{"id":2848,"date":"2017-02-02T12:59:55","date_gmt":"2017-02-02T11:59:55","guid":{"rendered":"http:\/\/semmelweis.hu\/patologia1\/?page_id=2848"},"modified":"2025-12-16T07:12:05","modified_gmt":"2025-12-16T06:12:05","slug":"neuropatologia-munkacsoport","status":"publish","type":"page","link":"https:\/\/semmelweis.hu\/patologia1\/kutatas\/neuropatologia-munkacsoport\/","title":{"rendered":"Neuropatol\u00f3gia munkacsoport"},"content":{"rendered":"<p><strong>F\u0151bb kutat\u00e1si ter\u00fcleteink:<\/strong><\/p>\n<p><strong>I.<\/strong>\u00a0<strong>Meningeom\u00e1k komplex kliniko-patol\u00f3giai \u00e9s molekul\u00e1ris anal\u00edzise, \u00faj prognosztikus biomarkerek \u00e9s ter\u00e1pi\u00e1s c\u00e9lpontok azonos\u00edt\u00e1sa \u00e9s k\u00eds\u00e9rletes valid\u00e1l\u00e1sa c\u00e9lj\u00e1b\u00f3l<\/strong><\/p>\n<p>Kutat\u00f3csoportunk a leggyakoribb primer k\u00f6zponti idegrendszeri tumorok, a meningeom\u00e1k komplex kliniko-patol\u00f3giai \u00e9s molekul\u00e1ris jellemz\u00e9s\u00e9vel foglalkozik. C\u00e9lunk els\u0151sorban \u00faj prognosztikus biomarkerek \u00e9s ter\u00e1pi\u00e1s c\u00e9lpontok azonos\u00edt\u00e1sa, valamint ezek valid\u00e1l\u00e1sa in vitro \u00e9s in vivo k\u00eds\u00e9rletes k\u00f6r\u00fclm\u00e9nyek k\u00f6z\u00f6tt. Jelenlegi kutat\u00e1saink az epigenetikai szab\u00e1lyoz\u00f3 EZH2 molekula \u00e9s a metabolikus plaszticit\u00e1s szerep\u00e9re koncentr\u00e1lnak els\u0151sorban.<\/p>\n<p><strong>T\u00e9mavezet\u0151:<\/strong> Dr. Scheich B\u00e1lint<\/p>\n<p><strong>Akt\u00edv p\u00e1ly\u00e1zat:<\/strong> NKFIH-PD-146549<\/p>\n<p><strong>Publik\u00e1ci\u00f3k:<\/strong><\/p>\n<ul>\n<li>Sz\u0151ke P, Sztankovics D, Dank\u00f3 T, Mohammed AA, V\u00e1ncza L, Papp G, M\u00e1rk \u00c1, B\u00f6d\u00f6r C, Sebesty\u00e9n A, Dezs\u0151 K, Scheich B. EZH2 overexpression is associated with aggressive behavior and promotes cell proliferation in CNS WHO grade 3 meningiomas. Neurooncol Adv. 2025 Jun 5;7(1):vdaf112. doi: 10.1093\/noajnl\/vdaf112. PMID: 40718644; PMCID: PMC12290454.<\/li>\n<li>Bedics G, Sz\u0151ke P, B\u00e1tai B, Nagy T, Papp G, Kr\u00e1nitz N, Rajnai H, Reiniger L, B\u00f6d\u00f6r C, Scheich B. Novel, clinically relevant genomic patterns identified by comprehensive genomic profiling in ATRX-deficient IDH-wildtype adult high-grade gliomas. Sci Rep. 2023 Oct 27;13(1):18436. doi: 10.1038\/s41598-023-45786-w. PMID: 37891325; PMCID: PMC10611758.<\/li>\n<li>Bedics G, Cs\u00f3ka M, Reiniger L, Varga E, Liptai Z, Papp G, Bek\u0151 A, Cervi C, B\u00f6d\u00f6r C, Scheich B. Novel actionable ROS1::GIT2 fusion in non-Langerhans cell histiocytosis with central nervous system involvement. Acta Neuropathol. 2023 Jan;145(1):153-156. doi: 10.1007\/s00401-022-02520-6. Epub 2022 Nov 23. PMID: 36416966; PMCID: PMC9807475.<\/li>\n<li>Bedics G, Kotmayer L, Zajta E, Hegyi LL, Br\u00fcckner E\u00c1, Rajnai H, Reiniger L, B\u00f6d\u00f6r C, Garami M, Scheich B. Germline MUTYH mutations and high-grade gliomas: Novel evidence for a potential association. Genes Chromosomes Cancer. 2022 Oct;61(10):622-628. doi: 10.1002\/gcc.23054. Epub 2022 May 21. PMID: 35545820; PMCID: PMC9541377.<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<p><strong>II. Hum\u00e1n agyi \u00e1tt\u00e9tek mikrok\u00f6rnyezet\u00e9nek vizsg\u00e1lata<\/strong><\/p>\n<p>Az intracranialis tumorok t\u00f6bb mint fel\u00e9t a solid daganatok agyi metaszt\u00e1zisai adj\u00e1k, melyek megjelen\u00e9se a betegs\u00e9g kedvez\u0151tlen progn\u00f3zis\u00e1val t\u00e1rsul. A tumorok mikrok\u00f6rnyezet\u00e9nek vizsg\u00e1lata, k\u00f6zt\u00fck a jelen l\u00e9v\u0151 immunsejtek, immunter\u00e1pi\u00e1s c\u00e9lpontok, feh\u00e9rjeexpresszi\u00f3-elt\u00e9r\u00e9sek azonos\u00edt\u00e1sa seg\u00edtheti esetleges \u00faj ter\u00e1pi\u00e1s strat\u00e9gia meghat\u00e1roz\u00e1s\u00e1t a k\u00f6zponti idegrendszeri metaszt\u00e1zissal rendelkez\u0151 betegek eset\u00e9ben. Vizsg\u00e1latainkat els\u0151sorban t\u00fcd\u0151- \u00e9s vesetumoros betegek agyi \u00e1tt\u00e9ti mint\u00e1in v\u00e9gezz\u00fck.<\/p>\n<p><strong>T\u00e1mavezet\u0151: <\/strong>Dr. T\u00e9gl\u00e1si Vanda<\/p>\n<p><strong>Publik\u00e1ci\u00f3k:<\/strong><\/p>\n<ul>\n<li>T\u00e9gl\u00e1si V,\u00a0Pipek O, L\u00f3zsa R, Berta K, Sz\u00fcts D, Hark\u00f3 T, Vad\u00e1sz P, Rojk\u00f3 L, D\u00f6me B, Bag\u00f3 AG, T\u00edm\u00e1r J, Moldvay J, Sz\u00e1ll\u00e1si Z,\u00a0Reiniger L: PD-L1 Expression of Lung Cancer Cells, Unlike Infiltrating Immune Cells, Is Stable and Unaffected by Therapy During Brain Metastasis. Clin Lung Cancer. 2019 Sep;20(5):363-369.e2. doi: 10.1016\/j.cllc.2019.05.008.<\/li>\n<li>Reiniger L, T\u00e9gl\u00e1si V, Pipek O, Rojk\u00f3 L, Glasz T, V\u00e1gv\u00f6lgyi A, Kovalszky I, Gyulai M, Lohinai Z, R\u00e1s\u00f3 E, T\u00edm\u00e1r J, D\u00f6me B, Sz\u00e1ll\u00e1si Z, Moldvay J. Tumor necrosis correlates with PD-L1 and PD-1 expression in lung adenocarcinoma. Acta Oncol. 2019 Aug;58(8):1087-1094. doi: 10.1080\/0284186X.2019.1598575.<\/li>\n<li>Rojk\u00f3 L, Reiniger L, T\u00e9gl\u00e1si V, F\u00e1bi\u00e1n K, Pipek O, V\u00e1gv\u00f6lgyi A, Ag\u00f3cs L, Fillinger J, Kajd\u00e1csi Z, T\u00edm\u00e1r J, D\u00f6me B, Sz\u00e1ll\u00e1si Z, Moldvay J: Chemotherapy treatment is associated with altered PD-L1 expression in lung cancer patients. J Cancer Res Clin Oncol. 2018 Jul;144(7):1219-1226. doi: 10.1007\/s00432-018-2642-4.<\/li>\n<li>T\u00e9gl\u00e1si V, Reiniger L,\u00a0F\u00e1bi\u00e1n K, Pipek O, Csala I, Bag\u00f3 AG, V\u00e1rallyai P, V\u00edzkeleti L, Rojk\u00f3 L, T\u00edm\u00e1r J, D\u00f6me B, Sz\u00e1ll\u00e1si Z, Swanton C, Moldvay J.: Evaluating the significance of density, localization and PD-1\/PD-L1 immunopositivity of mononuclear cells in the clinical course of lung adenocarcinoma patients with brain metastasis. Neuro Oncol. 2017 Aug 1;19(8):1058-1067. doi: 10.1093\/neuonc\/now309.<\/li>\n<\/ul>\n<p><strong>Hazai \u00e9s nemzetk\u00f6zi kollabor\u00e1ci\u00f3k:<\/strong><\/p>\n<p>Dr. Reiniger Lilla, University Hospital Muenster, N\u00e9metorsz\u00e1g<\/p>\n<p>Dr. Moldvay Judit, Orsz\u00e1gos Kor\u00e1nyi Pulmonol\u00f3giai Int\u00e9zet \u00e9s Szegedi Tudom\u00e1nyegyetem<\/p>\n<p>Dr. Sz\u00e1ll\u00e1si Zolt\u00e1n, Harvard University, Boston, USA<\/p>\n<p>Prof. Charles Swanton, UCL, London \u00e9s Francis Crick Institute, London, UK<\/p>\n<p>Dr. Bag\u00f3 Attila, Idegseb\u00e9szeti \u00e9s Neurointervenci\u00f3s Klinika, Semmelweis Egyetem<\/p>\n","protected":false},"excerpt":{"rendered":"<p>F\u0151bb kutat\u00e1si ter\u00fcleteink: I.\u00a0Meningeom\u00e1k komplex kliniko-patol\u00f3giai \u00e9s molekul\u00e1ris anal\u00edzise, \u00faj prognosztikus biomarkerek \u00e9s ter\u00e1pi\u00e1s c\u00e9lpontok azonos\u00edt\u00e1sa \u00e9s k\u00eds\u00e9rletes valid\u00e1l\u00e1sa c\u00e9lj\u00e1b\u00f3l Kutat\u00f3csoportunk a leggyakoribb primer k\u00f6zponti idegrendszeri tumorok, a meningeom\u00e1k komplex kliniko-patol\u00f3giai \u00e9s molekul\u00e1ris jellemz\u00e9s\u00e9vel foglalkozik. C\u00e9lunk els\u0151sorban \u00faj prognosztikus biomarkerek \u00e9s ter\u00e1pi\u00e1s c\u00e9lpontok azonos\u00edt\u00e1sa, valamint ezek valid\u00e1l\u00e1sa in vitro \u00e9s in vivo k\u00eds\u00e9rletes k\u00f6r\u00fclm\u00e9nyek k\u00f6z\u00f6tt. &hellip;<\/p>\n","protected":false},"author":101021,"featured_media":0,"parent":42,"menu_order":0,"comment_status":"closed","ping_status":"closed","template":"","meta":{"_acf_changed":false,"footnotes":""},"categories":[],"tags":[],"class_list":["post-2848","page","type-page","status-publish","hentry"],"acf":[],"_links":{"self":[{"href":"https:\/\/semmelweis.hu\/patologia1\/wp-json\/wp\/v2\/pages\/2848","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/semmelweis.hu\/patologia1\/wp-json\/wp\/v2\/pages"}],"about":[{"href":"https:\/\/semmelweis.hu\/patologia1\/wp-json\/wp\/v2\/types\/page"}],"author":[{"embeddable":true,"href":"https:\/\/semmelweis.hu\/patologia1\/wp-json\/wp\/v2\/users\/101021"}],"replies":[{"embeddable":true,"href":"https:\/\/semmelweis.hu\/patologia1\/wp-json\/wp\/v2\/comments?post=2848"}],"version-history":[{"count":10,"href":"https:\/\/semmelweis.hu\/patologia1\/wp-json\/wp\/v2\/pages\/2848\/revisions"}],"predecessor-version":[{"id":8896,"href":"https:\/\/semmelweis.hu\/patologia1\/wp-json\/wp\/v2\/pages\/2848\/revisions\/8896"}],"up":[{"embeddable":true,"href":"https:\/\/semmelweis.hu\/patologia1\/wp-json\/wp\/v2\/pages\/42"}],"wp:attachment":[{"href":"https:\/\/semmelweis.hu\/patologia1\/wp-json\/wp\/v2\/media?parent=2848"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/semmelweis.hu\/patologia1\/wp-json\/wp\/v2\/categories?post=2848"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/semmelweis.hu\/patologia1\/wp-json\/wp\/v2\/tags?post=2848"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}