{"id":13556,"date":"2024-05-10T13:04:51","date_gmt":"2024-05-10T11:04:51","guid":{"rendered":"https:\/\/semmelweis.hu\/pharmacology\/?page_id=13556"},"modified":"2024-10-12T14:03:17","modified_gmt":"2024-10-12T12:03:17","slug":"gasztrointesztitalis-munkacsoport","status":"publish","type":"page","link":"https:\/\/semmelweis.hu\/pharmacology\/kutatas\/neurotranszlacios-es-neuromodulacios-kutatocsoport\/gasztrointesztitalis-munkacsoport\/","title":{"rendered":"Gasztrointesztin\u00e1lis farmakol\u00f3giai munkacsoport"},"content":{"rendered":"<p><iframe loading=\"lazy\" title=\"Gastrointestinal Research Group\" width=\"753\" height=\"424\" src=\"https:\/\/www.youtube.com\/embed\/AQUBvURaWeQ?feature=oembed\" frameborder=\"0\" allow=\"accelerometer; autoplay; clipboard-write; encrypted-media; gyroscope; picture-in-picture; web-share\" referrerpolicy=\"strict-origin-when-cross-origin\" allowfullscreen><\/iframe><\/p>\n<div class=\"responsive-tabs\">\n<h2 class=\"tabtitle\">Projektek<\/h2>\n<div class=\"tabcontent\">\n\n<p><strong>A nem-szteroid gyullad\u00e1sg\u00e1tl\u00f3k \u00e1ltal okozott v\u00e9konyb\u00e9lk\u00e1rosod\u00e1s pathomechanizmus\u00e1nak anal\u00edzise<\/strong><\/p>\n<p>A nem-szteroid gyullad\u00e1sg\u00e1tl\u00f3k (NSAID-ok), melyek ciklooxigen\u00e1z (COX) g\u00e1tl\u00f3 hat\u00e1suk r\u00e9v\u00e9n f\u00e1jdalom-, l\u00e1z- \u00e9s gyullad\u00e1scs\u00f6kkent\u0151 hat\u00e1s\u00faak, vil\u00e1gszerte a leggyakrabban alkalmazott gy\u00f3gyszerek k\u00f6z\u00e9 tartoznak. J\u00f3l ismert, hogy gyomor- \u00e9s nyomb\u00e9lfek\u00e9lyt okozhatnak, mely savszekr\u00e9ci\u00f3 g\u00e1tl\u00f3kkal m\u00e9rs\u00e9kelhet\u0151. Az NSAID-ok azonban a gasztrointesztin\u00e1lis rendszer diszt\u00e1lis r\u00e9szeit is k\u00e1ros\u00edtj\u00e1k, az \u00faj, modern diagnosztikai elj\u00e1r\u00e1sok (pl. vide\u00f3 kapszula endoszk\u00f3pia) elterjed\u00e9s\u00e9vel pedig kider\u00fclt, hogy a v\u00e9konyb\u00e9lk\u00e1rosod\u00e1s (enterop\u00e1tia) j\u00f3val gyakoribb \u00e9s s\u00falyosabb, mint azt kor\u00e1bban gondolt\u00e1k.<\/p>\n<p>Az elm\u00falt k\u00e9t \u00e9vtizedben t\u00f6rt\u00e9nt er\u0151fesz\u00edt\u00e9sek ellen\u00e9re az NSAID enterop\u00e1tia komplex pathomechanizmusa egyel\u0151re csak r\u00e9szben felt\u00e1rt (1. \u00e1bra).<\/p>\n<p><img loading=\"lazy\" decoding=\"async\" class=\"alignnone  wp-image-13604\" src=\"https:\/\/semmelweis.hu\/pharmacology\/files\/2024\/05\/fig1-400x207.png\" alt=\"\" width=\"895\" height=\"463\" srcset=\"https:\/\/semmelweis.hu\/pharmacology\/files\/2024\/05\/fig1-400x207.png 400w, https:\/\/semmelweis.hu\/pharmacology\/files\/2024\/05\/fig1-1024x530.png 1024w, https:\/\/semmelweis.hu\/pharmacology\/files\/2024\/05\/fig1-768x398.png 768w, https:\/\/semmelweis.hu\/pharmacology\/files\/2024\/05\/fig1-753x390.png 753w, https:\/\/semmelweis.hu\/pharmacology\/files\/2024\/05\/fig1.png 1267w\" sizes=\"auto, (max-width: 895px) 100vw, 895px\" \/><\/p>\n<p>1. \u00e1bra. Az NSAID enterop\u00e1tia pathomechanizmus\u00e1ban szerepet j\u00e1tsz\u00f3 legismertebb faktorok. (Az \u00e1bra egyes elemeinek forr\u00e1sa: Servier Medical Art (https:\/\/smart.servier.com\/)<\/p>\n<p>Kutat\u00e1sunk c\u00e9lja az NSAID-ok \u00e1ltal okozott b\u00e9lk\u00e1rosod\u00e1sban szerepet j\u00e1tsz\u00f3 \u00faj mechanizmusok \u00e9s ter\u00e1pi\u00e1s c\u00e9lpontok azonos\u00edt\u00e1sa, mely seg\u00edts\u00e9g\u00e9vel a j\u00f6v\u0151ben \u00faj kezel\u00e9si lehet\u0151s\u00e9gek kifejleszt\u00e9s\u00e9re ny\u00edlhat lehet\u0151s\u00e9g. A k\u00eds\u00e9rletekhez sz\u00e9les k\u00f6rben alkalmazott \u00e1llatk\u00eds\u00e9rletes modellt alkalmazunk; patk\u00e1nyokat \u00e9s egereket kezel\u00fcnk k\u00fcl\u00f6nb\u00f6z\u0151 NSAID-okkal, majd a kialakult gasztrointesztin\u00e1lis k\u00e1rosod\u00e1st makroszk\u00f3posan, hisztol\u00f3giai m\u00f3dszerrel, illetve k\u00f6l\u00f6nb\u00f6z\u0151 molekul\u00e1ris biol\u00f3giai m\u00f3dszerekkel vizsg\u00e1ljuk (pl. Western blot, ELISA, qPCR, enzimaktivit\u00e1s m\u00e9r\u00e9sek) (2. \u00e1bra).<\/p>\n<p><img loading=\"lazy\" decoding=\"async\" class=\"alignnone  wp-image-13603\" src=\"https:\/\/semmelweis.hu\/pharmacology\/files\/2024\/05\/fig2-400x152.png\" alt=\"\" width=\"884\" height=\"336\" srcset=\"https:\/\/semmelweis.hu\/pharmacology\/files\/2024\/05\/fig2-400x152.png 400w, https:\/\/semmelweis.hu\/pharmacology\/files\/2024\/05\/fig2-1024x388.png 1024w, https:\/\/semmelweis.hu\/pharmacology\/files\/2024\/05\/fig2-768x291.png 768w, https:\/\/semmelweis.hu\/pharmacology\/files\/2024\/05\/fig2-753x285.png 753w, https:\/\/semmelweis.hu\/pharmacology\/files\/2024\/05\/fig2.png 1280w\" sizes=\"auto, (max-width: 884px) 100vw, 884px\" \/>\u00a0<\/p>\n<p>2. \u00e1bra. K\u00eds\u00e9rleteink folyamat\u00e1br\u00e1ja. Az NSAID-ok \u00e1ltal okozott gasztrointesztin\u00e1lis k\u00e1rosod\u00e1s meghat\u00e1roz\u00e1s\u00e1hoz t\u00f6bbek k\u00f6z\u00f6tt pro- \u00e9s anti-inflammatorikus citokinek, szabadgy\u00f6k\u00f6k, tight junction feh\u00e9rj\u00e9k sz\u00f6veti szintj\u00e9t m\u00e9rj\u00fck k\u00fcl\u00f6nb\u00f6z\u0151 m\u00f3dszerekkel. (Az \u00e1bra egyes elemeinek forr\u00e1sa: Servier Medical Art (https:\/\/smart.servier.com\/)<\/p>\n<p>Mivel a b\u00e9lbakt\u00e9riumok \u00e9s epesavak kiemelten fontos szerepet j\u00e1tszanak a b\u00e9lk\u00e1rosod\u00e1s kialakul\u00e1s\u00e1ban, kutat\u00e1sunk sor\u00e1n az NSAID-okkal kezelt \u00e1llatok b\u00e9lfl\u00f3r\u00e1j\u00e1nak \u00f6sszet\u00e9tel\u00e9t, valamint a primer \u00e9s szekunder epesavak mennyis\u00e9g\u00e9t is vizsg\u00e1ljuk.<\/p>\n<p>Elsaj\u00e1t\u00edthat\u00f3 k\u00e9pess\u00e9gek: k\u00eds\u00e9rleti \u00e1llatok kezel\u00e9se, az enterop\u00e1tia s\u00falyoss\u00e1g\u00e1nak makroszk\u00f3pos ki\u00e9rt\u00e9kel\u00e9se, hisztol\u00f3gia, Western blot, ELISA, qPCR<\/p>\n<p>&nbsp;<\/p>\n<p>T\u00e9macsoport vezet\u0151: Dr. Z\u00e1dori Zolt\u00e1n, egyetemi docens<\/p>\n<p>&nbsp;<\/p>\n<p>A t\u00e9m\u00e1ban kor\u00e1bban megjelent cikkeink:<\/p>\n<ul>\n<li>Hutka B, V\u00e1rallyay A, L\u00e1szl\u00f3 SB, T\u00f3th AS, Scheich B, Paku S, V\u00f6r\u00f6s I, P\u00f3s Z, Varga ZV, Norman DD, Balogh A, Beny\u00f3 Z, Tigyi G, Gyires K, Z\u00e1dori ZS. A dual role of lysophosphatidic acid type 2 receptor (LPAR2) in nonsteroidal anti-inflammatory drug-induced mouse enteropathy. Acta Pharmacol Sin. 2024 45: 339-53.<\/li>\n<li>Z\u00e1dori ZS, Kir\u00e1ly K, Al-Khrasani M, Gyires K. Interactions between NSAIDs, opioids and the gut microbiota &#8211; Future perspectives in the management of inflammation and pain. Pharmacol Ther. 2023 241:108327.<\/li>\n<li>Hutka B, L\u00e1z\u00e1r B, T\u00f3th AS, \u00c1gg B, L\u00e1szl\u00f3 SB, Makra N, Ligeti B, Scheich B, Kir\u00e1ly K, Al-Khrasani M, Szab\u00f3 D, Ferdinandy P, Gyires K, Z\u00e1dori ZS. The Nonsteroidal Anti-Inflammatory Drug Ketorolac Alters the Small Intestinal Microbiota and Bile Acids Without Inducing Intestinal Damage or Delaying Peristalsis in the Rat. Front Pharmacol. 2021 12:664177.<\/li>\n<li>L\u00e1z\u00e1r B, L\u00e1szl\u00f3 SB, Hutka B, T\u00f3th AS, Mohammadzadeh A, Berekm\u00e9ri E, \u00c1gg B, Balogh M, Sajtos V, Kir\u00e1ly K, Al-Khrasani M, F\u00f6ldes A, Varga G, Makra N, Ostorh\u00e1zi E, Szab\u00f3 D, Ligeti B, Kem\u00e9ny \u00c1, Helyes Z, Ferdinandy P, Gyires K, Z\u00e1dori ZS. A comprehensive time course and correlation analysis of indomethacin-induced inflammation, bile acid alterations and dysbiosis in the rat small intestine. Biochem Pharmacol. 2021 190:114590.<\/li>\n<li>L\u00e1z\u00e1r B, Brenner GB, Makkos A, Balogh M, L\u00e1szl\u00f3 SB, Al-Khrasani M, Hutka B, Bat\u00f3 E, Ostorh\u00e1zi E, Juh\u00e1sz J, Kem\u00e9ny \u00c1, L\u00e1szl\u00f3 T, Tiszlavicz L, Bihari Z, Giricz Z, Szab\u00f3 D, Helyes Z, Ferdinandy P, Gyires K, Z\u00e1dori ZS. Lack of Small Intestinal Dysbiosis Following Long-Term Selective Inhibition of Cyclooxygenase-2 by Rofecoxib in the Rat. Cells. 2019 8(3):251.<\/li>\n<\/ul>\n\n<\/div><h2 class=\"tabtitle\">Tagok<\/h2>\n<div class=\"tabcontent\">\n\n<p><strong>Munkacsoport vezet\u0151<\/strong>:<\/p>\n<p><a href=\"https:\/\/semmelweis.hu\/telefonkonyv\/?emp_id=2004\">Dr. Z\u00e1dori Zolt\u00e1n, PhD<\/a><\/p>\n<p><strong>Professor emerita:<\/strong><\/p>\n<p><a href=\"https:\/\/semmelweis.hu\/telefonkonyv\/?emp_id=1936\">Prof. Dr. Gyires Kl\u00e1ra, PhD<\/a><\/p>\n<p><strong>Kutat\u00f3k \/ posztdoktorok<\/strong>:<\/p>\n<p><a href=\"https:\/\/semmelweis.hu\/telefonkonyv\/?emp_id=21922\">Dr. Wachtl Gerda, PhD<\/a><\/p>\n<p><strong>PhD hallgat\u00f3k<\/strong>:<\/p>\n<p><a href=\"https:\/\/semmelweis.hu\/telefonkonyv\/?emp_id=22522\">Haghighi Arezoo<\/a><br \/>\nZsidai Anna<br \/>\n<a href=\"https:\/\/semmelweis.hu\/telefonkonyv\/?emp_id=18879\">Demeter Zsuzsanna Orsolya<\/a><\/p>\n<p><strong>Asszisztensek<\/strong>:<\/p>\n<p><a href=\"https:\/\/semmelweis.hu\/telefonkonyv\/?emp_id=7743\">Pol-Maruzs Veronika<\/a><\/p>\n\n<\/div><h2 class=\"tabtitle\">K\u00e9pek<\/h2>\n<div class=\"tabcontent\">\n\n\r\n        [slb_exclude]\r\n        <div class=\"row galeria-wrapper mx-0 h-auto\">\r\n            <div class=\"col-9 pl-0 pr-2\">\r\n            <span class=\"gallery-item frame\">\r\n\t\t\t\t<div class=\"galeria-left-img\"><a href=\"https:\/\/semmelweis.hu\/pharmacology\/files\/2024\/08\/BAL8360-scaled.jpg\"><img src=https:\/\/semmelweis.hu\/pharmacology\/files\/2024\/08\/BAL8360-scaled.jpg  \r\n                            alt=\"\" \r\n                            class=\"attachment-sote-gallery-big size-sote-gallery-big\" \r\n                            srcset=\"https:\/\/semmelweis.hu\/pharmacology\/files\/2024\/08\/BAL8360-400x267.jpg 400w, https:\/\/semmelweis.hu\/pharmacology\/files\/2024\/08\/BAL8360-1024x683.jpg 1024w, https:\/\/semmelweis.hu\/pharmacology\/files\/2024\/08\/BAL8360-768x512.jpg 768w, https:\/\/semmelweis.hu\/pharmacology\/files\/2024\/08\/BAL8360-1536x1024.jpg 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      <\/a><\/div><\/span>\r\n            <\/div>\r\n\r\n            [\/slb_exclude]\r\n\t\n<\/div><\/div>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>A nem-szteroid gyullad\u00e1sg\u00e1tl\u00f3k \u00e1ltal okozott v\u00e9konyb\u00e9lk\u00e1rosod\u00e1s pathomechanizmus\u00e1nak anal\u00edzise A nem-szteroid gyullad\u00e1sg\u00e1tl\u00f3k (NSAID-ok), melyek ciklooxigen\u00e1z (COX) g\u00e1tl\u00f3 hat\u00e1suk r\u00e9v\u00e9n f\u00e1jdalom-, l\u00e1z- \u00e9s gyullad\u00e1scs\u00f6kkent\u0151 hat\u00e1s\u00faak, vil\u00e1gszerte a leggyakrabban alkalmazott gy\u00f3gyszerek k\u00f6z\u00e9 tartoznak. J\u00f3l ismert, hogy gyomor- \u00e9s nyomb\u00e9lfek\u00e9lyt okozhatnak, mely savszekr\u00e9ci\u00f3 g\u00e1tl\u00f3kkal m\u00e9rs\u00e9kelhet\u0151. Az NSAID-ok azonban a gasztrointesztin\u00e1lis rendszer diszt\u00e1lis r\u00e9szeit is k\u00e1ros\u00edtj\u00e1k, az \u00faj, modern diagnosztikai &hellip;<\/p>\n","protected":false},"author":102374,"featured_media":0,"parent":13542,"menu_order":1,"comment_status":"closed","ping_status":"closed","template":"","meta":{"_acf_changed":false,"footnotes":""},"categories":[],"tags":[],"class_list":["post-13556","page","type-page","status-publish","hentry"],"acf":[],"_links":{"self":[{"href":"https:\/\/semmelweis.hu\/pharmacology\/wp-json\/wp\/v2\/pages\/13556","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/semmelweis.hu\/pharmacology\/wp-json\/wp\/v2\/pages"}],"about":[{"href":"https:\/\/semmelweis.hu\/pharmacology\/wp-json\/wp\/v2\/types\/page"}],"author":[{"embeddable":true,"href":"https:\/\/semmelweis.hu\/pharmacology\/wp-json\/wp\/v2\/users\/102374"}],"replies":[{"embeddable":true,"href":"https:\/\/semmelweis.hu\/pharmacology\/wp-json\/wp\/v2\/comments?post=13556"}],"version-history":[{"count":9,"href":"https:\/\/semmelweis.hu\/pharmacology\/wp-json\/wp\/v2\/pages\/13556\/revisions"}],"predecessor-version":[{"id":14210,"href":"https:\/\/semmelweis.hu\/pharmacology\/wp-json\/wp\/v2\/pages\/13556\/revisions\/14210"}],"up":[{"embeddable":true,"href":"https:\/\/semmelweis.hu\/pharmacology\/wp-json\/wp\/v2\/pages\/13542"}],"wp:attachment":[{"href":"https:\/\/semmelweis.hu\/pharmacology\/wp-json\/wp\/v2\/media?parent=13556"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/semmelweis.hu\/pharmacology\/wp-json\/wp\/v2\/categories?post=13556"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/semmelweis.hu\/pharmacology\/wp-json\/wp\/v2\/tags?post=13556"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}