gallery-small\" \r\n                                srcset=\"https:\/\/semmelweis.hu\/pharmacology\/files\/2024\/08\/BAL8198-400x267.jpg 400w, https:\/\/semmelweis.hu\/pharmacology\/files\/2024\/08\/BAL8198-1024x683.jpg 1024w, https:\/\/semmelweis.hu\/pharmacology\/files\/2024\/08\/BAL8198-768x512.jpg 768w, https:\/\/semmelweis.hu\/pharmacology\/files\/2024\/08\/BAL8198-1536x1024.jpg 1536w, https:\/\/semmelweis.hu\/pharmacology\/files\/2024\/08\/BAL8198-2048x1365.jpg 2048w, https:\/\/semmelweis.hu\/pharmacology\/files\/2024\/08\/BAL8198-753x502.jpg 753w, https:\/\/semmelweis.hu\/pharmacology\/files\/2024\/08\/BAL8198-203x135.jpg 203w\" ><\/a><\/div>\r\n                    <\/span>\r\n\r\n                <\/div>\r\n\r\n            <\/div>\r\n\r\n            <span class=\"gallery-item\"><div class=\"hidden\"><a href=\"https:\/\/semmelweis.hu\/pharmacology\/files\/2024\/08\/BAL8199-scaled.jpg\">\r\n        <img src=https:\/\/semmelweis.hu\/pharmacology\/files\/2024\/08\/BAL8199-scaled.jpg alt=\"\" class=\"attachment-sote-gallery-big size-sote-gallery-big\" srcset=\"https:\/\/semmelweis.hu\/pharmacology\/files\/2024\/08\/BAL8199-400x267.jpg 400w, https:\/\/semmelweis.hu\/pharmacology\/files\/2024\/08\/BAL8199-1024x683.jpg 1024w, https:\/\/semmelweis.hu\/pharmacology\/files\/2024\/08\/BAL8199-768x512.jpg 768w, https:\/\/semmelweis.hu\/pharmacology\/files\/2024\/08\/BAL8199-1536x1024.jpg 1536w, https:\/\/semmelweis.hu\/pharmacology\/files\/2024\/08\/BAL8199-2048x1365.jpg 2048w, https:\/\/semmelweis.hu\/pharmacology\/files\/2024\/08\/BAL8199-753x502.jpg 753w, https:\/\/semmelweis.hu\/pharmacology\/files\/2024\/08\/BAL8199-203x135.jpg 203w\" >\r\n        <\/a><\/div><\/span>\r\n            <\/div>\r\n\r\n            [\/slb_exclude]\r\n\t\n<\/div><\/div>\n","protected":false},"excerpt":{"rendered":"<p>Deciphering the pathogenesis of small intestinal damage caused by nonsteroidal antiinflammatory drugs\u00a0 Nonsteroidal anti-inflammatory drugs (NSAIDs) are among the most widely used drugs worldwide. Their mucosal damaging effect in the stomach and duodenum is well-recognized and can be effectively prevented and treated by antisecretory drugs. However, NSAIDs also injure the lower gastrointestinal tract, and the &hellip;<\/p>\n","protected":false},"author":102374,"featured_media":0,"parent":13559,"menu_order":1,"comment_status":"closed","ping_status":"closed","template":"","meta":{"_acf_changed":false,"footnotes":""},"categories":[],"tags":[],"class_list":["post-13607","page","type-page","status-publish","hentry"],"acf":[],"_links":{"self":[{"href":"https:\/\/semmelweis.hu\/pharmacology\/wp-json\/wp\/v2\/pages\/13607","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/semmelweis.hu\/pharmacology\/wp-json\/wp\/v2\/pages"}],"about":[{"href":"https:\/\/semmelweis.hu\/pharmacology\/wp-json\/wp\/v2\/types\/page"}],"author":[{"embeddable":true,"href":"https:\/\/semmelweis.hu\/pharmacology\/wp-json\/wp\/v2\/users\/102374"}],"replies":[{"embeddable":true,"href":"https:\/\/semmelweis.hu\/pharmacology\/wp-json\/wp\/v2\/comments?post=13607"}],"version-history":[{"count":10,"href":"https:\/\/semmelweis.hu\/pharmacology\/wp-json\/wp\/v2\/pages\/13607\/revisions"}],"predecessor-version":[{"id":14218,"href":"https:\/\/semmelweis.hu\/pharmacology\/wp-json\/wp\/v2\/pages\/13607\/revisions\/14218"}],"up":[{"embeddable":true,"href":"https:\/\/semmelweis.hu\/pharmacology\/wp-json\/wp\/v2\/pages\/13559"}],"wp:attachment":[{"href":"https:\/\/semmelweis.hu\/pharmacology\/wp-json\/wp\/v2\/media?parent=13607"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/semmelweis.hu\/pharmacology\/wp-json\/wp\/v2\/categories?post=13607"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/semmelweis.hu\/pharmacology\/wp-json\/wp\/v2\/tags?post=13607"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}