The main research area of our working group is the investigation of various forms of liver regeneration in rat models and the interpretation of the obtained results in the context of human liver diseases.<\/p>\n
Main results of our group:<\/strong><\/p>\n We used fluorescent immunohistochemistry to study liver regeneration and characterize the small bile ductules that serve as a source of somatic stem cells in healthy human and rat livers. We studied in detail the development of the lobular structure of the rat liver during liver regeneration from hepatocytes and stem cells. Our results showed that during regeneration either from hepatocytes or stem cells, liver mass was restored exclusively through the enlargement of the preexisting lobules. In our current experiments we are investigating whether altered liver structure resulting from regeneration has any functional consequences. Preliminary results suggest that the regenerated livers may be more susceptible to damage.<\/p>\n We have also successfully distinguished two forms of regeneration in human liver samples after massive hepatic necrosis. Restoration of liver mass is achieved either by AFP-positive acinary- arranged hepatocytes or by regenerative foci derived from stem cells. Regenerative foci are formed around the terminal branches of the portal vein, highlighting the unquestionable role of the portal vein in coordinating the regenerative process.<\/p>\n \u00a0Liver cirrhosis can also be understood as a prolonged regenerative process. We hypothesise that disrupting the connection between bile ductules \u2014 which behave like stem cells \u2014 and the parenchyma may lead to ‘irregular’ regeneration. In clinical practice, this results in a condition known as advanced or irreversible phase of liver cirrhosis.<\/p>\n \u00a0<\/p>\n Publications:<\/strong><\/p>\n Dezs\u0151 K, Paku S, Juh\u00e1sz MM, K\u00f3bori L, Nagy P. Evolutionary view of liver pathology. Evolutionary applications 2024:17:e70059<\/p>\n Dezs\u0151 K, Paku S, K\u00f3bori L, Thorgeirsson SS, Nagy P What makes cirrhosis irreversible?- Consideration on structural changes. Frontiers in Medicine 9,876293, 2022<\/p>\n Dezs\u0151 K, Nagy P, Paku S Human liver regeneration following massive hepatic necrosis: Two distinct patterns. Journal Gastroenterol hepatol 35:124-134, 2019<\/p>\n Dezs\u0151 K, R\u00f3kusz A, Bugyik E, Sz\u00fccs A, Szu\u00e1k A, Dorogi B, Kiss M, Nemesk\u00e9ri \u00c1, Nagy P, Paku S. Human liver regeneration in advanced cirrhosis is organized by the portal tree. J Hepatol. 2017 66:778-786]<\/p>\n Papp V, R\u00f3kusz A, Dezs\u0151 K, Bugyik E, Szab\u00f3 V, P\u00e1vai Z, Paku S, Nagy P. Expansion of hepatic stem cell compartment boosts liver regeneration. Stem Cells Dev, 23:56-65, 2014.<\/p>\n Dezs\u0151 K, Papp V, Bugyik E, Hegyesi H, S\u00e1fr\u00e1ny G, B\u00f6d\u00f6r C, Nagy P, Paku S. Structural analysis of oval cell mediated liver regeneration in rats. Hepatology. 56:1457-67, 2012.<\/p>\n \u00a0<\/p>\n The research group:<\/strong><\/p>\n P\u00e9ter Nagy, professor Collaborators:<\/strong><\/p>\n Ezio Laconi \u2013 Universit\u00e0 degli studi di Cagliari, Sardinia<\/p>\n Melinda Rezeli – Lund University<\/p>\n Julio Diaz-Perez \u2013 Virginia Commonwealth University<\/p>\n Bal\u00e1zs D\u00f6me \u2013 Medical University of Vienna<\/p>\n Emilio Casanova \u2013 Medical University of Vienna<\/p>\n","protected":false},"excerpt":{"rendered":" (Katalni Dezs\u0151, MD) Research area: The main research area of our working group is the investigation of various forms of liver regeneration in rat models and the interpretation of the obtained results in the context of human liver diseases. Main results of our group: We used fluorescent immunohistochemistry to study liver regeneration and characterize the …<\/p>\n","protected":false},"author":101021,"featured_media":0,"parent":228,"menu_order":0,"comment_status":"open","ping_status":"open","template":"","meta":{"_acf_changed":false,"footnotes":""},"categories":[],"tags":[],"class_list":["post-2736","page","type-page","status-publish","hentry"],"acf":[],"_links":{"self":[{"href":"https:\/\/semmelweis.hu\/patologia1\/wp-json\/wp\/v2\/pages\/2736","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/semmelweis.hu\/patologia1\/wp-json\/wp\/v2\/pages"}],"about":[{"href":"https:\/\/semmelweis.hu\/patologia1\/wp-json\/wp\/v2\/types\/page"}],"author":[{"embeddable":true,"href":"https:\/\/semmelweis.hu\/patologia1\/wp-json\/wp\/v2\/users\/101021"}],"replies":[{"embeddable":true,"href":"https:\/\/semmelweis.hu\/patologia1\/wp-json\/wp\/v2\/comments?post=2736"}],"version-history":[{"count":7,"href":"https:\/\/semmelweis.hu\/patologia1\/wp-json\/wp\/v2\/pages\/2736\/revisions"}],"predecessor-version":[{"id":8874,"href":"https:\/\/semmelweis.hu\/patologia1\/wp-json\/wp\/v2\/pages\/2736\/revisions\/8874"}],"up":[{"embeddable":true,"href":"https:\/\/semmelweis.hu\/patologia1\/wp-json\/wp\/v2\/pages\/228"}],"wp:attachment":[{"href":"https:\/\/semmelweis.hu\/patologia1\/wp-json\/wp\/v2\/media?parent=2736"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/semmelweis.hu\/patologia1\/wp-json\/wp\/v2\/categories?post=2736"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/semmelweis.hu\/patologia1\/wp-json\/wp\/v2\/tags?post=2736"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}![\"\"](\"https:\/\/semmelweis.hu\/patologia1\/files\/2025\/12\/maj-400x341.jpg\")
<\/p>\n
\nS\u00e1ndor Paku, senior research fellow
\nKatalin Dezs\u0151, senior lecturer
\nL\u00f3r\u00e1nd V\u00e1ncza, resident
\nM\u00e1ria Manuela Juh\u00e1sz, PhD student
\nM\u00e1t\u00e9 Man\u00f3 Hunyadi, scientific student worker<\/p>\n