{"id":13538,"date":"2024-05-10T11:42:29","date_gmt":"2024-05-10T09:42:29","guid":{"rendered":"https:\/\/semmelweis.hu\/pharmacology\/?page_id=13538"},"modified":"2024-11-11T09:43:25","modified_gmt":"2024-11-11T08:43:25","slug":"onkofarmakologiai-kutatocsoport","status":"publish","type":"page","link":"https:\/\/semmelweis.hu\/pharmacology\/kutatas\/onkofarmakologiai-kutatocsoport\/","title":{"rendered":"Onkofarmakol\u00f3giai kutat\u00f3csoport"},"content":{"rendered":"<div class=\"responsive-tabs\">\n<h2 class=\"tabtitle\">Projektek<\/h2>\n<div class=\"tabcontent\">\n\n<p style=\"text-align: center\"><strong>Prec\u00edzi\u00f3s onkol\u00f3giai sejtkult\u00fara vizsg\u00e1latok<\/strong><\/p>\n<p style=\"text-align: justify\">Vil\u00e1gszerte n\u00f6vekszik a r\u00e1kos betegek sz\u00e1ma (Thun, DeLancey, Center, Jemal, &amp; Ward, 2010), ezen bel\u00fcl is az eml\u0151r\u00e1k az egyik leggyakrabban diagnosztiz\u00e1lt daganatos megbeteged\u00e9s, \u00e9vente 2,3 milli\u00f3 \u00fajonnan felismert esettel (Sung et al., 2021). A daganatok genetikailag heterog\u00e9n betegs\u00e9gek, mely a g\u00e9nv\u00e1ltoz\u00e1sok nagyfok\u00fa variabilit\u00e1s\u00e1val jellemezhet\u0151k (Testa, Castelli, &amp; Pelosi, 2020). Azonos\u00edthat\u00f3k ugyanakkor a c\u00e9lzott ter\u00e1pi\u00e1t lehet\u0151v\u00e9 tev\u0151 \u00fagynevezett \u201edriver\u201d g\u00e9nek, melyek kiemelt fontoss\u00e1g\u00faak a betegs\u00e9g kialakul\u00e1s\u00e1ban, illetve a ter\u00e1pia megtervez\u00e9s\u00e9ben (Shin, Bode, &amp; Dong, 2017). Az elm\u00falt \u00e9vtizedekben nagysz\u00e1m\u00fa, \u00faj c\u00e9lzott ter\u00e1pi\u00e1s- egy adott g\u00e9n elv\u00e1ltoz\u00e1s eset\u00e9n hat\u00e9kony &#8211; gy\u00f3gyszer ker\u00fclt enged\u00e9lyez\u00e9sre (Bashraheel, Domling, &amp; Goda, 2020). Ugyanakkor az adott beteg sz\u00e1m\u00e1ra legmegfelel\u0151bb ter\u00e1pia kiv\u00e1laszt\u00e1sa tov\u00e1bbra is neh\u00e9z feladat. Erre keres\u00fcnk megold\u00e1sokat munk\u00e1nk sor\u00e1n.<\/p>\n<p><strong>1.1: Prec\u00edzi\u00f3s onkol\u00f3giai ter\u00e1pia javasl\u00f3 algoritmus fejleszt\u00e9se \u00e9s k\u00eds\u00e9rletes valid\u00e1ci\u00f3ja<\/strong><\/p>\n<p><strong>Projekt felel\u0151s\u00f6k: <\/strong>Dr. Pet\u00e1k Istv\u00e1n, Dr. Makkos Andr\u00e1s, Somogyi Orsolya, Tak\u00e1cs \u00c1kos<\/p>\n<table>\n<tbody>\n<tr>\n<td><img loading=\"lazy\" decoding=\"async\" class=\"aligncenter wp-image-13826\" src=\"https:\/\/semmelweis.hu\/pharmacology\/files\/2024\/07\/PetakIstvan.jpg\" alt=\"\" width=\"143\" height=\"190\" \/><\/td>\n<td><img loading=\"lazy\" decoding=\"async\" class=\"aligncenter wp-image-12855\" src=\"https:\/\/semmelweis.hu\/pharmacology\/files\/2023\/11\/7-1.png\" alt=\"\" width=\"126\" height=\"190\" \/><\/td>\n<td><img loading=\"lazy\" decoding=\"async\" class=\"aligncenter size-full wp-image-13824\" src=\"https:\/\/semmelweis.hu\/pharmacology\/files\/2024\/07\/SomogyiOrsolya.png\" alt=\"\" width=\"122\" height=\"190\" \/><\/td>\n<td><img loading=\"lazy\" decoding=\"async\" class=\"aligncenter wp-image-13825\" src=\"https:\/\/semmelweis.hu\/pharmacology\/files\/2024\/07\/TakacsAkos.jpg\" alt=\"\" width=\"157\" height=\"190\" \/><\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n<p><strong>Tanul\u00e1si lehet\u0151s\u00e9gek:<\/strong><\/p>\n<ul>\n<li>Sejtkult\u00fara metodik\u00e1k, technik\u00e1k (sejtek fenntart\u00e1sa, teny\u00e9szt\u00e9se)<\/li>\n<li>Akt\u00edv labor munka, k\u00eds\u00e9rletek megtervez\u00e9s\u00e9t\u0151l a v\u00e9grehajt\u00e1sig<\/li>\n<li>F\u00e9nymikroszk\u00f3pos megfigyel\u00e9s \u00e9s k\u00e9pk\u00e9sz\u00edt\u00e9s<\/li>\n<li>Fluoreszcens \u00e9s lumineszcens vizsg\u00e1lati technik\u00e1k<\/li>\n<li>K\u00eds\u00e9rletek ki\u00e9rt\u00e9kel\u00e9se, statisztikai programok alkalmaz\u00e1sa<\/li>\n<li>\u00c1brak\u00e9sz\u00edt\u00e9s, eredm\u00e9nyek tudom\u00e1nyos bemutat\u00e1sa<\/li>\n<li>Prezent\u00e1ci\u00f3 k\u00e9sz\u00edt\u00e9s \u00e9s az eredm\u00e9nyek TDK konferenci\u00e1n t\u00f6rt\u00e9n\u0151 bemutat\u00e1sa<\/li>\n<\/ul>\n<p style=\"text-align: justify\"><strong>Projekt le\u00edr\u00e1sa: <\/strong>A daganatok egy\u00e9ni genetikai profil elemz\u00e9s\u00e9vel meg lehet hat\u00e1rozni azokat a g\u00e9nhib\u00e1kat vagy genetikai v\u00e1ltoz\u00e1sokat, amelyek hozz\u00e1j\u00e1rulhatnak a daganat kialakul\u00e1s\u00e1hoz vagy n\u00f6veked\u00e9s\u00e9hez. A molekul\u00e1ris diagnosztika \u00e9s az onkol\u00f3giai szoftverek kombin\u00e1l\u00e1s\u00e1val lehet\u0151s\u00e9g van meghat\u00e1rozni a daganat ter\u00e1pia lehets\u00e9ges molekul\u00e1ris c\u00e9lpontj\u00e1t \u00e9s \u00edgy kiv\u00e1lasztani a legmegfelel\u0151bb, c\u00e9lzott ter\u00e1pi\u00e1s kezel\u00e9st, amely c\u00e9lzottan hat az adott beteg adott daganat\u00e1ra.<\/p>\n<p><img loading=\"lazy\" decoding=\"async\" class=\"aligncenter size-full wp-image-13830\" src=\"https:\/\/semmelweis.hu\/pharmacology\/files\/2024\/07\/onc_1.png\" alt=\"\" width=\"826\" height=\"408\" srcset=\"https:\/\/semmelweis.hu\/pharmacology\/files\/2024\/07\/onc_1.png 826w, https:\/\/semmelweis.hu\/pharmacology\/files\/2024\/07\/onc_1-400x198.png 400w, https:\/\/semmelweis.hu\/pharmacology\/files\/2024\/07\/onc_1-768x379.png 768w, https:\/\/semmelweis.hu\/pharmacology\/files\/2024\/07\/onc_1-753x372.png 753w\" sizes=\"auto, (max-width: 826px) 100vw, 826px\" \/><\/p>\n<p style=\"text-align: justify\">A project\u00fcnk c\u00e9lja az Oncompass Ltd-vel egy\u00fcttm\u0171k\u00f6d\u00e9sben egy ilyen prec\u00edzi\u00f3s onkol\u00f3giai ter\u00e1pia v\u00e1laszt\u00e1st el\u0151seg\u00edt\u0151 szoftver k\u00eds\u00e9rletes valid\u00e1l\u00e1sa ismert g\u00e9nmut\u00e1ci\u00f3kat hordoz\u00f3 sejtvonalakon.<\/p>\n<p><img loading=\"lazy\" decoding=\"async\" class=\"aligncenter size-full wp-image-13846\" src=\"https:\/\/semmelweis.hu\/pharmacology\/files\/2024\/07\/onc_hun_extra_1.png\" alt=\"\" width=\"591\" height=\"167\" srcset=\"https:\/\/semmelweis.hu\/pharmacology\/files\/2024\/07\/onc_hun_extra_1.png 591w, https:\/\/semmelweis.hu\/pharmacology\/files\/2024\/07\/onc_hun_extra_1-400x113.png 400w\" sizes=\"auto, (max-width: 591px) 100vw, 591px\" \/><\/p>\n<p><img loading=\"lazy\" decoding=\"async\" class=\"aligncenter size-full wp-image-13845\" src=\"https:\/\/semmelweis.hu\/pharmacology\/files\/2024\/07\/onc_hun_extra_2.png\" alt=\"\" width=\"883\" height=\"207\" srcset=\"https:\/\/semmelweis.hu\/pharmacology\/files\/2024\/07\/onc_hun_extra_2.png 883w, https:\/\/semmelweis.hu\/pharmacology\/files\/2024\/07\/onc_hun_extra_2-400x94.png 400w, https:\/\/semmelweis.hu\/pharmacology\/files\/2024\/07\/onc_hun_extra_2-768x180.png 768w, https:\/\/semmelweis.hu\/pharmacology\/files\/2024\/07\/onc_hun_extra_2-753x177.png 753w\" sizes=\"auto, (max-width: 883px) 100vw, 883px\" \/><\/p>\n<p><strong>1.2. A CDK12 overexpresszi\u00f3 jelent\u0151s\u00e9ge a eml\u0151 tumorok PARP g\u00e1tl\u00f3 szerekkel szembeni rezisztenci\u00e1j\u00e1ban<\/strong><\/p>\n<p><strong>Projekt felel\u0151s\u00f6k:<\/strong> Somogyi Orsolya, dr. Makkos Andr\u00e1s<\/p>\n<p style=\"text-align: justify\"><strong>Projekt le\u00edr\u00e1sa: <\/strong>A tumorok kialakul\u00e1s\u00e1ban szerepet j\u00e1tszanak a DNS instabilit\u00e1sa. A DNS-k\u00e1rosod\u00e1sa homol\u00f3g rekombin\u00e1ci\u00f3s mechanizmusok r\u00e9v\u00e9n is jav\u00edthat\u00f3. A poli (ADP-rib\u00f3z) polimer\u00e1zok (PARP-ok) \u00e9s BRCA1\/2 g\u00e9nek a homol\u00f3g rekombin\u00e1ci\u00f3s jav\u00edt\u00e1si \u00fatvonalak kulcsfontoss\u00e1g\u00fa elemei. Ez k\u00e9pezi a BRCA-mut\u00e1ns eml\u0151r\u00e1kban szenved\u0151 betegek PARP-inhibitorokkal t\u00f6rt\u00e9n\u0151 ter\u00e1pi\u00e1j\u00e1nak az alapj\u00e1t. Azonban a tumorok egy r\u00e9sz rezisztens a PARP-inhibitorokkal szemben. A CDK12 g\u00e9nexpresszi\u00f3 szerepet j\u00e1tszhat a PARP-inhibitorokkal szembeni rezisztenci\u00e1ban.<\/p>\n<p><img loading=\"lazy\" decoding=\"async\" class=\"aligncenter wp-image-13829 size-large\" src=\"https:\/\/semmelweis.hu\/pharmacology\/files\/2024\/07\/onc_2-1024x608.png\" alt=\"\" width=\"753\" height=\"447\" srcset=\"https:\/\/semmelweis.hu\/pharmacology\/files\/2024\/07\/onc_2-1024x608.png 1024w, https:\/\/semmelweis.hu\/pharmacology\/files\/2024\/07\/onc_2-400x238.png 400w, https:\/\/semmelweis.hu\/pharmacology\/files\/2024\/07\/onc_2-768x456.png 768w, https:\/\/semmelweis.hu\/pharmacology\/files\/2024\/07\/onc_2-753x447.png 753w, https:\/\/semmelweis.hu\/pharmacology\/files\/2024\/07\/onc_2.png 1199w\" sizes=\"auto, (max-width: 753px) 100vw, 753px\" \/><\/p>\n<p style=\"text-align: justify\">Ebben a tanulm\u00e1nyunkban c\u00e9lul t\u0171zt\u00fck ki a CDK12 overexpresszi\u00f3 szerep\u00e9nek vizsg\u00e1lat\u00e1t a PARP inhibitor rezisztencia kialakul\u00e1s\u00e1ban. Jelen kutat\u00e1sunk sor\u00e1n szeretn\u00e9nk megvizsg\u00e1lni eml\u0151r\u00e1k sejtvonalak CDK12 g\u00e9n k\u00f3piasz\u00e1m\u00e1t \u00e9s kifejez\u0151d\u00e9s\u00e9t, tov\u00e1bb\u00e1 CDK12 inhibitorok hat\u00e1s\u00e1t a PARP-inhibitor rezisztenci\u00e1ra.<\/p>\n<p style=\"text-align: center\">Genom instabilit\u00e1s mut\u00e1ci\u00f3s r\u00e1ta<\/p>\n<p><img loading=\"lazy\" decoding=\"async\" class=\"wp-image-13836 size-full\" src=\"https:\/\/semmelweis.hu\/pharmacology\/files\/2024\/07\/onc_3.jpeg\" alt=\"\" width=\"840\" height=\"244\" srcset=\"https:\/\/semmelweis.hu\/pharmacology\/files\/2024\/07\/onc_3.jpeg 840w, https:\/\/semmelweis.hu\/pharmacology\/files\/2024\/07\/onc_3-400x116.jpeg 400w, https:\/\/semmelweis.hu\/pharmacology\/files\/2024\/07\/onc_3-768x223.jpeg 768w, https:\/\/semmelweis.hu\/pharmacology\/files\/2024\/07\/onc_3-753x219.jpeg 753w\" sizes=\"auto, (max-width: 840px) 100vw, 840px\" \/><\/p>\n<p style=\"text-align: center\">A genetikai instabilit\u00e1s az egys\u00e9gnyi id\u0151 alatt bek\u00f6vetkez\u0151 mut\u00e1ci\u00f3k sz\u00e1m\u00e1val ar\u00e1nyos.<\/p>\n\n<\/div><h2 class=\"tabtitle\">Tagok<\/h2>\n<div class=\"tabcontent\">\n\n<p><strong>Munkacsoport vezet\u0151<\/strong>:<\/p>\n<p>Dr. Pet\u00e1k Istv\u00e1n, PhD<\/p>\n<p><strong>PhD hallgat\u00f3k<\/strong>:<\/p>\n<p><a href=\"https:\/\/semmelweis.hu\/telefonkonyv\/?emp_id=11976\">Dr. Makkos Andr\u00e1s<\/a>, PhD<br \/>\n<a href=\"https:\/\/semmelweis.hu\/telefonkonyv\/?emp_id=21659\">Somogyi Orsolya<\/a><br \/>\n<a href=\"https:\/\/semmelweis.hu\/telefonkonyv\/?emp_id=18877\">Tak\u00e1cs \u00c1kos<\/a><\/p>\n<\/div><\/div>\n","protected":false},"excerpt":{"rendered":"<p>Prec\u00edzi\u00f3s onkol\u00f3giai sejtkult\u00fara vizsg\u00e1latok Vil\u00e1gszerte n\u00f6vekszik a r\u00e1kos betegek sz\u00e1ma (Thun, DeLancey, Center, Jemal, &amp; Ward, 2010), ezen bel\u00fcl is az eml\u0151r\u00e1k az egyik leggyakrabban diagnosztiz\u00e1lt daganatos megbeteged\u00e9s, \u00e9vente 2,3 milli\u00f3 \u00fajonnan felismert esettel (Sung et al., 2021). A daganatok genetikailag heterog\u00e9n betegs\u00e9gek, mely a g\u00e9nv\u00e1ltoz\u00e1sok nagyfok\u00fa variabilit\u00e1s\u00e1val jellemezhet\u0151k (Testa, Castelli, &amp; Pelosi, 2020). Azonos\u00edthat\u00f3k &hellip;<\/p>\n","protected":false},"author":102374,"featured_media":0,"parent":14,"menu_order":3,"comment_status":"closed","ping_status":"closed","template":"","meta":{"_acf_changed":false,"footnotes":""},"categories":[],"tags":[],"class_list":["post-13538","page","type-page","status-publish","hentry"],"acf":[],"_links":{"self":[{"href":"https:\/\/semmelweis.hu\/pharmacology\/wp-json\/wp\/v2\/pages\/13538","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/semmelweis.hu\/pharmacology\/wp-json\/wp\/v2\/pages"}],"about":[{"href":"https:\/\/semmelweis.hu\/pharmacology\/wp-json\/wp\/v2\/types\/page"}],"author":[{"embeddable":true,"href":"https:\/\/semmelweis.hu\/pharmacology\/wp-json\/wp\/v2\/users\/102374"}],"replies":[{"embeddable":true,"href":"https:\/\/semmelweis.hu\/pharmacology\/wp-json\/wp\/v2\/comments?post=13538"}],"version-history":[{"count":11,"href":"https:\/\/semmelweis.hu\/pharmacology\/wp-json\/wp\/v2\/pages\/13538\/revisions"}],"predecessor-version":[{"id":14432,"href":"https:\/\/semmelweis.hu\/pharmacology\/wp-json\/wp\/v2\/pages\/13538\/revisions\/14432"}],"up":[{"embeddable":true,"href":"https:\/\/semmelweis.hu\/pharmacology\/wp-json\/wp\/v2\/pages\/14"}],"wp:attachment":[{"href":"https:\/\/semmelweis.hu\/pharmacology\/wp-json\/wp\/v2\/media?parent=13538"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/semmelweis.hu\/pharmacology\/wp-json\/wp\/v2\/categories?post=13538"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/semmelweis.hu\/pharmacology\/wp-json\/wp\/v2\/tags?post=13538"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}